- |||||||||| Darzalex (daratumumab) / J&J
Autologous Stem Cell Mobilization and Transplantation for Multiple Myeloma - Current Status and Future Perspectives in Japan - (Room A (2F)) - Sep 24, 2024 - Abstract #ICBMT2024ICBMT_165;
IFM/DFCI group reported that triplet induction (bortezomib, lenalidomide, and dexamethasone) followed by up-front high-dose melphalan and autologous stem-cell transplantation (HDM/ASCT) and maintenance therapy lead to median PFS of 50 months...The use of lenalidomide before stem cell mobilization is known to reduce the amount of collected CD34-positive cells and concomitant use of plerixafor with G-CSF is recommended...Daratumumab, lenalidomide, and dexamethasone have also been reported to prolong PFS for newly diagnosed transplant-ineligible MM...On the other hands, the success of CAR-T therapy revealed that cellular immunotherapy may play important roles in the treatment of MM. In this lecture, current standard of care and future perspectives for transplant eligible MM in Japan will be discussed.
- |||||||||| Strategies to Mitigate CAR T-Cell-Associated Cytokine Release Syndrome and Neurologic Toxicity (Room A (2F)) - Sep 24, 2024 - Abstract #ICBMT2024ICBMT_47;
I will spotlight promising data from a recent clinical trial investigating the JAK-1 inhibitor itacitinib to prevent CRS and ICANS after axi-cel treatment (Frigault et al., ASH Abstract...Lastly, I will share our experience with anakinra to prevent CRS and ICANS in patients with large B-cell lymphoma receiving the CD19 CAR T-cell product lisocabtagene maraleucel on an investigator-initiated clinical trial (Liang et al., Tandem Meeting Abstract...2023). Learning objectives: - Identify clinical and laboratory factors associated with severe CRS and ICANS - Recognize differences in the toxicity profile across distinct CAR T-cell products - Become acquainted with current toxicity prophylactic strategies
- |||||||||| Blincyto (blinatumomab) / Astellas, Amgen
Korean Real-World Experience of Blinatumomab for 8 Years Regarding Predictive Factors Including Lymphocyte Kinetics for Response and Survival Outcome in Adult Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia (Room A (2F)) - Sep 24, 2024 - Abstract #ICBMT2024ICBMT_6;
The standard protocol consisted of pre-phase dexamethasone, first cycle blinatumomab 28-days (9mcg during initial 7d followed by 28mcg for 21d) was followed by 2-week resting period and second or more cycle of 28mcg blinatumomab for 28-days...We observed early relapse with short CR duration, PB blast prior to blinatumomab, and later-line salvage were related with poor response to blinatumomab and old age and early relapse for poor OS even after allo-HCT. Regarding absolute lymphocyte count (ALC), ALC at first day of blinatumomab was not significantly affecting the response and outcome, but we observed ALC2000/mcL at 2-weeks after blinatumomab was predictive for poor response and poor survival Conclusions : Our long-term data showed blinatumomab was effective even with low ALC before blinatumomab, but preserved ALC was related with good response and better survival outcome.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
The Effect of Intravenous Methylprednisolone on Serum Antibody Levels in TED (South Level 1 Lobby: STATION 1) - Sep 24, 2024 - Abstract #AAO2024AAO_1295;
Conclusion IVMP decreased the antibody level significantly for 3 months, compared with no treatment group, but the groups did not differ significantly after 12 months. Patients with high total cholesterol levels showed poor response.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Androgens suppress corticosteroid binding globulin in male mice, affecting the endocrine stress response. (Pubmed Central) - Sep 24, 2024
Stress-induced total plasma corticosterone levels were increased, whereas the suppression of corticosterone after dexamethasone treatment under basal conditions was attenuated...The reduction in negative feedback on the HPA axis under basal condition would suffice to explain the enhanced stress reactivity after androgen deprivation. Overall our data demonstrate that, in mice, tonic AR activation affects CBG levels, in conjunction with effects on gene expression and HPA-axis reactivity.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Efficacy and mechanism of action of ginsenoside Rg3 on radiation proctitis in rats. (Pubmed Central) - Sep 24, 2024
GRg3 may also inhibit intestinal cell apoptosis by suppressing the TNF-?/caspase-8 signaling cascade, thereby reducing radiological rectal injury. Our results verify that GRg3 is a promising therapeutic agent for RP treatment and shed light on its mechanism.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Pseudomonas aeruginosa exotoxin A as a novel allergen induced Non-TH2 inflammation in a murine model of steroid-insensitive asthma. (Pubmed Central) - Sep 24, 2024
Importantly, rPEA-induced asthmatic mice were unresponsive to dexamethasone treatment...Furthermore, mice developed steroid-resistant asthma, characterized by an atypical cytokine profile associated with non-TH2 inflammation, only after being sensitized and challenged with rPEA. These findings suggest a potentially significant role for PEA in asthma development, warranting consideration in clinical diagnosis and treatment strategies.
