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- | Journal: Lactate accelerates calcification in VSMCs through suppression of BNIP3-mediated mitophagy. (Pubmed Central) - Jul 19, 2020
In addition, BNIP3-mediated mitophagy played a protective role against VSMC calcification in the presence of lactate. This study suggests that lactate accelerates osteoblastic phenotype transition of VSMC and calcium deposition partly through the BNIP3-mediated mitophagy deficiency induced oxidative stress and apoptosis.
- | chloroquine phosphate / Generic mfg.
Journal: Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation. (Pubmed Central) - Jul 19, 2020
Addition of late stage autophagy inhibitor, chloroquine (CQ), further enhanced LC3-II and p62 level, as well as increased autophagosome accumulation, suggesting a blockage of autophagic flux by GLP in CRC cells...Finally, GLP inhibited tumor growth and also inhibited autophagic flux in vivo. These results unveil new molecular mechanism underlying anti-cancer effects of GLP, suggesting that GLP is a potent autophagy inhibitor and might be useful in anticancer therapy.
- | Journal: Nerve growth factor induced farnesoid X receptor upregulation modulates autophagy flux and protects hepatocytes in cholestatic livers. (Pubmed Central) - Jul 19, 2020
These findings support that NGF modulates autophagy flux via FXR upregulation and protects hepatocytes against BA-induced cytotoxicity. NGF/FXR axis is a novel therapeutic target for treatment of cholestatic liver diseases.
- | Journal: Systematic investigation of intracellular trafficking behavior of one-dimensional alumina nanotubes. (Pubmed Central) - Jul 19, 2020
Blocking endolysosomal pathways using autophagy inhibitors prevented the degradation of AANTs through lysosomes. Our results add new insights into the pathways and mechanisms of intracellular trafficking of AANTs, and suggest that intracellular trafficking and lysosomal degradation are highly interdependent and important for efficient drug delivery, and should be evaluated together for drug carrier development.
- | paclitaxel / Generic mfg.
Journal, Cancer stem cells: The nanoparticle-facilitated autophagy inhibition of cancer stem cells for improved chemotherapeutic effects on glioblastomas. (Pubmed Central) - Jul 19, 2020
More importantly, it was found that the combined delivery system FA-BSA-NP exhibited the most effective cell apoptosis. Our findings demonstrated that drug-loaded albumin nanoparticles could facilitate a combination of chemotherapy and autophagy inhibition for effective glioma therapy.
- | sirolimus / Generic mfg.
Journal: Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication. (Pubmed Central) - Jul 19, 2020
Moreover, activation of autophagy by rapamycin or overexpressing LC3 decreased SGIV replication. These results provide an antiviral strategy from the perspective of autophagy.
- [VIRTUAL] THE INTERPLAY OF ATG16L1 AND XBP-1 CRUCIALLY COORDINATES EPITHELIAL DNA DAMAGE RESPONSES AND PROTECTS FROM INTESTINAL CARCINOGENESIS (Hall 1) - Jul 19, 2020 - Abstract #UEGW2020UEGW_5846;
We conclude that dysfunctional macro-autophagy, which is associated with IBD, can promote DNA-damage induced cell death but also increase epithelial proliferation. In addition we show that UPR and autophagy mutually fine tune p53-dependent DNA damage response to protect from intestinal carcinogenesis.
- [VIRTUAL] GASTRIC NON-HELICOBACTER COMMENSAL BACTERIA AND THEIR PRODUCTS, SHORT-CHAIN FATTY ACIDS, COULD ENHANCE CD44V9-POSITIVE GASTRIC CANCER STEM-LIKE CELL DEVELOPMENT IN H. PYLORI-INFECTION (Hall 6) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1977;
In addition we show that UPR and autophagy mutually fine tune p53-dependent DNA damage response to protect from intestinal carcinogenesis. Butyrate-releasing gastric commensal bacteria could influence the risk of gastric cancer through promotion of the development of CAPZA1-overexpressing epithelial cells in the gastric mucosa with H. pylori infection.
