- |||||||||| epinephrine / Generic mfg.
Journal: Declaration of allergens on food labels: overview of Latin AmericaDeclara (Pubmed Central) - Jun 27, 2024 Of the 19 countries reviewed, 89% require a declaration of allergens on their nutrition labeling, 76% have legislation that explicitly require a statement on trace allergens, and 82% follow Codex Alimentarius recommendations with some modifications of food categories. Three pending challenges in the Region are: requiring statements on allergens as a food safety measure; making progress toward improved labeling of trace allergens; and ensuring universal availability of epinephrine.
- |||||||||| atomoxetine / Generic mfg.
Journal: Atomoxetine Associated Activation Syndrome in Adolescent Patients With ADHD. (Pubmed Central) - Jun 27, 2024 Three pending challenges in the Region are: requiring statements on allergens as a food safety measure; making progress toward improved labeling of trace allergens; and ensuring universal availability of epinephrine. No abstract available
- |||||||||| atomoxetine / Generic mfg.
Retrospective data, Review, Journal: Systematic Review and Meta-Analysis: Pharmacological and Nonpharmacological Interventions for Disruptive Mood Dysregulation Disorder. (Pubmed Central) - Jun 27, 2024 With research indicating potential benefits for irritability from a combination of pharmacological interventions and therapy, including ATX, stimulants in conjunction with antipsychotic or antidepressant medications, and cognitive-behavioral techniques such as Dialectical Behavior Therapy for Children. Future large-scale RCTs are essential to further explore and refine these treatment approaches, especially focusing on the efficacy of combining pharmacological with effective nonpharmacological to improve irritability and overall outcomes in this population.
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Rexulti (brexpiprazole) / Lundbeck, Otsuka
Retrospective data, Review, Journal: Comparative Efficacy of Dopamine Partial Agonists by Doses for Treatment-Resistant Depression: A Systematic Review and Dose-Response Model-Based Network Meta-analysis. (Pubmed Central) - Jun 27, 2024 Future large-scale RCTs are essential to further explore and refine these treatment approaches, especially focusing on the efficacy of combining pharmacological with effective nonpharmacological to improve irritability and overall outcomes in this population. Aripiprazole, brexpiprazole, and cariprazine may be effective in treatment-resistant depression in that order, with the maximum effective doses at 5.5 mg, 1.6 mg, and 1.5 mg, respectively.
- |||||||||| methamphetamine / Generic mfg.
Journal: Injection preparation filtration and health concerns among indigenous people who inject methamphetamine. (Pubmed Central) - Jun 27, 2024 Results illustrate a positive relationship between filtration of the injection preparation and health concerns among Indigenous people who inject methamphetamine. This likely reflects the use of filtration to reduce harms, and further research is needed to understand the full scope of prevention that may be associated with filtration of methamphetamine injection preparations.
- |||||||||| Neffy (epinephrine) / ARS Pharma, Neurelis
Review, Journal: Development of neffy, an Epinephrine Nasal Spray, for Severe Allergic Reactions. (Pubmed Central) - Jun 27, 2024 adrenergic receptors, which are the key components of epinephrine's mechanism of action. The results suggest that neffy will provide a safe and effective needle-free option for the treatment of severe allergic reactions, including anaphylaxis.
- |||||||||| dobutamine / Generic mfg.
Review, Journal: Impact of Stress Echocardiography on Aortic Valve Stenosis Management. (Pubmed Central) - Jun 27, 2024 Low-flow, low-gradient AS represents a challenge both in diagnosis and in therapeutic management. Low-dose dobutamine SE is the recommended method to distinguish true-severe from pseudo-severe stenosis and assess the existence of flow (contractile) reserve to appropriately guide the need for intervention in these patients.
- |||||||||| atenolol / Generic mfg.
