Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...346347348349350351352353354355356...10671068»
  • ||||||||||  dexamethasone / Generic mfg., methotrexate IV / Generic mfg., methotrexate / Generic mfg.
    Clinical, Clinical data, Journal:  Clinical Outcomes of RTOG 9310 Protocol for Primary Central Nervous System Lymphoma: Single-Center Experience with 87 Patients. (Pubmed Central) -  Mar 24, 2022   
    Dexamethasone was administered on a standard tapering schedule from the first week to the sixth week...Within three weeks of the completion of WBRT, patients received two courses of cytarabine, which were separated by 3-4 weeks...On multivariate analysis, the Eastern Cooperative Oncology Group performance score ≤ 2; the International Extranodal Lymphoma Study Group low-risk status; XBP-1, p53, and c-Myc negativity; homogenous enhancement; gross total resection, independently correlated with long PFS and OS. The RTOG 9310 protocol is effective for PCNSL and features good outcomes.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Opioid-free versus opioid-based anesthesia in pancreatic surgery. (Pubmed Central) -  Mar 24, 2022   
    OFA included a combination of continuous infusions of dexmedetomidine, lidocaine, and esketamine...All patients received intraoperative propofol, sevoflurane, dexamethasone, diclofenac, neuromuscular blockade...In this series, OFA during pancreatic resection is feasible and independently associated with a better outcome, in particular pain outcomes. The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  AL-Kappa Primary Amyloidosis with Apolipoprotein A-IV Deposition. (Pubmed Central) -  Mar 24, 2022   
    Western blotting of urine samples at the time of the renal biopsy showed that amyloid light-chain κ amyloidosis had been present since the onset. Unlike the myeloma, Congo red staining was positive in the plasma cells of the bone marrow.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Corticotroph pituitary carcinoma with skeletal metastases masquerading as ectopic ACTH syndrome: a long and winding road to diagnosis. (Pubmed Central) -  Mar 24, 2022   
    Under hydrocortisone substitution therapy she developed ACTH-dependent hypercortisolism without arguments for recurrence on pituitary MRI and without central-to-peripheral ACTH-gradient on inferior petrosal sinus sampling, both suggesting ectopic production...Treatment options for corticotroph carcinoma include primary tumour resection, radiation therapy, medical therapy, and chemotherapy. Sometimes bilateral adrenalectomy is necessary to achieve sufficient control of the cortisol excess.
  • ||||||||||  anselamimab (CAEL-101) / AstraZeneca
    Trial completion date, Trial primary completion date:  A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (clinicaltrials.gov) -  Mar 24, 2022   
    P3,  N=111, Recruiting, 
    Trial completion date: Feb 2022 --> Feb 2023 | Trial primary completion date: Feb 2022 --> Feb 2023 Trial completion date: Feb 2023 --> Dec 2024 | Trial primary completion date: Aug 2022 --> Dec 2024
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Blood metabolomics in infants enrolled in a dose escalation pilot trial of budesonide in surfactant. (Pubmed Central) -  Mar 23, 2022   
    A subset of glucocorticoid-regulated biochemicals is associated with lung inflammatory status as assessed by lung fluid cytokine concentration. Lower doses of budesonide in surfactant than currently used may provide adequate anti-inflammatory responses in the lung with fewer systemic effects, improving the benefit:risk ratio.
  • ||||||||||  Avastin (bevacizumab) / Roche
    Clinical, Journal:  Case Report: Postpartum Purtscher-like Retinopathy. (Pubmed Central) -  Mar 23, 2022   
    Purtscher-like Retinopathy can occur following childbirth, usually within 1-2 days postpartum and occasionally associated with pre-eclampsia. Clinical course and visual improvement vary, but novel treatments may aid in visual recovery.
  • ||||||||||  Veramyst (fluticasone furoate nasal spray) / GSK
    Journal:  Improving the risk-to-benefit ratio of inhaled corticosteroids through delivery and dose: current progress and future directions. (Pubmed Central) -  Mar 23, 2022   
    This paper gives an overview of novel treatment strategies regarding the safety of ICS therapy on the basis of the three most recent molecules introduced to our everyday clinical practice - ciclesonide, mometasone furoate, and fluticasone furoate...This applies both to the improvement of the PK/PD properties of ICS molecules but also includes technical aspects that lead to simplified applicability of the device with simultaneous optimal drug deposition in the lungs. Indubitably, the future of medicine lies not only in the development of new molecules but also in technology and digital revolution.
