Glucocorticoid Receptor 

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  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Lung Cancer Complicated by Relapsing Polychondritis. (Pubmed Central) -  Sep 8, 2022   
    We finally diagnosed him with lung cancer complicated by relapsing polychondritis. Treatment with oral prednisolone was initiated, followed by sequential chemoradiotherapy for lung cancer.
  • ||||||||||  Jakafi (ruxolitinib) / Novartis, Incyte
    Journal:  Ruxolitinib inhibits cytokine production by human lung macrophages without impairing phagocytic ability. (Pubmed Central) -  Sep 7, 2022   
    Overall, ruxolitinib's anti-inflammatory activities are less intense than (but somewhat different from) those of budesonide-particularly with regard to the production of the corticosteroid-resistant chemokine CXCL-10. Our results indicate that treatment with a JAK inhibitor might be a valuable anti-inflammatory strategy in chronic obstructive pulmonary disease, Th1-high asthma, and both viral and non-viral acute respiratory distress syndromes (including coronavirus disease 2019).
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Triamcinolone acetonide injectable suspension for suprachoroidal use in the treatment of macular edema associated with uveitis. (Pubmed Central) -  Sep 7, 2022   
    This unique delivery method suggests the potential to decrease side effects of anterior segment exposure such as glaucoma and cataract, but head-to-head trials are needed for further study of safety and efficacy. Additionally, there are promising prospective studies underway for utilization of the suprachoroidal space for other diseases including macular degeneration, diabetic macular edema, and ocular tumors.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Coadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma. (Pubmed Central) -  Sep 7, 2022   
    The modulation of inflammatory features was associated with significant inhibition of neutrophilia and oxidative and nitrative stress, decrease in HDAC2, and increase in IL-17 levels that are usually associated with steroid-resistant asthma. Our findings show that although STIG and DEX individually do not protect against steroid-resistant asthma, their coadministration results in significant modulation of inflammatory features and the associated molecular events that lead to steroid-resistant asthma.
  • ||||||||||  dexamethasone / Generic mfg., methylprednisolone acetate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Perineural Methylprednisolone Depot Formulation Decreases Opioid Consumption After Total Knee Arthroplasty. (Pubmed Central) -  Sep 7, 2022   
    This study aimed to investigate the effects of adding methylprednisolone acetate (MPA) to adductor canal blocks (ACB) and interspace between the popliteal artery and capsule of the posterior knee (iPACK) blocks on postoperative opioid consumption...The primary outcome was cumulative opioid consumption (oral milligram morphine equivalent, OME) during hospitalization for up to three days...Compared to perineural DEX alone, the addition of MPA further decreases postoperative opioid consumption without clinically significant changes on FSG and WBC. III.
  • ||||||||||  aspirin / Generic mfg.
    Journal:  Modulation of Arginase-2 mRNA Levels by ω-3 PUFAs and Aspirin in Asthmatic Human Lung Fibroblasts. (Pubmed Central) -  Sep 7, 2022   
    ASA upregulated ARG2 mRNA 5-fold and 7-fold in NHLF and DHLF, respectively, T1 cytokines downregulated ARG2, ODC, and OAT mRNA in DHLF 10-fold, 2-fold, and 2.5-fold, respectively, and cAMP downregulated ARG2 mRNA 2-fold in DHLF. These results are the first to show a direct effect of ω-3 PUFAs on ARG2 mRNA levels and provide further evidence for a role of ω-3 PUFAs in AR.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Pediatric spinal cord injury with radiographic abnormality: the Beijing experience. (Pubmed Central) -  Sep 7, 2022   
    The epidemiological and clinical characteristics of SCIWRA and SCIWORA are very different from each other. It is important to formulate tailor-made prevention, evaluation, and management strategies for the pediatric population to optimize the SCI outcomes.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Pharmacologically increased cortisol levels impair recall of associative background context memory in males, but not females. (Pubmed Central) -  Sep 7, 2022   
    Eighty-four female and male participants were tested in a placebo controlled, double-blind between-subject design, assigned to either a cortisol (10 mg hydrocortisone) or a placebo group...Moreover, the individual cortisol increase during the recognition task was negatively correlated to memory for the background scenes of the emotional foreground images only in male participants of the cortisol group. This study shows that pharmacologically increased cortisol levels distinctly affect associative memory in female and male participants, but have no effect on item memory, indicating a complex interaction for the stress effects on memory.
  • ||||||||||  relacorilant (CORT125134) / Corcept Therap
    Trial completion date, Trial primary completion date:  GRADIENT: Efficacy and Safety of Relacorilant in Patients with Cortisol-Secreting Adrenal Adenomas (clinicaltrials.gov) -  Sep 7, 2022   
    P3,  N=130, Recruiting, 
    Dexamethasone was superior to betamethasone and fluorometholone in preventing CME. Trial completion date: Aug 2022 --> Dec 2022 | Trial primary completion date: Jul 2022 --> Dec 2022
  • ||||||||||  dexamethasone / Generic mfg., cyclophosphamide / Generic mfg., carfilzomib / Generic mfg.
