- |||||||||| Management and Outcomes of Chemotherapy-Induced Nausea and Vomiting among Kenyan Breast Cancer Patients: A Prospective Study (E-Poster Stage 1, Metropolitan Centre, CC) - May 22, 2022 - Abstract #MASCCISOO2022MASCC_ISOO_246;
Most (87.3%) received ondansetron and dexamethasone as CINV prophylaxis...A low BMI (p=0.011), low BSA (p=0.028), a positive history of morning sickness (p=0.035), and earlier chemotherapy cycles (p=0.0001) led to an increased risk of emesis.Conclusions CINV still remains a challenge. Low BMI, low BSA, history of morning sickness, and earlier cycles of chemotherapy are implicated in CINV occurrence in breast cancer patients.
- |||||||||| dexamethasone / Generic mfg.
Patient-reported outcomes with dexamethasone sparing in CDDP-based chemotherapy: A randomized, placebo-controlled, phase ? study (SPARED trial) (E-Poster Stage 1, Metropolitan Centre, CC) - May 22, 2022 - Abstract #MASCCISOO2022MASCC_ISOO_245;
Introduction The SPARED trial demonstrated the non-inferior of dexamethasone (DEX) sparing on days 2–4 compared with DEX on days 1–4 in terms of the delayed CR for cisplatin (CDDP)-based chemotherapy (Shimomura et al, ESMO annual meeting 2021, LBA63)...Methods Patients (pts) with solid cancer who were treated with CDDP (>50 mg/m2) were randomly assigned to DEX on days 1–4 (Arm D4) or day 1 (Arm D1) with neurokinin-1 receptor antagonist, palonosetron, and olanzapine 5mg...Conclusions Although DEX sparing did not impair global health status in CDDP-based chemotherapy, it worsened nausea and appetite loss. Further analyses are required to select suitable pts for DEX sparing.
- |||||||||| Elzonris (tagraxofusp) / Menarini, Nippon Shinyaku
Journal: Characteristics and Outcomes of Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm Treated with Frontline HCVAD. (Pubmed Central) - May 22, 2022
We conducted a retrospective analysis of patients with BPDCN (n = 100), evaluating complete remission (CR) and median overall survival (OS) among 3 groups: those who received frontline HCVAD-based therapy (n = 35), SL-401 (n = 37), or other regimens (n = 28)...These results suggest a continued important role for HCVAD-based chemotherapy for BPDCN, even in the modern targeted-therapy era, with high CR rates in the frontline setting. Further studies must establish the clinical activity, feasibility, and safety, of doublet/triplet combinations of targeted therapies plus cytotoxic agents and addition of CNS prophylaxis, with ultimate goal of durable long-term remissions for patients with BPDCN.
- |||||||||| Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva, Theravance Biopharma
P3 data, Retrospective data, Journal: Longitudinal model-based meta-analysis of lung function response to support Phase 3 study design in Chinese patients with asthma. (Pubmed Central) - May 22, 2022
This model was the basis of a longitudinal model-based meta-analysis which was undertaken to describe the trough FEV1 responses ranging up to 1 year from nine clinical studies in a population with asthma (N = 3,896), following placebo, dual combination (fluticasone furoate/vilanterol), and triple combination (fluticasone furoate/umeclidinium/vilanterol) given via inhalation...Based on the trough FEV1, all active treatments were found to be significantly different when compared to placebo and showed clinically meaningful improvement in FEV1. The model was able to predict the longitudinal FEV1 response in Chinese patients with inadequately controlled asthma and was used to provide additional support with respect to the design for a shorter duration Phase 3 study to China National Medical Products Administration (NMPA).
- |||||||||| chloroquine phosphate / Generic mfg., hydroxychloroquine / Generic mfg., dexamethasone / Generic mfg.
Journal: Computational study on the affinity of potential drugs to SARS-CoV-2 main protease. (Pubmed Central) - May 22, 2022
Additionally, dexamethasone and betamethasone show a hydrogen bond with the His41 residue of the 6w63 protein, while the interaction between chloroquine and hydroxychloroquine with this amino acid is weak. Thus, we confirm the importance of His41 amino acid as a target to inhibit the SARS-CoV-2 Mpro activity.
- |||||||||| Duovent UDV (ipratropium bromide/fenoterol hydrobromide nebulizer solution) / Boehringer Ingelheim
Clinical, Journal: A randomized clinical trial on inhaled ciclesonide for managing acute asthma in the emergency room. (Pubmed Central) - May 22, 2022
Thus, we confirm the importance of His41 amino acid as a target to inhibit the SARS-CoV-2 Mpro activity. Inhaled ciclesonide was not inferior to systemic hydrocortisone for managing acute asthma exacerbations, and it improved both clinical and spirometric parameters.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Journal: Case of a Deep Neck Abscess During Treatment for COVID-19. (Pubmed Central) - May 22, 2022
Particularly, deep neck abscesses require more attention since they could be fatal if not treated immediately. If a secondary infection is suspected in a patient treated with immunosuppressive drugs for COVID-19, a thorough physical examination should be performed to avoid misdiagnosis.