- | Preclinical, Journal: Plumbagin induces autophagy and apoptosis of SMMC-7721 cells in vitro and in vivo. (Pubmed Central) - Jul 18, 2020
In contrast, administration of the apoptosis inhibitor Z-VAD did not affect PL-induced autophagy. Taken together, our findings strongly suggest that PL is a promising drug with significant antitumor activity in HCC.
- | hydroxychloroquine / Generic mfg.
Journal, Cytokine storm: Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage. (Pubmed Central) - Jul 18, 2020
Taken together, our findings strongly suggest that PL is a promising drug with significant antitumor activity in HCC. These results suggest that autophagy plays an important role in the pathogenesis of sepsis and could serve as a potential therapeutic target for sepsis.
- | modafinil / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal: Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation. (Pubmed Central) - Jul 18, 2020
These results suggest that autophagy plays an important role in the pathogenesis of sepsis and could serve as a potential therapeutic target for sepsis. The novel mechanism may deepen our knowledge of modafinil in the clinical therapy of impaired memory caused by sleep loss.
- | Journal: Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells. (Pubmed Central) - Jul 18, 2020
The novel mechanism may deepen our knowledge of modafinil in the clinical therapy of impaired memory caused by sleep loss. Autophagy might play a role as a self-defense mechanism in hypoxia-treated colon cancer cells, and its inhibition could be a promising strategy for the adjuvant chemotherapy of colon cancer.
- | Journal: Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis. (Pubmed Central) - Jul 15, 2020
Furthermore, we demonstrated that echinatin had a significant antitumor effect in the tumor xenograft model and markedly suppressed cell migration and invasion abilities of ESCC cells in a dose-dependent manner. Our findings provide the first evidence that echinatin could be a novel therapeutic strategy for treating ESCC.
- | chloroquine phosphate / Generic mfg.
Journal: Sphingosine-1-phosphate promotes pulmonary artery smooth muscle cells proliferation by stimulating autophagy-mediated E-cadherin/CDH1 down-regulation. (Pubmed Central) - Jul 15, 2020
Prior silencing TRAF2 or BECN1 using siRNA or pre-incubation of cells with autophagy inhibitor chloroquine phosphate (CQ) suppressed S1P-induced autophagy activation and subsequent CDH1 degradation and further PASMCs proliferation. Taken together, our study indicates that S1P promotes the activation of autophagy by accelerating TRAF2-mediated BECN1 up-regulation and ubiquitination, which in turn results in CDH1 reduction and contributes to PASMCs proliferation.
- | Journal: Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. (Pubmed Central) - Jul 15, 2020
Our findings disclose a novel autophagy/apoptosis-regulatory pathway that is composed of mir-20a-5p, circ-ADAM9, PTEN, and ATG7. Circ-ADAM9 is a potential novel target for regulating the function of diabetic EPCs and angiogenesis.
- azathioprine orodispersible / Generic mfg.
[VIRTUAL] Homozygous mutations of ARFGAP1 gene in severe sarcoidosis (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_3737;
RAC1 is one of the main targets of azathioprine (AZA), an immunosuppressive drug used in corticosteroid (CS) refractory sarcoidosis...We would hypothesize that ARFGAP1 mutated isoforms have lost their inhibitory function with a consequence of hyperactivation of RAC1 thus leading to autophagy inhibition. Autophagy disruption seems to be an interesting element of pathophysiology in sarcoidosis, previously evoked in WES studies and through the efficacy of autophagy modulating drug during sarcoidosis.
- sirolimus / Generic mfg.
[VIRTUAL] Cigarette-decreased NAD/SIRT1 aggravates pulmonary fibrosis by promoting senescence of alveolar type 2 cells through autophagy inhibition and mitochondrial oxidative stress induction (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_223;
After senescent markers were increased, they were treated with bleomycin (BLM) and smoke for 4 weeks...Then, effects of autophagy inducer rapamycin, SIRT1 activator SRT1720, NAD+ precursor NMN, PARP1 inhibitor olaparib and mitochondrial ROS (mtROS) scavenger, mitoquinone (MQ) were examined...Conclusion Cigarette-decreased NAD+/SIRT1 resulting from PARP1 activation induce AT2 senescence by inhibiting autophagy, which further activate PARP1 via mtROS-induced DNA damage by impairing mitophagy. Therefore, there is a positive loop in cigarette-induced senescence, which may play a key role in lung fibrosis.
