Glucocorticoid Receptor 

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  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Ambulatory management of ICI-induced hepatitis: a safe and effective management approach (Foyer mezzanine) -  Oct 21, 2022 - Abstract #ESMOIO2022ESMO_IO_237;    
    Grade 3-4 hepatitis is managed with intravenous methylprednisolone (IVMP) as per international protocols...Given the average number of patients requiring IVMP between 2020-22 was 34.5 (range 33-36) per year this is a saving of 268 bed days per annum resulting in a cost saving of £123,280 per annum. Conclusions The introduction of an ambulatory IVMP service for the management of immunotherapy induced hepatitis has been illustrated to be safe, effective, responsive to CST resistance and result in care provision efficiencies.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Journal:  Fewer COVID-19 neurological complications with dexamethasone and remdesivir. (Pubmed Central) -  Oct 21, 2022   
    Conclusions The introduction of an ambulatory IVMP service for the management of immunotherapy induced hepatitis has been illustrated to be safe, effective, responsive to CST resistance and result in care provision efficiencies. Treatment with dexamethasone, remdesivir or both in patients hospitalised with COVID-19 associated with a lower frequency of neurological complications in an additive manner, such that the greatest benefit was observed in patients who received both drugs together.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Hydrocortisone-Containing Animal-Derived Food Intake Affects Lipid Nutrients Utilization. (Pubmed Central) -  Oct 21, 2022   
    Treatment with dexamethasone, remdesivir or both in patients hospitalised with COVID-19 associated with a lower frequency of neurological complications in an additive manner, such that the greatest benefit was observed in patients who received both drugs together. Hydrocortisone originating from animal-derived food induces glycerophospholipids degradation and triglycerides hydrolysis through promoting adipose triglyceride lipase, hormone sensitive lipase, and phosphoglycerate kinase activity and further intervenes lipid nutrients utilization.
  • ||||||||||  AZD5423 / AstraZeneca
    Journal:  RIPK3 inhibitor-AZD5423 alleviates acute kidney injury by inhibiting necroptosis and inflammation. (Pubmed Central) -  Oct 21, 2022   
    Site-directed mutagenesis further revealed that AZD5423 reduces injury response via interacting with the key RIPK3 amino acid residues of Lys and Arg. In conclusion, our study has demonstrated that AZD5423 may serve as a potent inhibitor of RIPK3 kinase and a promising clinical candidate for AKI treatment.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Canavalia gladiata Pod Extract Mitigates Ovalbumin-Induced Asthma Onset in Male BALB/c Mice via Suppression of MAPK. (Pubmed Central) -  Oct 21, 2022   
    Six-week-old male BALB/c mice were orally administered with either sword bean pod extracts (SBP; 100 or 300 mg/kg) or dexamethasone (DEX; 5 mg/kg) once daily over 3 weeks, followed by ovalbumin sensitization (OVA/Alum.; intraperitoneal administration, 50 μg/2 mg/per mouse)...SBP markedly suppressed the activation of the MAPK signaling pathway and the expression of key inflammatory proteins (e.g., TNF-α) and Th2 type cytokines (IL-5 and IL-13). SBP was effective in ameliorating the allergic inflammation against OVA/Alum.-induced asthma by suppressing pulmonary inflammation.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Journal:  Acute heart failure due to left common iliac arteriovenous fistula: A case of VEXAS syndrome. (Pubmed Central) -  Oct 21, 2022   
    Although the patient achieved remission with high-dose oral prednisolone, the inflammatory symptoms relapsed, and he was resistant to colchicine and cyclosporine...We treated him with tocilizumab in addition to prednisolone, and the febrile events and elevated C-reactive protein levels improved...This case suggests that arteriovenous fistula could be a complication of VEXAS syndrome with large-vessel vasculitis, and adequate surgical intervention and prompt diagnosis are essential for rescue. Although arteriovenous fistula is a rare complication of VEXAS syndrome, physicians should be aware of this complication to ensure prompt diagnosis and timely surgical intervention.
