Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Biomarker, Review, Journal:  Highlights on molecular targets in the management of COVID-19: Possible role of pharmacogenomics. (Pubmed Central) -  Jan 31, 2023   
    Dexamethasone in low doses and immunomodulators such as IL-6 inhibitors are recommended to overcome the cytokine storm. This current narrative review highlights the place of other therapeutic choices such as proteasome inhibitors, protease inhibitors and nuclear factor kappa B inhibitors in the treatment of patients with COVID-19.
  • ||||||||||  Jakafi (ruxolitinib) / Incyte
    Trial completion date, Trial primary completion date:  LCI-HEM-MYE-CRD-004 (MMRC-073 CARJAK): Study of CRD for Carfilzomib-Refractory Multiple Myeloma (clinicaltrials.gov) -  Jan 30, 2023   
    P1/2,  N=12, Active, not recruiting, 
    This current narrative review highlights the place of other therapeutic choices such as proteasome inhibitors, protease inhibitors and nuclear factor kappa B inhibitors in the treatment of patients with COVID-19. Trial completion date: Dec 2028 --> Nov 2025 | Trial primary completion date: Dec 2023 --> Nov 2022
  • ||||||||||  Lynparza (olaparib) / Merck (MSD), AstraZeneca
    Trial completion date, Metastases:  Study of Olaparib (Lynparza (clinicaltrials.gov) -  Jan 30, 2023   
    P3,  N=387, Active, not recruiting, 
    Trial completion date: Dec 2028 --> Nov 2025 | Trial primary completion date: Dec 2023 --> Nov 2022 Trial completion date: Dec 2022 --> Jun 2023
  • ||||||||||  dexamethasone / Generic mfg., dexmedetomidine / Generic mfg.
    New P2/3 trial, Combination therapy, Surgery:  Any: Dexmedetomidine in Postoperative Analgesia (clinicaltrials.gov) -  Jan 30, 2023   
    P2/3,  N=100, Not yet recruiting, 
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Perillyl alcohol (PA) mitigates inflammatory, oxidative, and histopathological consequences of allergic asthma in rats. (Pubmed Central) -  Jan 29, 2023   
    Experimental asthma was induced by ovalbumin (OVA) sensitization and inhalation in five groups of rats including control, asthma, asthma + vehicle, asthma + PA, and asthma + dexamethasone (Dexa)...PA restored GPx, SOD, and TAC levels and reduced ROS, MDA, nitrite, and total protein in the lung and BALF. Overall, our findings demonstrated that PA can be used as a therapeutic agent in asthma patients, but it is essential to monitor its effects in future clinical studies.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis, Avastin (bevacizumab) / Roche
    Journal:  Suprachoroidal injection of triamcinolone acetonide plus intravitreal bevacizumab in diabetic macular edema: a randomized pilot trial. (Pubmed Central) -  Jan 29, 2023   
    Overall, our findings demonstrated that PA can be used as a therapeutic agent in asthma patients, but it is essential to monitor its effects in future clinical studies. Significant improvements in BCVA and retinal anatomical outcomes demonstrated the additive effects of SCTA to those of anti-vascular endothelial growth factors with no short-term side effects and this combination appears to be a promising option in the management of patients with CI-DME.
  • ||||||||||  dexamethasone / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  Icariin synergizes therapeutic effect of dexamethasone on adriamycin-induced nephrotic syndrome. (Pubmed Central) -  Jan 29, 2023   
    Significant improvements in BCVA and retinal anatomical outcomes demonstrated the additive effects of SCTA to those of anti-vascular endothelial growth factors with no short-term side effects and this combination appears to be a promising option in the management of patients with CI-DME. ICA enhances the therapeutic effect of DEX on the nephrotic syndrome.
