Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Oat β-glucan and L-arabinose synergistically ameliorate glucose uptake in insulin-resistant HepG2 cells and exert anti-diabetic activity via activation of the PI3K/AKT pathway in db/db mice. (Pubmed Central) -  Oct 6, 2022   
    We investigated the effect of variable compositions (OBG : LA = 1 : 1, 1 : 2, 1 : 4,1 : 6, 1 : 8, 1 : 10, 2 : 1, 4 : 1, 6 : 1, 8 : 1, 10 : 1) on glucose uptake in IR-HepG2 cells induced by dexamethasone (DEX) to find out the optimal composition showing synergistic effects...Moreover, the western blot results indicated that the OBG : LA = 1 : 1 group up-regulated the protein expression of glucose transporter-4 (GLUT4), phosphatidylinositol 3-kinase (PI3K), and phospho-protein kinase B (p-AKT), while down-regulating the protein expression of phospho-phosphorylated insulin receptor substrate-1 (p-IRS1) to enhance insulin transduction in liver tissues. These findings suggest that OBG : LA = 1 : 1 synergistically ameliorated glucose metabolism disorders and alleviated insulin resistance by promoting the PI3K/AKT pathway in the liver.
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca, budesonide/formoterol (PT009) / AstraZeneca
    Trial completion date, Trial primary completion date:  Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (LOGOS) (clinicaltrials.gov) -  Oct 6, 2022   
    P3,  N=2200, Recruiting, 
    The markedly low incidence of PCP may be attributed to the continuous chemoprophylaxis against PCP received by >50% of Japanese patients with AAV, though the effectiveness of chemoprophylaxis against PCP was not statistically confirmed. Trial completion date: Mar 2024 --> Dec 2024 | Trial primary completion date: Mar 2024 --> Dec 2024
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion date, Trial primary completion date:  Calcific Tendonitis Treatment: Barbotage vs. Barbotage With Cortisone Injection (clinicaltrials.gov) -  Oct 6, 2022   
    P4,  N=150, Recruiting, 
    Trial completion date: Mar 2024 --> Dec 2024 | Trial primary completion date: Mar 2024 --> Dec 2024 Trial completion date: Nov 2022 --> Nov 2023 | Trial primary completion date: Nov 2022 --> Nov 2023
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Abatacept For Immune Checkpoint Inhibitor associated Myocarditis (ATRIUM): A Phase 3, Investigator-Initiated, Randomized, Double-Blind, Placebo-Controlled Trial (Hall C) -  Oct 6, 2022 - Abstract #SITC2022SITC_1014;    
    P3
    Hospitalized participants diagnosed with ICI-related myocarditis, aged ≥18 years, with serum evidence of ongoing myocardial injury (troponin ≥5 times the upper limit normal), and treated, or with intent to treat, with 1000 mg of solumedrol/day are eligible...Clinical trial information: NCT05335928 . Ethics Approval The clinical trial protocol has been approved by the Mass General Brigham Institutional Review Board (Protocol #:2021P003690) and all participants will provide informed consent before taking part.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg., amphotericin b liposome / Generic mfg.
    Clinical, Journal:  Rare and Unusual Follow-up Sequelae of Coronavirus Disease 2019: Splenic Mucormycosis in a Renal Transplant Recipient. (Pubmed Central) -  Oct 5, 2022   
    The diagnosis and management of this dual infection during the pandemic is extremely challenging. In this case, the unusual location of mucormycosis complicating COVID-19 calls for a meticulous approach to opportunistic fungal infections in organ transplant recipients who are positive for COVID-19, especially in those patients with diabetes.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Tectoridin alleviates lipopolysaccharide -induced inflammaion via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro. (Pubmed Central) -  Oct 5, 2022   
    Experimental animals received tectoridin and Dexamethasone (DEX) before LPS injection for endotoxic shock mouse model in vivo...Furthermore, our results demonstrated that tectoridin inhibited the activation of TLR4-NF-κB/NLRP3 signaling proved by immunohistochemistry assay and Western blot. Taken all together, tectoridin might have the potential ability of anti-inflammatory effects and the possible mechanism may be relevant to its inhibition of TLR4-NF-κB/NLRP3 signaling.
  • ||||||||||  hydrocortisone / Generic mfg.