  • ||||||||||  Incidence and management of severe immune-related adverse events in a regional Australian setting. (Great Hall 3&4) -  Oct 20, 2022 - Abstract #COSA2022COSA_271;    
    A retrospective cohort of regional Victorian patients (Latrobe Regional Hospital, Bairnsdale Regional Health Service, Central Gippsland Health) receiving at least one dose of ICI (pembrolizumab, nivolumab, ipilimumab, atezolizumab, cemiplimab, durvalumab, avelumab) between 1 July 2018 - 30 June 2021...32/373 (9%) required IV methylprednisolone and infliximab in 3... Optimal management of ICI related severe irAE in a regional setting is achievable with contemporary protocols and responsive metropolitan support.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Juvenile Generalized Myasthenia Gravis: Presented as Unilateral Blepharoptosis and Successfully Managed with Pulse Intravenous Methylprednisolone. (Pubmed Central) -  Oct 20, 2022   
    She did not respond to high dose (26 mg/kg/day) of Pyridostigmine and oral Prednisolone (2 mg/kg/day), but was successfully treated with a combination of pulse intravenous Methylprednisolone (30 mg/kg once a month for 6 months) and daily doses of oral Prednisolone (2 mg/kg/day) along with Pyridostigmine without significant side effects. This combination can be considered a potential inexpensive treatment for Juvenile Myasthenia Gravis in a resource limited area where other immunosuppressive treatments such as intravenous immunoglobulin is expensive and unaffordable.
  • ||||||||||  dexamethasone / Generic mfg., bendamustine / Generic mfg.
    CHEMO OR CHEMO-FREE REGIMENS IN HEAVILY PRETREATED MULTIPLE MYELOMA? ROLE OF BENDAMUSTINEBORTEZOMIB-DEXAMETHASONE (BVD) IN NOVEL AGENTS’ ERA () -  Oct 19, 2022 - Abstract #AIOM2022AIOM_98;    
    Median time to response was 1.3 months (r.1-3), median OS from diagnosis was 67.3 months (r.6-151), median OS from start of Bendamustine was 9.6 months (r.2-36). The triplet Bendamustine-Bortezomib-Dexamethasone has shown significant efficacy in a particularly severe setting of patients, relapsed and refractory to all avail- able therapeutic resources, and, in particular cases, it could be considered as a bridge to a second autolo- gous or allogenic SCT, also after failure of novel agents.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Antenatal corticosteroids in Singapore: A clinical and scientific assessment. (Pubmed Central) -  Oct 19, 2022   
    The dexamethasone regimen used in Singapore today affords a very high maternofetal drug exposure over a brief period of time. Drawing on clinical and experimental data, we reviewed the pharmacokinetic profile and pharmacodynamic effects of dexamethasone treatment regimen in Singapore, with a view to creating a development pipeline for optimising this critically important antenatal therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Estrogenic, androgenic, and glucocorticoid activities and major causative compounds in river waters from three Asian countries. (Pubmed Central) -  Oct 19, 2022   
    GR agonist activities were detected in only Bangalore and Hanoi samples at dexamethasone (Dex)-equivalent levels of < 16-150 ng/l and exceeded the EBT value of 100 ng/l in only two Bangalore samples...The results for pooled samples showed that the major ER agonists were the endogenous estrogens E2 and estriol, and the major GR agonists were the synthetic glucocorticoids Dex and clobetasol propionate. The only AR agonist identified in major androgenic water extract fractions was DHT, but several unidentified compounds with the same molecular formulae as endogenous androgens were also found.
  • ||||||||||  Nasonex (mometasone furoate nasal spray) / Merck (MSD)
    Journal:  Intranasal Corticosteroid Treatment on Recovery of Long-Term Olfactory Dysfunction Due to COVID-19. (Pubmed Central) -  Oct 19, 2022   
    Overall, there was no significant difference in olfactory dysfunction between the two groups during follow-up. However, based on the significant between-group difference in terms of olfactory scores changes, it seems that the nasal corticosteroids may be a positive effect on the recovery process of patients who received more than 2 weeks.
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    FDA event, Review, Journal:  Scientific and Regulatory Activities Initiated by the U.S. Food and Drug Administration to Foster Approvals of Generic Dry Powder Inhalers: Bioequivalence Perspective. (Pubmed Central) -  Oct 19, 2022   
    A variety of research activities including in vivo and in vitro studies were used to support these recommendations, which have led to the first approval of a generic DPI in the U.S. for fluticasone propionate and salmeterol xinafoate inhalation powder in January of 2019. This review describes the scientific and regulatory activities that have been initiated by FDA to support the current BE recommendations for DPIs that led to the first generic DPI approvals, as well as research with novel in vitro and in silico methods that may potentially facilitate generic DPI development and approval.