Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg., asenapine / Generic mfg., cisplatin / Generic mfg.
    Preclinical, Journal:  Drug repositioning of antipsychotic drugs for cisplatin-induced pica behavior in mice. (Pubmed Central) -  Mar 19, 2022   
    Three antipsychotics failed to improve the cisplatin-induced decrease in food and water intake, and spontaneous motor activity. The findings suggest that prophylactic administration of antipsychotics besides olanzapine may improve cisplatin-induced nausea and vomiting in a delayed phase and de-escalate standard 3-drug antiemetics.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dual-Regulated Functionalized Liposome-Nanoparticle Hybrids Loaded with Dexamethasone/TGFβ1-siRNA for Targeted Therapy of Glomerulonephritis. (Pubmed Central) -  Mar 19, 2022   
    In addition, DXMS/siRNA@Au-ILs were capable of effectively reducing the expression levels of TNF-α, TGF-β1, and other cytokines, thereby improving pathological inflammatory and fibrotic conditions in the kidney, and significantly mediating the dual regulation of inflammation and fibrosis. In summary, our results demonstrated that effectively targeting the MCs of the glomerulus for drug delivery can inhibit local inflammation and fibrosis and produce better therapeutic effects, providing a new strategy and promising therapeutic approach for the development of targeted therapies for glomerular diseases.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Injectable glycol chitosan thermogel formulation for efficient inner ear drug delivery. (Pubmed Central) -  Mar 19, 2022   
    We prepared a new injectable thermogel to enhance the efficiency of inner ear delivery of dexamethasone (DEX)...Our formulations further showed good residual stability for more than 21 days without any cytotoxicity or inflammation in the middle and inner ear and could deliver a considerably high drug concentration into the inner ear. Therefore, HGC thermogel has great potential as an effective and safe formulation for inner ear drug delivery.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Effect of Corticosteroids on Peptide Transporter 2 Function and Induction of Innate Immune Response by Bacterial Peptides in Alveolar Epithelial Cells. (Pubmed Central) -  Mar 19, 2022   
    NCI-H441 (H441) cells were used as an in vitro model of human alveolar type II epithelial cells, and the effects of dexamethasone (DEX) and budesonide (BUD) on the transport function of PEPT2 and the innate immune response induced by bacterial peptides were examined...Taken together, these results clearly suggest that corticosteroids suppress PEPT2 function and bacterial peptide-induced innate immune response in alveolar epithelial cells. Therefore, PEPT2- and NOD1-dependent innate immune response induced by bacterial peptides in the lung alveolar region may be suppressed during the inhaled corticosteroid therapy.
  • ||||||||||  gabapentin / Generic mfg.
    Journal:  Pre-emptive analgesia with methylprednisolone and gabapentin in total knee arthroplasty in the elderly. (Pubmed Central) -  Mar 19, 2022   
    No infectious complications were observed in the first postoperative days; in the control group, one patient manifested transient ischemic attack (TIA). The use of gabapentin and methylprednisolone as a single dose decreased the level of postoperative pain on the day of surgery, the dose of opioid analgesic preparations, and the level of inflammatory parameters without infectious processes.
  • ||||||||||  Tepezza (teprotumumab) / Horizon Therapeutics, Roche
    Review, Journal:  Medical and Surgical Treatment of Thyroid Eye Disease. (Pubmed Central) -  Mar 18, 2022   
    Inactive but moderate to severe disease may be treated by orbital decompression, strabismus and eyelid surgery. Systematic assessment and management by both an endocrinologist and ophthalmologist to achieve and maintain euthyroidism and select and sequence treatments according to activity and severity of TED gives the best results for quality of life and vision.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Netrin-1 expression and targeting in multiple myeloma. (Pubmed Central) -  Mar 18, 2022   
    Ex vivo, NP137 lowered the plasma cells percentage in bone marrow aspirates in a fraction of the patient samples analyzed. These results suggest that netrin signaling could constitute a novel therapeutic target in multiple myeloma.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Links Between Gut Dysbiosis and Neurotransmitter Disturbance in Chronic Restraint Stress-Induced Depressive Behaviours: the Role of Inflammation. (Pubmed Central) -  Mar 18, 2022   
    Furthermore, a Pearson heatmap focusing on correlations between the microbiota, behaviours, and neurotransmitters showed that Helicobacter, Lactobacillus, and Oscillibacter were positively correlated with depressive behaviours but were negatively correlated with neurotransmitter metabolism, and Parabacteroides and Ruminococcus were negatively correlated with depressive behaviours but were positively correlated with neurotransmitter metabolism. Taken together, the results suggest that inflammation is involved in microbiota dysbiosis and the disturbance of neurotransmitter metabolism in CRS-induced depressive changes, and the delineation of the potential links between the microbiota and neurotransmitter metabolism will provide novel strategies for depression treatment.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Pentacyclic spermidine alkaloids with radioprotective and anti-inflammatory activities from Orychophragmus violaceus. (Pubmed Central) -  Mar 18, 2022   
    Compared to Ex-RAD (sodium salt of 4-carboxystyryl-4-chlorobenzylsulfone), (-)-1 exhibited a significant radioprotective effect on cell survival and DNA damage. (-)-1 also exhibited remarkable anti-inflammatory activity by inhibiting the production of NO in RAW 264.7 cells activated by lipopolysaccharide with an IC value of 20.3 ± 1.58 μM, which was equivalent to that of dexamethasone.
