Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Photobiomodulation effects in metalloproteinases expression in zymosan-induced arthritis. (Pubmed Central) -  Sep 30, 2022   
    C57BL/6 mice were distributed into four groups (n = 8): zymosan-induced arthritis without treatment; zymosan-induced arthritis and dexamethasone-treated; zymosan-induced arthritis and PBM at energy density of 3 Jcm treated; and zymosan-induced arthritis and PBM at energy density of 30 Jcm treated...PBM promotes a better arthritis prognostic, modulating metalloproteinase and its inhibitor, especially MMP-9 and TIMP-2 protein expression that is important inflammatory markers. These findings may also corroborate that PBM may regulate MMPs expression using different pathways.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Comparison of the in vitro Anti-Inflammatory Effect of Cannabidiol to Dexamethasone. (Pubmed Central) -  Sep 29, 2022   
    These results suggested that CBD and DEX exhibit similar anti-inflammatory effects on LPS-induced RAW264.7 macrophages mainly through suppressing the MAPK and NF-κB signaling pathways, but with different intracellular mechanisms. These findings suggested that CBD may be considered a natural anti-inflammatory agent for protecting skin from immune disorders.
  • ||||||||||  triamcinolone acetonide topical / Generic mfg.
    Journal:  Changes in Intraocular Pressure with Use of Periocular Triamcinolone Cream. (Pubmed Central) -  Sep 29, 2022   
    Two patients experienced a significant elevation in IOP of 10 mm Hg, one through the concomitant consequences of systemic corticosteroids usage and the other through prolonged topical application. In patients taking periocular triamcinolone cream, there was no clinically meaningful change in mean IOP between baseline and follow-up visits, and IOP measurements were not related to variances in prescription strength or duration of therapy.
  • ||||||||||  doxycycline / Generic mfg., fluticasone / Generic mfg., itraconazole / Generic mfg.
    Journal:  The efficacy of itraconazole, fluticasone and doxycycline in chronic rhinosinusitis. (Pubmed Central) -  Sep 29, 2022   
    In patients taking periocular triamcinolone cream, there was no clinically meaningful change in mean IOP between baseline and follow-up visits, and IOP measurements were not related to variances in prescription strength or duration of therapy. There were no significant differences between the clinical condition of patients receiving intranasal fluticasone, intranasal fluticasone in combination with doxycycline or itraconazole.
  • ||||||||||  verapamil intralesional / Stada
    Review, Journal:  Laser therapy for treating hypertrophic and keloid scars. (Pubmed Central) -  Sep 29, 2022   
    Laser versus other treatments: We are uncertain whether treatment with 585-nm PDL impacts on hypertrophic and keloid scar severity compared with intralesional corticosteroid triamcinolone acetonide (TAC), intralesional Fluorouracil (5-FU) or combined use of TAC plus 5-FU (very low-certainty evidence)...Other comparisons included 585-nm PDL versus silicone gel sheeting, fractional CO laser versus TAC and fractional CO laser versus verapamil...Due to the heterogeneity of the studies, conflicting results, study design issues and small sample sizes, further high-quality trials, with validated scales and core outcome sets should be developed. These trials should take into consideration the consumers' opinion and values, the need for long-term follow-up and the necessity of reporting the rate of recurrence of scars to determine whether lasers may achieve superior results when compared with other therapies for treating hypertrophic and keloid scars.
  • ||||||||||  dexamethasone / Generic mfg., etoposide IV / Generic mfg.
    Journal:  Gaucher Disease Type 2 Manifested as Hemophagocytic Lymphohistiocytosis in a Neonate in the COVID-19 Era. (Pubmed Central) -  Sep 29, 2022   
    These trials should take into consideration the consumers' opinion and values, the need for long-term follow-up and the necessity of reporting the rate of recurrence of scars to determine whether lasers may achieve superior results when compared with other therapies for treating hypertrophic and keloid scars. Gaucher disease can rarely present in neonates as hemophagocytic lymphohistiocytosis.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia. (Pubmed Central) -  Sep 29, 2022   
    Gaucher disease can rarely present in neonates as hemophagocytic lymphohistiocytosis. Our single-cell-based results suggested that endothelial cells may play critical roles in sarcopenia development through interferon-GBP signalling pathways, highlighting new therapeutic directions to slow down or even reverse age-related sarcopenia.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Clinical, Retrospective data, Review, Journal:  The Efficacy and Safety of Corticosteroids in Total Joint Arthroplasty: A Direct Meta-Analysis. (Pubmed Central) -  Sep 29, 2022   
    Strong evidence supports the use of a single dose or multiple doses of intravenous dexamethasone to reduce postoperative pain, opioid consumption, nausea and vomiting after primary TJA. There is insufficient evidence on perioperative dexamethasone in primary TJA to determine the optimal dose, number of doses, or risk of postoperative adverse events.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Literature Highlights. (Pubmed Central) -  Sep 29, 2022   
    Literature Highlights is a digest of notable papers recently published in the leading respiratory journals, allowing our readers to stay up-to-date with research advances. This month we include coverage on use of monoclonal antibodies for prevention of COVID-19, acoustic epidemiology and cough assessment; immunotherapeutic interventions for viral and bacterial infections; the potential for harmful use of dexamethasone in COVID-19 patients; diagnostic accuracy of a new finger stick blood test for TB; Clinical standards for pulmonary TB.
  • ||||||||||  Journal, IO biomarker:  ALL-473 Dilemma of Diagnosing and Treating BPDCN; Case Report With Clinicopathological Correlation. (Pubmed Central) -  Sep 29, 2022   
    The diagnosis and management of such cases are challenging at all levels from the beginning of the disease, through the steps of diagnosis and finally in choosing the appropriate treatment protocol. We recommend ALL-based chemotherapy protocols especially Hyper-CVAD then allogenic SCT for better response and overall survival.
