Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal, Lipid Nanoparticle:  Development of Organ Targeting Lipid Nanoparticles with Low Immunogenicity and Its Application in the Treatment of Pulmonary Fibrosis. (Pubmed Central) -  Jul 31, 2024   
    Herein, we formulate various dLNPs with diminished immunogenicity by incorporating dexamethasone (Dex) into liver-, spleen-, and lung-targeting LNPs formulations that exhibit excellent abilities to target specific organs and deliver various types of RNA, such as mRNA and siRNA...Intriguingly, the encapsulation of runt-related transcription factor-1 siRNA (siRUNX1) into lung-targeting dLNPs (dLNPs@siRUNX1) demonstrates remarkable advantages in the treatment of pulmonary fibrosis through the synergy of gene therapy and drug therapy. This research establishes secure and universal platforms for the precise delivery of nucleic acid therapeutics, showcasing promising clinical applications in gene therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  The Differential Diagnosis between Cushing's Disease and Pseudocushing Syndrome in a Pre-agonic Patient. (Pubmed Central) -  Jul 31, 2024   
    This research establishes secure and universal platforms for the precise delivery of nucleic acid therapeutics, showcasing promising clinical applications in gene therapy. Our clinical case described a patient with pseudo-Cushing's syndrome during sepsis and pre-agonist phase, with a difficult differential diagnosis, in which the combination of the low-dose dexamethasone suppression test and the CRH test allowed a conclusive and correct diagnostic orientation.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Effect of Methylprednisolone on Systemic Inflammatory Response During Pediatric Congenital Open-Heart Surgery (clinicaltrials.gov) -  Jul 31, 2024   
    P4,  N=60, Recruiting, 
    Reduced-dose methylprednisolone is effective in improving kidney outcomes in high risk IgAN; however, it is associated with a modestly higher number of SAEs compared to placebo. Trial completion date: Feb 2025 --> Jun 2025 | Trial primary completion date: Dec 2024 --> Apr 2025
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Salivary Cortisol Measurement Contamination After Oral Hydrocortisone: A Randomized Crossover Trial. (Pubmed Central) -  Jul 30, 2024   
    In multivariate analysis, serum potassium?3.9 mEq/l was the only predictor for SC contamination [multi-adjusted OR (95% CI): 7.1 (1.4-36.1); p=0.018]. SC measured during the two hours after Hc intake is inaccurate for glucocorticoid replacement therapy assessment in SAI patients treated with Hc in tablet form.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Effects of stress-related neuromodulators on amygdala and hippocampus resting state functional connectivity. (Pubmed Central) -  Jul 30, 2024   
    P=N/A
    We recruited 165 participants who received 10 mg yohimbine and/or 10 mg hydrocortisone in a randomized, placebo-controlled design...Compared to placebo, we found no differences in the groups receiving only one medication, suggesting that increasing one neuromodulator alone may not induce differences in neurofunctional responses. The study procedure has been registered at clinicaltrials.gov (ID: NCT04359147).
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. (Pubmed Central) -  Jul 29, 2024   
    A total of 36 mice were divided into six groups (control, model, LJF, FF, LF, dexamethasone) based on the treatments they received after undergoing sham-operation/LPS tracheal instillation...The combination of LJF and FF increases the therapeutic effect on LPS-induced ALI, which may be mechanistically related to the combined effect inhibition of cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) and NOD-like receptor family protein 3 (NLRP3) inflammasomes pathways by LJF and FF. Our study provides new medicine candidates for the clinical treatment of ALI.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dexamethasone-loaded ROS stimuli-responsive nanogels for topical ocular therapy of corneal neovascularization. (Pubmed Central) -  Jul 28, 2024   
    In a rabbit model with chemically burned eyes, the once-daily topical application of DEX@INHANGs was observed to effectively suppress CNV. These results collectively indicate that the nanomedicine formulation of DEX@INHANGs may offer a promising treatment option for CNV, offering significant advantages such as reduced dosing frequency and enhanced patient compliance.
  • ||||||||||  hydrocortisone / Generic mfg.
