Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


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  • ||||||||||  prednisolone / Generic mfg.
    Enrollment change, Trial termination:  NorPEPS: The Norwegian Prednisolone in Early Psychosis Study (clinicaltrials.gov) -  Aug 1, 2022   
    P2,  N=12, Terminated, 
    Completed --> Terminated; Lack of enrollment N=90 --> 12 | Recruiting --> Terminated; Stopped because of COVID 19 pandemic
  • ||||||||||  acetazolamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    A Surge of Fulminant Idiopathic Intracranial Hypertension One Year After The Start of the COVID 19 Pandemic A case series (Halifax Convention Centre -603/604) -  Jul 31, 2022 - Abstract #COS2022COS_619;    
    The negative impact of the covid lockdown on the health and wellbeing including the recent increase in weight in a large proportion of the population is thought to play a role in this recent surge of fulminant IIH. Urgent surgery coupled with acetazolamide is recommended in these patients, and temporizing measures such as large volume lumbar punctures, lumbar drains, and IV steroids can be considered.
  • ||||||||||  hydrocortisone / Generic mfg.
    Modeling Gene by Environment Interactions in Post-Traumatic Stress Disorder Using hiPSC-Derived Neurons (Spadolini Pavilion Main Floor) -  Jul 31, 2022 - Abstract #WCPG2022WCPG_313;    
    These genes enrich in GWAS catalog genes including generalized epilepsy (p=9.65E-08), bipolar disorder (p=9.36E-06), and body mass index (p=1.48E-07), traits associated with stress and glucocorticoid response. Genes with particularly strong interactions include PNPLA2 (p=5.6E-04), LRP8 (p=6.59E-04), and MXD4 (p=4.16E-04), which have been associated with chronic defeat stress, learning/memory formation, and amygdala signatures in a PTSD-like mouse model, respectively.
  • ||||||||||  Journal:  Vanishing Bile Duct Syndrome Secondary to Hodgkin Lymphoma in a Child. (Pubmed Central) -  Jul 31, 2022   
    VBDS is considered a dismal paraneoplastic syndrome with a high-case fatality. This case report highlights the importance of early recognition and initiation of appropriate full-dose chemotherapy as the only way to achieve complete resolution of VBDS.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Energy Metabolism and Lipidome Are Highly Regulated during Osteogenic Differentiation of Dental Follicle Cells. (Pubmed Central) -  Jul 30, 2022   
    Human DFCs were cultured, and osteogenic differentiation was induced by either dexamethasone or bone morphogenetic protein 2 (BMP2)...Concordantly, inhibition of fatty acid synthesis impeded the osteogenic differentiation of DFCs. This study demonstrates that energy metabolism is highly regulated during osteogenic differentiation of DFCs including changes in the lipidome suggesting enhanced de novo synthesis of lipids, which are required for the differentiation process.
  • ||||||||||  Journal:  Management of Acute and Chronic Pouchitis. (Pubmed Central) -  Jul 30, 2022   
    Pouchitis represents a spectrum of disease phenotypes, ranging from acute antibiotic responsive pouchitis to chronic antibiotic refractory pouchitis. The management of pouchitis is primarily directed by the disease phenotype.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis, Beovu (brolucizumab-dbll) / Novartis
    Journal:  Sub-Tenon's capsule triamcinolone acetonide injection to prevent brolucizumab-associated intraocular inflammation. (Pubmed Central) -  Jul 30, 2022   
    Clinicians should be aware that persistent hiccups might be one of the initial manifestations of LGI1 subtype of voltage-gated potassium channel complex antibody associated autoimmune encephalitis. The results indicated the possible preventative effect of a STTA injection on development of brolucizumab-associated IOI.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Pre-surgery immune profiles of adult glioma patients. (Pubmed Central) -  Jul 30, 2022   
    We show that pre-surgery blood immune profiles vary by glioma subtype, age, and more critically, by use of dexamethasone. Our results highlight the importance of considering dexamethasone exposures in all studies of immune profiles and of obtaining immune measures prior to use of dexamethasone, if possible.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Retrospective data, Journal:  Secondary Organising Pneumonia Among COVID-19 Patients: A Retrospective Case-Control Study. (Pubmed Central) -  Jul 30, 2022   
    In conclusion, SARS-CoV-2-induced OP may be more frequent than previously thought, especially among hospitalised patients and patients with a more severe disease, particularly those who fail to improve after the second week of disease or who present higher inflammatory markers on admission. It increases the length of stay, but not all patients require specific treatment and OP may improve despite the absence of high-dose corticosteroid treatment.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Journal:  Prise en charge des formes graves de Covid-19 en réanimation (Pubmed Central) -  Jul 29, 2022   
