Adrenergic Receptor 

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  • ||||||||||  dobutamine / Generic mfg.
    Journal:  Pulmonary 4D-flow MRI imaging in landrace pigs under rest and stress. (Pubmed Central) -  May 31, 2024   
    The current study showed that pulmonary flow and velocity assessed through 4D-flow MRI follow the physiological alterations during cardiac cycle and after stress induced by dobutamine. A clinical translation to assess pulmonary diseases with 4D-flow MRI under stress conditions needs investigation.
  • ||||||||||  risperidone / Generic mfg., olanzapine / Generic mfg., quetiapine / Generic mfg.
    Journal:  Atypical Antipsychotic Prescribing in Australian Children and Adolescents: A Survey of Medical Practitioners. (Pubmed Central) -  May 31, 2024   
    Children and adolescents were prescribed a number of atypical antipsychotics for a variety of indications, with variable perceived confidence and a relatively heavy reliance on "own or peer experience" as opposed to good quality evidence. Challenges exist for both prescribers and policymakers, and further "head-to-head" studies are needed in this age group to ensure that a balance is maintained between therapeutic benefit and safety.
  • ||||||||||  quetiapine / Generic mfg.
    Journal:  Cerebral Anoxia in an 18-year-old Patient Being Treated for Major Depressive Disorder: How Forensic Detective Work Uses Medical Knowledge Including Clinical Pharmacology to Solve Cases. (Pubmed Central) -  May 31, 2024   
    Second, the patient had been switched from extended to immediate-release quetiapine, resulting in a doubling of the peak concentration of the drug, which produced higher occupancy of alpha-1 adrenergic, histamine-1, and dopamine-2 receptors, causing a further drop in his blood pressure as well as increased sedation and impairment of his gag reflex...These 3 factors together led the patient to aspirate and suffer a hypoxic brain injury after an episode of vomitus. This column explains the process by which the cause of this sad outcome was determined, how it was related to a dereliction of duty to the patient, and how other proposed causes were ruled out.
  • ||||||||||  tamsulosin / Generic mfg.
    Trial initiation date, Trial primary completion date, Surgery:  PrePOURTS: Prevention of Post Operative Urinary Retention After Thoracic Surgery Trial (clinicaltrials.gov) -  May 31, 2024   
    P2,  N=60, Not yet recruiting, 
    Our findings suggest that antiplatelet drug monitoring with LT-LA and PFA-100 may be useful in high-risk and complicated cardiovascular patients. Initiation date: Apr 2024 --> Jul 2024 | Trial primary completion date: Apr 2025 --> Dec 2024
  • ||||||||||  Natacyn (natamycin) / Novartis
    Review, Journal:  Fostering the unleashing potential of nanocarriers-mediated delivery of ocular therapeutics. (Pubmed Central) -  May 30, 2024   
    Taken together, in a nutshell, this book chapter provides a comprehensive perspective on the numerous facets of ocular drug delivery with a special focus on bioactive nanocarrier-based approaches, including the difficulties and constraints involved in the fabrication of nanocarriers. This also provides the detailed invention and applications of nanocarriers for the ophthalmic delivery of therapeutics.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Crystal Clear: Metal-Organic Frameworks Pioneering the Path to Future Drug Detox. (Pubmed Central) -  May 30, 2024   
    stacking in a vast majority of considered cases. The performance and influence on the living organisms were evaluated throughout the in vitro and in vivo experiments, indicating that Zr-based MOFs could serve as efficient, organic, safe drug adsorbents.
  • ||||||||||  aripiprazole / Generic mfg.
    Retrospective data, Journal:  Aripiprazole as protector against COVID-19 mortality. (Pubmed Central) -  May 30, 2024   
    Aripiprazole has been shown to have a differentiated beneficial effect in protecting against fatal clinical outcome in COVID-19 infected individuals. We speculate that the differential effect of aripiprazole on controlling immunological pathways and inducible inflammatory enzymes, that are critical in COVID19 illness, may be associated with our findings herein.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Methamphetamine Use Disorder and Inflammation: A Case-Control Study. (Pubmed Central) -  May 30, 2024   
    We speculate that the differential effect of aripiprazole on controlling immunological pathways and inducible inflammatory enzymes, that are critical in COVID19 illness, may be associated with our findings herein. The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.
