Glucocorticoid Receptor 

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  • ||||||||||  fluticasone / Generic mfg.
    Clinical, Journal:  A TRIAL OF INTRANASAL CORTICOSTEROIDS TO TREAT THE CHILDHOOD OBSTRUCTIVE SLEEP APNEA SYNDROME. (Pubmed Central) -  Oct 12, 2022   
    P3
    In children with OSAS, treatment with INCS did not result in significant polysomnography, neurobehavioral, or symptom changes at 3 and 12 months of treatment. Twelve months of INCS treatment resulted in a statistically significant but not clinically relevant OAHI reduction.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Review, Journal:  Lenalidomide, bortezomib and dexamethasone induction therapy for the treatment of newly diagnosed multiple myeloma: a practical review. (Pubmed Central) -  Oct 12, 2022   
    This review discusses the rationale for use of RVD as induction therapy and aims to provide guidance in prescribing this regimen in order to optimise efficacy while minimising the toxicities of treatment. We also highlight the increasing evidence for the utility of addition of a monoclonal antibody to the RVD backbone to deepen responses and potentially provide longer disease control.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Glucocorticoid receptor function and cognitive performance in women with HIV. (Pubmed Central) -  Oct 12, 2022   
    No abstract available Collectively, these data suggest that HIV serostatus and age may modify the influence of the GCR, such that the receptor is likely engaged to a similar extent, but the downstream influence of the receptor is altered, potentially through epigenetic modification of target genes.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Immunomodulatory efficacy of Cousinia thomsonii C.B. Clarke in ameliorating inflammatory cascade expressions. (Pubmed Central) -  Oct 12, 2022   
    Collectively, these data suggest that HIV serostatus and age may modify the influence of the GCR, such that the receptor is likely engaged to a similar extent, but the downstream influence of the receptor is altered, potentially through epigenetic modification of target genes. The results indicate that Cousinia thomsonii contains therapeutically active compounds and thus could serve as potential therapeutic regimen against diverse inflammatory diseases.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Hemocompatibility Multi-in-One Hydrogel Coating with ROS-Triggered Inflammation Suppression and Anti-Infection Properties for Blood-Contacting Device. (Pubmed Central) -  Oct 12, 2022   
    In this work, we propose a self-adaptive anti-inflammatory coating strategy combined with anti-infection and anticoagulant capacity, which was accomplished based on nano-Ag particles and dexamethasone (Dex)-loaded hydrogel coating...As an anti-inflammatory drug, Dex was grafted onto hydrogel coating by a reactive oxygen species (ROS)-cleavable thioketal (TK) bond and released upon the trigger of an inflammatory environment, blocking further inflammatory cascade, providing self-adaptive anti-inflammatory properties, and avoiding side effects of the drug. It was demonstrated that the coating worked as a precise strategy to resist coagulation, infection, and inflammation, provided a new perspective for designing clinical complication-conformable coatings, and had great application prospects on blood-contacting medical devices.
  • ||||||||||  budesonide / Generic mfg.
    Review, Journal:  Pathogenesis and progression of anosmia and dysgeusia during the COVID-19 pandemic. (Pubmed Central) -  Oct 11, 2022   
    It is important to note that the variants of SARS-CoV-2 are genetically distinguished from the original virion due to a mutation in their spike proteins, giving them a different symptom profile regarding anosmia and dysgeusia. This variability in symptomatology is an area of study that needs to be further explored.
  • ||||||||||  remdesivir / Generic mfg.
    Journal:  Remdesivir in kidney transplant patients with SARS-CoV-2 pneumonia. (Pubmed Central) -  Oct 11, 2022   
    Our study suggests that the use of remdesivir could be useful in KT patients with SARS-CoV-2 pneumonia without side effects. Additional studies are necessary with a larger number of patients to improve the knowledge of this drug in SARS-CoV-2 infection.
  • ||||||||||  paracetamol / Generic mfg.
