Glucocorticoid Receptor 

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  • ||||||||||  Cortone (cortisone acetate) / Merck (MSD)
    Preclinical, Journal:  Vaccine-Induced Protection in Two Murine Models of Invasive Pulmonary Aspergillosis. (Pubmed Central) -  Oct 22, 2021   
    The lung fungal burden was inversely correlated with the peak anti-AF.KEX1 IgG titer achieved following vaccination. These studies provide the basis for further evaluation of a novel vaccine strategy to protect individuals at risk of invasive aspergillosis due to immunosuppressive treatments.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Effectiveness and safety of repeat dexamethasone for bronchopulmonary dysplasia. (Pubmed Central) -  Oct 22, 2021   
    Repeat dexamethasone for BPD was less effective in weaning respiratory support compared to initial course. Changes in growth parameters to discharge were comparable between controls and infants treated with 1 or 2 dexamethasone courses.
  • ||||||||||  triamcinolone acetonide / Generic mfg., pentoxifylline / Generic mfg.
    Journal:  Intralesional pentoxifylline, triamcinolone acetonide and their combination for treatment of keloid scars. (Pubmed Central) -  Oct 22, 2021   
    Intralesional injection of PTX is a potentially helpful, safe, and well-tolerated therapeutic tool for keloids, but with lower efficacy than intralesional TAC when used solely. Combining PTX and TAC produces significantly better results for keloid treatment and lowers the risk of TAC-induced side effects.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Retrospective data, Journal:  Therapeutic plasma exchange in MS refractory relapses: Long-term outcome. (Pubmed Central) -  Oct 22, 2021   
    Although ADEM-ON is related to the presence of anti-MOG antibodies, factors other than anti-MOG antibodies could contribute to the development of ADEM-ON. TPE is a safe and well tolerated procedure that decreases long-term disability in RRMS patients with IVMPS-refractory relapses.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Review, Journal:  Recent advances in management of COVID-19: A review. (Pubmed Central) -  Oct 22, 2021   
    Finally, phase III, the hyper-inflammatory phase, tocilizumab, dexamethasone, selective serotonin reuptake inhibitors (SSRI), and melatonin are used. The aim of this study is to summarize current findings and suggest gaps in knowledge that can influence future COVID-19 treatment study design.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Neurokinin-1 Receptor as a potential drug target for COVID-19 treatment. (Pubmed Central) -  Oct 22, 2021   
    It is responsible for the increased inflammation and the signature symptoms associated with this disease. It is the main switch that needs to be switched off by administering Aprepitant along with glucocorticosteroid, dexamethasone.
  • ||||||||||  hydrocortisone / Generic mfg.
    Trial completion, Enrollment change, Trial completion date:  The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression (clinicaltrials.gov) -  Oct 22, 2021   
    P1,  N=192, Completed, 
    Suspended --> Active, not recruiting Recruiting --> Completed | N=80 --> 192 | Trial completion date: Jul 2020 --> Nov 2020
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
    Trial completion date, Trial primary completion date:  The Effect and Safety Profile of Thymoglobulin (clinicaltrials.gov) -  Oct 22, 2021   
    P2,  N=60, Enrolling by invitation, 
    Recruiting --> Completed | N=80 --> 192 | Trial completion date: Jul 2020 --> Nov 2020 Trial completion date: Jun 2021 --> Oct 2024 | Trial primary completion date: Jun 2021 --> Oct 2024
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Clinical, Journal:  First Case of COVID-19 Positive Candida auris Fungemia in Turkey (Pubmed Central) -  Oct 22, 2021   
    The patient died on the ninth day after developing candidemia. The present case is the first case of fungemia caused by C.auris in a COVID-19 positive patient in Turkey, and it emphasizes the need of caution for fungemia due to C.auris in intensive care units in our country which has a high COVID-19 incidence.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Clinical, Journal:  Role of Dexamethasone on Oxygen Requirement, Mortality, and Survival Incidence among COVID-19 Patients: Quasi-Experimental Study. (Pubmed Central) -  Oct 22, 2021   
    Study participants in Group A received standard care, while those in Group B received standard care along with 6 mg intravenous dexamethasone for 10 days (or until discharge, if earlier)...It was observed from the study that there was reduction in the intensive care unit (ICU) stay and mortality among the study participants requiring high-flow oxygen or noninvasive ventilation in Group B as compared to Group A. After 7 days of treatment, 50% of the study participants in Group B got discharged as compared to 15% of the study participants in Group A. The number of study participants requiring mechanical ventilation remained 1 in Group B as compared to 5 in Group A. After the completion of treatment schedule, 91% study participants were discharged. There was 1 case of mortality reported in Group B as compared to 6 cases of mortality in Group A. The current study highlighted that fewer number of COVID-19-positive study participants in Group B required high-flow oxygen supplementation and noninvasive positive pressure ventilation as compared to those included in Group A. The corticosteroid treatment also reduced the number of ICU transfer and mortality.
