Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Review, Journal:  Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants. (Pubmed Central) -  Mar 14, 2023   
    Despite the fact that the studies investigating higher versus lower dosage regimens showed that higher-dosage regimens may reduce the incidence of death or neurodevelopmental impairment, we cannot conclude what the optimal type, dosage, or timing of initiation is for the prevention of BPD in preterm infants, based on current level of evidence. Further high quality trials would be needed to establish the optimal systemic postnatal corticosteroid dosage regimen.
  • ||||||||||  indomethacin / Generic mfg., hydrocortisone / Generic mfg., paracetamol / Generic mfg.
    Journal:  Evaluation of Health-Related Values and Preferences of Adults Who Were Preterm Infants and Parents of Preterm Infants Concerning Use of Prophylactic Cyclooxygenase Inhibitor Drugs. (Pubmed Central) -  Mar 14, 2023   
    To explore the health-related values and preferences of adults who were preterm infants and families of preterm infants concerning the prophylactic use of indomethacin, ibuprofen, and acetaminophen initiated within the first 24 hours after birth...Relative importance of clinical outcomes, willingness to use each of the COX-Is when presented as the only option, preference for using prophylactic hydrocortisone vs indomethacin, willingness to use any of the COX-Is when all 3 options are available, and relative importance of having family values and preferences included in decision-making...The findings of this cross-sectional study of former preterm infants and parents of preterm infants suggest that there was minimal variability in how participants valued the main outcomes, with death and severe IVH being rated as the 2 most important undesirable outcomes. While indomethacin was the most preferred form of prophylaxis, variability was noted in the choice of COX-I interventions when participants were presented with the benefits and harms of each drug.
  • ||||||||||  dexamethasone / Generic mfg.
    Optimizing Endotracheal Tube Length Management for Preterm Infants () -  Mar 14, 2023 - Abstract #PAS2023PAS_5050;    
    Demographic data compared between initial extubation success or failure revealed significant differences in birth weight and type of delivery in univariate analyses. Multivariable logistic regression analysis demonstrated a significant association between extubation success and duration of primary intubation (OR 1.11, p=0.025) and birth weight (OR=1.00, p=0.035) but not the number of ETT adjustments (OR 1.14, p=0.588), surfactant administration (OR=5.18, p=0.203), or low-dose dexamethasone administration (OR=0.12, p=0.092).
  • ||||||||||  dexamethasone injection / Generic mfg.
    Long-term cardiopulmonary effects of ante- and post-natal dexamethasone in adult mice () -  Mar 14, 2023 - Abstract #PAS2023PAS_4810;    
    Compared to those exposed to antenatal corticosteroids, mice exposed to both ante- and post-natal corticosteroids had reduced overall body weight at 90 days of life (29.7g vs 26.5g, p< 0.001). Mice with ante- and post-natal corticosteroid exposure
  • ||||||||||  dexamethasone / Generic mfg.
    Impact of Postnatal Dexamethasone on Right Heart Performance in Premature Neonates () -  Mar 14, 2023 - Abstract #PAS2023PAS_4809;    
    Mean cumulative dose of Dexamethasone was 0.98 mg/kg given over 8-10 days. Analysis of echocardiographic parameters before Dexamethasone and at treatment completion (Table 1) showed a significant improvement in RV FAC (.45 vs .49, P 0.025) and in TAPSE (.65cm vs .70 cm ,P .013).
  • ||||||||||  hydrocortisone / Generic mfg., milrinone / Generic mfg.
    Variability in Hemodynamic Support Practices for Infants with Congenital Diaphragmatic Hernia (CDH) across the Children () -  Mar 14, 2023 - Abstract #PAS2023PAS_4799;    
    Most survey respondents 1) had guidelines for hemodynamic support (90%) and 2) targeted BP values based on adequate signs of tissue perfusion (68%). Forty two percent of responding sites use echo-guided (EG) vasoactive support decision-making, 42% have pre-determined algorithms (non-echo guided (NEG)) while 16% have no vasoactive medication algorithm (Fig.
  • ||||||||||  dexamethasone / Generic mfg.
    The Use of Low-Dose Dexamethasone in Chronic Neonatal Respiratory Failure. () -  Mar 14, 2023 - Abstract #PAS2023PAS_4248;    
    Twenty-eight (67%) infants had successful extubation with DART compared to 11 (79%) infants with Ah-DART . Only one patient receiving Ah-DART received a standard DART course prior to the Ah-DART course.