  • ||||||||||  dexamethasone / Generic mfg., ropivacaine / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Research progress on analgesic effect of adductor canal block after knee arthroplasty (Pubmed Central) -  Jan 29, 2023   
    It is generally safe and efficient to use 0.2% ropivacaine ACB with initial loading doses of 15-30 mL and continual loading doses of less than 8 mL/hour to give analgesia comparable to FNB with minimal impact on lower extremity muscular strength...Adjuvants like dexmedetomidine and dexamethasone used in ACB can increase the analgesic duration and postoperative analgesic impact...ACB is a safe and effective analgesia method after knee arthroplasty. The adductor canal anatomy, the optimum blocking strategy and blocking site of ACB are all hotly debated and still require additional study due to the significant variety of the nerve structures in adductor canal.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Journal:  Efficacy and safety of lenalidomide combined with bortezomib and dexamethasone induction therapy in newly diagnosed patients with multiple myeloma (Pubmed Central) -  Jan 29, 2023   
    The incidence of adverse thrombocytopenia (90.0% vs 63.7%, P=0.001) , neutropenia (54.2% vs 36.3%, P=0.038) , anemia (33.3% vs 13.7%, P=0.005) , diarrhea (27.1% vs 12.7%, P=0.030) , limb edema (20.8% vs 3.9%, P=0.030) , fever (20.8% vs 4.9%, P=0.006) , thrombosis (8.3% vs 0, P=0.016) , and renal function deterioration (20.8% vs 3.9%, P=0.030) in patients with renal insufficiency was higher than that in patients with normal renal function. The VRD regimen has a significant effect on newly diagnosed MM, does not affect the hematopoietic stem cell collection, and has controllable adverse events; however, the incidence of adverse events was higher in patients with renal insufficiency.
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Journal:  Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity. (Pubmed Central) -  Jan 28, 2023   
    In addition, methylone (5-30 mg/kg) exhibited anxiolytic effects measured as increased time spent in the center of an open field. Taken together, and consistent with initial clinical findings, our study suggests that methylone may have potential for treating depression and anxiety.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Successful pharmacological intervention at different levels of the complement system in an in vitro complement fixation model for bullous pemphigoid. (Pubmed Central) -  Jan 28, 2023   
    Sera from 10 patients were analyzed in a complement fixation assay in the presence of C1 inhibitor, anti-factor B monoclonal antibody (mAb), anti-C3 mAb and anti-C5 mAb and compared with dexamethasone...This study shows that selective intervention in either the classical, alternative or terminal pathway prevented deposition of complement along the BM in an in vitro BP model. The results of our study greatly encourage the clinical development of complement inhibitors for the treatment of BP.
  • ||||||||||  levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg., azathioprine / Generic mfg.
    Journal:  Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report. (Pubmed Central) -  Jan 28, 2023   
    Our findings suggested early diagnosis and prompt immunotherapy treatment beneficial for the outcome. ase reports; encephalitis; immunotherapy; methylprednisolone.
  • ||||||||||  levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg., dexamethasone injection / Generic mfg.
    Journal:  Loss of Consciousness and Cardiac Arrest as an Atypical Presentation of Tubercular Meningitis: A Case Report. (Pubmed Central) -  Jan 28, 2023   
    Electroencephalogram revealed diffuse right fronto-parietal seizure activity ceasing with midazolam injection, hence levetiracetam was started...The patient was started on anti-tubercular therapy and an injection of dexamethasone was added...Delay in treatment leads to irreversible neurological damage and even death. cardiac arrest; case report; tubercular meningitis; unconsciousness.
  • ||||||||||  fluticasone / Generic mfg.
    Journal, Monotherapy:  Effect of MP-AzeFlu compared to monotherapy on COX-2, PGE , and EP2 gene expression in upper airway mucosa. (Pubmed Central) -  Jan 28, 2023   
    MP-AzeFlu (intranasal fluticasone and azelastine) has been widely studied and has demonstrated efficacy in Allergic rhinitis with a superior effect compared to these drugs administered individually; however, the mechanism by which MP-AzeFlu produces this improved clinical effect has not yet been fully explained...MP-AzeFlu and FP both upregulated EP2 mRNA expression, though neither upregulated EP2 protein expression. This downregulation of COX-2 and PGE coupled with upregulation of EP2 receptor expression reinforces the anti-inflammatory effect of MP-AzeFlu in upper airway inflammation.
