Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


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  • ||||||||||  budesonide inhalation solution (AQ001S) / Aquilon
    Trial completion, Enrollment change:  BORA: Single-dose AQ001S PK Study in Healthy Volunteers (clinicaltrials.gov) -  Feb 21, 2022   
    P1,  N=29, Completed, 
    Recruiting --> Completed | N=20 --> 29
  • ||||||||||  Riarify (beclometasone/formoterol/glycopyrrolate) / Chiesi
    Enrollment closed, Trial primary completion date, HEOR, Adherence:  TriOptimize: Non-interventional Study Related to Fixed LAMA/LABA/ICS Triple Therapy (clinicaltrials.gov) -  Feb 21, 2022   
    P=N/A,  N=200, Active, not recruiting, 
    Recruiting --> Completed | N=20 --> 29 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2022 --> Jun 2022
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion date, Trial primary completion date:  Transforaminal Versus Lateralized Interlaminar Cervical Epidurals (clinicaltrials.gov) -  Feb 21, 2022   
    P2,  N=116, Recruiting, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2022 --> Jun 2022 Trial completion date: Apr 2022 --> Apr 2023 | Trial primary completion date: Feb 2022 --> Feb 2023
  • ||||||||||  Efmody (hydrocortisone modified release) / Neurocrine
    Enrollment change, Trial termination:  RESTORE: Open-label Comparison of Chronocort (clinicaltrials.gov) -  Feb 21, 2022   
    P3,  N=2, Terminated, 
    Trial completion date: Apr 2022 --> Apr 2023 | Trial primary completion date: Feb 2022 --> Feb 2023 N=132 --> 2 | Suspended --> Terminated; Protocol re-design required following EU Phase III results
  • ||||||||||  dexamethasone sodium phosphate (AVM0703) / AVM Biotechnology
    Trial primary completion date, Immunomodulating:  The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies (clinicaltrials.gov) -  Feb 21, 2022   
    P1/2,  N=144, Recruiting, 
    N=132 --> 2 | Suspended --> Terminated; Protocol re-design required following EU Phase III results Trial primary completion date: Jun 2022 --> Apr 2023
  • ||||||||||  Vaxzevria (ChAdOx1-S recombinant) / Oxford Biomedica, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca, University of Oxford
    Acute Disseminated Encephalomyelitis-like presentation following SARS-CoV-2 mRNA vaccine. (Virtual Poster Hall) -  Feb 20, 2022 - Abstract #ACTRIMSForum2022ACTRIMS_Forum_537;    
    He was initially treated with high-dose intravenous methylprednisolone; plasma exchange (PE) was later initiated due to worsening encephalopathy and respiratory failure...He was discharged home on 100mg daily prednisone, tapered over three months. This case highlights the importance of maintaining high-suspicion for immune-mediated encephalitis in patients presenting with neurological symptoms post-vaccination.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    From Diagnosis to Prognosis: The Clinical Dilemma of Neurosarcoidosis (Virtual Poster Hall) -  Feb 20, 2022 - Abstract #ACTRIMSForum2022ACTRIMS_Forum_350;    
    Individuals with chronic granulomatous diseases might be predisposed to invasive aspergillosis due to genetic defects in nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, resulting in an impaired phagocytic respiratory burst, essential for microbial elimination. Prophylactic antifungal therapy is not widely implemented although recommended before immunosuppression.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  PLA mediates the innate immune response in Asian corn borer, Ostrinia furnacalis. (Pubmed Central) -  Feb 19, 2022   
    We report here that the PLA inhibitor, dexamethasone (DEX), impaired the innate immune response including nodulation, encapsulation, and melanization in Ostrinia furnacalis larvae, while AA partially reversed these effects of DEX...Injection of recombinant OfsPLA into larvae resulted in increased transcript levels of attacin, defencin, and moricin-3 genes. Our results demonstrate the involvement of the eicosanoid signaling pathway in the innate immune response of O. furnacalis larvae and provide new information about the roles of O. furnacalis secretory PLA in activating PPO and antimicrobial peptide production.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal, IO biomarker:  Multidisciplinary Management of Brain Metastases from Non-Small Cell Lung Cancer in the Era of Immunotherapy. (Pubmed Central) -  Feb 19, 2022   
