Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...379380381382383384385386387388389...10671068»
  • ||||||||||  Riarify (beclometasone/formoterol/glycopyrrolate) / Chiesi
    Trial completion, Metastases:  DARWiIN: Functional Respiratory Imaging Study (clinicaltrials.gov) -  Jan 25, 2022   
    P3,  N=25, Completed, 
    Recruiting --> Completed
  • ||||||||||  batoclimab (IMVT-1401) / Roivant
    Trial completion:  A Study of HBM9161 in NMOSD Patients (clinicaltrials.gov) -  Jan 25, 2022   
    P1,  N=9, Completed, 
    Trial primary completion date: Jun 2022 --> Jun 2021 Recruiting --> Completed
  • ||||||||||  dexamethasone injection / Generic mfg.
    Enrollment open, Trial initiation date:  DEXA-SEPSIS: Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis (clinicaltrials.gov) -  Jan 25, 2022   
    P1/2,  N=102, Recruiting, 
    Trial completion date: Sep 2022 --> Sep 2024 | Initiation date: Jan 2022 --> Aug 2022 | Trial primary completion date: Jul 2022 --> Jul 2023 Not yet recruiting --> Recruiting | Initiation date: Dec 2021 --> Jan 2021
  • ||||||||||  dexamethasone / Generic mfg., clarithromycin / Generic mfg., pomalidomide / Generic mfg.
    Trial completion date, Trial primary completion date:  Autologous Stem Cell Transplant With Pomalidomide (CC-4047 (clinicaltrials.gov) -  Jan 24, 2022   
    P2,  N=23, Active, not recruiting, 
    Not yet recruiting --> Recruiting | Initiation date: Dec 2021 --> Jan 2021 Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
    Trial completion date, Trial primary completion date:  MT2015-20: Biochemical Correction of Severe EB by Allo HSCT and Serial Donor MSCs (clinicaltrials.gov) -  Jan 24, 2022   
    P2,  N=84, Recruiting, 
    Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023 Trial completion date: Sep 2022 --> Dec 2024 | Trial primary completion date: Dec 2021 --> Dec 2024
  • ||||||||||  Xpovio (selinexor) / Karyopharm, Menarini, FORUS Therap
    Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date:  STARR: Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Disease (clinicaltrials.gov) -  Jan 24, 2022   
    P1,  N=10, Recruiting, 
    Trial completion date: Sep 2022 --> Dec 2024 | Trial primary completion date: Dec 2021 --> Dec 2024 Not yet recruiting --> Recruiting | Trial completion date: Dec 2024 --> Dec 2025 | Initiation date: Dec 2021 --> Mar 2022 | Trial primary completion date: Dec 2023 --> Dec 2024
  • ||||||||||  dexamethasone / Generic mfg., epinephrine / Generic mfg.
    Clinical, Journal:  Epinephrine and Dexamethasone as Adjuvants in Upper Extremity Peripheral Nerve Blocks in Pediatric Patients. (Pubmed Central) -  Jan 23, 2022   
    In group 3 (dexamethasone) the duration of the sensory and motor block was significantly longer compared with the first two groups (p<0.0001). Epinephrine and dexamethasone prolong the duration of action of local anesthetics in peripheral nerve blocks of the upper extremity in pediatric patients and thus reduce the need for analgesics in the postoperative period.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Journal:  Switching to intravitreal fluocinolone acetonide implant for refractory diabetic macular edema: 12- and 24-month results. (Pubmed Central) -  Jan 21, 2022   
    Only five eyes required additional treatment for DME and only three eyes required treatment for raised IOP. Our results show that the visual and the anatomical improvements achieved by a single injection of a fluocinolone acetonide implant were maintained up to 24 months with minimal additional therapy even in eyes with a long and heavy history; however, IOP monitoring remains essential.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Ex vivo glucocorticoid-induced secreted proteome approach for discovery of glucocorticoid-responsive proteins in human serum. (Pubmed Central) -  Jan 21, 2022   
    Our results show that the visual and the anatomical improvements achieved by a single injection of a fluocinolone acetonide implant were maintained up to 24 months with minimal additional therapy even in eyes with a long and heavy history; however, IOP monitoring remains essential. Using an ex vivo proteomic approach in PBMC, we have identified circulating glucocorticoid-responsive proteins which may have potential as serum biomarkers of glucocorticoid activity.
  • ||||||||||  Korlym (mifepristone) / Corcept Therap, CORT125329 / Corcept Therap, Mifeprex (mifepristone) / Danco Laboratories
    Clinical, Journal:  The development of novel glucocorticoid receptor antagonists: From rational chemical design to therapeutic efficacy in metabolic disease models. (Pubmed Central) -  Jan 21, 2022   
    Yet, the only GR antagonist that is clinically approved to date - mifepristone - exhibits cross-reactivity with other nuclear steroid receptors like the progesterone receptor...Rather, we propose that CORT125329 treatment restores metabolic activity in brown adipose tissue by stimulating lipolysis, mitochondrial activity and thermogenic capacity. In summary, we have identified CORT125329 as a selective GR antagonist with strong beneficial activities in metabolic disease models, paving the way for further clinical investigation.