- [VIRTUAL] Autophagy Regulates the Therapeutic Potential of Adipocyte Stem Cells in LPS-Induced Pulmonary Microvascular Barrier Damage (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_7516;
Autophagy is a positive mediating factor in the paracrine process of ADSC, the regulation of autophagy might be a potential strategy for modulating the treatment efficacy of ADSCs in lung injury. These results are helpful for illuminating the role and mechanism of ADSC paracrine effects and developing effective therapies in acute lung injury.
- sirolimus / Generic mfg.
[VIRTUAL] Autophagy Mediates the High Mobility Group Box 1 (HMGB1)-Compromised Macrophage Phagocytosis in Hyperoxia (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5938;
Inhibition of hyperoxia-induced autophagy with chloroquine significantly improved macrophage phagocytosis. Taken together, these data suggest that autophagy mediates HMGB1-compromised phagocytosis in hyperoxic macrophages.
- hydroxychloroquine / Generic mfg.
[VIRTUAL] Endothelial Autophagy and the Lung Tumor Microenvironment (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5774;
This stimulation does not appeared to be related to acidic or poor nutrient conditions suggesting an active mediator process. Intact autophagy is necessary for endothelial cells to invade the extracellular matrix as well as for the expression of active endothelial MMP14.
- sirolimus / Generic mfg., norethindrone / Generic mfg.
[VIRTUAL] Treatment as Old as Time for Pulmonary Lymphangioleiomyomatosis (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5390;
In the MILES trial, sirolimus showed improvement in FVC, FEV1, quality of life, and functional performance when compared to the placebo group 3 . Sirolimus is an agent for the treatment of LAM, indicated for FEV1 of less than 70% of predicted, patients on traditional therapies are recommended to be transitioned to newer FDA approved drugs for LAM.
- tamoxifen / Generic mfg.
[VIRTUAL] The Influence of Autophagy Inhibition on Sepsis-Induced Skeletal Muscle Wasting, Metabolic Derangements and Mortality (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_3747;
We conclude that autophagy plays a protective role by preserving muscle mitochondrial quality and function and that autophagy inhibition in skeletal muscles worsens sepsis-induced loss of body weight and muscle atrophy possibly due to exaggerated responses to catabolic stimuli triggered by sepsis. Our results also indicate that autophagy in septic skeletal muscles play a protective role against sepsis-induced metabolic derangements and mortality.
- sirolimus / Generic mfg.
[VIRTUAL] Cigarette-Decreased NAD + /SIRT1 of Alveolar Type 2 Cells Aggravates Pulmonary Fibrosis by Promoting Cellular Senescence Through Autophagy Inhibition and Mitochondrial Oxidative Stress Induction (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_2065;
RESULTS Mice with 3 weeks history of smoking exhibited senescent AT2 and more severe fibrotic changes after bleomycin administration...Their effects were reversed by SIRT1 inhibitor Ex527...Autophagy suppression further promoted DNA damage by inducing mitochondrial reactive oxidative stress due to impaired mitophagy. Consequently, there is a positive loop in cigarette-induced senescence of AT2, which may play a key role in lung fibrogenesis.
- [VIRTUAL] Macrophage Migration Inhibitory Factor Promotes Asthmatic Airway Remodeling by Inducing Autophagy of Airway Smooth Muscle Cell (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1230;
Overall, this study demonstrates that MIF can promote airway remodeling in experimental asthma model by modulating ASMC autophagy and MIF may be produced by activated macrophage. Moreover, the specific mechanism is possibly that MIF binds to its receptor CD74.
- [VIRTUAL] NLRP3 Deficiency Alleviates Chronic Intermittent Hypoxia-Induced Neuroinflammation and Oxidative Stress Via Parkin-Mediated Mitophagy (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1014;
In summary, these results revealed NLRP3 deficiency acted as a protective promotor through enhancing Parkin-depended mitophagy in CIH-induced neuroinflammation. Thus, NLRP3 gene knockout or pharmacological blockage could be as a potential therapeutic strategy for OSA-associated neurocognitive impairment.
