Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   94663 News 


«12345678910111213...10631064»
  • ||||||||||  chlorpromazine / Generic mfg.
    A RARE CASE OF CHLORPROMAZINE-INDUCED IMMUNE HEMOLYTIC ANEMIA (Convention Center Exhibit Hall: Poster Area 2) -  Sep 19, 2024 - Abstract #CHEST2024CHEST_7313;    
    The hematologist was consulted immediately, and the patient received one dose of IV Epoetin alfa 20000 units, one dose of IV Venofer 200 mg and she was also started on IV methylprednisolone 80 mg...The patient's home medications included Chlorpromazine, Divalproex, and Fluoxetine...He was discharged to home with prednisone and divalproex...Cephalosporins, nonsteroidal anti-inflammatory agents, levofloxacin, oxaliplatin, and teicoplanin have been reported to cause IHA... Chlorpromazine is a widely used drug in psychiatry and physicians should be aware of this rare adverse event of hemolytic anemia.
  • ||||||||||  HR20013 / Jiangsu Hengrui Pharma
    Enrollment open, Trial primary completion date:  HR20013 for Nausea and Vomiting Associated With Moderate Emetic Risk Anticancer Agents (clinicaltrials.gov) -  Sep 19, 2024   
    P3,  N=700, Recruiting, 
    Trial completion date: Oct 2028 --> Jan 2027 Not yet recruiting --> Recruiting | Trial primary completion date: Jun 2025 --> Sep 2025
  • ||||||||||  NMS-812 / Nerviano Medical Sciences
    Enrollment change, Trial completion date, Trial termination:  Ph I Study in Adult Patients With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) -  Sep 19, 2024   
    P1,  N=5, Terminated, 
    Trial completion date: Dec 2026 --> Oct 2027 | Trial primary completion date: Dec 2024 --> May 2025 N=65 --> 5 | Trial completion date: Apr 2025 --> Jan 2024 | Recruiting --> Terminated; The decision is not based on emerging safety or efficacy concerns but on strategic reasons related to the changing and competitive treatment options in Multiple Myeloma
  • ||||||||||  Zejula (niraparib) / GSK, J&J
    Enrollment change, Trial completion date, Trial initiation date, Trial withdrawal, Trial primary completion date, Metastases:  LUNAAR: 177Lu-PSMA, Niraparib/AA Plus Prednisone for Prostate Cancer (clinicaltrials.gov) -  Sep 19, 2024   
    P1/2,  N=0, Withdrawn, 
    N=65 --> 5 | Trial completion date: Apr 2025 --> Jan 2024 | Recruiting --> Terminated; The decision is not based on emerging safety or efficacy concerns but on strategic reasons related to the changing and competitive treatment options in Multiple Myeloma N=30 --> 0 | Trial completion date: Jul 2028 --> Oct 2028 | Initiation date: Jul 2024 --> Oct 2024 | Not yet recruiting --> Withdrawn | Trial primary completion date: Jul 2026 --> Oct 2026
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion:  A Novel Analgesia Technique for ACL Reconstruction (clinicaltrials.gov) -  Sep 19, 2024   
    P4,  N=78, Completed, 
    Recruiting --> Active, not recruiting Active, not recruiting --> Completed
  • ||||||||||  dexamethasone / Generic mfg., Rituxan (rituximab) / Roche
    Journal:  IT-DEX and B cell depletion in a child with anti-GAD 65 autoimmune encephalitis presenting as NORSE: A case report. (Pubmed Central) -  Sep 18, 2024   
    The patient received 6 doses of IT-DEX in conjunction with rituximab which correlated with subsequent decreased neuroinflammation, reduced seizure burden and aided in weaning anesthetic infusions. Our case with literature review suggests IT-DEX may be utilized as an early intervention in those with refractory status epilepticus from various etiologies.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Mesalazine-induced myocarditis in a patient with ulcerative colitis: a case report. (Pubmed Central) -  Sep 16, 2024   
    Oral prednisolone was also introduced for IBD control...This case report highlights the importance of access to early CMR in order establish the diagnosis and withdrawal of the culprit medication. In the majority of cases, CMR will replace the need for endomyocardial biopsy; however, this may still be required in the most severe cases.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Corticosteroid-loaded chitosan-based in-situ forming gel combined with microneedle technology for improvement of burn eschar wound healing. (Pubmed Central) -  Sep 15, 2024   
    A chitosan-based in-situ forming gel of hydrocortisone was applied to human burn eschar using microneedles...In all ex-vivo and in-vivo stages, gel plus microneedle (length of 1.5?mm and application mode of 2) produced the best results concerning increased flux and faster recovery of burn eschar. In conclusion, the in-situ forming gel with appropriate texture, quality, and stability in combination with microneedle can be a good candidate for the controlled release of drugs in third-degree burn eschars.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Oligolysine-based hydrogel dressing with antibacterial, anti-inflammatory, and tissue-adhesion activities for infected wound treatment. (Pubmed Central) -  Sep 15, 2024   
    The anti-inflammatory drug, dexamethasone sodium phosphate (DEX), was encapsulated in this hydrogel...In vitro and in vivo experiment results showed that the PVBDL-gel with good biocompatibility and efficient anti-infection ability can effectively eradicate 99.9?% of pathogenic bacteria within 3?h and promote the repair and regeneration of bacterial infection wounds. This novel multifunctional injectable hydrogel has great application in the field of bacterial infection wound repair.
