Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


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  • ||||||||||  Yonsa (abiraterone acetate) / Churchill Pharma, Sun Pharma, Erleada (apalutamide) / J&J
    Enrollment closed, Enrollment change, Metastases:  Advanced ChemoHormonal Therapy for Treatment Naive Metastatic Prostate Cancer (clinicaltrials.gov) -  Apr 19, 2023   
    P2,  N=7, Active, not recruiting, 
    Recruiting --> Active, not recruiting | N=76 --> 7
  • ||||||||||  Enrollment closed, Trial primary completion date:  Allo HSCT Using RIC for Hematological Diseases (clinicaltrials.gov) -  Apr 19, 2023   
    P2,  N=156, Active, not recruiting, 
    Recruiting --> Active, not recruiting | N=76 --> 7 Suspended --> Active, not recruiting | Trial primary completion date: Mar 2024 --> Apr 2023
  • ||||||||||  Kenalog-10 (triamcinolone acetonide) / BMS
    Trial completion, Trial completion date, Trial primary completion date:  Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis (clinicaltrials.gov) -  Apr 19, 2023   
    P4,  N=10, Completed, 
    Suspended --> Active, not recruiting | Trial primary completion date: Mar 2024 --> Apr 2023 Recruiting --> Completed | Trial completion date: Dec 2022 --> Mar 2023 | Trial primary completion date: Dec 2022 --> Mar 2023
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Elucidating the Effect of Antenatal Corticosteroids in the Late Preterm Period. (Pubmed Central) -  Apr 19, 2023   
    Based on our results, we propose that expansins control root growth by a delicate orchestration of CW biomechanical properties, possibly regulating both CW loosening and CW remodeling. A total of 126 patients who had received antenatal corticosteroids (prenatal administration of either betamethasone or dexamethasone, minimum one dose) during the late preterm period were taken as cases, and 135 patients who had not received steroids antenatally due to various reasons, for example, who were clinically unstable, presented with active bleeding, non-reassuring foetal status that obligated an imminent delivery and those in active labour were included as controls...Antenatal corticosteroids administered to patients between 34 and 36
  • ||||||||||  lenalidomide / Generic mfg., carfilzomib / Generic mfg., pomalidomide / Generic mfg.
    Trial primary completion date:  Study of Early Relapsed, Lenalidomide-refractory Subjects Eligible for Carfilzomib Triplet (clinicaltrials.gov) -  Apr 18, 2023   
    P2,  N=54, Active, not recruiting, 
    Metformin, OCP, dexamethasone, flutamide, and rosiglitazone use were associated with a significant reduction in biochemical hyperandrogenemia in women with PCOS, though their individual use may be limited due to their side effects. Trial primary completion date: Dec 2025 --> Nov 2022
  • ||||||||||  triamcinolone acetonide / Generic mfg., enalapril / Generic mfg.
    Trial completion date, Trial primary completion date:  Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars (clinicaltrials.gov) -  Apr 18, 2023   
    P2/3,  N=30, Not yet recruiting, 
    Initiation date: Mar 2023 --> Aug 2023 Trial completion date: Oct 2023 --> Oct 2024 | Trial primary completion date: Aug 2023 --> Aug 2024
  • ||||||||||  Trial completion date, Trial primary completion date:  Allo HSCT Using RIC for Hematological Diseases (clinicaltrials.gov) -  Apr 18, 2023   
    P2,  N=124, Suspended, 
    Trial completion date: Apr 2023 --> Dec 2023 | Trial primary completion date: Apr 2023 --> Dec 2023 Trial completion date: Mar 2023 --> Mar 2024 | Trial primary completion date: Mar 2023 --> Mar 2024
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Engineering High-Quality Cartilage Microtissues using Hydrocortisone Functionalised Microwells. (Pubmed Central) -  Apr 18, 2023   
    Hydrocortisone was found to be the key factor within EGM that enhanced the chondrogenic capacity of MSCs within these microwell arrays. This strategy represents a promising means of generating large numbers of high-quality, scaffold-free cartilage microtissues for diverse biofabrication applications.
  • ||||||||||  cefazolin / Generic mfg., tobramycin/dexamethasone / Generic mfg., levofloxacin / Generic mfg.
    Journal, Surgery:  Clinical features and treatment of endophthalmitis after cataract surgery (Pubmed Central) -  Apr 18, 2023   
    Our study shows combining daratumumab with lenalidomide in patients with prior lenalidomide use is a viable and effective treatment option. Povidone iodine and third generation fluoroquinolone as a method of acute endophthalmitis prevention after cataract surgery demonstrate comparable efficacy to intracameral antibiotic injections.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dexamethasone for Inpatients With COVID-19 in a National Cohort. (Pubmed Central) -  Apr 18, 2023   
    In this national multicenter cohort study of inpatients with COVID-19, early administration of dexamethasone was associated with significantly reduced odds of mortality or discharge to hospice in those requiring supplemental oxygen or MV and/or ECMO but not in those requiring no supplemental oxygen or NIPPV. These results support the continued use of systemic dexamethasone in patients hospitalized with COVID-19.
  • ||||||||||  Journal:  An evaluation of pharmacological options for Cushing's disease: what are the state-of-the-art options? (Pubmed Central) -  Apr 17, 2023   
    : Since there is still no standardized pharmacological approach and the superiority of one drug over another has not been established yet due to the lack of comparative studies, each time clinicians' choices should be patient-tailored. Age, gender, tumor features, severity of hypercortisolism, comorbidities/complications, rapidity of action of each drug, side effects, drug-drug interactions, contraindications, availability, patients' preferences and costs should be all taken into account.
  • ||||||||||  hydrocortisone / Generic mfg., epinephrine / Generic mfg.
    Journal:  Use of vasopressors for septic shock in the neonatal intensive care unit. (Pubmed Central) -  Apr 14, 2023   
    Compared to infants treated with dopamine alone, adjusted odds of mortality were significantly higher for those treated with epinephrine alone (aOR 4.7 [95% CI: 2.3-9.2]). Adjuvant hydrocortisone was associated with significantly lower adjusted odds of mortality (aOR 0.60 [0.42-0.86]) The use of epinephrine as either a solo agent or in combination therapy was associated with significantly worse outcomes, while adjuvant hydrocortisone was associated with decreased mortality.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Protective Effect of the Eluting Fraction of Da-Yuan-Yin Decoction on Acute Lung Injury. (Pubmed Central) -  Apr 14, 2023   
    The team divided the mice into seven groups of six mice: (1) a control group; (2) a negative control group-the DYY-5 group with mice treated only with a high dosage, 60 mg/kg, of DYY-5 to investigate the effects of DYY-5 on normal mice; (3) the positive control group, the LPS group, with induced ALI but no treatments; (4) the LPS+60 mg/kg-DYY-5 group with induced ALI treated with a high dosage of DYY-5; (5) the LPS+30 mg/kg-DYY-5 group with induced ALI treated with a medium dosage of DYY-5; (6) the LPS+15 mg/kg-DYY-5 group with induced ALI treated with a low dosage of DYY-5; and (7) a reference drug control group, the LPS+DXM group, with induced ALI treated with 5 mg/kg of dexamethasone (DXM)...The protective effects of DYY-5 on ALI were related to antioxidation, anti-complementary activities, and regulation of inflammatory factors through the IKK/NF-?B signal pathway. DYY-5 may be useful as a potential therapeutic agent for treating ALI in clinics.