  • ||||||||||  Eylea (aflibercept intravitreal) / Bayer, Regeneron
    Clinical, Journal:  Involvements of choroidal vascular structures with local treatments in patients with diabetic macular edema. (Pubmed Central) -  Jan 21, 2022   
    All patients underwent laser photocoagulation (Laser), sub-tenon triamcinolone acetonide injection (TA), or intravitreal aflibercept injection (IVA)...The L/C ratio in pretreatment showed a significantly inverse correlation with CMT (-0.60, p = 0.02) and subsequent BCVA (logMAR) (-0.59, p = 0.03). This study highlighted that the L/C ratio in pretreatment might predict a change of the visual acuity in DME.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Anterior chamber changes assessment by Scheimpflug analysis after intravitreal dexamethasone implantation. (Pubmed Central) -  Jan 21, 2022   
    Anterior chamber depth (ACD) and iridocorneal angle (ICA) was measured by a Scheimflug camera (Sirius, CSO, Italy) the day before the injection of the dexamethasone implant and on postoperative day 1, first week, and first month...This study confirmed that there was an increase in IOP. However, these changes were not accompanied with a change in ACD or ICA.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Spontaneous Hypoglycemia: A Diagnostic Challenge (Pubmed Central) -  Jan 21, 2022   
    It is important to ensure that hormone analysis is carried out immediately in hypoglycemia. The ratio of insulin, C-peptide and proinsulin to blood glucose and the constellation of counter-regulatory hormones such as cortisol, ACTH, growth hormone, Insulin-like growth factor 1 (IGF-1) and catecholamines can provide information about the etiology of hypoglycemia.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Femtosecond laser-assisted deep anterior lamellar keratoplasty: A safer option in keratoconus surgery. (Pubmed Central) -  Jan 21, 2022   
    The ratio of insulin, C-peptide and proinsulin to blood glucose and the constellation of counter-regulatory hormones such as cortisol, ACTH, growth hormone, Insulin-like growth factor 1 (IGF-1) and catecholamines can provide information about the etiology of hypoglycemia. Anvil-shaped femtosecond laser deep anterior lamellar keratoplasty in keratoconus surgery increases safety and readiness of recovery, decreasing the incidence of corneal rejection, epithelial defects, graft failures, and producing better best-corrected visual acuity after removal of sutures.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Observational data, Journal, Real-world evidence:  Real-world corticosteroid use in severe pneumonia: a propensity-score-matched study. (Pubmed Central) -  Jan 21, 2022   
    Corticosteroid treatment may be of benefit for patients with CAP who have septic shock and/or a high inflammatory response and requirement for invasive mechanical ventilation. Corticosteroids appear to have no impact on mortality when these features are not present.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Barley Sprout Water Extract and Saponarin Mitigate Triacylglycerol Accumulation in 3T3-L1 Adipocytes. (Pubmed Central) -  Jan 21, 2022   
    BSW elicited superior antiadipogenic effects when compared with BSE in MDI mixture [IBMX 0.5 mM + dexamethasone 1 μM + insulin 1 μg/mL]-treated 3T3-L1 preadipocytes...Further investigation of saponarin-mediated hypotriacylglycerolemic activity and related gene expression revealed that saponarin significantly inhibited TAG accumulation, which was attributed to reductions in TAG synthesis-related gene expression. Taken together, these findings provide a basis for further development of barley sprout extract for functional health food purposes.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Review, Journal:  Pediatric Adrenal Insufficiency: Challenges and Solutions. (Pubmed Central) -  Jan 21, 2022   
    However, children that experience low cortisol concentrations and symptoms of cortisol insufficiency can take advantage using a modified release hydrocortisone formulation. The acute adrenal crisis is a life-threatening condition in all ages, treatment is effective if administered promptly, and it must not be delayed for any reason.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Clinical, Review, Journal:  Myelin Oligodendrocyte Glycoprotein Antibody Associated Cerebral Cortical Encephalitis: Case Reports and Review of Literature. (Pubmed Central) -  Jan 21, 2022   
    For acute CCE, 30 patients were treated with high-dose intravenous methylprednisolone, and the symptoms of most patients were completely relieved after immunotherapy. This study reported our experience and lessons learned in the diagnosis and treatment of MOG-Ab-positive CCE and provides a systematic review of the literature to analyse this rare clinical phenotype.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Clinical, Journal:  Effectiveness of oral probiotics supplementation in the treatment of adult small chalazion. (Pubmed Central) -  Jan 21, 2022   
    This study reported our experience and lessons learned in the diagnosis and treatment of MOG-Ab-positive CCE and provides a systematic review of the literature to analyse this rare clinical phenotype. The considerable difference in time taken for complete resolution of small chalazia between the two groups in favor of the experimental one confirms the presence of a gut-eye axis.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  Bone Age Maturation and Growth Outcomes in Young Children with CAH Treated with Hydrocortisone Suspension. (Pubmed Central) -  Jan 21, 2022   
    Our data indicate that treatment with alcohol-free HC suspension decreased androgen exposure as shown by lower bone age z-scores, allowed lower average and cumulative daily HC dose compared to HC tablets, and generated no significant differences in SDS in growth parameters in children with CAH at 4 years of age. Longitudinal studies of treating with smaller HC doses during childhood are needed.
  • ||||||||||  Viracept (nelfinavir) / ViiV Healthcare, Roche
    Trial completion date, Trial primary completion date:  SAKK 39/10: Nelfinavir and Lenalidomide/Dexamethasone in Progressive Multiple Myeloma (clinicaltrials.gov) -  Jan 21, 2022   
    P1/2,  N=33, Active, not recruiting, 
    Longitudinal studies of treating with smaller HC doses during childhood are needed. Trial completion date: Dec 2021 --> Jun 2022 | Trial primary completion date: Dec 2021 --> Jun 2022