- |||||||||| methylprednisolone acetate / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Enrollment change, Trial termination: Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone (clinicaltrials.gov) - Jan 27, 2022
P4, N=62, Terminated,
N=1000 --> 62 | Suspended --> Terminated; Enrollment and study activities were initially suspended due to COVID-19. The investigator has also left Emory and the study will not resume.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: Hypercortisolism and altered glucose homeostasis in obese patients in the pre-bariatric surgery assessment. (Pubmed Central) - Jan 27, 2022
These data suggest that increased intrinsic sensitivity of vHi NPC-derived neurons to chronic glucocorticoid exposure may underlie the increased vulnerability of the vHi to chronic stress-induced reductions in neurogenesis. In obese patients, hypercortisolism was more frequent across the entire spectrum of altered glucose homeostasis including the very early stages; this relation could not be detected for the other criteria of the MS, as waist, hypertension and atherogenic dyslipidemia.
- |||||||||| dexamethasone / Generic mfg.
Journal: Cytotoxic activity of human dendritic cells induces RIPK1-dependent cell death. (Pubmed Central) - Jan 27, 2022
Dexamethasone-pre-treated tolerogenic DCs induced less intensive death indicating that the tissue microenvironment can downregulate DC-mediated killing...Our work revealed that the supernatant of activated DCs induces the apoptosis of target cells in a RIPK1-dependent manner. This phenomenon could be relevant for the initiation of cross-presentation and may broaden the plethora of cytotoxic mechanisms acting against tumor cells.
- |||||||||| dexamethasone / Generic mfg.
Journal: GelMA/bioactive silica nanocomposite bioinks for stem cell osteogenic differentiation. (Pubmed Central) - Jan 27, 2022
The inorganic building block was formulated by incorporating mesoporous silica nanoparticles functionalized with calcium, phosphate and dexamethasone (MSNCaPDex), which previously proven to induce osteogenic differentiation...Viability and differentiation studies showed that hBM-MSCs remained viable and exhibited osteogenic differentiation biomarkers when incorporated in GelMA/MSNCaPDex constructs and without requiring further biochemical nor mechanical stimuli. Overall, our nanocomposite bioink has demonstrated excellent processability via extrusion bioprinting into osteogenic constructs with potential application in bone tissue repair and regeneration.
- |||||||||| dexamethasone / Generic mfg.
Journal: Transglutaminase 2 mediates transcriptional regulation through BAF250a polyamination. (Pubmed Central) - Jan 27, 2022
Overall, our nanocomposite bioink has demonstrated excellent processability via extrusion bioprinting into osteogenic constructs with potential application in bone tissue repair and regeneration. Thus, our results indicate that TG2 regulates transcriptional activity through BAF250a polyamination.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Effects of hydrocortisone and yohimbine on selective attention to emotional cues. (Pubmed Central) - Jan 27, 2022
Only hydrocortisone administration led to an attentional bias away from sad faces. Future studies should investigate these effects in major depression disorder, as this disorder is characterised by glucocorticoid resistance and increased processing of sad stimuli.
- |||||||||| Maxidex (dexamethasone eye drops, suspension) / Novartis, dexamethasone cyclodextrin nanoparticle ophthalmic suspension (OCS-01) / Oculis
Review, Journal: Aqueous eye drops containing drug/cyclodextrin nanoparticles deliver therapeutic drug concentrations to both anterior and posterior segment. (Pubmed Central) - Jan 27, 2022
Phase II studies with similar dexamethasone/γCD nanoparticle eye drops in diabetic macular oedema and postcataract surgery inflammation have recently been completed. This technology has the potential to be used with other classes of drug molecules and to replace or complement invasive treatments, providing safer, non-invasive therapies, particularly for posterior segment conditions, that can be self-administered as eye drops by patients.
- |||||||||| dexamethasone / Generic mfg.