    Retrospective data, Journal:  Clinical and electroencephalography characteristics of 41 children with epileptic spasms onset after 1 year of age. (Pubmed Central) -  Oct 5, 2022   
    Forty-eight percent of patients responded to hydrocortisone and/or adrenocorticotropic hormone...However, ES onset after 1 year of age caused by a tumor, brain malformation, or other focal lesions, may be cured by focal cortical resection despite a lack of clearly localized EEG surface anomalies. Delays in motor, language, and cognitive development, or behavioral problems were observed in all but three patients.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia. (Pubmed Central) -  Oct 5, 2022   
    A recent large, randomized trial of hydrocortisone administered beginning between the 2 and 4 postnatal weeks provided strong evidence that this therapy promotes successful extubation but does not lower BPD rates. Ongoing studies within the NRN will address important, unanswered questions on the risks and benefits of intratracheal surfactant/corticosteroid combinations and treatment versus expectant management of the patent ductus arteriosus to prevent BPD.
  • ||||||||||  Tepezza (teprotumumab) / Horizon Therapeutics, Roche
    Journal:  Literature Commentary. (Pubmed Central) -  Oct 5, 2022   
    Epub ahead of print. PMID: 35364222.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Primary adrenal insufficiency masking as an adrenal B-cell lymphoma. (Pubmed Central) -  Oct 5, 2022   
    The patient had a previous history of aphthous ulcers on dexamethasone and was referred to endocrinology with symptoms of fatigue and orthostasis...Adrenal biopsy confirmed the diagnosis of primary adrenal lymphoma of the B-cell type. This case demonstrates the importance of including lymphoma in the differential diagnosis of adrenal insufficiency, particularly in the elderly population and in the setting of negative 21-hydroxlyase antibody results.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Sesquiterpenes from Rhododendron nivale and Their Anti-inflammatory Activity. (Pubmed Central) -  Oct 5, 2022   
    The structures of compounds 1 and 2 were elucidated by integrating spectroscopic analyses, including NMR, UV, IR, as well as HR-MS data. Anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells revealed that compared with the positive control dexamethasone (IC50 = 2.50 μM), compounds 1 and 2 showed mild anti-inflammatory activity, with IC50 value of 27.55 μM and 53.26 μM, respectively.
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie
    Journal, IO biomarker:  Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics. (Pubmed Central) -  Oct 4, 2022   
    Mass spectrometry-based proteomic analysis reveals rewiring of signaling pathways regulating apoptosis, proliferation and mitochondrial metabolism between isogenic AL amyloidosis and multiple myeloma cells that divergently alter their sensitivity to therapies. These findings provide a roadmap for the use of BH3 mimetics to exploit endogenous and induced apoptotic vulnerabilities in AL amyloidosis.
  • ||||||||||  Retrospective data, Review, Journal:  Analgesic Efficacy of Adjuvant Medications in the Pediatric Caudal Block for Infraumbilical Surgery: A Network Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) -  Oct 4, 2022   
    Dexmedetomidine reduced the frequency of analgesic dose administrations within 24 h [29 RCTs, 1765 patients; -1.2 dose (95% CI: -1.6, -0.9)] and the total dose of acetaminophen within 24 h [18 RCTs, 1156 patients; -350 mg (95% CI: -467, -232)] the most.  Among caudal adjuvants, neostigmine (moderate certainty), tramadol (low certainty), and dexmedetomidine (low certainty) prolonged the duration of analgesia the most. Dexmedetomidine also reduced the analgesic frequency and consumption more than other caudal adjuvants (moderate certainty).
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  miR-642a-5p increases glucocorticoid sensitivity by suppressing the TLR4 signalling pathway in THP-1 cells. (Pubmed Central) -  Oct 4, 2022   
    miR-642a-5p mimics transfected into THP-1 cells could synergize with dexamethasone (DEX) to reduce lipopolysaccharide (LPS)-induced inflammatory factor levels such as TNF-α, IL-1β, IL-6 and IL-12 (P < 0.05)...These results suggest that miR-642a-5p can inhibit the inflammation by suppressing the TLR4 signalling pathway in THP-1 cells. It also highlights the TLR4 signalling pathway as a potential therapeutic target in anti-inflammation.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Expression of long noncoding RNA Xist is induced by glucocorticoids. (Pubmed Central) -  Oct 4, 2022   
    Our data revealed that the long noncoding RNA Xist is a GR regulated gene and its expression is induced by GC both in vitro and in vivo. To our knowledge, this is the first evidence showing that Xist is transcriptionally regulated by GC/GR signaling.