  • ||||||||||  CORT108297 / Corcept Therap
    Trial completion date, Trial primary completion date:  Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study) (clinicaltrials.gov) -  Oct 22, 2021   
    P2a,  N=88, Not yet recruiting, 
    There was 1 case of mortality reported in Group B as compared to 6 cases of mortality in Group A. The current study highlighted that fewer number of COVID-19-positive study participants in Group B required high-flow oxygen supplementation and noninvasive positive pressure ventilation as compared to those included in Group A. The corticosteroid treatment also reduced the number of ICU transfer and mortality. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
  • ||||||||||  spironolactone / Generic mfg.
    Reimbursement, Journal:  Trends and patterns of neurotology drug prescriptions on a nationwide insurance database. (Pubmed Central) -  Oct 22, 2021   
    Triamterene-hydrochlorothiazide, prednisone, montelukast, amoxicillin-clavulanate, azelastine, spironolactone, and mupirocin had statistically significant increases in average number of prescriptions per physician, whereas ofloxacin and mometasone had significant decreases...This study is the first to analyze neurotologists' trends in prescribing patterns, regional prescription cost distributions, and commonly treated pathologies. This can lead to better standardization of prescribing patterns and cost in the future.
  • ||||||||||  Darzalex Faspro (daratumumab and hyaluronidase-fihj) / J&J
    Enrollment open, Minimal residual disease:  Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE) (clinicaltrials.gov) -  Oct 21, 2021   
    P2,  N=20, Recruiting, 
    This study demonstrates that the SHAC, alone or in combination with other peripheral nerve blocks, is an attractive alternative for shoulder pain management, especially when physiotherapy is required to recover shoulder function. Not yet recruiting --> Recruiting
  • ||||||||||  budesonide / Generic mfg.
    Enrollment open, Trial primary completion date:  Acupuncture Therapy for COVID-Related Olfactory Loss (clinicaltrials.gov) -  Oct 21, 2021   
    P=N/A,  N=100, Recruiting, 
    Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting | Trial primary completion date: Jul 2022 --> Jul 2023
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    [VIRTUAL] METHYLPREDNISOLONE ASSOCIATED DRUG-INDUCED LIVER INJURY () -  Oct 21, 2021 - Abstract #AASLD2021AASLD_1443;    
    MP DILI is characterized by hepatocellular injury with/without jaundice, short latency and rapid recovery . In DILIN, MP DILI was seen largely in MS patients where the complete or partial haplotype prevalent in the MS population HLA-DRB1*15-HLA DQA1*01:02-DQB1*06:02 was present in all 5 HC MP cases tested .
  • ||||||||||  Lysodren (mitotane) / HRA Pharma
    Journal:  Low dose mitotane-induced neurological and endocrinological complication in a 5-year-old girl with adrenocortical carcinoma. (Pubmed Central) -  Oct 21, 2021   
    The mitotane levels decreased to sub-therapeutic levels several months after discontinuation of mitotane, at which time endocrinopathy (central hypothyroidism, hypercholesterolemia, and secondary central precocious puberty) also developed. The case shows that low-dose mitotane can trigger neurological and endocrinological complications in a pediatric patient; the drug dose should be individualized with frequent monitoring of the therapeutic level.
