Glucocorticoid Receptor 

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  • ||||||||||  Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
    Journal:  Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures. (Pubmed Central) -  May 17, 2023   
    The objective of this investigation was to study the effect of induced vibrations on adhesive mixtures containing budesonide and salbutamol sulphate as active pharmaceutical ingredients (APIs) and InhaLac 70 as carrier...However, no significant difference was observed for mixtures with larger weight fractions of API (2 and 4% API) but these have a drawback of reduced fine particle fraction (FPF). It is concluded that vibrations induced on the adhesive mixtures during handling potentially have a significant effect on the dispersibility of the API and the total amount of drug delivered to the lungs.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Single vs two-dose dexamethasone for pediatric asthma exacerbations. (Pubmed Central) -  May 17, 2023   
    It is concluded that vibrations induced on the adhesive mixtures during handling potentially have a significant effect on the dispersibility of the API and the total amount of drug delivered to the lungs. No abstract available
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Anti-NMDA Receptor Encephalitis Induced Psychosis Post-Covid 19 Infection in an Adolescent (Hall B Foyer, Exhibition Level Moscone South) -  May 17, 2023 - Abstract #APA2023APA_1046;    
    He was started on immunotherapy of IVIG, IV Methylprednisolone, and Rituximab with clinical improvement, and he was discharged with a plan to continue outpatient immunotherapy. Given our patient
  • ||||||||||  Thalamic Strokes Mimicking Extra-Pyramidal Symptoms After Long-Acting Injectable Antipsychotic Administration in a Young Veteran (Hall B Foyer, Exhibition Level Moscone South) -  May 17, 2023 - Abstract #APA2023APA_944;    
    Neurology reviewed a head CT obtained on admission which redemonstrated a stable 2.4cm pontine AVM and showed up to four previously missed bilateral thalamic infarcts.They recommended obtaining an MRI, CT angiogram, and starting the patient on aspirin 81mg daily...was treated with physical therapy and dexamethasone 2mg with a planned taper...was discharged to inpatient physical rehabilitation, and has returned home and continues to improve. In this poster, we discuss the challenges of differentiating stroke deficits from EPS symptoms and stress the importance of collaboration with other specialties in providing comprehensive care to patients with histories of psychiatric illness.
  • ||||||||||  risperidone / Generic mfg., lorazepam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Anti-NMDA Receptor Encephalitis in the Late Postpartum Period (Hall B Foyer, Exhibition Level Moscone South) -  May 17, 2023 - Abstract #APA2023APA_892;    
    She subsequently developed catatonia, so risperidone was discontinued and lorazepam was initiated...Her encephalitis was treated with a five-day course of intravenous methylprednisolone...This case illustrates that anti-NMDAR encephalitis should remain in the differential diagnosis even if the symptom timeline is atypical. This poster will explore treatment options, disease course, and relapse rates of anti-NMDAR encephalitis in antepartum and postpartum patients.
  • ||||||||||  prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Observational data, Retrospective data, Journal:  Oral or pulse glucocorticoid use at the onset of giant cell arteritis and its influence on the risk of relapse: a retrospective study. (Pubmed Central) -  May 17, 2023   
    The objective is to investigate whether initial therapy with intravenous methylprednisolone pulses (ivMTP) or oral glucocorticoid (OG) influences the relapse rate in giant cell arteritis (GCA) patients...Mean (SD) cumulative prednisone dose (mg) at 6-month follow-up was 3790.7 (1832.7) for patients with ivMTP vs 4298.1 (2930.6) for the OG group, p?=?0.37...Initial therapy with ivMTP or OG does not influence the relapse rate of GCA patients. Fever at disease onset and dyslipidemia are independent predictors of disease relapse.
  • ||||||||||  A severe form of chronic cholestasis in hepatic sarcoidosis: A case report (Hepatology Arena) -  May 17, 2023 - Abstract #EASLILC2023EASL_ILC_2458;    
    On outpatient follow-up, the patient remains symptomatic, with refractory pruritus (medicated with ursodeoxycholic acid, cholestyramine and hydroxyzine)...2) Should UDCA be the first-line treatment for hepatic sarcoid in the presence of cholestatic injury? 3) In light of scarce current evidence which is the soundest therapeutic option: TNF antagonists, antimetabolites, other?
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Determining the Optimal Dosage of Corticosteroid Injection in Trigger Finger. (Pubmed Central) -  May 16, 2023   
    The purpose of this study is to compare the efficacy of 3 different injection dosages of triamcinolone acetonide for the treatment of trigger finger...When compared with 5-mg and 10-mg doses, a 20-mg dose was found to have a significantly higher rate of clinical effectiveness at 6-month follow-up. The VAS and QuickDASH scores were not significantly different between the 3 groups.
  • ||||||||||  methylprednisolone oral / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats. (Pubmed Central) -  May 16, 2023   
    The implications of the present results for the mechanisms mediating methylone's aversive effects were discussed. Understanding such mechanisms is important in predictions relevant to drug history and abuse liability as a variety of subject and experiential factors known to affect (reduce) a drug's aversive effects may increase its use and potential for abuse.