Journal: Sustainable Synthesis of the Active Pharmaceutical Ingredient Atenolol in Deep Eutectic Solvents. (Pubmed Central) - Jun 27, 2024 The scalability of the process to gram-scale production was successfully demonstrated, emphasizing its potential in industrial applications. Finally, the 'greenness' evaluation, performed using the First Pass CHEM21 Metrics Toolkit, highlighted the superiority in terms of the atom economy, the reaction mass efficiency, and the overall process mass intensity of the DES-based synthesis compared with the already existing methods.
- |||||||||| mirtazapine / Generic mfg., fluoxetine / Generic mfg., duloxetine / Generic mfg.
Journal: Comparison of Protective Effects of Antidepressants Mediated by Serotonin Receptor in A?-Oligomer-Induced Neurotoxicity. (Pubmed Central) - Jun 27, 2024 Furthermore, pretreatment with a 5-hydroxytryptamine 1A (5-HT1A) antagonist suppressed their effects, suggesting that the 5-HT1A receptor is involved in the antioxidant mechanism of the antidepressants' neuroprotection. These findings suggest the beneficial effects of antidepressant treatment in AD through the prevention of A?-induced oxidative stress.
- |||||||||| carvedilol / Generic mfg.
Journal: Drug solubilization in dog intestinal fluids with and without administration of lipid-based formulations. (Pubmed Central) - Jun 26, 2024 In this study we used molecular dynamics simulations to investigate solubilization patterns for three model drugs (carvedilol, felodipine and probucol) in dog intestinal fluid, a lipid-based formulation, and a mixture of both...Hence, a simplified dissolution medium suitable for in vitro studies provided physiologically relevant data for the systems explored. The computational protocol used in this study, coupled with in vitro studies using simulated intestinal fluids, can serve as a useful prescreening tool in the process of drug delivery strategies development.
- |||||||||| dobutamine / Generic mfg.
Journal: Perioperative dobutamine infusion in an African lion (Panthera leo). (Pubmed Central) - Jun 26, 2024 The computational protocol used in this study, coupled with in vitro studies using simulated intestinal fluids, can serve as a useful prescreening tool in the process of drug delivery strategies development. The lion was immobilized via intramuscular darts containing midazolam (0.033 mg/kg), medetomidine (50
- |||||||||| epinephrine / Generic mfg.
Clinical guideline, Journal: 2024 RECOVER Guidelines: Updated treatment recommendations for CPR in dogs and cats. (Pubmed Central) - Jun 26, 2024 Very low quality of evidence due to absence of clinical data in dogs and cats continues to compromise the certainty with which recommendations can be made. While the majority of the BLS and ALS recommendations remain unchanged, some noteworthy changes were made due to new evidence that emerged over the past 10
- |||||||||| atenolol / Generic mfg., methamphetamine / Generic mfg.
Journal: The Impact of Combined Sewer Overflows on Pharmaceutical and Illicit Drug Levels in New York/New Jersey Waterways. (Pubmed Central) - Jun 26, 2024 The most frequently detected analytes in 2021 were metoprolol (n?=?206, 92%), benzoylecgonine (n?=?151, 67%), atenolol (n?=?142, 63%), and methamphetamine (n?=?118, 53%), and in 2022 the most frequently detected were methamphetamine (n?=?194, 84%), atenolol (n?=?177, 76%), metoprolol (n?=?177, 76%), and 2-ethylene-1,5-dimethyl-3,3-diphenylpyrrolidine (n?=?159, 69%). Environ Toxicol Chem 2024;00:1-12.
- |||||||||| methamphetamine / Generic mfg.
Journal: Methamphetamine Removal from Aquatic Environments by Magnetic Microrobots with Cyclodextrin Chiral Recognition Elements. (Pubmed Central) - Jun 26, 2024 A dramatically enhanced capture of MA from water with active magnetically powered microrobots when compared with static passive CD-modified particles is demonstrated. This work shows the advantages of enhanced mass transfer provided by the externally controlled magnetic navigation in microrobots that together with the versatility of their design is an efficient strategy to clean polluted waters.
