Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...93949596979899100101102103...10651066»
  • ||||||||||  Paxlovid (nirmatrelvir/ritonavir) / Pfizer
    Journal:  COVID-19 and pregnancy: interrelationships with asthma and allergy. (Pubmed Central) -  Dec 17, 2023   
    Although overall risks are low, pregnant people who get infected with COVID-19 are at higher risk for maternal and pregnancy complications. Antiviral treatment is available for pregnant people with mild to moderate symptoms of COVID-19 with reassuring safety data to date, and dexamethasone is the mainstay of inpatient therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Drug kinetics and antimicrobial properties of quaternary bioactive glasses 81S(81SiO-(16-x)CaO-2PO-1NaO-xMgO); an in-vitro study. (Pubmed Central) -  Dec 16, 2023   
    Further long-term randomised control studies are necessary to validate the potential clinical benefit of utilising steroids in paediatric cardiac surgery, especially in the more fragile neonatal population. Being confirmed MGO_4 nBG as a bioactive material, various concentrations of drug (Dexamethasone (DEX)) loading and release kinetics are examined...The mesoporous structure of MGO_4 having an average pore diameter of 5
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
    Trial initiation date, Trial primary completion date:  IKANOS: Breztri Maintenance Versus Any Non-Triple Inhaled Therapy After Hospitalization for a COPD Exacerbation in the US (clinicaltrials.gov) -  Dec 15, 2023   
    P4,  N=1000, Not yet recruiting, 
    Being confirmed MGO_4 nBG as a bioactive material, various concentrations of drug (Dexamethasone (DEX)) loading and release kinetics are examined...The mesoporous structure of MGO_4 having an average pore diameter of 5 Initiation date: Sep 2023 --> Jan 2024 | Trial primary completion date: Dec 2024 --> Dec 2025
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Trial completion date, Trial primary completion date:  Medrol Dosepak for Outpatient Total Knee Arthroplasty (clinicaltrials.gov) -  Dec 15, 2023   
    P4,  N=420, Recruiting, 
    Trial completion date: Jul 2024 --> Dec 2024 | Trial primary completion date: Jul 2024 --> Dec 2024 Trial completion date: Nov 2024 --> Nov 2025 | Trial primary completion date: Nov 2023 --> Nov 2024
  • ||||||||||  aspirin / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Trial completion date, Trial primary completion date:  Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease (clinicaltrials.gov) -  Dec 15, 2023   
    P3,  N=3200, Recruiting, 
    Trial completion date: Nov 2024 --> Nov 2025 | Trial primary completion date: Nov 2023 --> Nov 2024 Trial completion date: Dec 2023 --> Sep 2025 | Trial primary completion date: Dec 2023 --> Sep 2024
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Glucocorticoids improve sperm performance in physiological and pathological conditions: their role in sperm fight/flight response. (Pubmed Central) -  Dec 15, 2023   
    GR involvement in mediating DEXA effects, was confirmed by using the GR inhibitor mifepristone (M2F)...Collectively, our data suggests a role for glucocorticoids in determining semen quality and function, as well as in participating on sperm immune defensive mechanisms. The novelty of this study may be beneficial and needs to take into account in artificial insemination/drug discovery aimed to enhancing sperm quality.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Global gene regulatory network underlying miR165a in Arabidopsis shoot apical meristem. (Pubmed Central) -  Dec 14, 2023   
    Here, we over-expressed miR165a in a dexamethasone inducible manner and identified differentially expressed genes in the SAM through RNA-Seq...Among the up-regulated genes, GIBBERELLIN 2-OXIDASEs, various elemental transporters (YSL3, ZIFL1, SULTR), and other transporter genes were prominent. Thus, the genes identified in this study help to unravel the molecular mechanism of miR165a and HD-ZIPIII regulated plant development and stress response.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Evaluation of Dexamethasone Dosing Strategies in Pediatric Asthma Exacerbations. (Pubmed Central) -  Dec 14, 2023   
    Thus, the genes identified in this study help to unravel the molecular mechanism of miR165a and HD-ZIPIII regulated plant development and stress response. A standardized dosing strategy for dexamethasone in pediatric asthma exacerbations showed favorable outcomes and may lead to improved adherence.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date, Surgery:  Interscalene Block Versus Combined Infraclavicular-Anterior Suprascapular Blocks for Shoulder Surgery (clinicaltrials.gov) -  Dec 13, 2023   
    P=N/A,  N=50, Recruiting, 
    A standardized dosing strategy for dexamethasone in pediatric asthma exacerbations showed favorable outcomes and may lead to improved adherence. Not yet recruiting --> Recruiting | Trial completion date: Dec 2023 --> Jun 2024 | Trial primary completion date: Dec 2023 --> Jun 2024
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    A CASE OF NECROBIOTIC PULMONARY NODULES PRESENTING AS AN EXTRAINTESTINAL MANIFESTATION OF INFLAMMATORY BOWEL DISEASE IN A 37-YEAR-OLD FEMALE (Promenade Lobby (Sunset Center)) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_645;    
    After transfer to our facility 11 days later on antibiotics and IV solumedrol, extensive infectious and autoimmune work-up failed to reveal such etiologies, and antibiotics were discontinued...On day 7 after admission, all presenting symptoms had nearly resolved, and the patient was discharged on oral prednisone with a weekly taper...However, the patient was admitted twice over the following 3 months for severe IBD flares despite oral and IV steroids, azathioprine, infliximab, dietary modifications, and close follow-up...Here, we described a case of pulmonary necrobiotic nodules in a complex case of IBD that showed improvement and eventual resolution with steroids despite increasing severity of gastrointestinal disease, similar to previous reports. However, further protocoling of steroid therapy for necrobiotic pulmonary nodules has not been well-described, representing an avenue for further research.