- |||||||||| Rituxan (rituximab) / Roche
Primary Adrenal Lymphoma - a case series based review () - Sep 24, 2024 - Abstract #ESUR2024ESUR_309;
Dexamethasone was administered at admission with possible influence on the following hormonal examinations: serum cortisol - 685 nmol/l, serum aldosterone <0.970ng/dl, ACTH <5.0pg/ml...Patient was qualified for chemotherapy with R-CHOP with initial good response...Core needle biopsy is required to confirm the diagnosis. Chemotherapy is the treatment modality of choice.
- |||||||||| Vyloy (zolbetuximab) / Astellas
Journal: Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets. (Pubmed Central) - Sep 23, 2024
Fosaprepitant showed suppressive effects on emesis, and use of dexamethasone or concomitant use of fosaprepitant with other antiemetics tended to alleviate gastric tissue damage. The onset of emesis in humans receiving zolbetuximab may be associated with damage in the gastric mucosa, and antiemetics may mitigate gastrointestinal adverse events.
- |||||||||| dexamethasone / Generic mfg.
Journal: Progressive 11?-Hydroxysteroid Dehydrogenase Type 2 Insufficiency as Kidney Function Declines. (Pubmed Central) - Sep 23, 2024
A continuum of declining 11?HSD2 activity was observed with progressively lower eGFR in individuals spanning a wide spectrum of kidney function, including those with apparently normal kidney function. These findings implicate cortisol-mediated MR activation in the pathophysiology of hypertension and cardiovascular disease in CKD.
- |||||||||| Journal: Atypical Presentation of Severe Bullous Pemphigoid: A Case Report. (Pubmed Central) - Sep 23, 2024
With no clinical improvement, tissue biopsy was performed that confirmed bullous pemphigoid and treatment with steroid taper, doxycycline, and triamcinolone acetonide 0.1% cream was started. The aim of this case report is to present an atypical presentation of BP and to highlight maintaining a high index of suspicion of BP in patients presenting with disseminated significantly pruritic lesions.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Acute Hemorrhagic Leukoencephalitis in a Patient With Hepatitis B. (Pubmed Central) - Sep 23, 2024
Despite aggressive treatment with intravenous (IV) methylprednisolone, IV immunoglobulin, and anti-edema measures, the patient's condition rapidly deteriorated, leading to a diagnosis of AHLE following the emergence of hemorrhagic white matter lesions on repeat MRI...Clinicians should maintain a high index of suspicion for AHLE in patients with chronic viral infections presenting with neurological symptoms. Prompt and aggressive management can be life-saving, and ongoing research is needed to better understand the pathogenesis and optimal treatment strategies for this rare but devastating condition.
- |||||||||| triamcinolone acetonide / Generic mfg.
Journal: Nonsurgical Treatment of Oral Mucocele With Intralesional Corticosteroid Injections: A Case Report. (Pubmed Central) - Sep 23, 2024
The treatment involved the administration of intralesional injections of triamcinolone acetonide at the base of the lesion...No recurrence was observed during the six-month follow-up period. This case highlights the effectiveness of intralesional corticosteroid injections as a non-surgical treatment option for mucoceles.