  • ||||||||||  budesonide / Generic mfg.
    Review, Journal:  Inhaled corticosteroids for the treatment of COVID-19. (Pubmed Central) -  Mar 18, 2022   
    We expect to incorporate the findings of these studies in future versions of this review. We monitor newly published results of RCTs on inhaled corticosteroids on a weekly basis and will update the review when the evidence or our certainty in the evidence changes.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Impact of remdesivir in covid-19 patients under non-invasive ventilation in an intermediate care unit () -  Mar 18, 2022 - Abstract #ISICEM2022ISICEM_112;    
    In our unit, a strict protocol was used, including a 5-day cycle of 20 mg dexamethasone and start of HFNC/CPAP when increased work of breathing became noticeable, along with prolonged periods of awake prone position. In our cohort of patients under NIV, RDV use was associated with lower mortality, less need for IMV and shorter duration of ventilation.
  • ||||||||||  dexamethasone / Generic mfg.
    Sars-cov-2 associated aspergillus and hsv opportunistic infections. () -  Mar 18, 2022 - Abstract #ISICEM2022ISICEM_101;    
    We identified a total of 18 (43%) Aspergillus positive and 30 (71%) HSV DNA positive BAL results. Despite the retrospective analysis inherent bias, our study suggests a strong correlation between the use of CS and Asp and HSV opportunistic infection in SARS-CoV-2 critical ill patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Management of steroid induced hyperglycaemia in patients critically unwell with covid19 () -  Mar 18, 2022 - Abstract #ISICEM2022ISICEM_100;    
    These results highlight a necessity for consensus management of steroid induced hyperglycaemia. In line with these findings, the devised SOP recommends initial therapy with rapid acting insulin and administration of a sliding scale if hyperglycaemia persists.
  • ||||||||||  dexamethasone / Generic mfg.
    Organising pneumonia due to covid-19 and its impact on prognosis () -  Mar 18, 2022 - Abstract #ISICEM2022ISICEM_95;    
    High prevalence of OP was demonstrated in this severe COVID cohort associated with longer IMV time but not a significant increase in mortality. More data is required to determine adequate treatment and impact on prognosis.
  • ||||||||||  dobutamine / Generic mfg., meropenem / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    First own experience of intensive care multisystem inflammatory syndrome in children (mis-c) associated with covid-19. () -  Mar 18, 2022 - Abstract #ISICEM2022ISICEM_92;    
    Prescribed: Meropenem 20 mg / kg / d, Methylprednisolone 2 mg / kg / d. After 8 hours - septic shock.0.3 μg / kg / min norepinephrine was started...Dobutamine 3 μg / kg / min was added to the therapy... Thus, the timely diagnosis of MIS-C associated with COVID-19 and the appointment of intensive therapy with the inclusion of methylprednisolone and IV IgG allows achieving a positive result in the shortest possible time.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Phase classification, Trial completion date, Trial primary completion date, Metastases:  Physical Activity and Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Advanced Cancer (clinicaltrials.gov) -  Mar 18, 2022   
    P2/3,  N=87, Active, not recruiting, 
    Thus, the timely diagnosis of MIS-C associated with COVID-19 and the appointment of intensive therapy with the inclusion of methylprednisolone and IV IgG allows achieving a positive result in the shortest possible time. Phase classification: P2 --> P2/3 | Trial completion date: Aug 2021 --> Dec 2022 | Trial primary completion date: Aug 2021 --> Dec 2022
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD), Ozurdex (dexamethasone intravitreal implant) / AbbVie, Exparel (bupivacaine liposome injectable suspension) / Pacira
    Trial completion date, Trial primary completion date:  Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty (clinicaltrials.gov) -  Mar 18, 2022   
    P4,  N=60, Recruiting, 
    Trial completion date: Sep 2022 --> Jan 2023 | Trial primary completion date: Sep 2022 --> Jan 2023 Trial completion date: Apr 2023 --> Oct 2023 | Trial primary completion date: Apr 2022 --> Oct 2022
  • ||||||||||  Blenrep (belantamab mafodotin-blmf) / GSK
    Trial completion date, Trial primary completion date, Combination therapy:  DREAMM 9: Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma (clinicaltrials.gov) -  Mar 18, 2022   
    P1,  N=144, Recruiting, 
    Trial completion date: Apr 2023 --> Oct 2023 | Trial primary completion date: Apr 2022 --> Oct 2022 Trial completion date: Jun 2027 --> Nov 2025 | Trial primary completion date: Jul 2022 --> Apr 2025