Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...305306307308309310311312313314315...10671068»
  • ||||||||||  dexamethasone / Generic mfg.
    Observational data, Retrospective data, Journal:  Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation. (Pubmed Central) -  Jun 15, 2022   
    Given the antigen specificity of this technique, this paper presents an attractive preclinical autoimmune therapy. In critically ill COVID-19 patients, dexamethasone as standard of care was strongly and independently associated with superinfections.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion date, Trial primary completion date, Surgery:  Neostigmine and Dexamethasone in Adductor Canal Block (clinicaltrials.gov) -  Jun 15, 2022   
    P=N/A,  N=90, Recruiting, 
    doi:10.36849/JDD.6715. Trial completion date: Oct 2021 --> Jul 2022 | Trial primary completion date: Oct 2021 --> Jun 2022
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Journal:  Role of suprascapular nerve block in idiopathic frozen shoulder treatment: a clinical trial survey. (Pubmed Central) -  Jun 15, 2022   
    Subtenon injection of TA is a safe and effective modality of treatment for resolving a persistent or progressive SCD after glaucoma surgeries. Suprascapular nerve block is an effective therapy with long-term pain relief and increased mobility of the shoulder joint in patients with adhesive capsulitis.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  A Pitfall of Falsely Elevated ACTH: A Case Report and Literature Review. (Pubmed Central) -  Jun 15, 2022   
    However, both of the diagnoses were excluded by screening tests including the overnight dexamethasone suppression test, the 24-hour urinary free cortisol excretion, and the ACTH stimulation test in spite of the consistent elevation of the plasma ACTH levels...After reviewing our case and several reported cases of falsely elevated plasma ACTH levels, we conclude that when discrepancy between clinical symptoms and laboratory measurements exists, medical practitioners ought to rely on formal diagnostic criteria rather than misleading laboratory results to avoid misdiagnosis or even unnecessary invasive testing and procedures. In addition, current methods for investigation and elimination of immunoassay interferences should be applied with caution due to variable efficacy and inevitable deviations.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial completion:  Triamcinolone for Ahmed Glaucoma Valve (clinicaltrials.gov) -  Jun 14, 2022   
    P=N/A,  N=106, Completed, 
    Oxygen use, diabetes, heart diseases, and cough were also found to affect oral health. Unknown status --> Completed
  • ||||||||||  fludrocortisone / Generic mfg., hydrocortisone / Generic mfg.
    Trial completion date, Trial primary completion date:  COCCA: Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock. (clinicaltrials.gov) -  Jun 14, 2022   
    P3,  N=380, Recruiting, 
    Unknown status --> Completed Trial completion date: Jul 2022 --> Aug 2023 | Trial primary completion date: Apr 2022 --> Apr 2023
  • ||||||||||  dexamethasone injection / Generic mfg.
    Trial completion date, Trial primary completion date:  Intracochlear Dexamethasone Application During Cochlear Implantation for Preserving Cochlear Cells (clinicaltrials.gov) -  Jun 14, 2022   
    P=N/A,  N=21, Recruiting, 
    Trial completion date: Jul 2022 --> Aug 2023 | Trial primary completion date: Apr 2022 --> Apr 2023 Trial completion date: Mar 2022 --> Sep 2022 | Trial primary completion date: Mar 2022 --> Aug 2022
  • ||||||||||  dexamethasone / Generic mfg.
    Enrollment change, Trial termination:  Glucocorticoid Therapy in Coronavirus Disease COVID-19 Patients (clinicaltrials.gov) -  Jun 14, 2022   
    P4,  N=127, Terminated, 
    Trial completion date: Jun 2026 --> Jun 2028 | Trial primary completion date: Jun 2026 --> Jun 2028 N=290 --> 127 | Recruiting --> Terminated; Impossibility of reaching the sample size established by protocol
  • ||||||||||  Enerzair Breezhaler (glycopyrrolate/indacaterol/mometasone) / Novartis
    Enrollment open, Real-world evidence, Real-world:  A 24-week rPMS Study in Real-world Setting for Enerzair (clinicaltrials.gov) -  Jun 14, 2022   
    P=N/A,  N=600, Recruiting, 
    Trial completion date: Apr 2024 --> Jul 2024 | Trial primary completion date: Apr 2024 --> Jul 2024 Not yet recruiting --> Recruiting
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure. (Pubmed Central) -  Jun 14, 2022   
    Any future trials should examine whether adjunctive steroids may be useful in certain clinical settings such as type of causative organism or etiology. These studies should include outcomes that take patients' symptoms and clinical examination into account; report outcomes in a uniform and consistent manner; and follow up at short- and long-term intervals.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Negative Regulator Nlrc3-like Maintain the Balanced Innate Immune Response During Mycobacterial Infection in Zebrafish. (Pubmed Central) -  Jun 14, 2022   
    Our findings uncovered an important role of nlrc3-like in the negative regulation of macrophage inflammasome activation and neutrophil infiltration during mycobacterial infection. This highlights the importance of a balanced innate immune response during mycobacterial infection and provides a potential molecular basis to explain how anti-inflammatory drugs can improve treatment outcomes in TB patients whose infection is accompanied by a hyperinflammatory response.
