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| Not yet recruiting | 3 | 582 | | | Eisai Ltd, Pharmaceutical Research Associate Ltd. | Newly diagnosed partial epilepsy | | | | |
ACTRN12608000096358: A double blind, randomised, placebo-controlled, mulitcentre study to assess the efficacy and safety of adjunctive zonisamide in primary generalised tonic clonic seizures. |
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| Terminated | 3 | 154 | | | Eisia G.C.D., Eisai Ltd., Eisai Global Clinical Development, Eisia Ltd. | epilepsy | | | | |
ACTRN12608000516381: Open label extension study following a double-blind, randomized, placebo-controlled, multicenter study to assess the efficacy and safety of adjunctive zonisamide in primary generalized tonic-clonic seizures. |
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| Terminated | 3 | 154 | | | Eisai Ltd, Eisai Ltd | Epilepsy | | | | |
NCT00056576: Dose Response Study of Zonegran in Patients With Newly Diagnosed Epilepsy |
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| Completed | 3 | 165 | US, Europe, RoW | Zonisamide | Eisai Inc. | Epilepsy, Complex Partial | 10/04 | 10/04 | | |
| Completed | 3 | 240 | RoW | Zonisamide, Zonegran, Placebo | Eisai Inc. | Partial Seizures | 05/08 | 05/08 | | |
NCT00401973: Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine |
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| Completed | 3 | 199 | US, RoW | olanzapine, LY170053, Zyprexa, amantadine, metformin, zonisamide, Wellness education | Eli Lilly and Company | Schizophrenia, Schizoaffective Disorders | 09/08 | 09/08 | | |
| Terminated | 3 | 10 | Europe, RoW | Zonisamide, Zonegran, Placebo | Eisai Limited, Eisai Ltd | Epilepsy | 11/08 | | | |
| Terminated | 3 | 21 | Europe, RoW | Zonisamide, Zonegran, Placebo | Eisai Limited | Epilepsy | 11/08 | 01/09 | | |
NCT00221442: Zonegran in the Treatment of Binge Eating Disorder Associated With Obesity |
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| Completed | 3 | 60 | US | Zonegran, sugar pill | Lindner Center of HOPE, Eisai Inc., University of Cincinnati | Binge Eating Disorder Associated With Obesity | 03/09 | 03/09 | | |
NCT00292461 / 2016-004954-13: A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures |
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| Completed | 3 | 64 | RoW | Zonisamide, Lamotrigine | Eisai Inc. | Epilepsy | 08/09 | 09/09 | | |
NCT00477295 / 2006-000156-40: A Double-blind Study to Compare the Efficacy and Safety of Zonisamide and Carbamazepine as Monotherapy, in Newly Diagnosed Partial Epilepsy |
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| Completed | 3 | 583 | Europe, RoW | Zonisamide, Zonegran, Carbamazepine | Eisai Inc. | Epilepsy | 12/10 | 01/11 | | |
NCT00363376: A Study of Zonisamide to Prevent Olanzapine-Associated Weight Gain |
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| Completed | 3 | 42 | US | zonisamide, Zonegran, olanzapine, Zyprexa, Zydis, Zonisamide, Sugar Pill (placebo) | Lindner Center of HOPE, Eli Lilly and Company, University of Cincinnati | Weight Gain | 02/11 | 02/11 | | |
| Completed | 3 | 207 | Europe, RoW | Zonisamide, Zonegran, Placebo | Eisai Inc. | Epilepsy; Paediatric Partial Onset Seizures | 03/11 | 03/11 | | |
NCT00848549 / 2008-001159-23: Assessing The Long-Term Safety And To Explore The Long-Term Efficacy Of Zonisamide As Monotherapy In Newly Diagnosed Partial Seizures |
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| Completed | 3 | 295 | Europe, RoW | Zonisamide, Zonegran, Carbamazepine | Eisai Inc. | Epilepsy | 06/11 | 11/11 | | |
| Completed | 3 | 144 | Europe | Zonisamide, Zonegran | Eisai Limited | Partial Seizures | 01/12 | 03/12 | | |
| Completed | 3 | 24 | Europe | zonegran, placebo | Assistance Publique - Hôpitaux de Paris | Myoclonus Dystonia | 07/14 | 07/14 | | |
2007-006696-36: Open label Extension Study Following Double-blind, Randomized, Placebo-controlled, Multicentre Study to Assess Efficacy and Safety of Adjunctive Zonisamide in Myoclonic Seizures associated with Idiopathic Generalized Epilepsy |
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| | 3 | 43 | Europe | Zonisamide 25mg, Zonisamide 50mg, Zonisamide 100mg, E2090, Zonegran, Zonisamide 50mg, Zonegran, Zonisamide 50mg | Eisai Limited | myoclonic seizures in idiopathic generalised epilepsy (IGE). | | | | |
2007-006695-10: Open Label Extension Study Following Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess Efficacy and Safety of Adjunctive Zonisamide in Primary Generalized Tonic-Clonic Seizures |
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| | 3 | 52 | Europe | Zonisamide 25mg, Zonisamide 50mg, Zonisamide 100mg, E2090, Zonegran, Zonegran | Eisai Limited | Primary generalised tonic-clonic seizures (PGTCS) in idiopathic generalised epilepsy (IGE) | | | | |
NCT02368431: Effectiveness of Zonisamide in Alcohol Dependent Veterans |
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| Terminated | 3 | 92 | US | Zonisamide, Zonegran, Placebo | VA Office of Research and Development | Alcohol Use Disorder | 10/18 | 10/18 | | |
Z-Comp, NCT02900352: Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action |
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| Completed | 3 | 156 | US | Zonisamide, Brand name: Zonegran, Placebo | Virginia Commonwealth University, University of Connecticut, Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA), VA Connecticut Healthcare System | Alcohol Use Disorder | 04/21 | 04/21 | | |
| Completed | 3 | 26 | US | Zonisamide, zonegran, Bupropion, wellbutrin, Zyban, Halo G6 e-cigarette, e-cigarette | Rose Research Center, LLC, Foundation for a Smoke-Free World | Smoking Cessation | 06/21 | 09/21 | | |
NCT02901041: Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism |
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| Completed | 3 | 81 | US | Zonisamide, Zonegran, Take Control, Placebo (for Zonisamide) | Boston University Charles River Campus, Mclean Hospital, University of Houston | Alcohol Dependence | 01/22 | 01/22 | | |
NCT05205811: The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette |
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| Recruiting | 3 | 180 | US | Bupropion, Wellbutrin, Zyban, Zonisamide, zonegran, Placebo bupropion, Placebo zonisamide, E-cigarette, JUUL | Rose Research Center, LLC, Foundation for a Smoke Free World INC | Smoking Cessation | 02/24 | 06/24 | | |
| Recruiting | 3 | 600 | RoW | Zonisamide 50 MG, group A, Propranolol, group B | Kafrelsheikh University | Migraine | 03/25 | 04/25 | | |
| Recruiting | 3 | 600 | RoW | Zonisamide 50 MG, group A, Topiramate 50 MG, group B | Kafrelsheikh University | Migraine | 04/25 | 05/25 | | |
| Withdrawn | 2/3 | 0 | NA | Zonisamide, Placebo | Mazandaran University of Medical Sciences | Parkinson Disease | 02/13 | 02/13 | | |