- |||||||||| timolol maleate ophthalmic solution / Generic mfg., propranolol / Generic mfg.
Journal: Beta-blockers for the treatment of infantile haemangiomas in premature infants. (Pubmed Central) - Jun 26, 2024 A retrospective study was performed to review the safety of oral propranolol and topical timolol in the treatment of IH in a cohort of preterm infants treated at our tertiary paediatric hospital. It was observed that there was an increased risk of adverse events amongst the preterm infants with chronic lung disease, retinopathy of prematurity and gastroesophageal reflux, when treated with oral propranolol.
- |||||||||| Journal: Treating Benzodiazepine Withdrawal in a Bridge Clinic. (Pubmed Central) - Jun 26, 2024
Managing benzodiazepine withdrawal with a 4- to 6-week intensive outpatient taper in patients with benzodiazepine and opioid use disorders is challenging. More work is needed to refine patient selection, balance safety risks with feasibility, and study long-term, patient-centered outcomes.
- |||||||||| olanzapine / Generic mfg., quetiapine / Generic mfg., clozapine / Generic mfg.
Journal: Pneumonia Risk, Antipsychotic Dosing, and Anticholinergic Burden in Schizophrenia. (Pubmed Central) - Jun 26, 2024 Moreover, monotherapy antipsychotics and antipsychotics with high anticholinergic burden are associated with increased pneumonia risk in a dose-dependent manner. These findings call for prevention strategies aimed at patients with schizophrenia requiring high-risk antipsychotics.
- |||||||||| methamphetamine / Generic mfg.
Preclinical, Journal: Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration. (Pubmed Central) - Jun 26, 2024 Lactobacillus changes were significantly negatively correlated with total MA uptake in rats (Pearson R?=??-?0.666, p?=?0.035; Spearman R?=??-?0.721, p?=?0.023), whereas its change was also highly negatively correlated with total MA uptake in rhesus monkeys (Pearson R?=??-?0.882, p?=?0.118; Spearman R?=??-?1.000, p?=?0.083), although this was not significant. These findings suggest that MA causes significant alterations in GM in both rhesus monkeys and rats and that the genus Lactobacillus might be a common therapeutic target for MA uptake prevention across the species.
- |||||||||| propranolol / Generic mfg.
Review, Journal: Diagnosis and Management of Fetal Arrhythmias in the Current Era. (Pubmed Central) - Jun 26, 2024 Diagnosis and management of fetal arrhythmias have changed over the past 40-50 years since propranolol was first used to treat fetal tachycardia in 1975 and when first attempts were made at in utero pacing for complete heart block in 1986...Pharmacologic management of fetal arrhythmias remains one of the most successful achievements of fetal intervention. Patience, vigilance, and multidisciplinary collaboration are key to successful diagnosis and treatment.
- |||||||||| propranolol / Generic mfg.
Journal: Early Screening for Long QT Syndrome and Cardiac Anomalies in Infants: A Comprehensive Study. (Pubmed Central) - Jun 26, 2024 Treatment options included propranolol (39.8%), nadolol (22.2%), inderal (11.1%), metoprolol (11.1%), and no treatment (16.7%)...(4) This screening approach has demonstrated effectiveness in the early identification of LQTS and other cardiac rhythm anomalies, with additional identification of mutations and/or prolonged QTc intervals in family members. Identifying other ECG abnormalities and congenital heart malformations further enhances the benefits of the screening.
- |||||||||| epinephrine / Generic mfg.
Preclinical, Journal: Ischemic Post-Conditioning in a Rat Model of Asphyxial Cardiac Arrest. (Pubmed Central) - Jun 26, 2024 Identifying other ECG abnormalities and congenital heart malformations further enhances the benefits of the screening. IPoC demonstrated no harm in a model of short arrest using a new arrest etiology for CPR based IPoC intervention in a rat model.
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