  • ||||||||||  AT7519 / Novartis, Otsuka, seliciclib (CYC202) - Cyclacel, Cedars / Sinai
    Journal:  Inhibition of Cyclin-Dependent Kinase 9 Downregulates Cytokine Production Without Detrimentally Affecting Human Monocyte-Derived Macrophage Viability. (Pubmed Central) -  Jun 14, 2022   
    Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-roscovitine and AT7519, induce neutrophil apoptosis in vitro and enhance the resolution of inflammation in a number of in vivo models...In addition, enhanced efferocytosis, induced by the glucocorticoid dexamethasone, was also unaffected after a short time treatment with R-roscovitine...Overall, this study demonstrates that pharmacological and genetic targeting of CDK9 inhibits an inflammatory phenotype in human MDMs. As such these data indicate that CDK9 may be key to therapeutically targeting pro-inflammatory macrophage functions during chronic inflammation.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Inhibitory Effects of Donkey Hide Gelatin on DNCB-Induced Atopic Dermatitis in NC/Nga Mice. (Pubmed Central) -  Jun 14, 2022   
    NC/Nga mice were induced by DNCB, administered Dexamethasone (3 mg/kg) or DHG water extracts (100-400 mg/kg) for 3 weeks...Furthermore, DHG suppressed the activation of NF-κB and mitogen-activated protein kinases (MAPK) signaling pathway induced by TNF-α/IFN-γ. Taken together, DHG maybe a potential therapeutic agent or supplement for skin inflammatory disease such as atopic dermatitis.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Impact of COVID-19 therapy on hyperglycemia. (Pubmed Central) -  Jun 14, 2022   
    Individualized /personalized patient care is required for diabetic mellitus patients with COVID-19 infection. Improper drug therapy aggravates hyperglycemic conditions and other comorbid conditions, leading to increased morbidity and mortality.
  • ||||||||||  methotrexate / Generic mfg., hydrocortisone / Generic mfg.
    chronic urticaria and the impact of corticotherapy: series of 34 patients (e-Poster Hall) -  Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_522;    
    Methotrexate was prescribed in 14.7% of patients...It may generate corticosteroid dependence and significant side effects in a skin condition that is certainly invalidating in terms of quality of life, but benign. we recommend that this drug must be avoided for patients with CSU.
  • ||||||||||  dexamethasone / Generic mfg.
    Innovative method of vitiligo therapy in Uzbekistan (e-Poster Hall) -  Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_452;    
    Materials and methods According to our observation, there were 65 patients aged 15 to 57 years with NSV who received mini pulse therapy with oral dexamethasone in the stage of progression of vitiligo...It is recommended for wide use in dermatological practice of regional branches. During external therapy, side effects in the form of progression of the skin process were not observed.
  • ||||||||||  Kaposi varicelliform eruption in a pemphigus foliaceus patient (e-Poster Hall) -  Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_379;    
    The immunosuppressive therapy for his PF included oral prednisolone, azathioprine, calcium supplement and PPIs prophylaxis...The patient was administered oral valacyclovir 1g x 3 times a day for 10 days, intravenous ceftriaxone 2g daily for 7 days and topical fusidic acid cream twice daily...For this reason the clinical suspicion of HSV infection should be verified by laboratory tests such as Tzanck smear, viral culture or polymerase chain reaction (PCR) detection of HSV DNA. Appropriate treatment should not be postponed due to the significant percentage of morbidity and mortality related to bacterial superinfections with impetiginization, bacteremia and viremia with systemic dissemination in immunosuppressed patients.
  • ||||||||||  dapsone / Generic mfg., prednisolone / Generic mfg., thalidomide / Generic mfg.
    Leprosy with Lucio Phenomenon: A Report of Two Patients In Malaysia and Clinical Outcome (e-Poster Hall) -  Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_375;    
    These two cases illustrate the good response to steroid treatment together with MDT. Complications including prolonged treatment duration, scarring and physical disabilities, can be minimized by early detection and aggressive treatment.
  • ||||||||||  methylprednisolone oral / Generic mfg., colchicine / Generic mfg.
    Behcet’s disease of fatal evolution. (e-Poster Hall) -  Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_266;    
    It was only during his hospitalization for a febrile consciousness disorder that the skin lesions associated with the notion of posterior uveitis, depression and meningoencephalitis made the diagnosis. The treatment is based on colchicine +/- oral corticotherapy or immunosuppressants depending on the systemic involvement.