Adrenergic Receptor 

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  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Biomarker, Review, Journal:  Exploring the impact of pharmacogenetics on personalized medicine: A systematic review. (Pubmed Central) -  Jun 9, 2024   
    The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in personalized medicine, but further research is required.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Blocking sigmar1 exacerbates methamphetamine-induced hypertension. (Pubmed Central) -  Jun 9, 2024   
    Our results suggest that Sigmar1 is involved in METH-induced hypertension and vascular fibrosis by blocking the activation of the TGF-?/Smad2/3 signaling pathway. Accordingly, Sigmar1 may be a novel therapeutic target for METH-induced hypertension and vascular fibrosis.
  • ||||||||||  Retrospective data, Review, Journal:  Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysis. (Pubmed Central) -  Jun 9, 2024   
    Subgroup analyses and heterogeneity figures point to factors not accounted for by diagnosis, medication, or trial-related characteristics, and might indicate subjective factors on the part of investigators, patients, or both. Residual or re-emerging psychopathology needs to be considered when interpreting the results, but our findings can inform clinicians and patients about the probable extent of antidepressant discontinuation symptoms without causing undue alarm.
  • ||||||||||  propranolol / Generic mfg.
    Journal:  Chronic activation of ?-adrenergic receptors leads to tissue water and electrolyte retention. (Pubmed Central) -  Jun 8, 2024   
    These isoproterenol-induced changes were reduced by propranolol, a non-selective beta-receptor inhibitor...Significance Statement We have shown that chronic ?-AR stimulation causes cardiac hypertrophy associated with sodium-driven water retention in the heart and increases the accumulation of body sodium, potassium and water at the tissue level. This characterisation of the ?-AR-induced abnormalities in electrolyte and water balance at the tissue level improves our understanding of the roles of ?-AR in physiology and pathophysiology and the pharmacological effects of ?-AR inhibitors.
  • ||||||||||  Torin1 / InvivoGen
    Journal:  Aging-related Alterations in mTOR Signaling Promote Platelet Hyperreactivity and Thrombosis. (Pubmed Central) -  Jun 8, 2024   
    This characterisation of the ?-AR-induced abnormalities in electrolyte and water balance at the tissue level improves our understanding of the roles of ?-AR in physiology and pathophysiology and the pharmacological effects of ?-AR inhibitors. Aging-related changes in mTOR phosphorylation enhance Rac1 and p38 activation, to enhance thromboxane generation, platelet hyperactivity and thrombosis.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Geographic and Racial/Ethnic Differences in Access to Methamphetamine Detoxification Services, United States, 2021. (Pubmed Central) -  Jun 7, 2024   
    During an unprecedented national methamphetamine crisis, access to a critical health care service was disproportionately lower in communities that were predominately Black and Hispanic. We orient our findings around a discussion of health disparities, residential segregation, and the upstream causes of the systematic exclusion of minoritized communities from health care.
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  Alpha-Gal syndrome as a novel food allergy: a case report study. (Pubmed Central) -  Jun 7, 2024   
    Treatment protocols for hypersensitivity reactions are contingent upon the severity of the reaction, with therapies ranging from antihistamine medications to the administration of epinephrine...Some individuals with AGS can safely consume dairy products without any adverse reactions, while others are advised to abstain due to potential allergenic responses. This variability in dairy tolerance among AGS patients warrants further investigation.
  • ||||||||||  propranolol / Generic mfg.
    Journal:  Inhibition of ?2-adrenergic receptor regulates necroptosis in prostate cancer cell. (Pubmed Central) -  Jun 7, 2024   
    Furthermore, cells treated with propranolol exhibited necrotic morphology as observed by transmission electron microscopy...MLKL and RIPK3 levels were significantly higher in xenograft tumor sections from the sh-?2AR group compared to levels in the sh-NC group. To conclude, our research indicates the proliferation of PC-3 and DU-145 cprostate cancer cells can be suppressed by inhibiting ?2AR, and this occurs through the RIP/MLKL-mediated pathway of necroptosis.
  • ||||||||||  Journal:  Effect of ultra-high-density polyethylene microplastic on the sorption and biodegradation of organic micropollutants. (Pubmed Central) -  Jun 6, 2024   
    Growth of a biofilm on the polyethylene particles had a beneficial effect on the sorption of bromoxynil, caffeine and chloridazon and on the biodegradation of irbesartan, atenolol and benzotriazole...These results showed that ultra-high density polyethylene particles can affect both in a positive and negative way for the abiotic and biotic removal of organic micropollutants in wastewater. This project highlights the need for further investigation regarding the interaction between microplastics and organic micropollutants in the aquatic environment.
  • ||||||||||  methamphetamine / Generic mfg.
    Preclinical, Journal:  The gut microbiota contributes to methamphetamine-induced reproductive toxicity in male mice. (Pubmed Central) -  Jun 6, 2024   
    FMT conveyed similar reproductive damage from METH-treated mice to healthy recipient mice. The aforementioned findings suggest that the gut microbiota plays a substantial role in facilitating the reproductive toxicity caused by METH, thereby highlighting a prospective avenue for therapeutic intervention in the context of METH-induced infertility.
