Glucocorticoid Receptor 

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  • ||||||||||  prednisolone / Generic mfg.
    Clinical, Journal:  Post periorbital carboxytherapy orbital emphysema: a case report. (Pubmed Central) -  Feb 3, 2022   
    Oral prednisolone 50 mg per day was prescribed, and the patient was observed closely. Gradually, periorbital pain and swelling subsided, and the symptoms resolved within one week.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Effect of regular and irregular stimulation cycles of dexamethasone on circadian clock in NIH3T3 cells. (Pubmed Central) -  Feb 3, 2022   
    Regular dexamethasone stimulation three times with 24 h cycles also caused upregulation of Per1 and Per2 expression, but not c-Myc and p53 expression. In conclusion, our study identified the entrainable range of the circadian clock in NIH3T3 cells to the dexamethasone stimulation cycle and demonstrated that irregular dexamethasone treatment could disturb the expression of cell cycle genes.
  • ||||||||||  Symbicort (budesonide/formoterol) / AstraZeneca
    Clinical, Journal:  Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome. (Pubmed Central) -  Feb 3, 2022   
    Our trial has demonstrated that co-administering Probio-M8 synergized with conventional therapy to alleviate asthma symptoms. The findings of the present study provide new insights into the pathogenesis and treatment of asthma, mechanisms of novel therapeutic strategies, and application of probiotics-based therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Erector spinae plane block reduces pain after laparoscopic cholecystectomy. (Pubmed Central) -  Feb 3, 2022   
    The findings of the present study provide new insights into the pathogenesis and treatment of asthma, mechanisms of novel therapeutic strategies, and application of probiotics-based therapy. An ESP block can provide superior postoperative analgesia and reduction in opioid requirement after laparoscopic cholecystectomy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Plant secondary cell wall proteome analysis with an inducible system for xylem vessel cell differentiation. (Pubmed Central) -  Feb 3, 2022   
    To this end, we tested multiple methods for cell wall extraction with cultured Arabidopsis cells carrying the VND7-VP16-GR system, with which cells can be transdifferentiated into xylem-vessel-like cells with lignified SCWs by dexamethasone treatment...These results demonstrate the usefulness of our CWP analysis method. Further analyses of SCW-related CWPs could be expected to produce information useful for understanding the roles of CWPs in plant cell functions.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study. (Pubmed Central) -  Feb 3, 2022   
    The study concludes that Combination therapy works wonders in the case of OSMF in stages I, II, III and can be a good option, comparatively safe and with negligible side effects, but potent and equally effective management of oral submucous fibrosis. Henceforth, it will be better to do such kinds of studies on a vast scale including larger samples and longer duration to check the efficacy and durability of this ancient ayurvedic regimen.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19. (Pubmed Central) -  Feb 3, 2022   
    Finally, broad anti-inflammatory treatment was associated with a reduction in CRP, IL-6 levels as well as length of ICU and hospital stay in critically ill COVID-19 patients. Our data provides insights into the transient functional dysregulation of myeloid immune cells against subsequent bacterial infections in COVID-19 patients and describe a beneficial role for the use of dexamethasone in these patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Timing of congenital heart block in relation to fetal echocardiography in anti-Ro/La positive pregnancies ([VIRTUAL]) -  Feb 3, 2022 - Abstract #CRAAHPA2022CRA_AHPA_248;    
    Despite this, one fetus (out of five) reversed from 3rd to 1st-degree AVB after dexamethasone initiation. Our findings illustrate the need for further studies to identify an alternative diagnostic strategy more sensitive at detecting earlier reversible cardiac involvement in anti-Ro/La positive pregnancies.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    Probable Hughes-Stovin Syndrome Presenting with Recurrent Massive Hemoptysis ([VIRTUAL]) -  Feb 3, 2022 - Abstract #CRAAHPA2022CRA_AHPA_229;    
    For probable HHS, the patient received induction therapy with high-dose intravenous methylprednisolone followed by oral prednisone and 6 doses of monthly cyclophosphamide...He subsequently developed a new pulmonary embolism, requiring re-induction with high-dose prednisone and transition from azathioprine to methotrexate and infliximab...Tumor necrosis factor alpha inhibitors may be considered in refractory cases. Our case supports observations that early recognition and aggressive immunosuppression may improve outcomes in HSS.
  • ||||||||||  lenalidomide / Generic mfg., clarithromycin / Generic mfg.