- |||||||||| hydrocortisone / Generic mfg.
Review, Journal: Rheumatoid Vasculitis Involving Gastrointestinal Tract Pre-dating Rheumatoid Arthritis: A Case Study and Literature Review. (Pubmed Central) - Sep 23, 2024
Treatment with intravenous hydrocortisone led to rapid improvement, and the patient is now being monitored on an outpatient basis with progressive recovery...It highlights the importance of considering RV as a primary diagnosis, even in the absence of a prior RA diagnosis. Early recognition and intervention are critical for managing complications, emphasizing the need for a high index of suspicion in rheumatic diseases' unusual presentations.
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Imbruvica (ibrutinib) / AbbVie, J&J
Journal, IO biomarker: Paraneoplastic myelitis associated with Waldenstr (Pubmed Central) - Sep 23, 2024
However, he subsequently relapsed and symptomatically worsened while on rituximab therapy...Our observation of sustained disease response in this patient may support a role for concurrent BTK and BCL2 inhibition in paraneoplastic myelitis associated with B-cell lymphoproliferative disorders. However, this observation needs to be validated in larger cohort studies and potentially in clinical trials if further data are supportive.
- |||||||||| Journal: Evaluation of outcomes of clinical phenotyping-based treatment for bladder pain syndrome/interstitial cystitis. (Pubmed Central) - Sep 23, 2024
Patients with Hunner's lesions (HL) (CP4) underwent hydro distension and ablation of the lesion, followed by intravesical instillation of heparin and hydrocortisone...Overall, 16% (4/25) patients had unsatisfactory, 56% (14/25) attained good, and 28% (7/25) had an excellent response at the completion of the study. Using clinical phenotyping-based features indicative of etiology could potentially improve treatment outcomes by targeting the specific pathological processes contributing to the patients' symptoms.
- |||||||||| dexamethasone / Generic mfg.
Journal: Hyperandrogenic eumenorrheic NON-PCOS women versus women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone. (Pubmed Central) - Sep 23, 2024
It has previously been shown that around half of PCOS women exhibit a hyper-response of serum 17-hydroxy-progesterone (17-OHP) to the stimulation by GnRH-agonists, also indicated as functional ovarian hyperandrogenism (FOH)...Interestingly, treatment of women with PCOS with Dex suppression and GnRH-agonist stimulation (buserelin) highlighted the possible existence of two clusters of patients: hyper-responders (HR) and normal responders (NR)...Moreover, within women with PCOS, the HR subgroup has higher insulin levels compared to the NR subgroup, when OGTT is performed. The alteration of the glucose-insulin balance and elevation of circulating androgens were more pronounced in PCOS, thus indicating that [i.] metabolic alterations might be crucial in the onset of PCOS itself and, [ii] EuHyperA might represent a milder form of PCOS.
- |||||||||| dexamethasone / Generic mfg.
Journal: Dexamethasone Inhibits the Growth of B-Lymphoma Cells by Downregulating DOT1L. (Pubmed Central) - Sep 23, 2024
The alteration of the glucose-insulin balance and elevation of circulating androgens were more pronounced in PCOS, thus indicating that [i.] metabolic alterations might be crucial in the onset of PCOS itself and, [ii] EuHyperA might represent a milder form of PCOS. Overall, our findings indicated that DOT1L may serve as a potential drug target and a promising biomarker of Dex sensitivity when it comes to treating B lymphoma.
- |||||||||| dexamethasone injection / Generic mfg.