  • ||||||||||  atenolol / Generic mfg., propranolol / Generic mfg., epinephrine / Generic mfg.
    Preclinical, Journal:  Role of Phenylethanolamine-N-methyltransferase on Nicotine-Induced Vasodilation in Rat Cerebral Arteries. (Pubmed Central) -  Jun 5, 2024   
    These results suggest that NE may be methylated by PNMT to form epinephrine and cause the release of NO and vasodilation. These results provide further evidence supporting the physiological significance of the axo-axonal interaction mechanism in regulating brainstem vascular tone.
  • ||||||||||  pregabalin / Generic mfg., epinephrine / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  A Novel Approach in Treating Phantom Limb Pain Using Erector Spinae Plane Block. (Pubmed Central) -  Jun 5, 2024   
    In literature, ESP block has been used as a regional technique for shoulder disarticulation surgery and other neuropathic pain conditions, but no account has shown its use for PLP treatment. The procedure was successfully done to alleviate the upper extremity phantom limb pain, significantly reduce analgesic requirements, and improve tolerance of physical therapy and overall quality of life.
  • ||||||||||  epinephrine / Generic mfg.
    Preclinical, Journal:  Research on the mechanism of Guanyu Zhixie Granule in intervening gastric ulcers in rats based on network pharmacology and multi-omics. (Pubmed Central) -  Jun 5, 2024   
    GYZXG could intervene in GU by regulating serum metabolites such as Glycocholic acid, Epinephrine, Ascorbic acid, and Linoleic acid, and by influencing bile secretion, the HIF-1 signaling pathway, and adipocyte catabolism...The changes in metabolites within metabolic pathways and the alterations in RELA, HIF1A, and EGF mRNA levels in RT-qPCR experiments provide further confirmation of this result. GYZXG can intervene in GU induced by anhydrous ethanol in rats by regulating gut microbiota and metabolic disorders, providing a theoretical basis for its use in GU intervention.
  • ||||||||||  aripiprazole / Generic mfg.
    Journal:  "It's been a long time since I drank like that": A case report of binge drinking associated with aripiprazole. (Pubmed Central) -  Jun 5, 2024   
    Individuals who engage in binge drinking demonstrate consistent impulse control deficits that are unrelated to the rewarding effects of alcohol. Aripiprazole may be related to this patient's return to binge drinking from an ICP standpoint rather than driven by alcohol cravings as other psychosocial factors remained stable throughout this time.
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Journal:  Clinical Implications of a Formulary Conversion From Budesonide/formoterol to Fluticasone/salmeterol at a VA Medical Center. (Pubmed Central) -  Jun 5, 2024   
    Patients with COPD that transitioned from budesonide/formoterol to fluticasone/salmeterol during the formulary conversion yield no clinical or statistically significant change in their clinical outcomes. Switching between these inhalers in the same therapeutic class may not impact clinical efficacy of the therapy for veterans with COPD but some intolerances and treatment failures should be expected.
  • ||||||||||  risperidone / Generic mfg., quetiapine / Generic mfg.
    Journal:  Idiopathic young-onset Fahr's disease with schizophrenia-like presentation: a case report. (Pubmed Central) -  Jun 5, 2024   
    This case underscores the importance of conducting comprehensive imaging studies at the time of initial psychiatric diagnosis, regardless of the apparent typicality of the presentation. Additionally, it emphasizes the need for patience and adherence to the "Start Low and Go Slow" approach in medication management to minimize the risk of exacerbating psychiatric symptoms and aggression.
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  Perfusion Dynamics during Secondary Flap Debulking with Liposuction. (Pubmed Central) -  Jun 4, 2024   
    ?Secondary debulking of a lower extremity flap can be safely and efficiently performed through liposuction combined with peripheral excision of the defatted flap in a single stage. Perfusion studies may show a misleading hypoperfusion of the defatted flap, which does not accurately predict subsequent necrosis or complications.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Recreational substance use among international travellers. (Pubmed Central) -  Jun 4, 2024   
    These findings emphasize the importance of addressing this issue to mitigate both health and well-being problems among travellers whilst promoting safer and more responsible travel experiences. In the context of travel health practices, practitioners should counsel travellers whose itineraries may include substance abuse, informing them about associated risks and consequences.
  • ||||||||||  epinephrine / Generic mfg.
    Clinical, Journal:  Epinephrine Dosing Intervals Are Associated With Pediatric In-Hospital Cardiac Arrest Outcomes: A Multicenter Study. (Pubmed Central) -  Jun 4, 2024   
    In the context of travel health practices, practitioners should counsel travellers whose itineraries may include substance abuse, informing them about associated risks and consequences. In patients receiving at least two doses of epinephrine, dosing intervals less than 3 minutes were not associated with neurologic outcome but were associated with sustained ROSC and shorter CPR duration.