Journal: Improving the Dexamethasone Suppression Test. (Pubmed Central) - Jan 27, 2022
Future studies corroborating our result of a predictive hair GC relationship with threat bias change in larger clinical samples are needed. No abstract available
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: T3 is linked to stress-associated reduction of prolactin in lactating women. (Pubmed Central) - Jan 27, 2022
A dexamethasone suppression test was also administered to determine the sensitivity of the hypothalamic-pituitary-adrenal axis to negative-feedback...Our data fit a speculative model in which elevated maternal stress increases cortisol, which suppresses T3, leading to decreased PRL. The decreases in PRL are associated with higher rates of bottlefeeding, which may further contribute to decreased PRL.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Transcriptome analysis of porcine PBMCs reveals lipopolysaccharide-induced immunomodulatory responses and crosstalk of immune and glucocorticoid receptor signaling. (Pubmed Central) - Jan 27, 2022
Therefore, in the present study, we treated porcine peripheral blood mononuclear cells (PBMCs) with lipopolysaccharide (LPS) and dexamethasone (DEX) separately or combined for 2 hours...This was apparent in four aspects: constitutive inhibition of T cell signaling by DEX through a subset of genes showing no response to LPS; inhibition of LPS-induced inflammatory genes by DEX; attenuation of DEX action by LPS paralleled by the regulation of genes implicated in cytokine and calcium signaling; and DEX-induced changes in genes associated with the activation of pro-inflammatory TLR, NF-κB, iNOS, and IL-1 signaling. Consequently, our study provides novel insights into inflammatory and GR signaling in pigs, as well as an understanding of the application of glucocorticoid drugs for the treatment of inflammatory disorders.
- |||||||||| hydrocortisone / Generic mfg.
Review, Journal: Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis-a systematic review. (Pubmed Central) - Jan 27, 2022
The first TCS, hydrocortisone (HC) introduced in the early 1950s led to the development of different steroidal moieties of varying potencies by inducing chemical modifications to the basic steroid structure...Thus, novel nanoformulations have been developed to overcome these problems. This review provides an insight into the current state of nanocarrier-mediated topical delivery of corticosteroids monotherapy and combination therapy with special emphasis on targeting psoriasis and AD.
- |||||||||| fluticasone / Generic mfg.
Preclinical, Journal: Protective effect of sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress. (Pubmed Central) - Jan 27, 2022
Thirty Wistar rats were randomized into five groups: (i) Normal control, (ii) Disease control (TNBS), (iii) Sarsasapogenin (SG) (50 µg/rat), (iv) Fluticasone (FC) (50 µg/rat), (v) Sarsasapogenin + Fluticasone (SG + FC) (25 µg/rat)...SG and SG + FC treatment also considerably restored the histopathological changes induced by TNBS. Thus, SG and SG + FC combination could alter the disease progression and could be a hopeful therapeutic target for the management of UC by reducing its dose in combination with FC to elude the long term adverse effects of FC.
- |||||||||| Darzalex IV (daratumumab) / J&J
Journal: The Role of Autologous Stem Cell Transplantation in Amyloidosis. (Pubmed Central) - Jan 27, 2022
The introduction of newer agents such as bortezomib and daratumumab (Darzalex), which lead to deep responses and have good safety profiles, encourage revisiting the benefit and timing of ASCT in the modern era. This review provides a comprehensive assessment of eligibility criteria for ASCT in AL amyloidosis, conditioning dosing, efficacy in terms of hematologic and organ response, and future areas of research.
- |||||||||| dexamethasone / Generic mfg.
Journal: A Chinese pedigree with glucocorticoid remediable aldosteronism. (Pubmed Central) - Jan 27, 2022
Captopril failed to suppress aldosterone secretion...Low-dose dexamethasone was effective...Moreover, a case of GRA combined with a CACNA1H gene mutation is reported for the first time. We found that dihydropyridine calcium channel blockers (CCBs) combined with aldosterone receptor antagonists exerted good therapeutic effects in controlling blood pressure in GRA patients for whom glucocorticoid therapy was not an option.
- |||||||||| prednisolone / Generic mfg., mycophenolate mofetil / Generic mfg., azathioprine / Generic mfg.
