Leukemia  >>  hydrocortisone  >>  Phase 1
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15 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
hydrocortisone / Generic mfg.
NCT00928200: Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)

Terminated
1
1
US
Erwinase, Asparaginase, Elspar, Kidrolase, L-Asparaginase, Erwinia L-Asparaginase, Vincristine, Oncovin, Vincasar Pfs, Vincristine Sulfate, LCR, VCR, Dexamethasone, Decadron, Dexasone, Diodex, Hexadrol, Maxidex, Dexamethasone sodium phosphate, Dexamethasone acetate, Doxorubicin, Adriamycin, Rubex, Cytarabine, Cytosar-U, Ara-C, Arabinosylcytosine, Methotrexate, Otrexup, Rasuvo, Rheumatrex, Trexall, Amethopterin, Methotrexate Sodium, MTX, Triple Intrathecal Therapy, Dexrazoxane, Zinecard
Therapeutic Advances in Childhood Leukemia Consortium
Relapsed Acute Lymphoblastic Leukemia, Allergy to PEG e.Coli Asparaginase, Allergy to Native e.Coli Asparaginase
06/10
06/10
NCT00957320: Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL)

Withdrawn
1
0
US
Sirolimus, PEG-asparaginase
Emory University
Acute Lymphoblastic Leukemia
08/12
08/12
NCT01861002: A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML

Completed
1
15
Canada, US, RoW
Azacytidine, 5 Azacytidine, Vidaza, Fludarabine, fludarabine phosphate, Fludara, 2-fluoro-ara-AMP, Oforta, Cytarabine, Cytosar-U, Ara-C, Arabinosylcytosine, cytosine arabinoside, Intrathecal (IT) Cytarabine, (See Cytarabine), Intrathecal Methotrexate (IT MTX), Otrexup, Rasuvo, Rheumatrex, Trexall, Amethopterin, Methotrexate Sodium
Therapeutic Advances in Childhood Leukemia Consortium, Gateway for Cancer Research
Lymphoblastic Leukemia, Acute, Childhood, Myelogenous Leukemia, Acute, Childhood
07/14
07/14
NCT01887587: Vincristine, Doxorubicin, And Dexamethasone + Ixazomib in Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma Or Mixed Phenotype Acute Leukemia

Terminated
1
5
US
MLN9708, Ixazomib, Vincristine, Oncovin, Doxorubicin, Doxil, hydroxydaunorubicin, Dexamethasone, Decadron, Dexasone, Solurex, Baycadron
Ehab L Atallah
Relapsed or Refractory Acute Lymphoblastic Leukemia, Relapsed or Refractory Lymphoblastic Lymphoma, Mixed Phenotype Acute Leukemia
02/16
02/16
NCT02270788: Crenolanib in Combination With Sorafenib in Patients With Refractory or Relapsed Hematologic Malignancies

Completed
1
10
US
Crenolanib, CP-868,596, IND 112201, Sorafenib, Sorafenib tosylate, BAY-43-9006, Nexavar®, methotrexate, hydrocortisone and cytarabine with leucovorin, Triple IT chemotherapy
St. Jude Children's Research Hospital, Arog Pharmaceuticals, Inc., Ohio State University
Acute Myeloid Leukemia
10/16
10/16
NCT01187810: Fenretinide in Children With Recurrent/Resistant ALL, AML, and NHL

Terminated
1
3
US
Fenretinide, N-(4-hydroxyphenyl) retinamide, 4-HPR, Cytarabine, Ara-C, Cytosine Arabinoside, Cytosar, Methotrexate, MTX, Amethopterin
South Plains Oncology Consortium
Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma
04/18
04/18
NCT02676323: Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Terminated
1
19
US
Panobinostat, LBH589, Fludarabine, Fludara®, Fludarabine phosphate, 2-fluoro-ara-AMP, Cytarabine, Cytosine arabinoside, Ara-C, Cytosar®, Intrathecal Triples, ITMHA, methotrexate/hydrocortisone/cytarabine, Leucovorin, Leucovorin calcium, Leucovorin rescue
St. Jude Children's Research Hospital
Acute Myeloid Leukemia, Myelodysplastic Syndrome
04/18
04/18
RELPALL, NCT03515200: Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia

