NCT00490828: Influence of Hydrocortisone on Immunologic Markers and Health Care Related Quality of Life in Patients After Cardiac Surgery |
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| Completed | 4 | 120 | Europe | Hydrocortisone, Stress doses of hydrocortisone | Ludwig-Maximilians - University of Munich | Systemic Inflammatory Response Syndrome, Posttraumatic Stress Disorder | 05/08 | 08/08 | | |
| Completed | 4 | 30 | US | Hydrocortisone, Saline | Hospital for Special Surgery, New York | Postoperative Inflammatory Response | 08/10 | 02/11 | | |
2017-001915-35: GLUCOCORTICOID HIGH-DOSE VS. GLUCOCORTICOID REPLACEMENT THERAPY IN IMMUNE CHECKPOINT INHIBITOR ASSOCIATED INFLAMMATION OF THE PITUITARY GLAND: AN OPEN, RANDOMIZED PILOT STUDY |
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| Ongoing | 4 | 20 | Europe | Hydrocortisone, Prednisolone, n.a., Tablet, Hydrocortone, Aprednislon | Medical University of Graz, Medical University of Graz | Immune regulatory antibodies (e.g. ipilimumab, pembrolizumab and nivolumab) inhibiting immunological checkpoints are increasingly used to treat various oncological entities. Potential side effects of are immune-related adverse events such as hypophysitis, affecting up to 10–15% of patients receiving ipilimumab. Hypophysitis manifests mostly in the form of multiple anterior pituitary hormone deficiencies (mostly central hypothyroidism and central adrenal insufficiency)., Immune regulatory antibodies are novel drugs used to treat various cancers. Potential side effects include inflammation of the pituitary gland, manifesting in the form of hormone deficiencies., Diseases [C] - Hormonal diseases [C19] | | | | |