  • ||||||||||  Review, Journal:  Systemic lupus erythematosus associated with multiple myeloma: Two case reports and a literature review. (Pubmed Central) -  Jan 28, 2023   
    This downregulation of COX-2 and PGE coupled with upregulation of EP2 receptor expression reinforces the anti-inflammatory effect of MP-AzeFlu in upper airway inflammation. An elevated monoclonal immunoglobulin level or newly unexplained renal dysfunction occurring in a patient with SLE should prompt monitoring and further screening of MM, rather than treatment as a secondary manifestation of SLE.
  • ||||||||||  methylphenidate tablet / Generic mfg.
    Journal:  Methylphenidate Reversal of Executive Dysfunction in a Patient with Bi-Frontal Lobe Glioblastoma. (Pubmed Central) -  Jan 28, 2023   
    Treatments were discontinued while dexamethasone improved his neurological functions and bevacizumab biosimilar was later added. This case demonstrates the activity of methylphenidate for managing executive dysfunction in patients with glioblastoma while minimizing the use of dexamethasone.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Preclinical, Journal:  Disturbed relationship between glucocorticoid receptor and 5-HT1AR/5-HT2AR in ADHD rats: A correlation study. (Pubmed Central) -  Jan 27, 2023   
    The GR agonist can upregulate the expression of 5-HT and 5-HT2AR and downregulate the expression of 5-HT1AR in the prefrontal cortex of SHR as well as reduce the hyperactivity and attention deficit behavior in SHR, while the opposite was true for the GR inhibitor. It is suggested that the dysfunction of the 5-HT system in ADHD rats is closely related to glucocorticoid receptor activity.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Secretomes derived from osteogenically differentiated jaw periosteal cells inhibit phenotypic and functional maturation of CD14 monocyte-derived dendritic cells. (Pubmed Central) -  Jan 27, 2023   
    To further expand our knowledge of JPCs' immunoregulative function, we investigated the effects of JPC secretomes derived from undifferentiated (CO) or osteogenically differentiated cells (treated with or without dexamethasone: OB+/-D) on CD14 monocyte-derived DCs (MoDCs)...At protein level, OB+/-D secretomes significantly up-regulated IL-10 and IDO (indoleamine-pyrrole 2,3-dioxygenase) levels whereas IL-12/IL-23p40 levels were down-regulated in supernatants of MoDCs when cultured under the presence of OB+/-D secretomes. Taken together, while secretomes from untreated JPCs had only little effects on the process of maturation of MoDCs, secretomes derived from osteogenically induced JPCs were able to inhibit the phenotypic and functional maturation of MoDCs.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD)
    Enrollment change, Trial withdrawal:  Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma. (clinicaltrials.gov) -  Jan 27, 2023   
    P2,  N=0, Withdrawn, 
    This paper presents a successful case of methylprednisolone plus intravenous immunoglobulin therapy, which provides a stronger evidence for the future diagnosis and treatment of the disease. N=64 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Enrollment change, Trial withdrawal:  Intradetrusor Triamcinolone Injection in the Management of Interstitial Cystitis/Bladder Pain Syndrome (clinicaltrials.gov) -  Jan 26, 2023   
    P=N/A,  N=0, Withdrawn, 
    If we find that corticosteroids prevent CAA and are safe, this is a cheap and widely available intervention that could be implemented immediately for the benefit of children. N=27 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  dexamethasone / Generic mfg., acetazolamide / Generic mfg.
    Journal:  Flying to high-altitude destinations: is the risk of acute mountain sickness greater? (Pubmed Central) -  Jan 26, 2023   
    To avoid frustrating travel experiences and health risks, appropriate and timely medical advice on how to prepare for air travel to high-altitude is of vital importance. Effective preparation options include the use of modern pre-acclimatization strategies and pharmacological prophylaxis by acetazolamide or dexamethasone, or even considering alternate itineraries with more gradual ascent.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Trial primary completion date:  Genomic Effects of Glucocorticoids in Patients With Systemic Lupus Erythematosus (clinicaltrials.gov) -  Jan 26, 2023   
    P1,  N=100, Recruiting, 
    Effective preparation options include the use of modern pre-acclimatization strategies and pharmacological prophylaxis by acetazolamide or dexamethasone, or even considering alternate itineraries with more gradual ascent. Trial primary completion date: Feb 2024 --> May 2022