  • ||||||||||  dexamethasone / Generic mfg., atorvastatin / Generic mfg.
    Journal:  Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release. (Pubmed Central) -  Sep 15, 2024   
    Our experimental findings provide further evidence that the combined treatment of ATO and DEX effectively mitigates the effects of DEX, resulting in the upregulation of osteogenic genes (Runx2, Alpl, Tnfrsf11b, Ctnnb1, Col1a) and the downregulation of adipogenic genes (Pparg, Cebpb, Lpl), meanwhile leading to the upregulation of Wnt5a expression. So, this study offers valuable insights into the potential mechanism by which ATO can be utilized in the prevention of SONFH, thereby holding significant implications for the prevention and treatment of SONFH in clinical settings.
  • ||||||||||  5-fluorouracil / Generic mfg.
    Review, Journal:  Intralesional 5-Fluorouracil for Keloids: A Systematic Review. (Pubmed Central) -  Sep 15, 2024   
    Larger prospective trials are needed to determine optimal therapy or combination therapy for the management of keloids. This detailed compilation of treatment protocols, outcomes, and relapse rates stand as a valuable resource for further research and clinical applications.
  • ||||||||||  Lysodren (mitotane) / Perrigo Company
    Journal, Adverse events:  Adverse Events of Adjuvant Mitotane Treatment for Adrenocortical Carcinoma. (Pubmed Central) -  Sep 15, 2024   
    Two (7.7%) patients discontinued mitotane due to adverse events. Careful monitoring and timely management are essential for ensuring mitotane treatment adherence and maximizing its benefits.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Prevalence and Risk Factors of Headache Associated with COVID-19. (Pubmed Central) -  Sep 14, 2024   
    Headache was present in one-third of patients with heterogenous phenotypes: tension headache in the non-dominant group, and migraine in the dominant and persistent headache groups. Persistent headache remains a challenge, with dexamethasone showing potential in reducing its incidence, emphasizing the need for tailored approaches in managing long-COVID headaches.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Cross-Linked Thiolated Hydroxypropil-?-Cyclodextrin for Pulmonary Drug Delivery. (Pubmed Central) -  Sep 14, 2024   
    Persistent headache remains a challenge, with dexamethasone showing potential in reducing its incidence, emphasizing the need for tailored approaches in managing long-COVID headaches. HP-?-CD-SH is promising for lung delivery, especially as stabilized nanoaggregates, offering versatile administration for labile molecules like natural extracts.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  [131I]6 (Pubmed Central) -  Sep 14, 2024   
    HP-?-CD-SH is promising for lung delivery, especially as stabilized nanoaggregates, offering versatile administration for labile molecules like natural extracts. [131I]6
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Lonicera japonica Fermented by Lactobacillus plantarum Improve Multiple Patterns Driven Osteoporosis. (Pubmed Central) -  Sep 14, 2024   
    In this study, we used dexamethasone to induce OP in the rat model...The results of the Spearman correlation analysis showed that FS may alleviate OP by restoring the abundance of 6 bacterial genera and the contents of 17 serum metabolites, reducing osteoclast differentiation, promoting osteoblast differentiation, and reducing the inflammatory response. This study revealed that Lactobacillus plantarum-fermented honeysuckle alleviated OP through intestinal bacteria and serum metabolites and provided a theoretical basis for the development of related functional foods.
  • ||||||||||  budesonide / Generic mfg., loperamide / Generic mfg.
    Review, Journal:  Update on the epidemiology and management of microscopic colitis. (Pubmed Central) -  Sep 14, 2024   
    There is an unmet need to further define the pathophysiology of microscopic colitis. Additionally, trials with novel therapies, particularly in patients with budesonide-refractory disease, are needed.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma. (Pubmed Central) -  Sep 13, 2024   
    The combination with dexamethasone and dexmedetomidine as adjuvants for TAP block reduced the incidence of moderate-to-severe pain and pain score both on movement and at rest at 24 The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.
  • ||||||||||  ketoconazole / Generic mfg., prednisolone / Generic mfg., griseofulvin / Generic mfg.
    Journal:  Clinical Consequences of Delayed Treatment for Tinea Capitis (Ringworm of the Scalp): A Case Report. (Pubmed Central) -  Sep 13, 2024   
    This case highlights how there exist areas of improvement in terms of interprofessional communication between physicians, as well a need to increase awareness of the proper treatment for this common pediatric skin condition. We postulate that in doing so, similar cases could be spared the unfortunate results of untreated tinea capitis, that is, kerion formation and the possible scarring this lesion can produce.
  • ||||||||||  dexamethasone / Generic mfg., acyclovir / Generic mfg.
    Journal:  Opsoclonus-myoclonus syndrome associated with West Nile virus (Pubmed Central) -  Sep 13, 2024   
    Then the symptoms gradually began to improve, rehabilitation was included with total recovery during the next 2 months. The doctors should be aware for possibility of neuroinvasive form of West Nile fever as the etiology of opsoclonus-myoclonus syndrome.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  3D printed personalized therapies for pediatric patients affected by adrenal insufficiency. (Pubmed Central) -  Sep 13, 2024   
    Adrenal insufficiency is usually diagnosed in children who will need lifelong hydrocortisone therapy...The results confirm the suitability and safety of the developed printlets for use in the clinical trial. The required technical information from The Spanish Medicines Agency for this clinical trial application was compiled to serve as guideline for healthcare professionals seeking to apply for and conduct clinical trials on 3DP oral dosage forms.