  • ||||||||||  dexamethasone / Generic mfg., indomethacin / Generic mfg., rosiglitazone / Generic mfg.
    Pathophysiological role of ZADH2 in Brown and White Adipocytes (Green Room (Sunset Center)) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_598;    
    Due to a low number of replicates, further investigation would be needed. In the next steps, it would be beneficial to duplicate such results with additional time points and levels of mRNA expression of ZADH2 with a higher number of replicates.
  • ||||||||||  hydrocortisone / Generic mfg.
    A case of nodular cystic fat necrosis after Whipple procedure (Carmel Women's Club) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_388;    
    She was on pancreatic enzyme supplementation and hydrocortisone...Two factors could have contributed to its pathophysiology. One being vascular compromise from the Whipple procedure, and the other being her systemic corticosteroid use resulting in diabetes mellitus and Cushing
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    EARLY RECOVERY FROM EPSTEIN BARR VIRUS-INDUCED PNEUMONITIS WITH EARLY CORTICOSTEROID ADMINISTRATION IN IMMUNOCOMPETENT ADOLESCENT (Ninth Avenue & Dolores St.) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_247;    
    Proposed mechanisms for acute lung injury in EBV-induced pneumonitis include accumulation of the virus secondary to rapid viral replication, an autoimmune reaction to the underlying infection and/or both. Most cases reports describe patients successfully treated with combinations of antivirals, corticosteroids and/or immunoglobulins.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD), Elitek (rasburicase) / Sanofi, Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
    HIV-Associated Burkitt Lymphoma presented as Submandibular Infection (Ninth Avenue & Dolores St.) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_246;    
    He was admitted and treated with IV Ampicillin/Sulbactam and discharged a day later with a 10-day course of Amoxicillin/Clavulanic Acid...A month later the patient was admitted for treatment with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (DA-R-EPOCH)...He received Decadron and swelling improved...Allopurinol 300mg was given daily, but no rasburicase was indicated because uric acid was not elevated. Sagital view of submandibular Burkitts Lymphoma.
  • ||||||||||  Takhzyro (lanadelumab-flyo) / Takeda, Decadron (dexamethasone) / Merck (MSD), Firazyr (icatibant) / Takeda
    Hereditary Angioedema: An acute exacerbation triggered by sun exposure (Ninth Avenue & Dolores St.) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_231;    
    The patient had been unable to obtain her monthly maintenance medications (Firazyr and Takhzyro) for the last two months due to homelessness and social issues...The patient was given 0.3 mg of epinephrine intramuscularly by emergency medical services on route to the emergency department...She was admitted to medicine and given 2 units of fresh frozen plasma, 10 mg of Decadron, and famotidine with noted improvement of symptoms...The first line therapies for acute treatment include C1 inhibitor, kallikrein inhibitor, or bradykinin B2-receptor antagonist; in addition to fresh frozen plasma, if first-line therapies are unavailable as utilized in this case. This case highlights that, in addition to medical management, the identification of factors that trigger acute episodes in an individual can significantly improve long-term disease management, allowing for prompt treatment and prevention of acute attacks.
  • ||||||||||  triamcinolone acetonide topical / Generic mfg., minocycline / Generic mfg.
    GRANULOMA ANNULARE ONSET FOLLOWING COVID-19 VACCINATION (Chapman #4 (Sunset Center)) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_59;    
    Despite the temporal association between COVID-19 vaccination and the development of GA, the exact causative relationship remains unclear. Further studies are needed to elucidate the underlying mechanisms and determine the true incidence and risk factors for GA associated with COVID-19 vaccination.
  • ||||||||||  amiodarone / Generic mfg.
    DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) CAUSED BY AMIODARONE (Chapman #4 (Sunset Center)) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_58;    
    Although there is no literature describing DRESS syndrome caused by amiodarone, it can be caused by any medication as seen in our patient. The RegiSCAR Scoring System is most commonly used to confirm diagnosis.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Journal:  A Pilot Study on Tocilizumab in Very-Late-Onset Myasthenia Gravis. (Pubmed Central) -  Dec 13, 2023   
    The results from our study support the efficacy and safety of this combination treatment option for VLOMG, and strongly suggests the therapeutic potential of tocilizumab in VLOMG. However, considering the limitation of retrospective nature and small sample size in this study, prospective randomized controlled studies including a larger sample size of selected patients are needed to validate our results.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Complete recovery after glucocorticoid replacement therapy in a case of primary adrenal insufficiency caused by adrenal tuberculosis infection. (Pubmed Central) -  Dec 13, 2023   
    After 6 months, hydrocortisone was discontinued due to the patient's good clinical condition and normal morning plasma cortisol levels...Clinical adjustments and a comprehensive understanding of epidemiological knowledge are necessary for diagnosing patients with endocrine diseases in limited-resource settings. Complete recovery in primary adrenal insufficiency caused by tuberculosis infection might be due to younger age, acute presentation, and absence of comorbidities.