Glucocorticoid Receptor 

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  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
    Journal:  Reactivation of IgA vasculitis following COVID-19 vaccination. (Pubmed Central) -  Dec 16, 2021   
    Reactivation or first presentation of IgA vasculitis is a rare but increasingly recognised complication of COVID-19 vaccination. This is an important new differential in the assessment of patients with haematuria following COVID-19 vaccination.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Clinical, Journal:  Managing solar retinopathy with suprachoroidal triamcinolone acetonide injection in a young girl: a case report. (Pubmed Central) -  Dec 16, 2021   
    This is an important new differential in the assessment of patients with haematuria following COVID-19 vaccination. Suprachoroidal triamcinolone acetonide injection using a custom-made needle showed both functional and anatomical improvement of macular changes post-solar retinopathy, with acceptable safety outcomes in a young female.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Dark urine as the initial manifestation of COVID-19: a case report. (Pubmed Central) -  Dec 16, 2021   
    Clinicians should be cognizant of atypical coronavirus disease 2019 presentations. The spectrum of damage of coronavirus disease 2019 is still an evolving topic, and more research is required to reveal the exact mechanisms by which severe acute respiratory syndrome coronavirus 2 leads to rhabdomyolysis.
  • ||||||||||  ketamine / Generic mfg., amphetamine / Generic mfg.
    Journal:  Analysis of drugs including illicit and new psychoactive substances in oral fluids by gas chromatography-drift tube ion mobility spectrometry. (Pubmed Central) -  Dec 16, 2021   
    Amphetamine, methylone, α-PVP, ketamine, lidocaine, MPHP, cocaine, THJ-2201, and 5F-ADB were employed as model compounds, providing limits of detection from 6 to 15 μg L and recoveries from 70 to 115% for field oral fluids spiked with target analytes at 250, 500, and 600 μg L. Moreover, two oral fluid certified reference materials were analysed by the proposed GC-IMS based methodology with obtained relative percentage errors lower than 8.4%, being the proposed GC-IMS procedure a reliable, selective, and sensitive technique for the determination of psychoactive substances in oral fluids.
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Retrospective data, Journal:  Effects of a Therapeutic Interchange Between Branded and Generic Inhaled Therapy on Chronic Obstructive Pulmonary Disease. (Pubmed Central) -  Dec 16, 2021   
    Objective To evaluate the difference in the occurrence of chronic obstructive pulmonary disease (COPD) exacerbations six months preconversion compared with six months postconversion from the branded inhaled corticosteroid/long-acting beta 2-agonist inhalers to the generic fluticasone/salmeterol inhalers...Conclusion While changing patients from branded to generic inhalers may be appealing because of the potential benefits in cost-reduction, the results of this study conclude that the inhaler switch may lead to increased exacerbations. Prescribers need to be aware of potential complications that may be related to a therapeutic interchange.
  • ||||||||||  Omblastys (131I-omburtamab) - Y / mAbs Therap
    Enrollment open:  131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma (clinicaltrials.gov) -  Dec 16, 2021   
    P2,  N=62, Recruiting, 
    Thus, the optimized RCTs are needed to provide more definitive evidence. Not yet recruiting --> Recruiting
  • ||||||||||  hydrocortisone / Generic mfg.
    New P2 trial:  CRISP: Corticosteroids to Treat Pancreatitis (clinicaltrials.gov) -  Dec 15, 2021   
    P2,  N=86, Not yet recruiting, 
  • ||||||||||  dexamethasone / Generic mfg., clarithromycin / Generic mfg.
    Clinical, Journal:  Potential prophylactic efficacy of mast cell stabilizers against COVID-19 vaccine-induced anaphylaxis. (Pubmed Central) -  Dec 15, 2021   
    In these studies, since mast cells were pre-incubated with these drugs or the food constituents before exocytosis was induced, the findings strongly indicated their prophylactic efficacy in stabilizing mast cells. Considering such pharmacological properties of these commonly prescribed medications or the food constituents, their prophylactic use may potentially be beneficial in preventing anaphylaxis caused by COVID-19 vaccination.
  • ||||||||||  dexamethasone / Generic mfg., atorvastatin / Generic mfg.