- |||||||||| apremilast / Generic mfg.
Preclinical, Journal: Effects of Apremilast on Induced Hypertrophic Scar of Rabbits. (Pubmed Central) - May 22, 2022
Apremilast was efficacious in the treatment of hypertrophic scars due to its ability to reduce inflammations and fibroblast counts and scar index. Nonetheless, the reduction of immunological scores was almost comparable to that of topical TAC.
- |||||||||| dexamethasone injection / Generic mfg.
Journal: Modulation of Negative Effects of Physiological Stress on Frozen-Thawed Semen with Nutrition of Organic Selenium in Ross 308 Rooster. (Pubmed Central) - May 22, 2022
Therefore, selenium supplementation in the diet of roosters without dexamethasone injection improved total motility, progressive motility, membrane integrity, viability, malondialdehyde, total antioxidant capacity, glutathione peroxidase and superoxide dismutase pre- and post-freezing. It can be concluded, selenium in organic forms in stressed and non-stressed rooster's diet might improve all motility and antioxidant parameters in fresh and frozen-thawed sperm.
- |||||||||| budesonide / Generic mfg.
Journal: Budesonide bests COVID-19. (Pubmed Central) - May 21, 2022
It can be concluded, selenium in organic forms in stressed and non-stressed rooster's diet might improve all motility and antioxidant parameters in fresh and frozen-thawed sperm. No abstract available
- |||||||||| triamcinolone acetonide / Generic mfg.
Journal: Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021. (Pubmed Central) - May 21, 2022
The content covers several pain models, including neuropathic pain caused by peripheral nerve constriction or malpositioned dental implants, tongue cancer, myogenous temporomandibular dysfunction, and oral ulcerative mucositis. In addition, a review paper on trigeminal neuralgia is included.
- |||||||||| mirtazapine / Generic mfg.
Journal: Cell Model of Depression: Reduction of Cell Stress with Mirtazapine. (Pubmed Central) - May 21, 2022
Our results demonstrated that hydrogen peroxide, and not hydrocortisone, can induce cellular stress, as evidenced by DNA damage and a global cellular viability reduction, which were alleviated by the antidepressant mirtazapine. The establishment of a cellular model of depression through stress induction is important to study new possibilities of treatment of this disease using cell cultures.
- |||||||||| tanimilast (CHF6001) / Chiesi
Journal: The PDE4 Inhibitor Tanimilast Restrains the Tissue-Damaging Properties of Human Neutrophils. (Pubmed Central) - May 21, 2022
In contrast, it promoted neutrophil survival by decreasing both spontaneous apoptosis and cell death in the presence of pro-survival factors. The present work suggests that tanimilast can alleviate the severe tissue damage caused by massive recruitment and activation of neutrophils in inflammatory diseases such as COPD.
- |||||||||| triamcinolone acetonide / Generic mfg.
Journal: Enhanced Antifungal and Wound Healing Efficacy of Statistically Optimized, Physicochemically Evaluated Econazole-Triamcinolone Loaded Silica Nanoparticles. (Pubmed Central) - May 21, 2022
Co-encapsulated econazole nitrate-triamcinolone acetonide loaded biocompatible, physically stable, and non-irritating mesoporous silica nanoparticles (EN-TA-loaded MSNs) were prepared and optimized by using a central composite rotatable design (CCRD) for providing better therapeutic efficacy against commonly prevailed resistant fungal infections...In skin irritation studies, MSNs did not show a grade of erythema compared to pure drugs, which showed a four-fold grade of erythema. As a result, MSNs loaded with combination therapy seem to have the potential of improving patient compliance and tolerability by providing enhanced synergistic antifungal effectiveness at a reduced dose with accelerated wound healing and reduced toxicity of therapeutics.
- |||||||||| dexamethasone / Generic mfg.
Investigation Of Anti-inflammatory Drugs For Their Ability To Reduce Equine Herpesvirus Type 1 (ehv-1) Replication And Depress The Expression Of Virus-induced Pro-inflammatory Chemokines (Exhibit and Poster Hall) - May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1956;
In this study, we are investigating the ability of a panel of NSAIDS (phenylbutazone, ketoprofen, flunixin-meglumine, and firocoxib), a steroid anti-inflammatory, (dexamethasone), a Rho-kinase inhibitor, (Y-27632), and a JAK-STAT signaling inhibitor (AG-490) to significantly reduce CXCL9-11 chemokine expression in EHV-1 infected cells...In addition, we are examining the time-course of CXCL9-11 chemokine expression by quantitating the amount of chemokine transcripts in cells infected with EHV-1 for 2, 4, 6, 8, 10, and 24 hours. These data will inform additional drug studies and provide information as to when in the virus life cycle these pro-inflammatory chemokines are induced by EHV-1.