    Preclinical, Journal:  Biotransformation of hydrocortisone succinate with whole cell cultures of Monascus purpureus and Cunninghamella echinulate. (Pubmed Central) -  Jul 28, 2024   
    It is noteworthy that these products have already shown biological potential, however a more thorough investigation of the anti-inflammatory properties of these metabolites would be of high value. These results not only emphasize upon the immense potential of biotransformation in catalysis of reactions, otherwise not-achievable chemically, but also holds promise for the development of novel anti-inflammatory compounds.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Anti-inflammatory action of geopropolis produced by stingless bees on human peripheral blood mononuclear cells. (Pubmed Central) -  Jul 28, 2024   
    Here, a possible synergism between GEO and dexamethasone (DEX) was assessed on human peripheral blood mononuclear cells (PBMC) stimulated by lipopolysaccharide (LPS)...No effects were seen on eicosanoids nor in intracellular pathways. Despite not always being more efficient than the isolated treatments, GEO + DEX seemed to be promising and allow the use of DEX in lower concentrations, reducing adverse effects.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency. (Pubmed Central) -  Jul 28, 2024   
    However, Trp53-deficient t(8;21) AML cells were still sensitive to several drugs such as dexamethasone. Cas9+ RUNX1-ETO9a cells with/without Trp53 deficiency can produce AML in vivo, can be cultured in vitro for several weeks, and allow efficient gene depletion using the CRISPR/Cas9 system, providing useful tools to advance our understanding of t(8;21) AML.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Management of Malignant Bowel Obstruction in Patients with Gynaecological Cancer: A Systematic Review. (Pubmed Central) -  Jul 27, 2024   
    Non-surgical treatments, such as the use of Gastrografin, Octreotide, and Dexamethasone, along with invasive procedures like nasogastric tubing, percutaneous gastrostomy, and stent placement, offer varying degrees of symptom relief and are often considered when surgery is not feasible...This review underscores the urgent need for high-quality research to develop clear, evidence-based guidelines for MBO management in patients with gynaecologic cancer. Establishing standardised protocols will improve patient outcomes by aiding clinicians in making informed, individualised treatment decisions.
  • ||||||||||  Humira (adalimumab) / AbbVie
    Journal, Immunomodulating:  A case of AZOOR under immunomodulatory treatment. (Pubmed Central) -  Jul 27, 2024   
    Complete diagnostic work-up is important to rule out other etiologies. Due to the lack of randomized controlled trials, therapeutic decisions obligatorily rely on empiric treatment decisions in combination with frequent follow-up examinations.
  • ||||||||||  Kineret (anakinra) / SOBI
    Review, Journal:  BPD: Latest Strategies of Prevention and Treatment. (Pubmed Central) -  Jul 27, 2024   
    Potentially disruptive therapies - MSCs, IGF-1/IGFBP-3, and anakinra - are being advanced to clinical trials and their efficacy in remains to be demonstrated. Continued research efforts are needed in the growing population of extremely preterm infants at risk of developing BPD.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Optic Neuritis Leading to Vision Loss: A Case of MOG-Associated Disease with Successful Immunotherapy. (Pubmed Central) -  Jul 27, 2024   
    The primary treatment was intravenous methylprednisolone for 2 weeks, after which the blurred vision improved and MRI showed the optic nerve lesions disappeared...CONCLUSIONS A 42-year-old woman presented with loss of vision due to optic neuritis and positive antibody testing for MOG. MOGAD was diagnosed, and timely immunotherapy was effective.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Multiple Administration of Dexamethasone Possesses a Deferred Long-Term Effect to Glycosylated Components of Mouse Brain. (Pubmed Central) -  Jul 26, 2024   
    A correlation analysis revealed an association between the mRNA level of the GR and the mRNA level of 8 of the 14 proteoglycans-coding and 4 of the 13 heparan sulfate metabolism-involved genes supporting GR involvement in the DXM regulation of the expression of these genes. In summary, multiple DXM administrations led to an increase in the total GAG content and reorganized the brain extracellular matrix in terms of its glycosylation pattern.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Novel PRKAR1A mutation in Carney complex: a case report and literature review. (Pubmed Central) -  Jul 26, 2024   
    Blood examination revealed hypercortisolemia, decreased adrenocorticotropic hormone (ACTH) levels and failure to suppress cortisol with low and high-dose dexamethasone suppression tests...This case reported a Carney complex in a Chinese patient, characterized clinically by non-ACTH-dependent Cushing's syndrome, familial recurrent cardiac myxomas, psammomatous melanotic schwannoma (PMS) and skin and mucosal pigmentation. A novel subtype of PRKAR1A mutation was discovered, which may affect the characteristics of the PRKAR1A protein and contribute to the development of Carney complex.