Terminated
1
12
US
Palbociclib Oral Capsule, Ibrance®, Intrathecal Triple Therapy, ITMHA, methotrexate/hydrocortisone/cytarabine, Dexamethasone, Decadron, Bortezomib, Velcade®, Dasatinib, Sprycel®, Doxorubicin, Adriamycin®, Ruxolitinib, Jakafi®
St. Jude Children's Research Hospital, Pfizer
Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia With Failed Remission
07/20
07/20
NCT03194932: Study of Venetoclax in Combination With Chemotherapy in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Leukemia of Ambiguous Lineage

Completed
1
62
US
Venetoclax, Venclextra®, ABT-199, Cytarabine, Cytosine arabinoside, Ara-C, Cytosar®, Idarubicin, Idamycin PFS, Intrathecal Triple Therapy, ITMHA, methotrexate/hydrocortisone/cytarabine, Azacitidine, VIDAZA®
St. Jude Children's Research Hospital, Gateway for Cancer Research
Acute Myeloid Leukemia
10/20
06/22
NCT03792256: Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)

Active, not recruiting
1
15
US
Palbociclib, Cytarabine, Methotrexate, Hydrocortisone, Doxorubicin, Prednisolone, Vincristine, Pegaspargase, Prednisone
Children's Oncology Group
Leukemia, Lymphocytic, Lymphoblastic Lymphoma, T-cell Lymphoma, T-cell Leukemia, Recurrent Disease, Acute Leukemia
06/21
06/25
NCT03349281: Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL

Completed
1
6
US
Pevonedistat, TAK-924, MLN4924, Vincristine, Oncovin, VCR, LCR, Dexamethasone, Decadron, Hexadrol, Dexone, Dexameth, PEG-asparaginase, Oncaspar, Pegaspargase, Polyethylene Glycol Conjugated L-asparaginase-H, Doxorubicin, Adriamycin, Cytarabine, ARA-C, Methotrexate, MTX, Amethopterin, Hydrocortisone, Cortisol
Julio Barredo, MD, Takeda
Refractory Acute Lymphoblastic Leukemia, Relapsed Acute Lymphoblastic Leukemia
08/21
10/22
SELCLAX, NCT04898894: Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Recruiting
1
42
US
Venetoclax, Venclextra®, ABT-199, Selinexor, KPT-330, Cytarabine, Cytosine arabinoside, Ara-C, Cytosar®, Fludarabine, Fludara®, Fludarabine phosphate, 2-fluoro-ara-AMP, Filgrastim, G-CSF, Methotrexate, MTX, amethopterin, Trexall®, methotrexate/hydrocortisone/cytarabine, ITMHA, Intrathecal triples
St. Jude Children's Research Hospital, Karyopharm Therapeutics Inc, AbbVie, Gateway for Cancer Research
Acute Leukemia of Ambiguous Lineage in Relapse, Acute Myeloid Leukemia, in Relapse, Refractory Acute Leukemia of Ambiguous Lineage, Refractory Acute Myeloid Leukemia
07/23
07/25
NCT06177067: Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Recruiting
1
24
US
Revumenib, SNDX-5613, Venetoclax, Venclextra®, Azacitidine, VIDAZA®, 5-azacitidine, intrathecal (IT) chemotherapy, ITMHA, methotrexate/hydrocortisone/cytarabine, Cytarabine, Ara-C, Cytosar®, Methotrexate, MTX, Trexall®
St. Jude Children's Research Hospital, Syndax Pharmaceuticals
Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Acute Leukemia of Ambiguous Lineage
01/26
07/26
NCT02303821 / 2014-001633-84: Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

Active, not recruiting
1
130
Europe, Canada, US, RoW
Carfilzomib, PR-171, PR171, Kyprolis® (carfilzomib) for Injection, Dexamethasone, Mitoxantrone, PEG-asparaginase, Vincristine, Intrathecal (IT) Methotrexate, Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate), 6-Mercaptopurine, Cyclophosphamide, Cytarabine, Daunorubicin
Amgen, Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) - Study Design & Execution Collaborator, Innovative Therapies For Children with Cancer Consortium
Acute Lymphoblastic Leukemia (ALL)
07/24
07/24
NCT05476770: Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Recruiting
1
54
US, RoW
Tagraxofusp, Elzonris, Fludarabine, Cytarabine, Cytosar, Dexamethasone, Decadron, Vincristine, Oncovin, Azacitidine, AZA, Vidaza, Methotrexate, MTX, Amethopterin, Cytarabine IT, Hydrocortisone
Therapeutic Advances in Childhood Leukemia Consortium
Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia
11/25
11/27

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