Glucocorticoid Receptor 

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  • ||||||||||  hydrocortisone / Generic mfg.
    Rebound Thymic Hyperplasia Following Corticotherapy: A Case Report Demonstrated on 2-[18F] FDG-PET/CT (e-Poster Area) -  Sep 27, 2024 - Abstract #EANM2024EANM_2715;    
    The interpretation of 2-[18F]FDG PET/CT findings in this context needs careful consideration of clinical history and imaging characteristics to avoid misdiagnosis. 2-[18F]FDG PET/CT is, therefore, a valuable emerging tool in these situations, facilitating optimal patient care by avoiding futile aggressive management strategies and allowing conservative approaches for follow-up.
  • ||||||||||  dexamethasone / Generic mfg.
    Comparison of PET/CT images with 18F-FDG and 18F-PSMA-1007 in metastatic acral melanoma: a case report. (e-Poster Area) -  Sep 27, 2024 - Abstract #EANM2024EANM_2593;    
    PSMA PET/CT emerges as a promising diagnostic imaging modality for detecting distant metastasis in AM, especially brain metastases since PSMA is not normally taken up by the central nervous system and is extremely avid for AM metastases. PSMA may be a potential Theranostic tool in specific cases.
  • ||||||||||  Agamree (vamorolone) / Santhera
    Review, Journal:  Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review. (Pubmed Central) -  Sep 27, 2024   
    According to our results, vamorolone offers a statistically and clinically significant benefit in the management of Duchenne muscular dystrophy, with fewer side effects than glucocorticoids. However, the number of studies limits the interpretability and generalisability of these data, requiring more studies with more participants to perform a meta-analysis.
  • ||||||||||  Mekinist (trametinib) / Novartis, BeiGene
    Journal:  Rosai-Dorfman-Destombes disease in adults: a single center experience. (Pubmed Central) -  Sep 27, 2024   
    Lenalidomide combined with dexamethasone is an effective and well-tolerated treatment option for select patients, especially those with refractory disease. Broad utilization of NGS and PET-CT can positively influence management decisions.
  • ||||||||||  pentoxifylline / Generic mfg.
    Retrospective data, Journal:  Radiomic Analysis of Treatment Effect for Patients with Radiation Necrosis Treated with Pentoxifylline and Vitamin E. (Pubmed Central) -  Sep 27, 2024   
    This experimental model, which has previously shown similarities to human infections, is also helpful in reproducing the morphological changes upon treatment with Albendazole and Dexamethasone. Ptx + VitE appears safe for the treatment of RN, but randomized data are needed to assess efficacy and validate radiomic models, which may assist with prognostication.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Assessing Receptor Activation in 2D and 3D Cultured Hepatocytes: Responses to a Single Compound and a Complex Mixture. (Pubmed Central) -  Sep 27, 2024   
    This study introduces the first 3D spheroid model for McA-RH7777 cells, assessing xenobiotic receptor activation, cellular signaling, and toxicity against dexamethasone and naphthenic acid (NA)-fraction components; NAFCs...The optimization of 3D culture conditions enhances the model's physiological relevance and enables the identification of genomic signatures under varied exposures. This study highlights the potential of 3D spheroid cultures in providing a more accurate representation of the liver's microenvironment and advancing our understanding of cellular mechanisms in toxicity testing.
  • ||||||||||  Impracor (ketoprofen) / Harrow Health
    Journal:  Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen. (Pubmed Central) -  Sep 27, 2024   
    Contact allergy to fragrance mix I, Myroxylon pereirae, black rubber mix, PFR-2, PTBP-FR, and to a somewhat lower extent, to fragrance mix II and budesonide, is common in individuals photoallergic to ketoprofen. It remains to be seen whether sensitisation to ketoprofen leads to simultaneous sensitisation to a number of other, chemically non-related, substances.