  • ||||||||||  FIBROMYALGIA MANAGEMENT IN LATIN AMERICA: DATA FROM THE FIBROLATAM SURVEY () -  May 29, 2024 - Abstract #EULAR2024EULAR_4551;    
    The management of fibromyalgia in the region follows the recommendations of the currently available guidelines; prioritizing multimodal therapies and the use of duloxetine, amitriptyline pregabalin, cyclobenzaprine and to a lesser extent opioids. Most rheumatologists considered the use of opioids inappropriate.
  • ||||||||||  trazodone ER / Generic mfg., mirtazapine / Generic mfg.
    WHAT TYPES OF FIBROMYALGIA AND CHRONIC PAIN PATIENTS BENEFIT FROM MULTIMODAL INPATIENT PAIN PROGRAMS? () -  May 29, 2024 - Abstract #EULAR2024EULAR_4334;    
    Our models indicate that social context, along with psychotropic and opioid medication are key determinants in the short-term response to multimodal inpatient pain programs. However, the full spectrum of benefits from multimodal treatments may extend beyond pain relief and are not fully measurable within a two-week timeframe.
  • ||||||||||  epinephrine / Generic mfg.
    Journal, Surgery:  New Frontiers in Wide-Awake Surgery. (Pubmed Central) -  May 29, 2024   
    Three disruptive innovations are changing the landscape of surgery: (1) minimally painful injection of large-volume, low-concentration tumescent local anesthesia eliminates the need for sedation for many procedures over the entire body; (2) epinephrine vasoconstriction in tumescent local anesthesia is a good alternative to the tourniquet and proximal nerve blocks in extremity surgery (sedation for tourniquet pain is no longer required for many procedures); and (3) evidence-based sterility and the elimination of sedation enable many larger procedures to move out of the main operating room into minor procedure rooms with no increase in infection rates. This continuing medical education article explores some of the new frontiers in which these changes affect surgery all over the body.
  • ||||||||||  Bystolic (nebivolol) / Menarini, AbbVie
    Biomarker, Journal:  (NDMA) METFORMIN AND (NTTP) SITAGLIPTIN INDUCED CUTANEOUS MELANOMAS: LINKS TO NITROSOGENESIS, NITROSO-PHOTOCARCINOGENESIS, ONCOPHARMACOGENESIS AND THE METABOLIC REPROGRAMMING. (Pubmed Central) -  May 29, 2024   
    Similarly to cutaneous melanomas occurring (and published in the scientific literature) after combined intake (or monomedication) of/ between ranitidine, valsartan, olmesartan, candesartan, telmisartan, irbesartan, losartan, enalapril, lisinopril, perindopril, hydrochlorothiazide, nifedipine, amlodipine, propafenone, bisoprolol, nebivolol, melitracen and a number of others, we inform about another rare but not unexpected clinical observation: occurrence of cutaneous melanomas after taking another class of drugs- oral antidiabetic ones...The data shared in patients one and two in the presented scientific work are confirmatory in relation to the potential pathogenetic action of nitrosamine contaminated drugs such as 1) bisoprolol/ nebivolol/ candesartan/ hydrochlorothiazide and amlodipine, as well as 2) furosemide in the direction of cutaneous melanoma...Apart from the "cancer-generating benefit", of course, which is already widely known. And let us not forget that: "A lie stops being a lie and becomes a truth the moment it is officially refuted".
  • ||||||||||  propranolol / Generic mfg.
    Trial completion, Trial completion date:  PeP-RALP: Perioperative Propranolol During Prostatectomy to Decrease Cancer Recurrence (clinicaltrials.gov) -  May 29, 2024   
    P2,  N=40, Completed, 
    The promising outcomes of this study underscore the potential for future applications, leveraging the advantages of electrochemical sensors, including affordability, rapid response, and user-friendly operation. Recruiting --> Completed | Trial completion date: Oct 2023 --> Jan 2024
  • ||||||||||  Review, Journal:  Challenges in the treatment of dysthymia: a narrative review. (Pubmed Central) -  May 28, 2024   
    However, these findings remain inconclusive due to the limited number of studies and substantial methodological limitations prevalent in a significant proportion of them. Limitations include factors like small sample sizes, the absence of placebo comparisons, and a lack of study blinding.
