Glucocorticoid Receptor 

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  • ||||||||||  fluticasone / Generic mfg.
    Journal:  A steroid-resistant cockroach allergen model is associated with lung and cecal microbiome changes. (Pubmed Central) -  Jul 9, 2023   
    We utilized a steroid-resistant chronic model of cockroach antigen-induced (CRA) asthma with corticosteroid (fluticasone) treatment to examine lung and gut microbiome during disease...Finally, a functional analysis of cecal microbiome metabolites using PiCRUSt showed several biosynthetic pathways were significantly enriched in the Flut-treated group, with tryptophan pathway verified by ELISA with increased kynurenine in homogenized cecum samples. While the implications of these data are unclear, they may suggest a significant impact of steroid treatment on future disease pathogenesis through microbiome and associated metabolite pathway changes.
  • ||||||||||  hydrocortisone / Generic mfg.
    Hydrocortisone! (Twitter) -  Jul 9, 2023   
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Glucocorticoids ameliorate cardiorenal syndrome through the NPR1/SGK1 pathway in natriuretic peptide receptor A?heterozygous mice. (Pubmed Central) -  Jul 7, 2023   
    However, glucocorticoids (dexamethasone) upregulated NPR1 and inhibited SGK1 and alleviated cardiac and renal dysfunction caused by Npr1 gene heterozygosity...Briefly, glucocorticoids inhibited SGK1 by upregulating NPR1, thereby ameliorating cardiorenal impairment caused by Npr1 gene heterozygosity. The present findings provided novel insight into the understanding of cardiorenal syndrome and suggested that glucocorticoids targeting the NPR1/SGK1 pathway may be a potential therapeutic target to treat cardiorenal syndrome.
  • ||||||||||  budesonide / Generic mfg.
    Clinical, Retrospective data, Review:  Effectiveness of Non-Budesonide Therapies in Management of Microscopic Colitis: A Systematic Review and Meta-analysis. (Pubmed Central) -  Jul 7, 2023   
    The present findings provided novel insight into the understanding of cardiorenal syndrome and suggested that glucocorticoids targeting the NPR1/SGK1 pathway may be a potential therapeutic target to treat cardiorenal syndrome. We performed a systematic review and meta-analysis to determine the effectiveness of non-budesonide therapies (thiopurines, bismuth subsalicylate [BSS], bile acid sequestrants [BAS], loperamide and biologics) for MC suggested by international guidelines...Treatment with tumor necrosis factor (TNF) inhibitors (infliximab and adalimumab) demonstrated a response rate of 73% (95% CI 0.63-0.83; I
  • ||||||||||  dexamethasone / Generic mfg.
    Exploring local immune modulation with rapamycin-eluting microparticles to preserve islet graft function in mice (Indigo 204) -  Jul 7, 2023 - Abstract #IPITAIXACTRMS2023IPITA_IXA_CTRMS_300;    
    Further validating our findings in a humanized mouse model can help us study rapa-microparticles tolerogenic effects in the context of the human immune system. Collectively, localized drug delivery has the potential to alter the immune environment, protect grafts, and may serve as a safe adjuvant approach in clinical islet transplantation.
  • ||||||||||  CORT108297 / Corcept Therap
    Trial completion date, Trial primary completion date:  Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X) (clinicaltrials.gov) -  Jul 7, 2023   
    P2,  N=52, Recruiting, 
    The follow up period is crucial as there are high chances of opportunistic infections. Trial completion date: Jan 2024 --> Jan 2027 | Trial primary completion date: Jun 2023 --> Jun 2025
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Rapidly Progressive Dementias: Case series in a South American hospital (Virtual) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_7952;    
    However, we observed 47.4% of cases without a definitive diagnosis. It could be associated with immune-mediated entities without a specified antibody at the time of evaluation.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Rapidly Progressive Dementias: Case series in a South American hospital (Virtual) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_5886;    
    However, we observed 47.4% of cases without a definitive diagnosis. It could be associated with immune-mediated entities without a specified antibody at the time of evaluation.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Rapidly Progressive Dementias: Case series in a South American hospital (Virtual) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_3640;    
    However, we observed 47.4% of cases without a definitive diagnosis. It could be associated with immune-mediated entities without a specified antibody at the time of evaluation.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Rapidly Progressive Dementias: Case series in a South American hospital (Virtual) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_1420;    
    However, we observed 47.4% of cases without a definitive diagnosis. It could be associated with immune-mediated entities without a specified antibody at the time of evaluation.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision. (Pubmed Central) -  Jul 6, 2023   
    The new findings supersede earlier concepts such as "relative", as opposed to "absolute", adrenal insufficiency and generalized systemic glucocorticoid resistance in the critically ill. They also question the scientific basis for broad implementation of stress dose hydrocortisone treatment of patients suffering from acute septic shock solely based on assumption of cortisol insufficiency.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial primary completion date:  Triamcinolone Acetonide Injections in Primary Cutaneous Lymphoma Plaques With a Novel Needle-free Drug-delivery System. (clinicaltrials.gov) -  Jul 6, 2023   
    P=N/A,  N=22, Not yet recruiting, 
    The study results confirm that neither the FLU or the AZE component in the combination product (MP-AzeFlu), nor the existing qualitative and quantitative differences in the formulation between the currently marketed AZE and FLU mono-product, display significant potential to impact the systemic exposure of AZE or FLU in Chinese subjects. Trial primary completion date: Jul 2023 --> Jun 2024
  • ||||||||||  dexamethasone / Generic mfg., lenalidomide / Generic mfg., thalidomide / Generic mfg.
    Journal:  Alterations in choroidal vascular structures due to serum levels of vascular endothelial growth factor in patients with POEMS syndrome. (Pubmed Central) -  Jul 5, 2023   
    We report oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin and dexamethasone) as a novel treatment for CE to improve the outcomes of successful pregnancy compared with those of oral antibiotics alone. Enhanced depth imaging optical coherence tomography (EDI-OCT) images were obtained, and serum VEGF levels were measured at baseline and 6
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Rational Multimodal Analgesia for Perioperative Pain Management. (Pubmed Central) -  Jul 5, 2023   
    Unless contraindicated, all patients should receive a combination of acetaminophen, non-steroidal anti-inflammatory drug or cycoxygenase-2-specific inhibitor, dexamethasone, and procedure-specific regional analgesic technique and/or surgical site local anesthetic infiltration...Non-pharmacological interventions are important components of an optimal multimodal analgesic technique. It is imperative to integrate multimodal analgesia regimens within a multidisciplinary enhanced recovery pathway.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Modulation of Immunological, Biochemical, and Histopathological Changes of Airway Remodeling by Withania somnifera in an Experimental Model of Allergic Asthma in Rats. (Pubmed Central) -  Jul 5, 2023   
    OVA-immunization and challenge in rats resulted in significant increases in the levels of IL-13, 8-OhdG, TGF-?, hydroxyproline, and periostin in bronchoalveolar lavage fluid (BALF) and serum/lung homogenate compared to normal control (saline only) rats, and these changes were attenuated after WS extract (200 and 400 mg/kg), as well as dexamethasone (DEX, 1 mg/kg) pretreatments...In herb-drug interactions, sub-threshold doses of WS extract and DEX showed synergistic effects on all parameters studied as compared to either form of monotherapy. These results indicated that WS exerted significant protective effects against airway remodeling in the experimental model by modulating inflammatory and fibrotic cytokines, and could have the potential for developing a therapeutic alternative/adjunct for the treatment of airway remodeling of bronchial asthma.