  • ||||||||||  Journal:  MPN-092 Paraneoplastic Eosinophilia: An Unusual Initial Presentation of Metastatic Pancreatic Adenocarcinoma. (Pubmed Central) -  Sep 29, 2022   
    We initiated first-line chemotherapy for advanced pancreatic adenocarcinoma with gemcitabine and nab-paclitaxel...She received second-line treatment with mFOLFIRINOX for 12 cycles...It is characterized by a more aggressive disease and dismal outcome. Clinicians must be aware of this condition and must exclude all other causes of hypereosinophilia before making this diagnosis.
  • ||||||||||  Darzalex (daratumumab) / J&J
    Journal:  MM-171 Upfront Treatment Practice Patterns in Multiple Myeloma. (Pubmed Central) -  Sep 29, 2022   
    Alternatively, given the fairly recent publication of the GRIFFIN trial, this finding may reflect the normal gap between published results and provider implementation of change in standard practice. Follow-up in late 2022 may demonstrate further permeation of this data as demonstrated in practice patterns.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., bendamustine / Generic mfg.
    Retrospective data, Journal:  MM-494 Chemo or Chemo-Free Regimens in Heavily Pretreated Multiple Myeloma? Role of Bendamustine-Bortezomib-Dexamethasone (BVD) in Novel Agents' Era. (Pubmed Central) -  Sep 29, 2022   
    KRD has shown significant efficacy in a particularly severe setting of patients, relapsed and refractory to all available therapeutic resources, including lenalidomide, and it could be considered as a bridge to a second autologous or allogenic SCT. BVD has shown significant efficacy in a particularly severe setting of patients, relapsed and refractory to all available therapeutic resources, and, in particular cases, it could be considered as a bridge to SCT, also after failure of novel agents.
  • ||||||||||  dexamethasone / Generic mfg., pomalidomide / Generic mfg.
    Retrospective data, Journal:  MM-501 Domestic Opportunity in Heavily Pretreated Multiple Myeloma Not Eligible for Hospital-Based Treatment: Role of Pomalidomide-Dexamethasone. (Pubmed Central) -  Sep 29, 2022   
    BVD has shown significant efficacy in a particularly severe setting of patients, relapsed and refractory to all available therapeutic resources, and, in particular cases, it could be considered as a bridge to SCT, also after failure of novel agents. Pomalidomide-dexamethasone has shown significant efficacy and a very good compliance, thanks to oral administration, in a particularly severe setting of heavily pretreated patients, relapsed and refractory to all available therapeutic resources, also after failure of novel agents.
  • ||||||||||  Neulasta (pegfilgrastim) / Amgen, Kyowa Kirin, Roche
    Journal:  MM-499 Pegfilgrastim Versus Filgrastim in the Supportive Care of Heavily Pretreated Multiple Myeloma in Treatment With Pomalidomide-Dexamethasone. (Pubmed Central) -  Sep 29, 2022   
    Pomalidomide-dexamethasone has shown significant efficacy and a very good compliance, thanks to oral administration, in a particularly severe setting of heavily pretreated patients, relapsed and refractory to all available therapeutic resources, also after failure of novel agents. In MM treated with pomalidomide-dexamethasone, pegfilgrastim seems to reduce the incidence of severe neutropenia and infections and may increase the possibility to maintain the scheduled time of treatment.
  • ||||||||||  Elitek (rasburicase) / Sanofi
    Biomarker, Review, Journal:  CT-058 Outcome of Chemotherapy in G6PD-Deficient Patients. (Pubmed Central) -  Sep 29, 2022   
    Clinicians must consider the potential benefit of treatment to decide on cytotoxic therapies in G6PD-deficient patients. As medical oncologists, we believe that more information is required to support the safety of chemotherapy in this population.
  • ||||||||||  Budenofalk granules (budesonide gastro-resistant granules) / Dr Falk
    Journal:  Effect of Biyanning Granules on local symptoms and immune function of chronic rhinosinusitis (Pubmed Central) -  Sep 29, 2022   
    It significantly improved the curative effect, regulated immune imbalance, accele-rated the recovery of immune function, reduced the recurrence rate of inflammatory reaction, and improved the quality of life. The combination of Chinese and western treatment is more effective than glucocorticoid alone and warrants further clinical study in large sample size.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Mechanism of "Ephedrae Herba-Descurainiae Semen Lepidii Semen" combination in treatment of bronchial asthma based on network pharmacology and experimental verification (Pubmed Central) -  Sep 29, 2022   
    Rats were classified into control group(CON), model group(M), dexamethasone group(DEX, 0.075 mg·kg~(-1)), and MT(1∶1.5) group...In vivo experiment showed that MT could effectively alleviate the symptoms of OVA-induced asthma rats, improve the pathological changes of lung tissue, reduce the production of goblet cells, inhibit the inflammatory response of asthma rats, suppress the expression of MAPK8, CCND1, IL6, and EGFR, and regulate the PI3 K/Akt signaling pathway. Therefore, MT may relieve the symptoms and inhibit inflammation of asthma rats by regulating the PI3 K/Akt signaling pathway, and quercetin and β-sitosterol are the candidate active components.
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Journal:  Experimental infection of cats with Cryptosporidium felis. (Pubmed Central) -  Sep 29, 2022   
    Clinical signs were not recognized in any of the cats for the duration of the study. FA was insensitive compared with qPCR for detecting cats with subclinical C felis infection.