  • ||||||||||  rifampicin / Generic mfg., dexamethasone injection / Generic mfg.
    Preclinical, Journal:  Roles of human cytochrome P450 3A4/5 in dexamethasone 6?-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin. (Pubmed Central) -  May 16, 2023   
    As a result, the glucose-sensitive nanofibers scaffolds offer a viable treatment option for people with diabetes with alveolar bone defects. The urinary metabolic ratio of 6?-hydroxydexamethasone to dexamethasone reportedly acts as a noninvasive marker for human cytochrome P450 (P450) 3A4/5, which is induced by rifampicin in humanized-liver mice...After intravenous dexamethasone administration, significant differences were observed in the time-dependent plasma and 24-h urinary concentrations of 6?-hydroxydexamethasone between untreated humanized-liver mice and humanized-liver mice treated with azamulin (daily oral doses of 15
  • ||||||||||  Zynlonta (loncastuximab tesirine-lpyl) / Overland ADCT BioPharma
    Trial primary completion date:  Loncastuximab Tesirine in WM (clinicaltrials.gov) -  May 16, 2023   
    P2,  N=36, Recruiting, 
    The urinary metabolic ratio of 6?-hydroxydexamethasone to dexamethasone reportedly acts as a noninvasive marker for human cytochrome P450 (P450) 3A4/5, which is induced by rifampicin in humanized-liver mice...After intravenous dexamethasone administration, significant differences were observed in the time-dependent plasma and 24-h urinary concentrations of 6?-hydroxydexamethasone between untreated humanized-liver mice and humanized-liver mice treated with azamulin (daily oral doses of 15 Trial primary completion date: May 2023 --> May 2025
  • ||||||||||  Nplate (romiplostim) / Amgen, Kyowa Kirin, Promacta (eltrombopag) / Novartis, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    New P4 trial, Immunomodulating:  Immune Thrombocytopenia Management in Adults (clinicaltrials.gov) -  May 16, 2023   
    P4,  N=467, Recruiting, 
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Advair‽ 😳 (Twitter) -  May 15, 2023   
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Efficacy of Intratympanic OTO-104 for the Treatment of M (Pubmed Central) -  May 15, 2023   
    P3
    Recruiting --> Completed In all three high-quality, randomized, double-blind, placebo-controlled, multicenter studies, a single intratympanic injection of 12 mg OTO-104 demonstrated numerically greater reductions in vertigo versus placebo in patients with M
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Improving COVID-19 Disease Severity Surveillance Measures: Statewide Implementation Experience. (Pubmed Central) -  May 15, 2023   
    Prior research showed that dexamethasone administration was highly correlated with other disease severity metrics and sensitive to the changing epidemiology associated with the emergence of immune-evasive variants...Adding a single data element to mandated reporting to estimate the frequency of severe COVID-19 in hospitalized patients was feasible and provided actionable information for health authorities and policy makers. Updates to surveillance methods are necessary to match data collection with public health response needs.
  • ||||||||||  triamcinolone acetonide / Generic mfg., methylprednisolone acetate / Generic mfg.
    Preclinical, Journal:  In Vitro Effects of Triamcinolone and Methylprednisolone on the Viability and Mechanics of Native Articular Cartilage. (Pubmed Central) -  May 15, 2023   
    Exposure of MP to articular cartilage explants was chondrotoxic, and exposure of articular cartilage explants to MP or TA resulted in significant decreases in mechanical properties of articular cartilage explants compared with controls. Clinicians should be judicious regarding use of intra-articular steroids, particularly in patients with intact healthy articular cartilage.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Lymphocytic colitis with macroscopic findings. (Pubmed Central) -  May 15, 2023   
    Unless TSH is ?10 The clinical case of a patient in the fifth decade of life with a diagnosis of lymphocytic colitis is presented, who comes for chronic diarrhea, which receives treatment with Budesonide with partial response.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, Surgery:  Dexamethasone remnant on the macula after vitreoretinal surgery (Pubmed Central) -  May 15, 2023   
    The clinical case of a patient in the fifth decade of life with a diagnosis of lymphocytic colitis is presented, who comes for chronic diarrhea, which receives treatment with Budesonide with partial response. No abstract available
  • ||||||||||  triamcinolone acetonide / Generic mfg., minoxidil / Generic mfg.
    Journal:  Granuloma annulare with alopecia areata in a 6-year-old girl: a case report. (Pubmed Central) -  May 15, 2023   
    Granuloma annulare is a benign inflammatory illness with no known cause that might be difficult to cure. The clinical course and prognosis might vary greatly depending on the disease subtype, and associating symptoms and diseases, such as alopecia areata, should be considered.
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  MIDCAB (Mid-Calf Block) for Foot Surgery (clinicaltrials.gov) -  May 15, 2023   
    P4,  N=20, Recruiting, 
    The use of local steroids could be effective in preventing recurrence of ocular inflammation after severe intraocular inflammation due to brolucizumab. Trial completion date: Apr 2023 --> Apr 2024 | Trial primary completion date: Apr 2023 --> Apr 2024