- sirolimus / Generic mfg.
[VIRTUAL] Relationship Between Autophagy-Lysosomes Pathway and Ventilator-Induced Diaphragmatic Dysfunction (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_930;
Methods : To determine the role of autophagy-lysosomes (AL) pathway on the MV-induced diaphragmatic injury and atrophy, thirty-two rats were assigned to control, MV (for 18 hours), MV+chloroquine and MV+rapamycin groups,respectively. This study demonstrated that activation of autophagy in the rat diaphragm contributed to the muscle atrophy and injury during MV.
- bortezomib / Generic mfg.
[VIRTUAL] DOWN REGULATION OF AUTOPHAGY ENHANCES BORTEZOMIB-INDUCED APOPTOSIS OF MYELOMA CELL BY UP REGULATION OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4366;
Our experiment showed crosstalk between autophagy and mitochondrial ROS and its redox enzymes during BTZ-induced MM cell apoptosis. Inhibition of autophagy with 3-MA potentiates BTZ-induced apoptosis of MM cells via up regulation of mitochondrial ROS.
- bortezomib / Generic mfg.
[VIRTUAL] DOWN REGULATION OF AUTOPHAGY ENHANCES BORTEZOMIB-INDUCED APOPTOSIS OF MYELOMA CELL BY UP REGULATION OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4365;
Our experiment showed crosstalk between autophagy and mitochondrial ROS and its redox enzymes during BTZ-induced MM cell apoptosis. Inhibition of autophagy with 3-MA potentiates BTZ-induced apoptosis of MM cells via up regulation of mitochondrial ROS.
- bortezomib / Generic mfg.
[VIRTUAL] DOWN REGULATION OF AUTOPHAGY ENHANCES BORTEZOMIB-INDUCED APOPTOSIS OF MYELOMA CELL BY UP REGULATION OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4364;
Our experiment showed crosstalk between autophagy and mitochondrial ROS and its redox enzymes during BTZ-induced MM cell apoptosis. Inhibition of autophagy with 3-MA potentiates BTZ-induced apoptosis of MM cells via up regulation of mitochondrial ROS.
- sirolimus / Generic mfg.
[VIRTUAL] AUTOPHAGY IN ENDOTHELIAL CELLS REGULATES THEIR HAEMATOPOIESIS-SUPPORTING ABILITY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3133;
Defective autophagy in BM ECs may be involved in the pathogenesis of PGF post-allotransplant. Although further validation is required, our data suggest that improving autophagy in BM ECs may be a potential therapeutic approach in PGF patients after allo-HSCT.
- sirolimus / Generic mfg.
[VIRTUAL] AUTOPHAGY IN ENDOTHELIAL CELLS REGULATES THEIR HAEMATOPOIESIS-SUPPORTING ABILITY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3132;
Defective autophagy in BM ECs may be involved in the pathogenesis of PGF post-allotransplant. Although further validation is required, our data suggest that improving autophagy in BM ECs may be a potential therapeutic approach in PGF patients after allo-HSCT.
- sirolimus / Generic mfg.
[VIRTUAL] AUTOPHAGY IN ENDOTHELIAL CELLS REGULATES THEIR HAEMATOPOIESIS-SUPPORTING ABILITY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3131;
Defective autophagy in BM ECs may be involved in the pathogenesis of PGF post-allotransplant. Although further validation is required, our data suggest that improving autophagy in BM ECs may be a potential therapeutic approach in PGF patients after allo-HSCT.
- [VIRTUAL] The bidirectional regulation of the Hippo pathway and autophagy in pancreatic beta cells (Salzburg Hall) - Jul 2, 2020 - Abstract #EASD2020EASD_513;
Although further validation is required, our data suggest that improving autophagy in BM ECs may be a potential therapeutic approach in PGF patients after allo-HSCT. This unravels the novel bidirectional role of the Hippo kinase LATS2 and autophagy in the regulation of beta-cell survival.
