- |||||||||| Darzalex (daratumumab) / J&J
Journal, Metastases: Treatment Approach for Advanced Systemic Light Chain Amyloidosis: A Case Report. (Pubmed Central) - Sep 2, 2024
Following treatment, the patient improved from stage IV to stage II systemic light chain amyloidosis per the National Comprehensive Cancer Network (NCCN) guidelines, indicating a more favorable prognosis. Hence, the successful integration of daratumumab in our case underscores its potential as a valuable addition to the treatment regimen for advanced systemic light chain amyloidosis, showcasing significant improvements across multiple organ systems.
- |||||||||| hydrocortisone / Generic mfg., azathioprine / Generic mfg.
Journal: Cohen Syndrome With Complex Medical Complications: A Case Report. (Pubmed Central) - Sep 2, 2024
CS presents with a spectrum of clinical features that overlap with other syndromic conditions, necessitating careful differential diagnosis. Early diagnosis and supportive care significantly improve quality of life and help manage complications effectively.
- |||||||||| dexamethasone / Generic mfg., pioglitazone / Generic mfg.
Journal: Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol. (Pubmed Central) - Sep 2, 2024
The effects of carvacrol and pioglitazone (Pio) alone and their combination on inhaled PQ-induced systemic and lung oxidative stress and inflammation as well as behavioral changes were examined in rats...PQ-exposed animals were treated with 0.03?mg/kg/day dexamethasone (Dexa), 20 and 80?mg/kg/day carvacrol (C-L and C-H), 5?mg/kg/day Pio, and Pio+C-L for 16 days...Inhaled PQ-induced changes were significantly improved in carvacrol, Pio, Dexa, and especially in the combination of the Pio+C-L treated groups (p < 0.05-p < 0.001). Carvacrol and Pio improved PQ-induced changes similar to Dexa, but ameliorative effects produced by combination treatments of Pio+C-L were more prominent than Pio and C-L alone, suggesting a potentiating effect for the combination of the two agents.
- |||||||||| dexamethasone / Generic mfg.
Journal: Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease. (Pubmed Central) - Sep 2, 2024
The combination of MMDS@DEX and magnet treatment exerted significantly better therapeutic effects against DED with smaller side effects than conventional treatments including DEX suspension, commercial DEX eye drops, as well as the MMDS@DEX treatment alone. The present work provided a new method for the effective delivery of DEX to ocular surface tissues while reducing its side effects, which will be beneficial to the treatments of a wide range of ocular surface diseases.
- |||||||||| mometasone furoate nasal spray / Generic mfg.
Clinical, Journal: Anti-IL-4R? monoclonal antibody (CM310) in patients with chronic rhinosinusitis with nasal polyps (CROWNS-2): Rationale and design of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. (Pubmed Central) - Sep 2, 2024
P3
Enrolled participants continued to use mometasone furoate nasal spray throughout the study...The CROWNS-2 is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical study to evaluate the efficacy and safety of CM310 in patients with CRSwNP. NCT05436275.
- |||||||||| Riarify (beclometasone/formoterol/glycopyrrolate) / Chiesi
Observational data, Journal, Real-world evidence, Real-world effectiveness, Real-world: The Real-World Efficacy of Fixed Triple Inhalation Therapy in the Treatment of Moderate COPD Patients (RATIONALE Study). (Pubmed Central) - Sep 2, 2024
RATIONALE was a non-interventional, prospective, 52 week study, assessing the effectiveness of beclometasone/formoterol/glycopyrronium-bromide (BDP/FF/G), in symptomatic COPD patients, with moderate airflow obstruction...Although limitations of observational studies are present, we observed that early introduction of fixed triple combination results in a marked improvement in adherence to treatment, symptom scores, exacerbation frequency and quality of life. The optimal choice of treatment is crucial for reaching the highest possible adherence.
- |||||||||| Journal, Adverse events: The annoyance of singultus: a case report of a rare adverse effect after epidural steroid injection. (Pubmed Central) - Sep 2, 2024
It underscores the importance of a multidisciplinary approach to diagnose and manage rare diseases, improving patient outcomes through timely genetic testing and coordinated care. Persistent hiccups after ESI or interventional pain procedures can be treated with conservative measures and non-pharmacologic methods, with escalation to therapy with baclofen, gabapentin, pregabalin, metoclopramide, chlorpromazine, other antipsychotic or antidopaminergic agents, and possible dual or triple therapy if further indicated.
