Glucocorticoid Receptor 

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  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Topical Steroid-Induced Cushing's Syndrome in a Newborn Following Goniotomy for Glaucoma. (Pubmed Central) -  Aug 25, 2022   
    The child was kept under observation and managed with a physiological dose of hydrocortisone. Parental counselling regarding the proper method of eye drop instillation and signs of steroid toxicity is of vital importance in all cases of paediatric ocular surgeries, especially where bilateral surgeries are undertaken.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial completion:  A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors (clinicaltrials.gov) -  Aug 25, 2022   
    P1,  N=10, Completed, 
    Prior bevacizumab will be a stratification factor in the phase 3 trial of RELA+NP (ROSELLA, NCT05257408) that is planned to start in mid-2022. Active, not recruiting --> Completed
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Repairing Effect of New Dexamethasone Nanoparticles in the Treatment of Acute Lung Injury and Cluster Nursing. (Pubmed Central) -  Aug 24, 2022   
    A mouse model of acute lung injury was established, and the anti-inflammatory effect of dexamethasone was evaluated by intravenous injection of dexamethasone nanoparticles in the intervention group and normal healthy mice in the control group...Anionic ICAM NLCs were less toxic than cationic cells and could better bind to lung vascular endothelial cells, which might reduce adverse drug reactions. Therefore, the building of bundled nursing could effectively alleviate respiratory dysfunction and reduce the infection rate of patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Standard in vitro evaluations of engineered bone substitutes are not sufficient to predict in vivo preclinical model outcomes. (Pubmed Central) -  Aug 24, 2022   
    In the first part of this study, human bone marrow - derived mesenchymal stromal cells (hBM-MSCs) were embedded in three commonly used biomaterials (hyaluronic acid methacrylate, gelatin methacrylate and fibrin) and combined with relevant bioactive osteogenesis factors (dexamethasone microparticles and polyphosphate nanoparticles) to form a TE construct that underwent in vitro osteogenic differentiation for 28 days...Within this study we investigate multiple combinations of materials and osteogenic stimulants and demonstrate a poor correlation between the in vitro and in vivo data. We propose rationale for why this may be the case and suggest a modified testing algorithm.
  • ||||||||||  dexamethasone / Generic mfg., ropivacaine / Generic mfg.
    Journal:  A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block. (Pubmed Central) -  Aug 24, 2022   
    The immunological analysis also showed significant differences in the expression of various immune cells in the 3 groups. AHSP, ALAS2, EPB42, HBB, and SLC4A1 are genes associated with hemoglobin, and dexamethasone combined with ropivacaine may prolong anesthesia by affecting local vasoconstriction to some extent.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Protective Effects of Platycodin D3 on Airway Remodeling and Inflammation via Modulating MAPK/NF-κB Signaling Pathway in Asthma Mice. (Pubmed Central) -  Aug 24, 2022   
    The asthma mice administrated with dexamethasone (DXM) were enrolled as the positive control group, and the normal control mice and asthma model mice separately received the same volume of saline...Furthermore, PD3 treatment inhibited the phosphorylation of NF-κBp65, p38, ERK1/2, and JNK1/2 proteins in asthma mice. PD3 treatment alleviated the airway remodeling and inflammation in asthmatic mice, which might be related to downregulating the phosphorylated proteins in the MAPK/NF-κB signaling pathway.
  • ||||||||||  budesonide/salbutamol (PT027) / AstraZeneca, Avillion
    Journal:  Effects of budesonide combined with salbutamol on pulmonary function and peripheral blood eosinophiles and IgE in patients with acute attack of bronchial asthma. (Pubmed Central) -  Aug 24, 2022   
    To explore the effect and value of salbutamol and budesonide in the treatment of patients with acute attack of bronchial asthma...Post treatment levels of EOS and IgE in peripheral blood of Group-II were significantly lower than those of Group-I (P<0.05). On the basis of routine treatment, budesonide combined with salbutamol atomization inhalation for the treatment of patients with acute attack of asthma can be more efficient in improving symptoms and pulmonary, function and promote the effective reduction of EOS and IgE levels in peripheral blood.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Regulation of the kiss2 promoter in yellowtail clownfish (Amphiprion clarkii) by cortisol via GRE-dependent GR pathway. (Pubmed Central) -  Aug 24, 2022   
    Applying transient transfection in HEK293T cells of the yellowtail clownfish kiss2 promoter, cortisol (dexamethasone) treatment was shown to enhance the promoter activities of the yellowtail clownfish kiss2 gene in the presence of GRs...Finally, point mutation studies on the kiss2 promoter showed that cortisol-stimulated promoter activity was mediated by one GRE site located at position -573 in the presence of GR1 and by each GRE site located at position -883, -860, -851, and -843 in the presence of GR2. Results of the present study provide novel evidence that cortisol could regulate the transcription of kiss2 gene in the yellowtail clownfish via GRE-dependent GR pathway.
  • ||||||||||  hydrocortisone / Generic mfg.
    Preclinical, Journal:  Development of a Chemically Defined Medium for in vitro Expansion of Primary Bovine Satellite Cells. (Pubmed Central) -  Aug 24, 2022   
    Based on a comprehensive literature analysis, a defined serum-free medium (SFM) composition was developed consisting of DMEM/F12 as basal medium, supplemented with L-ascorbic acid 2-phosphate, fibronectin, hydrocortisone, GlutaMAX, albumin, ITS-X, hIL-6, α-linolenic acid, and growth factors such as FGF-2, VEGF, IGF-1, HGF, and PDGF-BB...We conclude that the SFM formulation supported exponential cell growth up to 97% of the serum-containing golden standard growth medium. All reagents used in this study are chemically defined.