    Clinical protocol, Journal:  Paracetamol, ibuprofen and dexamethasone for pain treatment after total hip arthroplasty: protocol for the randomised, placebo-controlled, parallel 4-group, blinded, multicentre RECIPE trial. (Pubmed Central) -  Oct 11, 2022   
    P4
    Eligible participants undergoing total hip arthroplasty are randomised to:group A: oral paracetamol 1000 mg × 4+oral ibuprofen 400 mg × 4+intravenous placebo; group B: oral paracetamol 1000 mg × 4+intravenous dexamethasone 24 mg+oral placebo; group C: oral ibuprofen 400 mg × 4+intravenous dexamethasone 24 mg+oral placebo; group D: oral paracetamol 1000 mg × 4+oral ibuprofen 400 mg × 4+intravenous dexamethasone 24 mg.Primary outcome is cumulative opioid consumption at 0-24 hours...A total of 1060 participants are needed to demonstrate a difference of 8 mg in 24-hour morphine consumption assuming an SD of 24.5 mg, a risk of type I errors of 0.0083 and a risk of type 2 errors of 0.2...Plans for dissemination include publication in peer-reviewed journals and presentation at scientific meetings. NCT04123873.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Aseptic meningitis in multisystem inflammatory syndrome in children associated with coronavirus disease 2019: a case report. (Pubmed Central) -  Oct 11, 2022   
    Apart from the most common presentation of multisystem organ dysfunction, neurological manifestations of multisystem inflammatory syndrome in children such as aseptic meningitis, may be present as an immune response post-viral to coronavirus disease 2019. Given the rapid deterioration of children with multisystem inflammatory syndrome, early treatment with immunoglobulins and corticosteroids should be considered.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Edible Vitalmelon Fruit Extract Inhibits Adipogenesis and Ameliorates High-Fat Diet-Induced Obesity. (Pubmed Central) -  Oct 11, 2022   
    In fully differentiated 3T3-L1 adipocytes, the vitalmelon extract reduced the DMI- (dexamethasone, 3-isobutyl-1-methylxanthine, and insulin-) induced increases in lipid droplet number and intracellular glucose and triglyceride levels...Moreover, the HFD+vitalmelon-fed mice showed lower abdominal fat levels, smaller fat cells, lower weight, and fewer lipid droplets in the liver tissue than the HFD-fed mice. Therefore, in HFD-fed mice, vitalmelon regulated lipid metabolism through PPAR-γ, highlighting its potential as a promising antiobesity functional food.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Evaluation of drug-eluting nanoparticle coating on magnesium alloy for development of next generation bioabsorbable cardiovascular stents. (Pubmed Central) -  Oct 11, 2022   
    In this study, a magnesium based alloy (WE43) was coated with dexamethasone loaded polymeric nanoparticles via electrospraying method...SEM images indicated proper adhesion and proliferation of endothelial cells on the surface. The findings suggest that nanoparticle-coated surfaces could effectively inhibit SMC proliferation meanwhile provide desirable surface features for adhesion and proliferation of endothelial cell on magnesium alloy based stents.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  A comparative study of bone bioactivity and osteogenic potential of different bioceramics in methacrylated collagen hydrogels. (Pubmed Central) -  Oct 11, 2022   
    In addition, human MSCs (hMSCs) were encapsulated in bioceramic-laden CMA hydrogels and the effect of different bioceramics on osteogenic differentiation of hMSCs was investigated in two different culture medium-osteoconductive (without dexamethasone [DEX]) and osteoinductive (with DEX)...Furthermore, TCP incorporation significantly increased alkaline phosphatase activity (ALP; p < 0.05) in hMSCs. Together, these results indicate that TCP has superior osteogenic potential compared with BG and LAP and hence should be considered as a bioceramic of preferred choice for use in the biomimetic design of cell-laden hydrogels for BTE applications.
  • ||||||||||  dexamethasone injection / Generic mfg., ropivacaine / Generic mfg.
    Trial completion date, Trial primary completion date:  Respiratory Impact of LA Volume After IS Block (clinicaltrials.gov) -  Oct 10, 2022   
    P4,  N=60, Recruiting, 
    Initiation date: Sep 2022 --> Jan 2023 Trial completion date: Jun 2022 --> Dec 2023 | Trial primary completion date: Jun 2022 --> Dec 2023
  • ||||||||||  Trial completion date, Trial primary completion date:  I-SPY_COVID: I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients (clinicaltrials.gov) -  Oct 10, 2022   
    P2,  N=1500, Recruiting, 
    Trial completion date: Jun 2022 --> Dec 2023 | Trial primary completion date: Jun 2022 --> Dec 2023 Trial completion date: Nov 2022 --> Nov 2023 | Trial primary completion date: Jul 2022 --> Jul 2023
  • ||||||||||  triamcinolone acetonide topical / Generic mfg.
    MOMMY RN DERMATITIS (Exhibit Hall (Upper Concourse); Monitor 05) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_1035;    
    She has been prescribed topical 0.1% triamcinolone and a course of oral steroids with temporary improvement in symptoms...Discussion This case emphasizes the importance of cleaning gels and wipes as a cause of contact dermatitis. It particularly important to remember in the context of healthcare workers who frequently clean their hands, new parents who may using sanitizing wipes more often, and people with darker colored skin.