  • ||||||||||  Minocin for injection (minocycline intravenous) / Melinta Therap
    Journal, Cytokine storm:  Administration of Corticosteroids for Prompt Suppression of Cytokine Storm in Severe Cases of Japanese Spotted Fever. (Pubmed Central) -  Sep 27, 2024   
    Considering the high levels of C-reactive protein, procalcitonin, ferritin, and soluble interleukin-2 receptor, intravenous hydrocortisone (200 mg/day) was administered to control the cytokine storm...Early administration of corticosteroids along with antibiotics effectively suppressed the cytokine storm in this case. Reports have shown mixed results, indicating the need for further research to determine the optimal type, dosage, and duration of corticosteroid treatment.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Pregnancy-related factors induce immune tolerance through regulation of sCD83 release. (Pubmed Central) -  Sep 27, 2024   
    Treatment of B lymphocytes with pregnancy-related molecules (E2, P4, TGF-?1 and hCG) enhanced the LPS-mediated increase of CD83 expression, while dexamethasone led to a reduction...Finally, we found that the hormonal regulation of CD83 expression is likely a result from a balance between gene transcription from CD83 and the modulation of the metalloproteinase MMP-7. Thus, data supports and complements our previous murine studies on hormonal regulation of CD83 expression, reinforcing its immunomodulatory relevance in anti-bacterial responses during pregnancy.
  • ||||||||||  dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Phase classification:  Lenalidomide in Anti-MAG Neuropathy: Phase 1b Study (clinicaltrials.gov) -  Sep 27, 2024   
    P1,  N=11, Terminated, 
    Considering the inflammatory and destructive mechanism of PRP, the laser operator should use the minimum power necessary to avoid possible chorioretinal complications. Phase classification: P1b --> P1
  • ||||||||||  Darzalex (daratumumab) / J&J
    Journal, HEOR, Real-world evidence, Real-world:  Real-world treatment patterns and outcomes in relapsed/refractory multiple myeloma (1-3 prior lines): Flatiron database. (Pubmed Central) -  Sep 26, 2024   
    In 561 patients with 1 prior LOT at inclusion, cumulative attrition rate from LOT 2-5 was 85%, which included 25% patients who died and 60% with no further treatment. Patients with lenalidomide-refractory MM who have received 1-3 prior LOT have poor outcomes and progress rapidly through available therapies, highlighting the need for more effective treatments early in the disease course, before patients are lost to attrition.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Androgen and Cortisol Cosecreting Adrenal Adenoma and Tuberculous Lymphadenitis. (Pubmed Central) -  Sep 26, 2024   
    A 1-mg dexamethasone suppression test revealed an elevated serum morning cortisol concentration of 10.57??g/dL (291.58?nmol/L) (reference range, <1.8??g/dL; <?49.66?nmol/L)...Subsequently, the patient underwent an open right adrenalectomy and lymphadenectomy. Histological examination revealed the presence of an adrenal adenoma with myelolipomatous metaplasia, as well as a positive polymerase chain reaction (PCR) for Mycobacterium tuberculosis in the adenopathy.
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Steroids in the Management of Ionotropic-Resistant Septic Shock: A Comprehensive Review of Efficacy and Outcomes. (Pubmed Central) -  Sep 26, 2024   
    Key studies, such as the CORTICUS and ADRENAL trials, were analyzed to determine the effectiveness of steroid regimens, specifically low-dose hydrocortisone, in patients with septic shock resistant to ionotropic agents...Nonetheless, careful consideration of the risks and benefits is essential, and ongoing research is needed to refine treatment protocols and optimize patient outcomes. This review provides a detailed synthesis of current evidence and offers recommendations for clinical practice and future research in the management of septic shock resistant to ionotropic agents.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  A Nematode Isolate, Oscheius Tipulae, Exhibiting a Wide Entomopathogenic Spectrum and its Application to Control Dipteran Insect Pests. (Pubmed Central) -  Sep 26, 2024   
    The nematode virulence of O. tipulae to insects was enhanced by an addition of dexamethasone but suppressed by an addition of arachidonic acid, suggesting that the immune defenses of the target insects against the nematode infection is mediated by eicosanoids, which would be manipulated by the symbiotic bacteria of the nematode...O. tipulae showed particularly high control efficacies against the onion maggot, Delia platura, infesting the Welsh onion in the rhizosphere in both pot and field assays.
