hydrocortisone / Generic mfg.  >>  Phase 1
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18 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
hydrocortisone / Generic mfg.
NCT02256865: Hormonal Mechanisms of Sleep Restriction

Completed
1
40
US
Ketoconazole, Nizoral, Hydrocortisone, Cortef, Cortril, Hydrocortone, Testosterone, AndroGel, Placebo for ketoconazole, Placebo for hydrocortisone, Placebo for testosterone
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Insulin Resistance
11/17
10/23
NCT02843854: Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms

Not yet recruiting
1
36
US
Intravenous infusion of Plasmalyte A (placebo), Intravenous infusion of 1 million allogeneic MSCs/kg, Intravenous infusion of 3 million allogeneic MSCs/kg
Michael Murphy
AAA, Abdominal Aortic Aneurysm, Vascular Disease, Peripheral Artery Disease
08/19
04/20
NCT03194932: Study of Venetoclax in Combination With Chemotherapy in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Leukemia of Ambiguous Lineage

Completed
1
62
US
Venetoclax, Venclextra®, ABT-199, Cytarabine, Cytosine arabinoside, Ara-C, Cytosar®, Idarubicin, Idamycin PFS, Intrathecal Triple Therapy, ITMHA, methotrexate/hydrocortisone/cytarabine, Azacitidine, VIDAZA®
St. Jude Children's Research Hospital, Gateway for Cancer Research
Acute Myeloid Leukemia
10/20
06/22
NCT03792256: Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)

Active, not recruiting
1
15
US
Palbociclib, Cytarabine, Methotrexate, Hydrocortisone, Doxorubicin, Prednisolone, Vincristine, Pegaspargase, Prednisone
Children's Oncology Group
Leukemia, Lymphocytic, Lymphoblastic Lymphoma, T-cell Lymphoma, T-cell Leukemia, Recurrent Disease, Acute Leukemia
06/21
06/25
NCT03718234: Subcutaneous Hydrocortisone Children With Congenital Adrenal Hyperplasia

Completed
1
11
US
Subcutaneous hydrocortisone, Hydrocortisone delivered via subcutaneous pump, Standard glucocorticoid therapy
University of Minnesota
Congenital Adrenal Hyperplasia, Hyperplasia, Adrenal Hyperplasia, Congenital Disorders, Adrenocortical Hyperfunction, Disorders of Sex Development, Urogenital Abnormalities, Genetic Diseases, Inborn, Steroid Metabolic Diseases, Inborn, Adrenal Gland Disease, Hydrocortisone
02/23
02/23
Gluco-Feed, NCT05167084: Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals

Completed
1
20
Europe
Metyrapone 250 mg Oral Tablets, Placebo 250 mg Tablets, Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s, Placebo (0,9% NaCl solution)
Eleonora Seelig
Glucocorticoid Effect
06/23
06/23
SELCLAX, NCT04898894: Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Recruiting
1
42
US
Venetoclax, Venclextra®, ABT-199, Selinexor, KPT-330, Cytarabine, Cytosine arabinoside, Ara-C, Cytosar®, Fludarabine, Fludara®, Fludarabine phosphate, 2-fluoro-ara-AMP, Filgrastim, G-CSF, Methotrexate, MTX, amethopterin, Trexall®, methotrexate/hydrocortisone/cytarabine, ITMHA, Intrathecal triples
St. Jude Children's Research Hospital, Karyopharm Therapeutics Inc, AbbVie, Gateway for Cancer Research
Acute Leukemia of Ambiguous Lineage in Relapse, Acute Myeloid Leukemia, in Relapse, Refractory Acute Leukemia of Ambiguous Lineage, Refractory Acute Myeloid Leukemia
07/23
07/25
MsSCORE, NCT03237689: Effects of Glucocorticoids on Cognition in HIV-infected Women

