Glucocorticoid Receptor 

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  • ||||||||||  abiraterone acetate / Generic mfg.
    Trial completion date, Trial primary completion date:  Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1 (clinicaltrials.gov) -  Feb 24, 2022   
    P1,  N=36, Active, not recruiting, 
    Trial completion date: Jan 2022 --> Jan 2023 | Trial primary completion date: Jan 2022 --> Jan 2023
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Construction of a recombinant avipoxvirus expressing the env gene of Zika virus as a novel putative preventive vaccine. (Pubmed Central) -  Feb 23, 2022   
    The mixture of surfactant and corticosteroids deserves particular attention in the coming years. Although BALB/c mice appear to be an adequate model for ZIKV infection, as it mimics the natural mild infection in human beings, inadequate immune suppression seemed to occur by dexamethasone and different immune suppression strategies should be applied before challenge to reveal any protection of the mice.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Egg components reverse the atrophy induced by injury in skeletal muscles. (Pubmed Central) -  Feb 23, 2022   
    Furthermore, we investigated the effects of egg components such as avidin, lecithin, biotin, 3-sn-phosphatidylcholine, and L-α-phosphatidylcholine on dexamethasone (DEX)-treated C2C12 myotubes...Biotin, 3-sn-phosphatidylcholine, and L-α-phosphatidylcholine also attenuated atrogin-1 protein expression enhanced by DEX. Our findings reveal that egg yolk components could contribute to the reversal of skeletal muscle atrophy induced by muscle injury.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Role of Dexamethasone for Pain Management in Intervertebral Disc Surgery (Pubmed Central) -  Feb 23, 2022   
    The pain associated with these operations is one of the most common postoperative discomforts, has a significant impact on psychosocial aspects, and should therefore be treated effectively. Therefore, we present the importance of dexamethasone for multimodal pain management after intervertebral disc surgery.
  • ||||||||||  rocilinostat (ACY-1215) / Regenacy
    Trial completion, Trial completion date, Combination therapy:  Study of ACY-1215 in Combination With Lenalidomide, and Dexamethasone in Multiple Myeloma (clinicaltrials.gov) -  Feb 23, 2022   
    P1/2,  N=38, Completed, 
    Therefore, we present the importance of dexamethasone for multimodal pain management after intervertebral disc surgery. Active, not recruiting --> Completed | Trial completion date: Jun 2021 --> Mar 2021
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, IO biomarker:  BAG1 down-regulation increases chemo-sensitivity of acute lymphoblastic leukaemia cells. (Pubmed Central) -  Feb 22, 2022   
    Moreover, the BAG1 inhibitor Thio-2 induces a cytotoxic effect on RS4;11 cells both in vitro and in a zebrafish xenograft model and strongly synergizes with pan-BCL inhibitors. Collectively, these data sustain BAG1 deregulation as a critical event in assuring survival advantage to B-ALL cells.
  • ||||||||||  Journal:  Financial Burden of Drugs Prescribed for Cancer-Associated Symptoms. (Pubmed Central) -  Feb 22, 2022   
    For diarrhea, the cost of generic loperamide or diphenoxylate-atropine tablets was <$15 USD...For cancer-associated fatigue, the cost of generic dexamethasone or dexmethylphenidate was <$15 USD, whereas brand-name modafinil was more costly ($1,284 USD)...We highlight the high costs of many symptom control drugs and the wide variation in the costs of these drugs. These findings can guide patient-clinician discussions about cost-effectively managing symptoms, while promoting the use of less expensive formulations when possible.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Preclinical Dose-Escalation Study of ZSJ-0228, a Polymeric Dexamethasone Prodrug, in the Treatment of Murine Lupus Nephritis. (Pubmed Central) -  Feb 22, 2022   
    The reduction and/or resolution of the proteinuria, improvement in renal histological scores, and survival data indicate that the most effective dose range for ZSJ-0228 in treating LN in NZB/W F1 mice is between 1.0 and 3.0 mg/kg/day Dex equivalent. Typical GC-associated side effects (e.g., osteopenia, adrenal glands atrophy, etc.) were not observed in any of the ZSJ-0228 treatment groups, confirming its excellent safety profile.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, CAR T-Cell Therapy:  Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy. (Pubmed Central) -  Feb 22, 2022   
    With the model fit to experimental data, we demonstrate that high concentrations of dexamethasone antagonizes CAR T-cell efficacy by exhausting, or reducing the activity of CAR T-cells, and by promoting tumor cell growth. Finally, we identify a critical threshold in the ratio of CAR T-cell death to CAR T-cell proliferation rates that predicts eventual treatment success or failure that may be used to guide the dose and timing of CAR T-cell therapy in the presence of dexamethasone in patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Mechanism of Caspase-1 Inhibition by Four Anti-inflammatory Drugs Used in COVID-19 Treatment. (Pubmed Central) -  Feb 22, 2022   
    The SERM raloxifene has also been used as a repurposed drug in COVID-19 therapy...We also measured the antioxidant activities of dexamethasone and colchicine when scavenging the superoxide radical using cyclic voltammetry methods...In evaluating our computational and experimental results, we here formulate a mechanism for caspase-1 inhibition by these drugs, which involves the active site amino acid Cys285 residue and is mediated by a transfer of protons, involving His237 and Ser339. It is proposed that the molecular moiety targeted by all of these drugs is a carbonyl group which establishes a S(Cys285)-C(carbonyl) covalent bond.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Sick sinus syndrome as the initial manifestation of neuromyelitis optica spectrum disorder: a case report. (Pubmed Central) -  Feb 22, 2022   
    This indicated that there is a minimal risk of toxicity when dexamethasone and aspirin are co-administrated and a very low risk of toxicity and drug interaction with drugs that are a substrate for CYP3A2 in healthcare settings. Because SSS is a life-threatening complication, clinicians should be aware of the possibility that medullary lesions in NMOSD can cause SSS as the initial manifestation.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Practical application of steroids in palliative therapy. (Pubmed Central) -  Feb 22, 2022   
    In palliative care, steroids - mainly systemic glucocorticoids (dexamethasone, betamethasone, prednisolone, methylprednisolone) - are used especially for their anti-inflammatory and vascular permeability-reducing effects...Orv Hetil. 2022; 163(8): 294-300.
  • ||||||||||  verapamil intralesional / Stada
    Retrospective data, Journal:  Treatment of Keloids: A Meta-analysis of Intralesional Triamcinolone, Verapamil, and Their Combination. (Pubmed Central) -  Feb 22, 2022   
    When comparing the modalities of triamcinolone acetonide and verapamil for keloid treatment, triamcinolone acetonide shows more significant and rapid improvement compared with verapamil; however, there are also increased adverse effects. Minimal combination studies of these treatments have shown that perhaps using them together can augment their mechanisms without the unwanted side effects.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  Glucocorticoids and Bone in Graves' Ophthalmopathy (clinicaltrials.gov) -  Feb 22, 2022   
    P=N/A,  N=30, Active, not recruiting, 
    Future studies should link these results to clinical outcomes. Recruiting --> Active, not recruiting | Trial completion date: Nov 2021 --> Jul 2023 | Trial primary completion date: Jul 2021 --> Jul 2022
  • ||||||||||  felzartamab (MOR202) / HIBio
    Trial completion date, Trial primary completion date:  TJ202 Combined With Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) -  Feb 22, 2022   
    P2,  N=113, Active, not recruiting, 
    Recruiting --> Active, not recruiting | Trial completion date: Nov 2021 --> Jul 2023 | Trial primary completion date: Jul 2021 --> Jul 2022 Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Jul 2022