Journal: Granulomatous nephritis: A rare presentation of juvenile-onset sarcoidosis. (Pubmed Central) - Jan 27, 2022
She again defaulted on medicines and later presented with renal failure and was diagnosed with a renal sarcoidosis. She was treated with oral prednisolone and mycophenolate mofetil with which she gradually improved with normal renal functions.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Journal: Consensus statement and recommendations on the treatment of COVID-19: 2021 update. (Pubmed Central) - Jan 27, 2022
The consensus recommended against the use of lopinavir/ritonavir (IB), HCQ/CQ (IA), azithromycin (IA), convalescent plasma therapy (IA), and IVIG (IA). The inception of the consensus and task group have provided much needed evidence of the efficacy and safety of various therapies for the management of COVID-19 patients, and make a description about the benefits and harms for most treatments.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS
Clinical, Journal: Late-onset hypophysitis after discontinuation of nivolumab treatment for advanced skin melanoma: a case report. (Pubmed Central) - Jan 27, 2022
We conclude that even after discontinuation of nivolumab, isolated adrenal insufficiency can occur. Therefore, in case of administration of such agents, clinical assessment, and routine monitoring of blood pressure, sodium-, glucose-levels, pituitary hormones as well as magnetic resonance imaging are needed to identify such conditions and prevent an adrenal crisis.
- |||||||||| dexamethasone / Generic mfg., prednisone / Generic mfg.
Clinical, Journal: Dexamethasone Versus Prednisone in Children Hospitalized for Acute Asthma Exacerbations. (Pubmed Central) - Jan 27, 2022
More randomised clinical trials are required to confirm if this is a true effect, as it would have significant implications. Children hospitalized with mild-to-moderate asthma exacerbations have significantly shorter hospital LOS when starting DEX rather than PRED on admission.
- |||||||||| budesonide inhalation suspension / Generic mfg., montelukast / Generic mfg.
Clinical, Journal: Treatment of pediatric mild persistent asthma with low-dose budesonide inhalation suspension vs. montelukast in China. (Pubmed Central) - Jan 27, 2022
Children hospitalized with mild-to-moderate asthma exacerbations have significantly shorter hospital LOS when starting DEX rather than PRED on admission. Both treatments provided acceptable overall asthma control in children with mild persistent asthma; however, more reliever medication and more medical expenditures attributable to asthma were needed for BIS vs. montelukast in real-world settings, where factors such as compliance were also taken into account.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Review, Journal: Host-modifying drugs against COVID-19: some successes, but not yet the breakthrough. (Pubmed Central) - Jan 27, 2022
Azithromycin, an antibiotic with immunomodulatory activity, showed no effects in numerous clinical trials. The trials showed a clear need for new drugs instead of repurposed drugs and drugs that specifically target the SARS-CoV-2 virus or the pathology developing in COVID-19 patients.
- |||||||||| colchicine / Generic mfg.
Journal: Successful Treatment of IgA Vasculitis With Prolonged Cutaneous Manifestation With Colchicine in a 10-Year-Old Boy. (Pubmed Central) - Jan 27, 2022
His abdominal pain and haematochezia responded to the combination therapy with dapsone and low dose of prednisolone 5 mg/day and did not relapse even after discontinuation of dapsone...He had never complicated by kidney involvements. In conclusion, colchicine treatment exerts a beneficial effect in IgAV patients with prolonged cutaneous manifestation refractory to multiple drugs.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Dichotic listening performance and interhemispheric integration after administration of hydrocortisone. (Pubmed Central) - Jan 27, 2022
This suggests that an increase in cortisol does not influence dichotic listening performance on a behavioral level. As other studies reported an effect of stress hormones on functional hemispheric asymmetries on a neuro-functional level, future research using neuronal imaging methods would be helpful in the characterization of the relation of hemispheric asymmetries and stress hormones.
- |||||||||| dexamethasone injection / Generic mfg.
Preclinical, Journal, IO biomarker: High-dose dexamethasone injection disordered metabolism and multiple protein kinases expression in the mouse kidney. (Pubmed Central) - Jan 27, 2022
These protein kinases are involved in multiple signaling pathways in mice kidney, such as mitogen-activated protein kinase and phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. We profiled the gene expression of the kidney from high dose dexamethasone-treated mice and provided important information for further study the mechanism of side effects of glucocorticoids in clinical therapy.
- |||||||||| Kenalog-40 (triamcinolone acetonide injection suspension) / BMS
Journal: Knuckle pads: an ancient disease frequently misdiagnosed because of minimal modern attention. (Pubmed Central) - Jan 27, 2022
Treatment with intralesional triamcinolone acetonide injection produced significant clinical improvement. Our findings highlight the challenging diagnosis of knuckle pads and the importance of increasing the familiarity of knuckle pads in modern medical practice.
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