    Patients with symptomatic lesions should be started on dexamethasone and evaluated by a neurosurgeon as soon as possible...In some patients with poor performance status, best supportive care may be the most appropriate choice. Treatment decisions should always incorporate patients' goals of care and in many cases should be discussed in a multidisciplinary setting.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Case Report: Angiostrongylus cantonesis Myelitis in Thailand. (Pubmed Central) -  Feb 19, 2022   
    Results of an immunochromatographic test kit were positive for Angiostrongylus cantonesis but negative for Gnathostoma spinigerum. After a 4-week course of albendazole combined with a tapering dose of dexamethasone, he achieved nearly complete recovery.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Pituitary somatotroph adenoma-derived exosomes: characterization of nonhormonal actions. (Pubmed Central) -  Feb 19, 2022   
    Given the limited high-quality comparative efficacy data, choice of therapy must be individualized for each patient and broad therapeutic access for patients is critical to maximize outcomes. Our findings elucidate biological actions of somatotroph-derived exosomes and implicate exosomes as non-hormonal pituitary-derived messengers.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Intra-articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model. (Pubmed Central) -  Feb 19, 2022   
    In contrast to the administration of baicalein, dexamethasone injection showed similar effects to slow OA progression, while dexamethasone inhibited NLRP3 inflammasome partly through decreasing levels of SOD, GSH, and MDA. This study indicated that baicalein may have the potential for OA prevention and exerts anti-inflammatory effects partly via suppressing NLRP3 inflammasome activation without affecting oxidative stress-associated molecules, and inhibition of cartilage catabolism enzymes in an OA rat model.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  Acute Illness and Death in Children With Adrenal Insufficiency. (Pubmed Central) -  Feb 19, 2022   
    Local training programmes for management of AC are comprehensive, but insufficient to prevent the most serious crises. New strategies to encourage use of parenteral hydrocortisone need to be devised.
  • ||||||||||  Nexavar (sorafenib) / Bayer, Amgen
    Journal:  Effects of tyrosine kinase inhibitors on androgen, estrogen α, glucocorticoid and thyroid receptors. (Pubmed Central) -  Feb 19, 2022   
    Additionally, synergism was seen for 1-5 μM dasatinib and 500 nM hydrocortisone combination for glucocorticoid activity in MDA-kb2 cells...Imatinib in combination with 4-hydroxytamoxifen showed concentration-dependent effects on the metabolic activity of ERα-expressing AN3CA, MCF-7, and SKOV3 cells, and on cell proliferation and adhesion of MCF-7 cells. These findings contribute to the understanding of the endocrine effects of TKIs, in terms of toxicity and effectiveness, and define the need to further evaluate the endocrine disrupting activities of TKIs to safeguard human and environmental health.
  • ||||||||||  Review, Journal:  Drug Treatment of Cluster Headache. (Pubmed Central) -  Feb 19, 2022   
    The efficacy of monoclonal antibodies to the calcitonin gene-related peptide so far has been only demonstrated for episodic cluster headache. Several drug therapies are being investigated including ketamine, onabotulinumtoxinA, lysergic acid, and sodium oxybate.
  • ||||||||||  dexamethasone / Generic mfg.
    Observational data, Journal:  Attenuation Value in Adrenal Incidentalomas: A Longitudinal Study. (Pubmed Central) -  Feb 19, 2022   
    CT modification according to endocrine function: autonomous cortisol secretion (ACS) if cortisol >50 nmol/L after 1-mg dexamethasone test (DST)...Mean density is increased in patients with ACS and overt hypercortisolism. Mean density reduces during follow-up in all adrenal adenomas, suggesting an increase in lipid content, especially in those with ACS.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal, IO biomarker:  Targeting Nuclear Export Proteins in Multiple Myeloma Therapy. (Pubmed Central) -  Feb 19, 2022   
    Eltanexor is an investigational SINE compound that has shown a more positive toxicity profile in preclinical studies, with reduced central nervous system penetration and gastrointestinal side effects, and is now undergoing clinical investigation. These and other trials will further clarify the role of these innovative agents in the therapeutic advancement of RRMM.