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Subcutaneous administration of isatuximab by an on-body delivery system (OBDS) in multiple myeloma patients: results of a nurse survey (Exhibit Hall, Pavilion 3) -  Sep 26, 2024 - Abstract #IMW2024IMW_695;    
    P1
    Introduction: Intravenous (IV) isatuximab (Isa) in combination with pomalidomide-dexamethasone (Pd) is approved for the treatment of relapsed/refractory multiple myeloma (RRMM) patients...Extent of drug delivered not clear in case of interruption (83%) and need to press/hold a button to pause injection (67%) were agreed upon as potential disadvantages for HCPs; risk of allergy to the adhesive tape (50%) was reported as a potential disadvantage for patients, although no interruptions or allergy were observed in 581 administrations via OBDS in the Phase 1b study (IMS 2023; P-306). Findings from this nurse survey show a high level of confidence and preference for SC Isa treatment delivery using a hands-free OBDS vs IV administration, due to its ease of use, tolerability, and time savings, suggesting its applicability in routine clinical practice.
  • ||||||||||  Blenrep (belantamab mafodotin-blmf) / GSK
    Efficacy of Belantamab Mafodotin + Bortezomib + Dexamethasone (BVd) Compared to Alternative Regimens in 2L+ Relapsed/Refractory Multiple Myeloma (RRMM): A Network Meta-analysis of Randomized Trials (Exhibit Hall, Pavilion 3) -  Sep 26, 2024 - Abstract #IMW2024IMW_694;    
    P3
    The phase III DREAMM-7 study (NCT04246047) evaluated belamaf with bortezomib (V)+dexamethasone (d; BVd) vs daratumumab (D)+Vd (DVd) in patients with RRMM who had ?1 prior line of therapy (2L+)...All regimens compared to BVd included a proteasome inhibitor and were: cyclophosphamide (Cy)+Vd (CyVd), Cy + carfilzomib (K)+d (CyKd), DVd, elotuzumab (E)+Vd (EVd), D+K+d (DKd), isatuximab (Isa)+Kd (IsaKd), panobinostat (Pano)+Vd (PanoVd), pomalidomide (P)+Vd (PVd), selinexor (S)+Vd (SVd), Kd, and Vd... In the absence of any direct RCTs comparing BVd, this NMA indicated BVd offers the highest PFS, OS, and ORR of the included proteasome inhibitor-based regimens for 2L+ RRMM.
  • ||||||||||  Darzalex (daratumumab) / J&J
    A MULTICENTER OBSERVATIONAL RETROSPECTIVE STUDY OF SECOND-LINE TREATMENT WITH DARATUMUMAB  (Exhibit Hall, Pavilion 3) -  Sep 26, 2024 - Abstract #IMW2024IMW_693;    
    PFS was shorter than in the general population (27 mos), except for pts with ?VGPR, but two-fold longer than previously reported in the CASTOR study (7.8 mos), regardless of the number of prior lines of therapy. Overall, DaraVd remains an alternative option for len-ref pts at first relapse, especially for those ineligibles to receive pomalidomide-or carflizomib-based regimens.
  • ||||||||||  Xpovio (selinexor) / Karyopharm
    ALLG MM26/D1/AMN009 Novel Combinations for Orphan Myeloma (NORM) Platform Study (Exhibit Hall, Pavilion 3) -  Sep 26, 2024 - Abstract #IMW2024IMW_687;    
    The PoC platform study design allows rapid assessment of different novel therapeutic regimens, using one master protocol, in patient populations typically excluded from clinical trials. We aim to demonstrate efficacy and safety of available novel agents and combinations in these subgroups of MM patients.