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- | Preclinical, Journal: Evaluation of Lipids and Lipid-Related Transcripts in Human and Ovine Theca Cells and an in Vitro Mouse Model Exposed to the Obesogen Chemical Tributyltin. (Pubmed Central) - Apr 21, 2024
TBT induced dyslipidemia in primary human and ovine theca cells, which may be responsible for some of the TBT-induced fertility dysregulations reported in rodent models of TBT exposure. https://doi.org/10.1289/EHP13955.
- | Journal: Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking. (Pubmed Central) - Nov 20, 2023
Moreover, LXR agonists rescued the aberrant cholesterol distribution and mitigated the degeneration of SPG11 disease-mutated neurons. Taken together, our data demonstrate impaired cholesterol trafficking underlying axonal degeneration of SPG11 human neurons, and highlight the therapeutic potential of LXR agonists for SPG11 through restoring cholesterol homeostasis.
- | Journal: A caveolin-1 dependent Glucose-6-phosphatase trafficking contributes to hepatic glucose production. (Pubmed Central) - Mar 24, 2023
Our data evidence a pathway of glucose production that relies on Cav1-dependent trafficking of G6PC1 to the plasma membrane. This reveals a new cellular regulation of G6Pase activity that contributes to hepatic glucose production and glucose homeostasis.
- | Torin1 / InvivoGen
Journal: Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure. (Pubmed Central) - Mar 2, 2023
In vivo, mTORC1 inhibitor (Torin1, 4?mg?kg, i.p., every other day for 3 weeks) alleviated the cholesterol trafficking disorder-mediated hepatic lipotoxicity via upregulating the molecular machinery of lysosomes and mitochondria contacts mediated by NPC1 and TSPO interaction in the low dose of AFB1 exposure. Altogether, our data suggested a novel mechanism that lysosomal Rab7a-mTORC1 signaling determines the cholesterol trafficking regulated by NPC1-TSPO from the lysosome to mitochondria, which promotes hepatic lipotoxicity via lysosomal quality control and mitochondria-dependent necroptosis signaling pathways in chemical mixture exposure.
- || Review, Journal: Systemic consequences of abnormal cholesterol handling: Interdependent pathways of inflammation and dyslipidemia. (Pubmed Central) - Sep 14, 2022
In this review, we will discuss the overlapping pathways connecting cholesterol trafficking with innate immunity and present evidence that cholesterol accumulation in the bone marrow may drive systemic inflammation in chronically inflamed pathologies. Lastly, we will review the current therapeutic strategies that target both inflammation and cholesterol transport, and how biologic therapy restores lipoprotein function and mitigates the immune response.
- Deficient NNT Reduces Mitochondrial Mass and Cholesterol Trafficking in the Adrenal Cortex, Accumulating ROS and Impairing Steroids Production (ENDOExpo, Pod 7) - Jul 16, 2022 - Abstract #ENDO2022ENDO_2972;
Learning Objective 1: To understand the role of the mitochondrial function in adrenal cortex function and steroidogenesis Learning Objective 2: To understand the mechanisms by which loss-of-function mutations in the inner mitochondrial enzyme NNT results in primary adrenal insufficiency. Science Topic(s) for Adrenal (excluding mineralocorticoids): General Adrenal