    Trial completion date, Trial primary completion date, Combination therapy:  Carfilzomib, Cyclophosphamide, Dexamethasone in Multiple Myeloma (clinicaltrials.gov) -  Sep 7, 2022   
    P2,  N=199, Active, not recruiting, 
    Trial completion date: Jul 2022 --> Jul 2023 | Trial primary completion date: Jul 2022 --> Jul 2023 Trial completion date: Dec 2022 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2024
  • ||||||||||  Journal:  Current and future therapeutic options for COVID-19 (Pubmed Central) -  Sep 6, 2022   
    Monoclonal antibodies have shown limited or no efficacy against the omicron-variant of SARS-CoV-2. Fluvoxamine, l-arginine, AT-527 and ensovibep are considered as potential promising new therapies for the treatment of early COVID-19.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  An Unusual Presentation of Adrenocortical Carcinoma (ACC): Panic Attacks and Psychosis. (Pubmed Central) -  Sep 6, 2022   
    Elevated cortisol, positive dexamethasone (DXM) suppression test, low adrenocorticotropic hormone (ACTH), imaging revealing an adrenal mass, and postoperative histology confirmed the diagnosis of cortisol-producing ACC...Panic attacks, a common presentation of CS, can present with features mimicking pheochromocytoma (PCC), including palpitations, sweating, tachycardia, and paroxysmal hypertension. A comprehensive workup is warranted to reach a diagnosis, with a combination of hormonal levels, imaging, and histology.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion date, Trial primary completion date:  UARK 2008-02 A Trial for High-risk Myeloma Evaluating Accelerating and Sustaining Complete Remission (clinicaltrials.gov) -  Sep 6, 2022   
    P2,  N=90, Active, not recruiting, 
    Trial completion date: Dec 2025 --> Dec 2030 | Trial primary completion date: Dec 2024 --> Dec 2029 Trial completion date: Oct 2022 --> Oct 2023 | Trial primary completion date: Oct 2022 --> Oct 2023
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Severe Noncirrhotic Hyperammonemia: What Urea-lly Should Consider (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_3998;    
    Case Description/ A 57-year-old man with heart failure with recovered ejection fraction, atrial fibrillation, hypertension, and cervical neck fracture who had undergone a recent cervical spine corpectomy and fusion presented with worsening dysphagia and was found to have a cervical fluid collection for which he received a dexamethasone taper and a lumbar drain...His hyperammonemia resolved and his mentation improved with lactulose and rifaximin...Treatment for a potential IEM begins prior to confirmation of an etiology. Geneticists should be consulted early on for evaluation and management.
  • ||||||||||  Ninlaro (ixazomib) / Takeda
    Remission of Autoimmune Hepatitis Following Autologous Stem Cell Transplantation (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_3971;    
    She has since been continued on maintenance ixazomib and low dose dexamethasone once weekly but has been monitored off her previous AIH therapies for over 2 years...(C) H&E stain of the bone marrow showing cellular marrow with numerous plasma cells (blue arrows). (D) Bone marrow, Kappa in situ hybridization reveals Kappa-light chain restricted plasma cell neoplasm.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD)
    Positive Smooth Muscle Antibodies in a Patient With Pembrolizumab-Induced Liver Injury (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_3907;    
    Serum ethanol and acetaminophen levels were negative...She was treated with N-acetylcysteine, ceftriaxone & metronidazole, and methylprednisolone 60mg IV daily...She was changed to prednisone 80mg daily and was discharged on a steroid taper with normalization of her LFTs 1 month later...1B. Magnetic resonance cholangiopancreatography (MRCP) showing no intrahepatic or common bile ductal dilation or stricture, no choledocholithiasis, normal liver size, and periportal edema.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Paraneoplastic Mucous Membrane Pemphigoid: Not Your Typical Cause of Odynophagia (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_3882;    
    Patient was discharged with multidisciplinary team follow up for chemotherapy initiation and Rituxan induction...Less than 500 cases have been reported where clinical features, presentation, and autoantibodies profiles have varied widely between patients highlighting the challenge of diagnosis. Early recognition of Paraneoplastic MMP presenting as odynophagia is difficult due to the overlap of symptoms in more prevalent conditions.
  • ||||||||||  Kesimpta (ofatumumab subcutaneous) / Novartis, Genmab
    Monotherapy for Multiple Autoimmune Diseases: The Novel Use of Ofatumumab for Concurrent Multiple Sclerosis and Autoimmune Hepatitis (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_3833;    
    Notably, several studies have suggested a role for B-cell-driven autoimmune liver injury in AIH, and there have been reports of refractory AIH being successfully treated with rituximab, an anti-CD20 monoclonal antibody...The patient was started on oral budesonide followed by ofatumumab, an anti-CD20 monoclonal antibody approved for treatment of RRMS, as steroids were weaned...It highlights a possible alternative treatment modality for AIH that avoids a prolonged course of steroids and/or azathioprine. More research is still needed however.