    Clinical, Clinical protocol, Journal:  Atorvastatin combined with dexamethasone in chronic subdural haematoma (ATOCH II): study protocol for a randomized controlled trial. (Pubmed Central) -  Dec 14, 2021   
    We concluded that the drug interactions should be considered and more attention should be paid in the use of these drugs.Communicated by Ramaswamy H. Sarma. This multi-centre clinical trial aims to provide high-quality evidence on the efficacy and safety of the combined treatment of atorvastatin and low-dose dexamethasone to reduce inflammation and enhance angiogenesis in CSDH.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  A Core Omnigenic Non-coding Trait Governing Dex-Induced Osteoporotic Effects Identified Without DEXA. (Pubmed Central) -  Dec 14, 2021   
    Furthermore, we also confirmed that GC-pre-conditioned mesenchymal stem cells (MSCs) would give rise to defective osteogenesis by instigating epigenetic changes which affected the accessibility of enhancer marks. In line with these epigenetic changes, we propose that GC modulates a key regulatory network involving the scavenger receptor Cd36 in osteoblasts pre-conditioning pharmacological idiosyncrasy in GIO.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Carnitine and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study. (Pubmed Central) -  Dec 14, 2021   
    A genetic predisposition to high carnitine levels might reduce the susceptibility and severity of COVID-19. These results provide better understandings on the role of carnitine in the COVID-19 pathogenesis, and facilitate novel therapeutic targets for COVID-19 in future clinical trials.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Drug-peptide supramolecular hydrogel boosting transcorneal permeability and pharmacological activity via ligand-receptor interaction. (Pubmed Central) -  Dec 14, 2021   
    In the present study, we propose a drug-peptide supramolecular hydrogel based on anti-inflammatory drug, dexamethasone (Dex), and Arg-Gly-Asp (RGD) motif for boosting transcorneal permeability and pharmacological activity via the ligand-receptor interaction...On topical instillation in rabbit's eye, the proposed Dex-SA-K(NBD)RGD could effectively enhance the transcorneal distribution and permeability with respect to the Dex-SA-K(NBD)RGE. Overall, our findings demonstrate the performance of the ligand-receptor interaction for boosting transcorneal permeability and pharmacological activity of drug.
  • ||||||||||  Enerzair Breezhaler (glycopyrrolate/indacaterol/mometasone) / Novartis
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date:  XPERTT: Investigating the Effects of QVM149 on MRI Ventilation Defects (clinicaltrials.gov) -  Dec 14, 2021   
    P3,  N=0, Withdrawn, 
    Overall, our findings demonstrate the performance of the ligand-receptor interaction for boosting transcorneal permeability and pharmacological activity of drug. N=48 --> 0 | Trial completion date: Jul 2021 --> Dec 2022 | Not yet recruiting --> Withdrawn | Trial primary completion date: Jul 2021 --> Jul 2022
  • ||||||||||  Akynzeo oral (netupitant/palonesteron FDC) / Helsinn, Roche, Otsuka, Mundipharma, Immedica
    Trial completion date, Trial primary completion date:  Safety and Antiemetic Efficacy of Akynzeo Plus Dexamethasone During Radiotherapy and Concomitant Weekly Cisplatin (clinicaltrials.gov) -  Dec 14, 2021   
    P2/3,  N=80, Recruiting, 
    N=48 --> 0 | Trial completion date: Jul 2021 --> Dec 2022 | Not yet recruiting --> Withdrawn | Trial primary completion date: Jul 2021 --> Jul 2022 Trial completion date: Apr 2022 --> Apr 2023 | Trial primary completion date: Mar 2022 --> Mar 2023
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery. (Pubmed Central) -  Dec 13, 2021   
    In addition, dexamethasone phosphate (DEX) was incorporated in the hydrogel and drug delivery kinetics was studied. Hydrogel made at pH 10.0 was found to have the highest gel fraction 110.24%, swelling degree 956.32%, and sustained drug delivery for 72 h. The highest cell viability was observed for the hydrogel, which contained brushite (pH 6)-512.43%.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Divya-Herbal-Peya Decoction Harmonizes the Inflammatory Response in Lipopolysaccharide-Induced Zebrafish Model. (Pubmed Central) -  Dec 13, 2021   
    However, these locomotory deviations and behavioural fever were negligible in zebrafish groups pre-administered either with DHP in a dose dependent manner or dexamethasone (DEX)...DHP prophylactically prevented the LPS-induced abnormal behaviour and inflammation-related pathophysiology in zebrafish. Immunomodulatory properties of DHP may not have therapeutic intervention, but do confer nutraceutical health benefits against mild infections.
  • ||||||||||  Clinical, Journal:  A rare case of macroprolactinoma in a patient with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. (Pubmed Central) -  Dec 13, 2021   
    Abnormal pituitary hormones, particularly panhypopituitarism, would impose greater impact not only psychologically but also metabolically leading to cardiovascular, morbidity and mortality risks in this patient if not treated early. A multidisciplinary approach is necessary for patients presenting with MRKH to ensure appropriate treatments and follow-up across the lifespan of the patient.