- |||||||||| Bordetella Hinzii Pneumonia in a Patient with Sars-cov-2 Infection (Exhibit and Poster Hall) - May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1710;
hinzii was resistance to Amoxicillin, Cefotaxim and Ciprofloxacine, intermediate to Amoxicilline-Clavulanic acid, and Ceftazidime, and susceptibility to piperacillin/tazobactam, Meropenem, and Imipenem...Increasing reports of invasive B. hinzii may indicate its emergence as a pathogen in immunocompromised patients. Here we describe a B. hinzii and A. fumigatus co-infection in a SARS-CoV-2 infected immunocompetent patient with no anterior underlying conditions and likely transient immunosuppression due to dexamethasone treatment, and SARS-CoV-2 infection.
- |||||||||| dexamethasone / Generic mfg.
Journal: 2D Covalent Organic Framework Direct Stem Cell Differentiation. (Pubmed Central) - May 20, 2022
In addition, we are able to load osteogenic agent - dexamethasone within the porous structure of COFs for sustain delivery which further enhance the osteoinductive ability. Our results demonstrate for the first time, fabrication of hydrolytically-stable 2D COFs for sustained delivery of drugs and demonstrate its osteoinductive characteristics.
- |||||||||| progesterone / Generic mfg., hydrocortisone / Generic mfg.
Journal: Should DHEA be Administered to Women? (Pubmed Central) - May 20, 2022
Use of DHEA to improve induction of ovulation response in women with diminished ovarian reserve is not recommended. Risks of high physiologic or pharmacologic use of DHEA include androgenic and estrogenic side effects which are of concern for long-term administration.
- |||||||||| cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Journal: Amyloid-beta-related angiitis: a treatable rapidly progressive dementia. (Pubmed Central) - May 20, 2022
Extensive laboratory investigations found no cause but brain biopsy identified amyloid-beta-related angiitis (ABRA), a potentially treatable cause of rapid-onset dementia. We gave intravenous methylprednisolone and then two courses of intravenous cyclophosphamide, after which her cognitive skills gradually but significantly improved over several months.
- |||||||||| prednisolone / Generic mfg., acitretin / Generic mfg., lenvatinib / Generic mfg.
Journal: Dramatic improvement of lenvatinib-induced hand-foot skin reaction with 7-day oral prednisolone and acitretin. (Pubmed Central) - May 20, 2022
After 7-day oral prednisolone and acitretin, hyperkeratotic plaques improved dramatically and painful condition as well got relieved. We considered the combination therapy of oral prednisolone and acitretin can be a prospective therapeutic option to reduce chances of cancer treatment being interrupted by HFSR.
- |||||||||| dexamethasone / Generic mfg.
Journal: Dexamethasone in patients with diabetes mellitus. (Pubmed Central) - May 20, 2022
We considered the combination therapy of oral prednisolone and acitretin can be a prospective therapeutic option to reduce chances of cancer treatment being interrupted by HFSR. No abstract available
- |||||||||| dexamethasone / Generic mfg., pomalidomide / Generic mfg.
Review, Journal: Pomalidomide- and dexamethasone-based regimens in the treatment of refractory/relapsed multiple myeloma. (Pubmed Central) - May 20, 2022
Pomalidomide-dexamethasone is currently one of the powerful tools available for use in the relapsed/refractory MM setting. Insights into the synergistic immunomodulatory effects of pomalidomide and other anti-myeloma agents and the mechanisms that overcome clonal resistance will potentially allow targeted use of triplet combinations at each relapse.
- |||||||||| dexamethasone / Generic mfg.
Journal: SMART syndrome: a case report. (Pubmed Central) - May 20, 2022
Posterior reversible encephalopathy syndrome, post-ictal changes, meningoencephalitis, and cerebrovascular diseases are radiological differential diagnoses considered (3). Proper and early diagnosis of SMART syndrome is significant in preventing unnecessary aggressive approaches and appropriate treatment to avoid lesions of sequela.
- |||||||||| prednisolone / Generic mfg., prednisone / Generic mfg.
Trial completion date, Trial primary completion date, Head-to-Head: ADAPTinMCN: Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy (clinicaltrials.gov) - May 20, 2022
P4, N=96, Recruiting,
Proper and early diagnosis of SMART syndrome is significant in preventing unnecessary aggressive approaches and appropriate treatment to avoid lesions of sequela. Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
- |||||||||| Zyesami IV (aviptadil intravenous) / Relief Therap, NRx Pharma
Simultaneous Lung and Kidney Transplant in a Young Patient with COVID-19 (Hynes Halls C & D: Board No. C280) - May 20, 2022 - Abstract #ATC2022ATC_3303;
Despite treatment with Remdesivir and dexamethasone, the patient developed hypoxemic respiratory failure with acute renal injury requiring ICU care and intubation, V-V ECMO, and dialysis. We propose that SLK transplantation should be considered for carefully selected patients with COVID-19 ARDS.
- |||||||||| dexamethasone / Generic mfg.
COVID Infection Among Kidney Transplant Recipient During the Era of COVID Vaccination: Management Outcomes (Hynes Halls C & D: Board No. D115) - May 20, 2022 - Abstract #ATC2022ATC_3155;
Due to their immunocompromised state and often more severe clinical presentation, with majority requiring hospitalization, ICU admission, and mechanical ventilation. In this single center study, COVID vaccination did not seem to have an appreciable impact on the incidence of COVID infection and presentation.
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