    Finally, specific treatment is mainly based on systemic corticosteroid therapy with dexamethasone 6 mg/d, possibly combined with tocilizumab. Other Covid-19-specific treatments have not yet been proven to be effective in critical care patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Incidentalomes surrénaliens (Pubmed Central) -  Jul 29, 2022   
    For bilateral incidentalomas, morning cortisol and ACTH measurements before and after synacthen injection are essential. Surgical removal can be indicated and the latest recommendations for follow-up of non-operated incidentalomas have been relaxed.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population. (Pubmed Central) -  Jul 29, 2022   
    We divided our group into those who showed suppression in 1 mg overnight dexamethasone suppression test (DST) (NFAT) (serum cortisol level ≤1.8 μg/dL) and those who did not show suppression in the DST (MACS) (serum concentration of cortisol ˃1.8 μg/dL and ≤5ug/dL)...In MACS T2DM is more prevalent than in NFAT; hyperlipidaemia is more prevalent in NFAT. Accordingly, no differences were found in the incidence of obesity, hypertension, prediabetes, chronic kidney disease between studied groups as well as cardiovascular events.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Synergism Between Taurine and Dexamethasone in Anti-inflammatory Response in LPS-Activated Macrophages. (Pubmed Central) -  Jul 29, 2022   
    In summary, the results strongly indicate that a single pre-treatment of DEX or TAU may attenuate ERS and inflammation in LPS-induced macrophages at the concentrations tested in this study. Most importantly, concurrent treatment of macrophages by both agents reduced the level of ERS and pro-inflammatory cytokines in a synergistic fashion.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice. (Pubmed Central) -  Jul 29, 2022   
    Mice treated with high-dose dexamethasone (5 mg/kg) had a significantly lowered serum TNF-α (134.41 ± 15.83 vs. 408.83 ± 18.32) and IL-6 (22.08 ± 4.34 vs. 91.27 ± 8.56) compared with those without dexamethasone. This study provides essential insights that the suppression of early-phase hyperactivation of pro-inflammatory activities through the early initiation of high-dose dexamethasone therapy increases sepsis-related prognosis.
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly, Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
    PK/PD data, Review, Journal:  Developing New Treatments for COVID-19 through Dual-Action Antiviral/Anti-Inflammatory Small Molecules and Physiologically Based Pharmacokinetic Modeling. (Pubmed Central) -  Jul 29, 2022   
    Characterization of candidate AAI molecules with physiologically based pharmacokinetics (PBPK) modeling would provide critical data for the accurate dosing of new therapeutic agents against COVID-19. This review analyzes the dual mechanisms of AAI agents with potential anti-SARS-CoV-2 activity and discusses the principles of PBPK modeling as a conceptual guide to develop new pharmacological modalities for the treatment of COVID-19.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Preclinical, Journal:  Gene Dysregulation in the Adult Rat Paraventricular Nucleus and Amygdala by Prenatal Exposure to Dexamethasone. (Pubmed Central) -  Jul 29, 2022   
    Pregnant Wistar Kyoto rats received subcutaneous injections of dexamethasone (100 μg/kg) daily from gestational day 15-21 or vehicle only as sham controls...The expression of CACNA1C encoding the Ca1.2 pore subunit of L-type voltage-gated calcium channels was downregulated in male and female rats prenatally exposed to dexamethasone. Collectively, the results suggest that prenatal exposure to elevated levels of glucocorticoids plays a role in the dysregulation of the hypothalamic-pituitary-adrenal axis and potentially learning and memory by altering the expression of specific genes within the amygdala and PVN.
  • ||||||||||  EG-HPCP-03a / Evergreen Therap
    Trial completion date, Trial primary completion date:  Study to Evaluate the Efficacy and Safety of EG-009A Compared to DEX in Patients With COVID-19 Pneumonia (clinicaltrials.gov) -  Jul 29, 2022   
    P2,  N=96, Not yet recruiting, 
    Collectively, the results suggest that prenatal exposure to elevated levels of glucocorticoids plays a role in the dysregulation of the hypothalamic-pituitary-adrenal axis and potentially learning and memory by altering the expression of specific genes within the amygdala and PVN. Trial completion date: Dec 2022 --> Aug 2023 | Trial primary completion date: Oct 2022 --> Aug 2023
  • ||||||||||  Synacthen Depot (cosyntropin) / Novartis, Mallinckrodt, Alliance
    Trial completion date, Trial primary completion date:  Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation (clinicaltrials.gov) -  Jul 29, 2022   
    P=N/A,  N=84, Recruiting, 
    Trial completion date: Dec 2022 --> Aug 2023 | Trial primary completion date: Oct 2022 --> Aug 2023 Trial completion date: Mar 2022 --> Dec 2023 | Trial primary completion date: Aug 2021 --> Aug 2023
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion, Surgery:  Neostigmine and Dexamethasone in Adductor Canal Block (clinicaltrials.gov) -  Jul 29, 2022   
    P=N/A,  N=90, Completed, 
    Trial completion date: Mar 2022 --> Dec 2023 | Trial primary completion date: Aug 2021 --> Aug 2023 Recruiting --> Completed