  • ||||||||||  sildenafil / Generic mfg., hydrocortisone / Generic mfg.
    Clinical variables associated with ECMO use and non-survival in infants with CDH () -  Mar 14, 2023 - Abstract #PAS2023PAS_3744;    
    Pooled survival for ECMO patients was 42% (vs 88% for non-ECMO patients), but improved over time after implementation of a standardized guideline in 2012. Most ECMO patients and non-survivors had an antenatal diagnosis with lower 1- and 5-minute APGAR scores (Table 1).
  • ||||||||||  dexamethasone / Generic mfg.
    Perception of Chemotherapy-Induced Nausea and Vomiting Control in Pediatric Patients () -  Mar 14, 2023 - Abstract #PAS2023PAS_3266;    
    For nausea control: 7 encounters reported not/ somewhat well controlled, 11 moderately well, 14 extremely well (Table 1). For vomiting control: 5 encounters reported not/ somewhat well controlled, 11 moderately well, 16 extremely well (Table 2).
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., furosemide / Generic mfg.
    Hearing Loss Prevalence and Clinical Factors in Neonates Admitted to the Neonatal Intensive Care Unit () -  Mar 14, 2023 - Abstract #PAS2023PAS_2900;    
    41/189 (21.6%) of those who failed hearing screen had persistent hearing loss on Auditory Brainstem Response (ABR) testing 6 to 12 months after NICU discharge. Neonates who failed their hearing screen had significantly lower GA (p< 0.001) and birth weight (p< 0.01), had lower APGAR scores at 1 minute (p< 0.01) and 5 minutes (p< 0.01).
  • ||||||||||  hydrocortisone / Generic mfg.
    PDA Treatments and Hydrocortisone exposure in extremely preterm infants: A secondary analysis of the Hydrocortisone Trial. () -  Mar 14, 2023 - Abstract #PAS2023PAS_2747;    
    The interaction between PDA treatment and HC was not statistically significant for moderate to severe BPD or death (p=0.93). PDA treatment alone was associated with a significant increase in moderate to severe BPD or death at 36 weeks, moderate to severe CP or death, home oxygen, duration of ventilatory support, oxygen supplementation at 36 weeks, and BPD severity, and with decreased weight-for-age z-score at 36 weeks.
  • ||||||||||  fluconazole oral / Generic mfg.
    Comparative Safety of Fluconazole Loading Dose Regimens in Infants () -  Mar 14, 2023 - Abstract #PAS2023PAS_2406;    
    We found no difference in safety outcomes, except for a higher rate of AI in the 25 mg/kg group when defined as new or increased hydrocortisone [26 (31%) vs. 288 (22%), p=0.04] compared to the ? 12 mg/kg group (Table 2) .
  • ||||||||||  Cingal (hyaluronic acid/triamcinolone) / Anika Therap
    Trial primary completion date:  ECHO: A Prospective Evaluation of the Cingal Injection for Hip Osteoarthritis (clinicaltrials.gov) -  Mar 14, 2023   
    P=N/A,  N=100, Active, not recruiting, 
    Multi-drug treatments were superior to VEN? Trial primary completion date: Jan 2023 --> Jul 2023
  • ||||||||||  prednisolone / Generic mfg.
    Journal, Machine learning:  Prediction of Prednisolone Dose Correction Using Machine Learning. (Pubmed Central) -  Mar 14, 2023   
    ML is useful in complicated dose audits such as oral prednisolone. The online version contains supplementary material available at 10.1007/s41666-023-00128-3.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Clinical picture, diagnostics and treatment of bacterial meningitis. (Pubmed Central) -  Mar 13, 2023   
    The basis of treatment is the earliest possible administration of antibiotics, initially empirically and then purposefully according to the results. Corticosteroids, traditionally dexamethasone, are also used in therapy.
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Journal:  Optical photothermal infrared spectroscopy for nanochemical analysis of pharmaceutical dry powder aerosols. (Pubmed Central) -  Mar 13, 2023   
    The active ingredients fluticasone propionate and salmeterol xinafoate are widely used for the treatment of asthma and chronic obstructive pulmonary disease...In contrast, the suspension-spray dried formulation showed the drug content increased while the lactose content decreased in the particles collected down the NGI from stage 1 to stage 7, indicating heterogeneity in the ratio of drug-excipient distribution. The qualitative chemical compositions from O-PTIR were comparable to conventional wet chemical assays of various size fractions, indicating the suitability of O-PTIR to serve as a valuable analytical platform for screening the physicochemical properties of DPIs in solid state.