  • ||||||||||  citalopram / Generic mfg., olanzapine / Generic mfg., quetiapine / Generic mfg.
    Journal, Adverse events, Real-world evidence, Real-world:  A real-world pharmacovigilance study of drug-induced QT interval prolongation: analysis of spontaneous reports submitted to FAERS. (Pubmed Central) -  May 28, 2024   
    Our study offered a list of drugs that frequently caused QT interval prolongation based on the FAERS system, along with a description of some risk profiles for QT interval prolongation brought on by these drugs. When prescribing these drugs in clinical practice, we should closely monitor the occurrence of ADE for QT interval prolongation.
  • ||||||||||  Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
    New P3 trial:  AIRSA001: Anti-Inflammatory Reliever South Africa (clinicaltrials.gov) -  May 28, 2024   
    P3,  N=1038, Not yet recruiting, 
  • ||||||||||  CoAprovel (irbesartan hydrochlorothiazide) / Sanofi, Prezista (darunavir) / J&J
    Journal:  Comparing the adsorption of micropollutants on activated carbon from anaerobically stored, organics-depleted, and nitrified urine. (Pubmed Central) -  May 27, 2024   
    In addition, we showed that the relative pharmaceutical removal in all solutions was independent of the initial pharmaceutical concentration unless the background organics matrix changed considerably. We conclude that removal of micropollutants in GAC columns from organics-depleted urine can be performed without clogging, but with the drawback of a higher carbon usage compared to removal from nitrified urine.
  • ||||||||||  Biomarker, Journal, IO biomarker:  A Pharmacogenomics-Based In Silico Investigation of Opioid Prescribing in Post-operative Spine Pain Management and Personalized Therapy. (Pubmed Central) -  May 27, 2024   
    Protein-Drug Interaction (PDI) assessment showed that multiple drugs, including Ibuprofen, Nicotine, Tramadol, Haloperidol, Ketamine, L-Glutamic Acid, Caffeine, Citalopram, and Naloxone, had more than one interaction...Notably, 10 chemicals, including carbamylhydrazine, tetrahydropalmatine, Terazosin, beta-methylcholine, rubimaillin, and quinelorane, demonstrated dual interactions with the aforementioned target genes...The insights from this report can be applied in exome analysis as a pharmacogenomics (PGx) panel for pain susceptibility, facilitating individualized opioid prescribing through genotyping of related variants. The article also points out that African Americans represent an important group that displays a high catabolism of opioids and suggest the need for a personalized therapeutic approach based on genetic information.
  • ||||||||||  tranexamic acid IV / Generic mfg., propranolol / Generic mfg.
    Journal:  Management of non-cirrhotic variceal bleeding in pregnant women with Budd-Chiari syndrome in the early second trimester: A case report. (Pubmed Central) -  May 27, 2024   
    The patient was given strict fluid resuscitation and three packed red cells transfusion to stabilize the hemodynamic. Bleeding was successfully managed by intravenous octreotide, tranexamic acid, and vitamin K. The case highlights that the management of non-cirrhotic variceal bleeding in pregnancy with Budd-Chiari syndrome requires a multidisciplinary approach and regular fetal monitoring to ensure optimal outcomes.
  • ||||||||||  imipramine / Generic mfg.
    Journal:  Clinical values of serum neuropeptide changes in patients with chronic urticaria complicated with allergic rhinitis. (Pubmed Central) -  May 26, 2024   
    Overall, this study confirms the potential of functionalized polymers in ASD formulations, while the challenge of improving dissolution performance in these ASDs remains an area of further development. Our data indicates that substance P, VIP, and neuropeptide Y levels before treatment correlate strongly with the treatment outcomes of the patients, which could potentially serve as a decision support tool in clinical management of chronic urticaria complicated with allergic rhinitis.