    Trial completion date, Trial primary completion date:  BiRd vs Rd: BiRd vs. Rd as Initial Therapy in Multiple Myeloma (clinicaltrials.gov) -  Feb 3, 2022   
    P3,  N=12, Active, not recruiting, 
    PFS in this analysis is comparable to PFS observed in those clinical trials. Trial completion date: Aug 2023 --> Aug 2024 | Trial primary completion date: Feb 2022 --> Feb 2023
  • ||||||||||  Melflufen (melphalan flufenamide) / Oncopeptides
    Trial completion date, Trial termination:  BRIDGE: PK of Melphalan During Treatment With Melflufen and Dexamethasone in Patients With RRMM and Impaired Renal Function (clinicaltrials.gov) -  Feb 3, 2022   
    P2,  N=35, Terminated, 
    Early initiation of steroids and immunosuppressive drugs can improve the patient outcome and survival in an otherwise poor prognostic disease. Trial completion date: Sep 2022 --> Dec 2021 | Active, not recruiting --> Terminated; The sponsor decided to terminate the study following an FDA request of a partial clinical hold.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Trial completion date, Trial primary completion date:  Postoperative Dexamethasone on Post-Cesarean Pain (clinicaltrials.gov) -  Feb 3, 2022   
    P4,  N=40, Recruiting, 
    Trial completion date: Sep 2022 --> Dec 2021 | Active, not recruiting --> Terminated; The sponsor decided to terminate the study following an FDA request of a partial clinical hold. Trial completion date: May 2022 --> May 2023 | Trial primary completion date: Nov 2021 --> Nov 2022
  • ||||||||||  Alvesco (ciclesonide) / Covis Pharma, Teijin, Korea University Medical Center
    Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date:  Inhalation of Ciclesonide for Patients With COVID-19: A Randomised Open Treatment Study (HALT COVID-19) (clinicaltrials.gov) -  Feb 2, 2022   
    P2,  N=98, Active, not recruiting, 
    Recruiting --> Completed Recruiting --> Active, not recruiting | N=446 --> 98 | Trial completion date: May 2022 --> Jan 2022 | Trial primary completion date: Dec 2021 --> Aug 2021
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Chronic Toxoplasma gondii infection and sleep-wake alterations in mice. (Pubmed Central) -  Feb 2, 2022   
    We demonstrated for the first time the direct consequences of Tg infection on sleep-wake states. The persistently increased wakefulness and reduced sleep fit with the parasite's strategy to enhance dissemination through host predation and are of significance in understanding the neurodegenerative and neuropsychiatric disorders reported in infected patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, IO biomarker:  PON2 blockade overcomes dexamethasone resistance in acute lymphoblastic leukemia. (Pubmed Central) -  Feb 2, 2022   
    In xenograft tumor model, PON2 knockdown significantly reduced DEX-resistant ALL cells growth in immunodeficient mice. Collectively, inhibition of PON2 may represent a novel method to restore the sensitivity of treatment-resistant ALL to GC-induced cell death.
  • ||||||||||  dexamethasone / Generic mfg., sirolimus / Generic mfg.
    Clinical, Journal:  CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disorders. (Pubmed Central) -  Feb 2, 2022   
    Collectively, inhibition of PON2 may represent a novel method to restore the sensitivity of treatment-resistant ALL to GC-induced cell death. We report a patient with 4 concomitant hematological disorders: T-LGLL, MGUS, CB-LPD, and PRCA, aiming to represent the clinical and flow cytometry characteristics of these concomitant diseases, analyze the mechanism between diseases, and provide a clinical reference.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Baicalin alleviates LPS-induced acute lung injury in rats by regulating macrophage polarization (Pubmed Central) -  Feb 2, 2022   
    Methods Sixty SD rats were divided into six groups: normal control group, LPS group, (10, 50, 100) mg/kg baicalin combined with LPS group, and dexamethasone (DEX) group...Baicalin significantly decreased the mRNA and protein expression levels of IL-1β and iNOS, while increased the mRNA and protein expression levels of CD206 and Arg1 in lung tissues. Conclusion Baicalin can inhibit the lung macrophage polarization to M1 phenotype, promote the polarization to M2 phenotype, and reduce the M1/M2 ratio, thereby alleviating the LPS-induced pulmonary inflammatory response in ALI rats.
  • ||||||||||  telaglenastat (CB-839) / Calithera
    Enrollment closed, Trial completion date, Trial primary completion date, Combination therapy:  CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma (clinicaltrials.gov) -  Feb 2, 2022   
    P1,  N=36, Active, not recruiting, 
    Conclusion Baicalin can inhibit the lung macrophage polarization to M1 phenotype, promote the polarization to M2 phenotype, and reduce the M1/M2 ratio, thereby alleviating the LPS-induced pulmonary inflammatory response in ALI rats. Recruiting --> Active, not recruiting | Trial completion date: Jan 2022 --> Jan 2023 | Trial primary completion date: Jan 2022 --> Jan 2023
  • ||||||||||  methylprednisolone oral / Generic mfg., methamphetamine / Generic mfg.
    Journal:  Discriminative-stimulus effects of synthetic cathinones in squirrel monkeys. (Pubmed Central) -  Feb 1, 2022   
    Traumeel S might be a good alternative approach to dexamethasone for controlling pain, edema and trismus after third molar removal. These findings suggest that differences in the interoceptive effects of synthetic cathinones in nonhuman primates reflect differing compositions of monoaminergic actions that also may mediate their subjective effects in humans.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Estimating Fetal Exposure to the P-gp substrates, Corticosteroids, by PBPK modelling to inform Prevention of Neonatal Respiratory Distress Syndrome. (Pubmed Central) -  Feb 1, 2022   
    Here, we extended the application of this model to dynamically predict fetal exposure to drugs which are effluxed by placental P-glycoprotein, namely the antenatal corticosteroids (ACS; dexamethasone [DEX], and betamethasone [BET])...To our knowledge, this is the first study to dynamically predict fetal plasma concentrations of placental P-gp effluxed drugs. Our approach and our m-f PBPK model could be used in the future to predict maternal-fetal exposure to any drug and to design alternative dosing regimens of the drug.
  • ||||||||||  prednisolone / Generic mfg.
    Clinical, Review, Journal:  Immunoglobulin G4-related disease: case report and literature review. (Pubmed Central) -  Feb 1, 2022   
    The patient was started on oral prednisolone 60 mg/day (1.0 mg/kg/day) for 14 days, and a tapering dose of 5 mg every 2 weeks followed by maintenance therapy at low dose for 3 months...Clinical examination, careful histological observation, and immunostaining for appropriate markers are essential in establishing the diagnosis. Clinicians should become familiar with this alternative differential diagnosis.