  • ||||||||||  dexamethasone / Generic mfg.
    Dexamethasone and glycemic control (Channel 7 [VIRTUAL]) -  Oct 21, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_173;    
  • ||||||||||  Xipere (triamcinolone acetonide) / Clearside Biomedical, Bausch Health, Arctic Vision
    Uveitic Macular Edema: Visual Function and Ocular Anatomy by Severity of Vision Loss (Morial Convention Center) -  Oct 20, 2021 - Abstract #AAO2021AAO_1996;    
    Purpose To evaluate the relationship between vision at baseline and outcomes in two clinical trials of suprachoroidal CLS-TA in macular edema associated with noninfectious uveitis...Conclusion In subjects with uveitic macular edema, there is an inverse relationship between BCVA improvement and baseline vision, which reflects a ceiling effect. CST was improved to nearly 300 microns regardless of baseline vision, reflecting a floor effect.
  • ||||||||||  Xipere (triamcinolone acetonide) / Clearside Biomedical, Bausch Health, Arctic Vision
    Evaluation of Visual and Anatomic Temporal Biomarkers in Uveitic Macular Edema (Morial Convention Center) -  Oct 20, 2021 - Abstract #AAO2021AAO_1991;    
    Eyes with an early anatomical response experienced greater 24-week BCVA improvement than those without (14.6 versus 6.5 letters). Conclusions OCT anatomic features in UME correlate with BCVA; in CLS-TA-treated eyes, CST change precedes BCVA response.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  The effect of steroid treatment on whiplash associated syndrome: a controlled randomized prospective trial. (Pubmed Central) -  Oct 20, 2021   
    P2
    Conclusion Significantly greater CST reductions and greater BCVA improvement trends were observed in SCI unrescued CLS-TA group versus rescued control subjects in the Phase 3 PEACHTREE trial. Steroid treatment of patients with whiplash might be harmful to those who present with low cortisol concentrations (< 9.5 μg/dL).
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  dexamethasone- loaded polymeric porous sponge as a direct pulp capping agent. (Pubmed Central) -  Oct 20, 2021   
    Our study shows that 20% autologous serum drops can be safely prepared and stored at 4°C in an open system under a strict protocol for at least 28 days, and antimicrobial agents could reduce the risk of contamination. The porous bio-sponge loaded with dexamethasone with a neutral pH resulted in enhancement of the odontoblast differentiation from stem cells, resulting in the formation of a renewed dentin bridge without the slightest inflammatory response in the pulp.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Preoperative high-dose Steroids in Total Knee and Hip Arthroplasty - Protocols for three randomized controlled trials. (Pubmed Central) -  Oct 20, 2021   
    To investigate the effect of a higher than previously used dose of glucocorticoids (dexamethasone (DXM)), administered intravenously before surgery, as part of standardized fast-track regimen, on postoperative pain in TKA/THA subgroups...Predicted HPR groups consist of either PCs with PCS-score of ≥ 21 and/or history of ongoing opioid-treatment of 30 mg/day of morphine or equivalents > 30 days...Patients are completed for follow-up on day 90. Recruiting commenced February 2019 and is expected to finish September 2020.
  • ||||||||||  Revlimid (lenalidomide) / BMS, Darzalex IV (daratumumab) / J&J
    Clinical, Journal:  Early M-protein Dynamics Predicts Progression-Free Survival in Patients With Relapsed/Refractory Multiple Myeloma. (Pubmed Central) -  Oct 20, 2021   
    Specifically, the areas under the time-varying receiver operating characteristic curves for the model with the first two months of M-protein dynamic data were approximately 0.8 and 0.85 for POLLUX and CASTOR, respectively. Early M-protein data within first two months can provide a prospective and reasonable prediction of future long-term clinical benefit for MM patients.