  • ||||||||||  carbimazole / Generic mfg., methylprednisolone sodium succinate / Generic mfg., azathioprine / Generic mfg.
    Clinical, Journal:  When polymyositis meets Graves' disease: A rare case report. (Pubmed Central) -  Mar 23, 2022   
    She continued to show clinical and biochemical improvements during follow-ups. Polymyositis should be considered in the diagnostic workup of proximal myopathy in a patient with Graves' disease, especially in the setting of markedly raised muscle enzymes.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  11β-Hydroxysteroid dehydrogenase 2: a key mediator of high susceptibility to osteoporosis in offspring after prenatal dexamethasone exposure. (Pubmed Central) -  Mar 23, 2022   
    Moreover, dexamethasone promoted the nuclear translocation of glucocorticoid receptor (GR), which resulted in the stimulation of 11β-HSD2 expression due to the binding of GR to the 11β-HSD2 promoter region directly, as well as increasing H3K9ac level in the 11β-HSD2 promoter region by recruiting histone deacetylase 11 (HDAC11). Our results indicated that low expression of 11β-HSD2 in bone tissue is an important mediator for the high susceptibility to osteoporosis in PDE adult offspring.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  Adrenal function during long-term ACTH therapy for patients with developmental and epileptic encephalopathy. (Pubmed Central) -  Mar 23, 2022   
    Hydrocortisone replacement during stress was prepared in a case with lower cortisol peak than our cutoff level...The longer duration and larger cumulative dosage in LT-ACTH than conventional ACTH could increase the relative risk of AI. Careful evaluation with pediatric endocrinologists, including hormonal stimulation tests, might be useful for continuing this treatment safely.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Triamcinolone acetonide can be detected in cerebrospinal fluid after intratympanic injection. (Pubmed Central) -  Mar 23, 2022   
    Results suggest an equal distribution of triamcinolone acetonide to semicircular canals, which might support the use of triamcinolone acetonide as a treatment option for vestibular pathologies such as Menièrés disease. On the other hand, the distribution to cerebrospinal fluid might be limiting current approaches in gene therapy where a central distribution is unwanted.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Mannosylation Of Budesonide Palmitate Nanoprodrugs For Improved Macrophage Targeting. (Pubmed Central) -  Mar 23, 2022   
    After LPS-induced inflammation, the anti-inflammatory effect of mannosylated nanoparticles was assessed. After 48 hours of incubation, cytokines (MCP-1 and TNFα) were reduced demonstrating that the functionalization of nanoprodrugs is possible and efficient.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma. (Pubmed Central) -  Mar 23, 2022   
    This is the first clinical study in a large patient population showing that i.v. administered targeted drug delivery with a nanomedicine formulation improves the therapeutic index of glucocorticoids. Our study proves SUMOylation plays a crucial role in Dex resistance in MM and SUMOylation inhibition appears to be an attractive strategy to advance to the clinic for MM patients.
  • ||||||||||  dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Review, Journal:  Optimizing Thromboembolism Prophylaxis for the Contemporary Age of Multiple Myeloma. (Pubmed Central) -  Mar 23, 2022   
    Large studies which have mainly focused on the efficacy of thromboprophylaxis in patients with cancer at higher risk for VTE either had a very low representation of patients with MM, or excluded them all together, limiting our ability to draw evidence-based conclusions on how to effectively protect MM population from VTE. In this brief perspective, we highlight some of the greatest challenges that have hampered the field concerning the availability of high-quality clinical trial data for the formulation of best VTE prophylaxis strategies in patients with newly diagnosed MM, as well as the rationale for the latest updates in the NCCN Guidelines on this topic.
  • ||||||||||  ketorolac / Generic mfg., dexamethasone / Generic mfg.
    Review, Journal:  Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets. (Pubmed Central) -  Mar 23, 2022   
    Atropine, cyclopentolate, scopolamine, and homatropine are among the most frequently used medications for this purpose...A variety of commonly used agents, including prednisolone acetate, loteprednol, difluprednate, dexamethasone, fluorometholone, and methylprednisolone are discussed...Non-steroidal medications, such as ketorolac, bromfenac, nepafenac, and diclofenac, are additionally used for their efficacy in controlling ocular inflammation without incurring side effects seen with steroids...For example, several antibiotics, such as doxycycline and macrolides, have been used for their anti-inflammatory effects on specific cytokines that are upregulated during acute injuries...Neurotrophic corneal disease may occur as a result of severe or chronic injury. In such cases, recombinant human nerve growth factor (cenegermin), topical insulin, and several other novel agents may be an alternate and effective option for clinicians to consider.