- |||||||||| Mekinist (trametinib) / Novartis, BeiGene
Journal: CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia. (Pubmed Central) - Sep 2, 2024
Importantly, the MEK inhibitor trametinib exhibited higher synergy with GCs against CD9- than CD9+ lymphoblasts to reverse drug resistance in vitro and in vivo. Collectively, our results elucidate a previously unrecognized regulatory function of CD9 in GC sensitivity, and inform new strategies for management of children with resistant BCP-ALL.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron, Nemluvio (nemolizumab-ilto) / Galderma
Journal: A case of bullous pemphigoid following administration of anti-IL-31 receptor A antibody. (Pubmed Central) - Sep 2, 2024
Oral prednisolone (PSL) was initiated and nemolizumab was never used again...Adding high-dose cyclosporine and intravenous gamma globulin reduced new blister formation after 9?weeks, and PSL and cyclosporine were gradually tapered...This may be countered by blocking the IL-4/13 pathway with dupilumab. To our knowledge, this is the first case of nemolizumab-exacerbated BP.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Anti-LGI1 Antibody-Associated Encephalitis Misdiagnosed as Schizophrenia: A Case Report. (Pubmed Central) - Sep 2, 2024
This case highlights the critical importance of comprehensive antibody testing and neuroimaging in patients presenting with nonspecific psychiatric and neurological symptoms to prevent misdiagnosis and delays in appropriate treatment. The article also reviews the pathogenesis, clinical manifestations, diagnostic approaches, and therapeutic strategies for LGI1 antibody-associated encephalitis, aiming to enhance clinical awareness and optimize patient outcomes.
- |||||||||| dexamethasone / Generic mfg.
Journal: Hemophagocytic Lymphohistiocytosis Secondary to Acute Human Immunodeficiency Virus and COVID-19. (Pubmed Central) - Sep 1, 2024
Coinfection with HIV and SARS-CoV-2 presents unique challenges, especially when complicated by secondary conditions such as HLH, which remains a diagnostic and therapeutic dilemma. Prompt recognition and aggressive management are crucial, necessitating a high index of suspicion and comprehensive evaluation including bone marrow biopsy to improve diagnostic accuracy and guide therapeutic interventions in such complex scenarios.
- |||||||||| dexamethasone / Generic mfg.
Journal: Fragility Fractures and Cortisol Secretion in Patients With Nonfunctioning Adrenal Incidentalomas. (Pubmed Central) - Sep 1, 2024
Prompt recognition and aggressive management are crucial, necessitating a high index of suspicion and comprehensive evaluation including bone marrow biopsy to improve diagnostic accuracy and guide therapeutic interventions in such complex scenarios. Main outcome measures included serum cortisol after 1?mg-dexamethasone test (F-1mgDST), lumbar spinal (LS), and femoral neck (FN) bone mineral density (BMD) and VFx presence, by radiograph of the spine...The F-1mgDST cutoff for predicting an incident VFx was 1.2?
- |||||||||| dexamethasone / Generic mfg., GW-2580 / GSK
Journal: Bacterial nanocellulose as a simple and tailorable platform for controlled drug release. (Pubmed Central) - Sep 1, 2024
Mathematical modeling of the release data pointed to a diffusion-driven mechanism with non-fickian behavior. Overall, the results have demonstrated the potential of this simple approach for developing BNC-drug depots for localized and sustained release of therapeutic agents over adjustable timeframes.
- |||||||||| dexamethasone / Generic mfg.
Journal: A supramolecular hydrogel eye-drop alleviates inflammation via clathrin-mediated endocytosis. (Pubmed Central) - Sep 1, 2024
Here we covalently conjugate two molecules of clinically anti-inflammatory drug (i.e., dexamethasone) with a small peptide (i.e., Tyr-Glu-Asn-Pro-Thr-Tyr) to generate an anti-inflammatory hydrogel eye-drop...A rodent model of endotoxin-induced uveitis verifies that the supramolecular hydrogel eye-drop suppresses inflammation responses without ocular irritation. As a rational approach to design anti-inflammatory drugs as eye-drops, this work overcomes the frequent instillation of clinical eye-drops and further improves the bioavailability of anti-inflammatory drugs, which may provide an effective and household way to fight ocular surface inflammation.
- |||||||||| dexamethasone / Generic mfg., ropivacaine / Generic mfg.
Clinical, Journal, Surgery: Dexamethasone as a perineural adjuvant to a ropivacaine popliteal sciatic nerve block for pediatric foot surgery: a randomized, double-blind, placebo-controlled trial. (Pubmed Central) - Sep 1, 2024
P4
However, administration of TA with carrier increased cell viability, total antioxidant capacity, and reduced oxidative DNA damage. Perineural dexamethasone significantly prolonged postoperative motor block duration and did not influence blood glucose, NLR, or PLR levels.
- |||||||||| triamcinolone acetonide / Generic mfg., triamcinolone acetonide injection suspension / Generic mfg.
Retrospective data, Journal: Pulsed thulium laser combined with pulsed thulium laser injection for the treatment of failed urethral anastomosis (Pubmed Central) - Sep 1, 2024
The median follow-up time for the thulium laser group and plasma group was 21.0 months (IQR 16.0?24.0) and 21.0 months (IQR 17.0?25.0), respectively, with a statistically significant difference observed in the maximum urine flow rate before and after surgery at the 12-month mark (P < 0.01). No significant disparity was found in terms of relapse-free survival between the two groups (P = 0.398) Pulsed thulium laser combined with triamcinolone acetonide injection can effectively maintain a short-term cicatricial stability of the urethral stricture and satisfactory urethral patency, obviously superior to plasmotomy as a remedial treatment of urethral stricture after failed posterior urethral anastomosis.