  • ||||||||||  dexamethasone / Generic mfg., arsenic trioxide / Generic mfg.
    Journal:  The role of adjuvant chemotherapy in the management of acute promyelocytic leukemia differentiation syndrome. (Pubmed Central) -  Aug 24, 2022   
    However, induction with ATRA/ATO only regimens have been showing increased incidence of differentiation syndrome (DS), a potentially lethal complication, traditionally treated with dexamethasone...The lengths of hospital stay in patients receiving ATRO/ATO only was 38 days (n = 7), and in patients receiving combination therapy was 14 days (n = 17) (P = 0.0007). In conclusion, adding adjuvant chemotherapy to ATRA/ATO only protocol may reduce the duration of DS and the length of hospital stay during APL induction treatment.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Resection of Gastric Cancer Remitted Anti-signal Recognition Particle Myopathy. (Pubmed Central) -  Aug 24, 2022   
    Although the myopathy relapsed two times in two years under oral prednisolone and intravenous immunoglobulin therapy, the myopathy remained in remission for more than three years after resection of gastric cancer. Although the anti-SRP myopathy is not considered to be cancer-associated in general, we should note that some cases of anti-SRP myopathy may be ameliorated with appropriate cancer treatment.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  The Impact of Intratympanic Steroid Dosage on Hearing Recovery in Sudden Sensorineural Hearing Loss. (Pubmed Central) -  Aug 24, 2022   
    Subjects with Meniere's disease, autoimmune inner ear disease, subjects who received injections of non-dexamethasone steroid formulations, and subjects with missing audiogram data were excluded...Hearing recovery was not significantly different between the 10 mg/ml versus 24 mg/ml doses of intratympanic dexamethasone, suggesting that steroid dose may not impact the efficacy of IST. A shorter time-to-treatment was observed to be favorable for hearing improvement.
  • ||||||||||  Kenalog-40 (triamcinolone acetonide injection suspension) / BMS
    Clinical, Journal:  Fungal abscess after intra-orbital steroid injection: a case report. (Pubmed Central) -  Aug 24, 2022   
    Intraorbital steroids are given for idiopathic and thyroid-associated orbital inflammation. This is a report of a rare complication of fungal orbital abscess following intraorbital corticosteroid injection in an immunocompetent young patient.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Erythrocyte-derived liposomes for the treatment of inflammatory diseases. (Pubmed Central) -  Aug 24, 2022   
    In the presence of lipopolysaccharide (LPS)-stimulated macrophages, empty EDLs and EDLs incorporating diclofenac were able to reduce the levels of important pro-inflammatory cytokines, namely interleukin-6 (IL-6; ≈85% and 77%, respectively) and tumor necrosis factor-alpha (TNF-α; ≈64% and 72%, respectively). Strikingly, cytocompatible concentrations of EDLs presented similar effects to dexamethasone, a potent anti-inflammatory drug, in reducing IL-6 and TNF-α concentrations, demonstrating the EDLs potential to be used as bioactive carriers in the treatment of inflammatory diseases.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
    Journal:  SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis. (Pubmed Central) -  Aug 24, 2022   
    Strikingly, cytocompatible concentrations of EDLs presented similar effects to dexamethasone, a potent anti-inflammatory drug, in reducing IL-6 and TNF-α concentrations, demonstrating the EDLs potential to be used as bioactive carriers in the treatment of inflammatory diseases. COVID-19 vaccination can elicit a distinct T cell-dominant immune-mediated hepatitis with a unique pathomechanism associated with vaccination-induced antigen-specific tissue-resident immunity requiring systemic immunosuppression.
  • ||||||||||  hydrocortisone / Generic mfg.
    FDA event, Review, Journal:  Phosphate moiety in FDA-approved pharmaceutical salts and prodrugs. (Pubmed Central) -  Aug 24, 2022   
    Histamine phosphate is the first phosphate salt, and hydrocortisone phosphate was the first prodrug approved by FDA in 1939 and 1952, respectively...This review focuses on the FDA-approved phosphate salts and prodrugs from 1939 to 2021. The biopharmaceutical advantage of phosphate salts and prodrugs over the parent molecule is also deliberated.
  • ||||||||||  prednisolone / Generic mfg., ursodeoxycholic acid / Generic mfg.
    Journal:  Primary biliary cholangitis presenting with Fanconi syndrome: an important phenotype. (Pubmed Central) -  Aug 24, 2022   
    Kidney function was stabilised, but a sustained improvement was not seen. This case acts as a reminder of the rare association of tubulointerstitial nephritis and Fanconi syndrome with primary biliary cholangitis, which may be an under-recognised phenotype.
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
    Enrollment open, Real-world evidence, Patient reported outcomes, Real-world:  RECORD: REported Outcomes in COPD With Trixeo in Real worlD (clinicaltrials.gov) -  Aug 24, 2022   
    P=N/A,  N=500, Recruiting, 
    This case acts as a reminder of the rare association of tubulointerstitial nephritis and Fanconi syndrome with primary biliary cholangitis, which may be an under-recognised phenotype. Not yet recruiting --> Recruiting