  • ||||||||||  dexamethasone / Generic mfg.
    Recurrent Cryptococcal Meningitis in Patient with Anti-GM-CSF Autoantibodies (Exhibit Hall (Upper Concourse); Monitor 07) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_962;    
    He underwent multiple courses of antifungal induction therapy followed by antifungal prophylaxis and dexamethasone taper, yet remained symptomatic with persistent cryptococcal antigen in his CSF...Patients with recurrent cryptococcal infections should be screened for anti-GM-CSF autoantibodies, which can help tailor treatment including GM-CSF therapy and anti-CD20 therapy. Patients would also benefit from a basic immunologic workup and routine screening for PAP.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Deterioration of Respiratory Status in a CVID Patient with GLILD and COVID-19 (Exhibit Hall (Upper Concourse); Monitor 07) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_958;    
    Discussion Our case highlights the diagnostic dilemma of determining the cause of this patient's ongoing respiratory disease. The possibilities include GLILD relapse due to incomplete treatment or ineffective treatment, or sequelae of COVID-19 infection.
  • ||||||||||  Entyvio (vedolizumab) / Takeda
    Eosinophilic Cystitis in a Pediatric Patient with X-linked Chronic Granulomatous Disease (Exhibit Hall (Upper Concourse); Monitor 06) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_951;    
    His colitis was well-controlled with vedolizumab when he presented for evaluation of new onset dysuria and intermittent scrotal pain that improved with voiding...He was started on intravesical dexamethasone 10mg, to minimize complications from systemic steroid use, and oral loratadine 5mg on intravesical treatment days...Discussion Reported cases of pediatric eosinophilic cystitis are mostly in young children, only requiring a short course of intravesical steroids and oral antihistamine, unlike our patient2,3 . More research is needed to elucidate the history, optimal diagnosis and guide appropriate management of eosinophilic cystitis in pediatric X-CGD patients.
  • ||||||||||  diphenhydramine / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Premedication Regimen For The Prevention Of Adverse Reactions Associated With Therapeutic Plasma Exchange (Exhibit Hall (Upper Concourse); Monitor 02) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_852;    
    Discussion Although TPE hypersensitivity reactions have been commonly reported, an effective method of premedication has yet to be established. We aim to bring awareness of a premedication regimen prior to TPE using a 5 hour and 1 hour IV protocol in patients with hypersensitivity reactions related to the procedure.
  • ||||||||||  Firazyr (icatibant) / Takeda
    Successful Use of Icatibant Pre-treatment to Prevent Systemic Reaction During LDL Apheresis (Exhibit Hall (Upper Concourse); Monitor 02) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_848;    
    For 7 years before his COVID-19 infection, he tolerated apheresis with a pre-medication routine of solumedrol and diphenhydramine...For the following infusion, adjunctive prednisone, cetirizine, aspirin, montelukast administered the night prior and morning of the infusion and slowing the infusion rate to the lowest settings were unsuccessful...COVID-19 is associated with significant inflammation, but rarely angioedema. Further investigation is needed as to why this FH patient is more sensitive to the effects of bradykinin after COVID-19 infection.
  • ||||||||||  Spiriva Respimat (tiotropium bromide) / Boehringer Ingelheim, Dupixent (dupilumab) / Sanofi, Regeneron, Xolair (omalizumab) / Roche, Novartis
    A Case of Recurrent Idiopathic Anaphylaxis While on High-dose Antihistamine Therapy (Exhibit Hall (Upper Concourse); Monitor 02) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_847;    
    Due to his poor asthma control he may benefit from Dupilumab as a second biologic...Discussion Our case adds to sparse literature on malignant IA complicated by severe asthma. Off label trials of two biologics may be warranted when dealing with treatment failure in such settings.
  • ||||||||||  cetirizine oral / Generic mfg., diphenhydramine / Generic mfg., fluticasone / Generic mfg.
    Delayed, Persistent Anaphylaxis After An Allergy Injection (Exhibit Hall (Upper Concourse); Monitor 02) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_843;    
    Twelve hours after his first allergy injection, he developed pruritus, took a diphenhydramine and went to sleep...It is important to educate our immunotherapy patients on the signs of anaphylaxis as well as the possibility that though rare, symptoms can be delayed. In addition, it is important to emphasize the need for prompt medical attention in such situations.