- |||||||||| dexamethasone / Generic mfg.
Journal: A Novel Whole Tissue Explant Model of Hidradenitis Suppurativa. (Pubmed Central) - Sep 1, 2024
We also show that the explants were responsive to treatment with both dexamethasone and IL-2. Not only do our results show that this model effectively delivers treatments throughout the explants, but they also elucidate which cytokines are related to the explant process regardless of tissue state and which are related to HS tissue specifically, laying the groundwork for future implementations of this model.
- |||||||||| Filspari (sparsentan) / Travere Therap, Tarpeyo (budesonide) / Calliditas, Stada
Review, Journal: Therapy of IgA nephropathy: time for a paradigm change. (Pubmed Central) - Sep 1, 2024
Following remission, treatments may be adjusted and stripped back as necessary in the maintenance phase with close monitoring. This review discusses the current status of IgAN treatment and explores future strategies to improve outcomes for patients with IgAN.
- |||||||||| dexamethasone / Generic mfg.
Journal: NST3 induces ectopic transdifferentiation, forming secondary walls with diverse patterns and composition in Arabidopsis thaliana. (Pubmed Central) - Sep 1, 2024
These findings suggest NST3 and/or NST1 induce SCWs with shared characteristics of both xylem and fiber-like cells forming loosely arranged cell wall layers and cellulose organized at multiple angles relative to the cell growth axis and with varied cellulose and lignin abundance. This inducible system opens avenues to explore ectopic SCWs for bioenergy and bioproducts, offering valuable insights into SCW patterning across diverse cell types and developmental stages.
- |||||||||| paquinimod (ABR-215757) / Active Biotech
Journal: Calprotectin is regulated by IL-17A and induces steroid hyporesponsiveness in asthma. (Pubmed Central) - Sep 1, 2024
Targeting calprotectin may offer a promising approach to alleviate airway inflammation and restore steroid responsiveness in severe asthma. Further investigations are warranted to explore its therapeutic potential in clinical settings and elucidate its broader implications in steroid mechanisms of action.
- |||||||||| Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
Clinical, P3 data, Retrospective data, Journal: Effect of Triple Therapy on Cardiovascular and Severe Cardiopulmonary Events in COPD: A Post-hoc Analysis of a Randomized, Double-Blind, Phase 3 Clinical Trial (ETHOS). (Pubmed Central) - Sep 1, 2024
P3
In the Phase III, 52-week ETHOS trial (NCT02465567), triple therapy with budesonide/glycopyrrolate/formoterol fumarate (BGF) reduced rates of moderate/severe exacerbations and all-cause mortality versus dual therapy with glycopyrrolate/formoterol fumarate (GFF) or budesonide/formoterol fumarate (BFF)...Measurements and Main BGF 320 reduced the rate of first occurrence (hazard ratio [95% confidence interval]) of cardiovascular and severe cardiopulmonary events versus GFF, including for CVAESI (0.63 [0.48, 0.82]), cardiac AE (0.60 [0.48, 0.76]), and severe cardiopulmonary event (0.80 [0.67, 0.95]). BGF had a benefit on cardiovascular endpoints and severe cardiopulmonary events versus GFF in patients with moderate-to-very severe COPD.
- |||||||||| dexamethasone / Generic mfg.
Retrospective data, Journal: Impact of Antibiotic and Steroid Therapy on Leptospirosis Outcomes: A Retrospective Cohort Study in Transcarpathia, Ukraine. (Pubmed Central) - Aug 31, 2024
Our analysis of clinical and laboratory data from a single center revealed that dexamethasone showed significant effects on various clinical variables, as did investigated antibiotics...ROC analysis demonstrated high sensitivity and specificity of direct bilirubin as a predictor of mortality. These findings highlight the importance of targeted treatment strategies and the potential of specific laboratory markers in improving leptospirosis management.
- |||||||||| dexamethasone / Generic mfg.
Journal: Exploring the Therapeutic Potential of Green-Synthesized Gold Nanoparticles and Ericaria selaginoides Extract for Inflammatory Bowel Disease. (Pubmed Central) - Aug 31, 2024
In a murine model of Crohn's disease induced with 8% acetic acid, pretreatment with dexamethasone (0.2 mL/30 g) or Au@ES (25 and 50 mg/kg) effectively mitigated inflammatory features...They also impeded neutrophil activation, leading to reduced myeloperoxidase activity and lipid peroxidation, coupled with increased glutathione levels. In conclusion, ES and Au@ES exhibit potent efficacy in counteracting inflammation and oxidation processes in an experimental Crohn's disease model, suggesting their potential as alternative therapeutic strategies for IBD.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Biomarker, Review, Journal: Cancer-associated neuromyelitis optica spectrum disorder: a case report with literature review. (Pubmed Central) - Aug 31, 2024
She was treated by intravenous methylprednisolone, plasma exchange, and intravenous immunoglobulin, followed by oral prednisolone...A small population of NMOSD has the aspect of paraneoplastic neurological syndrome. The age of onset in patients with cancer-associated NMOSD tends to be higher than that in individuals with NMOSD due to any causes of NMOSD.
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