Enrollment open: Effects of SCALP Block on Postoperative Analgesia in Craniotomy Surgery (clinicaltrials.gov) - Sep 23, 2024
P=N/A, N=52, Recruiting,
Overall, our findings indicated that DOT1L may serve as a potential drug target and a promising biomarker of Dex sensitivity when it comes to treating B lymphoma. Not yet recruiting --> Recruiting
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Methylprednisolone pulse and prednisolone for intensification of primary treatment in Kawasaki disease patients at high risk of treatment resistance: a multicenter prospective cohort study. (Pubmed Central) - Sep 22, 2024
The purpose of this study is to determine whether adding intravenous methylprednisolone pulse (IVMP) to primary adjunctive prednisolone with intravenous immunoglobulin (IVIG) improves treatment resistance and coronary artery aneurysms (CAA) in patients with Kawasaki disease (KD) with a high risk of treatment resistance...Patients receiving IVIG alone achieved coronary outcomes comparable to those of patients receiving primary adjunctive corticosteroid therapy although they were more likely to require additional rescue treatment. KD inflammation should be resolved no later than the third line of additional treatment to reduce the risk of CAA.Trial registration: University Hospital Medical Information Network Clinical Trials Registry in Japan ( https://www.umin.ac.jp/ctr/index.htm ) under code UMIN000024937.
- |||||||||| Journal: Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis. (Pubmed Central) - Sep 22, 2024
Dexamethasone implants favor the therapeutic goal of prevention of recurrences, whereas the use of fluocinolone implants helps to attain better visual outcomes due to their longer duration of action. Thus, the review provides recent literature supporting the role and indication of sustained release intravitreal implants in the management of noninfectious intermediate and posterior uveitis.
- |||||||||| dexamethasone / Generic mfg.
Journal: Antibiotic-free ocular sterilization while suppressing immune response to protect corneal transparency in infectious keratitis treatment. (Pubmed Central) - Sep 21, 2024
In this work, photodynamic metal organic frameworks (PCN-224) were used as drug carrier to load Pt NPs with catalase-like activity and anti-inflammatory drug (Dexamethasone, DXMS) for endogenous oxygen generation and reduced corneal damage, respectively...The superior bactericidal effect of antibacterial materials could largely replace the bactericidal effect of the immune system. It is worth mentioning that this simultaneous sterilization and anti-inflammation treatment mode is a new exploration against the clinical treatment guidelines.
- |||||||||| Nanocort (liposomal prednisolone) / Galapagos, Enceladus, Sun Pharma
Journal: A bio-predictive release assay for liposomal prednisolone phosphate. (Pubmed Central) - Sep 21, 2024
It is worth mentioning that this simultaneous sterilization and anti-inflammation treatment mode is a new exploration against the clinical treatment guidelines. A three-point specification evaluated the key phases of in vivo release: early (T-5%), intermediate (T-20%), and late release behavior (T-40%), compared to the in vivo release profile of the reference product, NanoCort
- |||||||||| ketamine / Generic mfg., dexamethasone injection / Generic mfg.
Review, Journal: Adjuvant Analgesics in Acute Pain - Evaluation of Efficacy. (Pubmed Central) - Sep 21, 2024
Furthermore, ?2-agonists and dexamethasone can extend the analgesic effect of regional anesthesia techniques. However, findings for lidocaine remain inconclusive.
- |||||||||| triamcinolone acetonide / Generic mfg.
Journal: A Rare Skin Lesion Presentation With Sarcoidosis. (Pubmed Central) - Sep 21, 2024
Treatment with the intralesional steroid triamcinolone acetonide (5 mg/mL) monthly is considered. We hope to raise doctors' awareness of the various forms of sarcoidosis, consequently improving diagnostic skills and patient treatment.
- |||||||||| Journal: A Challenging Case of Idiopathic Hypereosinophilic Syndrome: An Itching in the Brain. (Pubmed Central) - Sep 21, 2024
The presentation of episodes of itching was like Gleich syndrome without angioedema and needed an injection of hydrocortisone and chlorpheniramine maleate to treat. Diethylcarbamazine, hydroxyurea, and steroids failed to decrease the eosinophilia as well as the episodic itching...Considering it as idiopathic non-steroid-responding HE, imatinib was started, and the patient immediately responded, and the eosinophil count
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