Completed
1
136
US
Hydrocortisone, Placebo Oral Tablet
Johns Hopkins University, National Institute of Mental Health (NIMH)
Hiv
09/23
09/23
MK-5684-001, NCT06136598: A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Recruiting
1
14
RoW
Opevesostat, MK-5684, Dexamethasone, Dexamethasone acetate, Fludrocortisone, Fludrocortisone acetate, Hydrocortisone, Hydrocortisone acetate
Merck Sharp & Dohme LLC, Orion Corporation, Orion Pharma
Prostatic Neoplasms, Metastatic Castration-Resistant Prostate Cancer
04/26
10/27
NCT06177067: Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Recruiting
1
24
US
Revumenib, SNDX-5613, Venetoclax, Venclextra®, Azacitidine, VIDAZA®, 5-azacitidine, intrathecal (IT) chemotherapy, ITMHA, methotrexate/hydrocortisone/cytarabine, Cytarabine, Ara-C, Cytosar®, Methotrexate, MTX, Trexall®
St. Jude Children's Research Hospital, Syndax Pharmaceuticals
Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Acute Leukemia of Ambiguous Lineage
01/26
07/26
NCT02303821 / 2014-001633-84: Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

Active, not recruiting
1
130
Europe, Canada, US, RoW
Carfilzomib, PR-171, PR171, Kyprolis® (carfilzomib) for Injection, Dexamethasone, Mitoxantrone, PEG-asparaginase, Vincristine, Intrathecal (IT) Methotrexate, Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate), 6-Mercaptopurine, Cyclophosphamide, Cytarabine, Daunorubicin
Amgen, Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) - Study Design & Execution Collaborator, Innovative Therapies For Children with Cancer Consortium
Acute Lymphoblastic Leukemia (ALL)
07/24
07/24
COBRAS, NCT06430580: Cannabinoids and Biological Reactivity to Stress

Not yet recruiting
1
36
NA
Hydrocortisone Oral, Yohimbine Hydrochloride, Cornstarch Placebo 20mg, Cornstarch Placebo 54mg
Auburn University, Wayne State University, National Institute on Drug Abuse (NIDA)
Cannabis Use Disorder
03/26
03/26
DUOC for MS, NCT04943289: Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis

Recruiting
1
20
US
DUOC-01
Joanne Kurtzberg, MD
Primary Progressive Multiple Sclerosis
08/25
08/25
NCT05919992: The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)

Recruiting
1
20
Europe
Metyrapone 250 mg Oral Tablets, Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s, Placebo 250 mg Tablets, Placebo (0,9% NaCl solution)
Eleonora Seelig
Glucocorticoid Effect
08/24
08/24
NCT02574910: Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1

Suspended
1
36
US
Abiraterone acetate, Zytiga
University of Texas Southwestern Medical Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Michigan, Children's Hospital Los Angeles
Congenital Adrenal Hyperplasia
01/25
01/25
NCT05476770: Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Recruiting
1
54
US, RoW
Tagraxofusp, Elzonris, Fludarabine, Cytarabine, Cytosar, Dexamethasone, Decadron, Vincristine, Oncovin, Azacitidine, AZA, Vidaza, Methotrexate, MTX, Amethopterin, Cytarabine IT, Hydrocortisone
Therapeutic Advances in Childhood Leukemia Consortium
Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia
11/25
11/27
MK-5684-005, NCT06104449: A Study of Opevesostat (MK-568)4 in Japanese Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC)

Active, not recruiting
1
6
Japan
Opevesostat, MK-5684, Dexamethasone, Decadron, Fludrocortisone acetate, Hydrocortisone
Merck Sharp & Dohme LLC, Orion Corporation, Orion Pharma
Prostatic Neoplasms, Metastatic Castration-Resistant Prostate Cancer
01/26
01/26
NCT05008146: Imaging CRF X NOP Interactions in CUD

Recruiting
1
80
US
Baseline [C-11]NOP-1A PET Scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET Scan
Rajesh Narendran, National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder
09/28
09/28

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