- [VIRTUAL] The circadian clock nuclear receptor Rev-erbα is implicated in autophagy alteration and beta cell deficit under diabetogenic conditions (Salzburg Hall) - Jul 2, 2020 - Abstract #EASD2020EASD_512;
Taken together, these data reveal for the first time an underexplored link between the core circadian clock nuclear receptor Rev-erbα, autophagy and beta-cell failure under diabetogenic conditions. These data also suggest a therapeutic potential of elaborating new Rev-erbα-based strategies to preserve a functional beta-cell mass in T2D.
- ||| temuterkib (LY3214996) / Eli Lilly
Enrollment open, Combination therapy, Metastases: LY3214996 +/- HCQ in Pancreatic Cancer (clinicaltrials.gov) - Jun 28, 2020
P2, N=52, Recruiting, Sponsor: Brian Wolpin, MD, MPH
These data also suggest a therapeutic potential of elaborating new Rev-erbα-based strategies to preserve a functional beta-cell mass in T2D. Not yet recruiting --> Recruiting
- | chloroquine phosphate / Generic mfg.
Journal: Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β). (Pubmed Central) - Jun 23, 2020
Human kidney-2 (HK-2) cells were stimulated by TGF-ß with or without a combined treatment of autophagy inhibitor chloroquine (CQ) or bafilomycin A1 (Baf)...Western blot analysis showed that TGF-ß-induced expression of extracellular matrix fibronectin was notably upregulated in the presence of autophagy inhibitors. CONCLUSIONS Inhibition of autophagy sensitizes the TECs to G1 arrest and proliferation suppression induced by TGF-ß that contributes to the induction of tubulointerstitial fibrosis.
- | New trial: GROSSAUTOP: Autophagy/Apoptosis Balance During Pregnancy (clinicaltrials.gov) - Jun 22, 2020
P, N=120, Not yet recruiting, Sponsor: Centre Hospitalier Universitaire de N?mes
- | Sutent (sunitinib) / Pfizer
Trial primary completion date, Metastases: Sunitinib Malate and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Chemotherapy (clinicaltrials.gov) - Jun 18, 2020
P1, N=40, Active, not recruiting, Sponsor: National Cancer Institute (NCI)
CONCLUSIONS Inhibition of autophagy sensitizes the TECs to G1 arrest and proliferation suppression induced by TGF-ß that contributes to the induction of tubulointerstitial fibrosis. Trial primary completion date: Jun 2020 --> Sep 2020
- | monalizumab (IPH2201) / AstraZeneca, Innate, ezurpimtrostat (GNS561) / Genoscience Pharma, Genfit, avdoralimab (IPH5401) / Innate
Trial suspension, Metastases: IMMUNONCOVID: Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection (clinicaltrials.gov) - Jun 15, 2020
P2, N=384, Suspended, Sponsor: Centre Leon Berard
Trial primary completion date: Jun 2020 --> Sep 2020 Recruiting --> Suspended
- | chloroquine phosphate / Generic mfg.
Journal: Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine. (Pubmed Central) - Jun 13, 2020
By elevating the pH of acidic endosomes/lysosomes, CQ/HCQ inhibit the autophagic process. In this short perspective, we discuss the roles of CQ/HCQ in the treatment of COVID-19 patients and propose new ways of possible treatment for SARS-CoV-2 infection based on the molecules that selectivity target autophagy.
- | monalizumab (IPH2201) / AstraZeneca, Innate, ezurpimtrostat (GNS561) / Genoscience Pharma, Genfit, avdoralimab (IPH5401) / Innate
Enrollment change, Metastases: IMMUNONCOVID: Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection (clinicaltrials.gov) - Jun 8, 2020
P2, N=384, Recruiting, Sponsor: Centre Leon Berard
In this short perspective, we discuss the roles of CQ/HCQ in the treatment of COVID-19 patients and propose new ways of possible treatment for SARS-CoV-2 infection based on the molecules that selectivity target autophagy. N=273 --> 384
- [VIRTUAL] Glycogen synthase 2 (gys2) restricts tumor metastatic ability via attenuating autophagy and breaking glycogenic homeostasis in hepatocelluar carcinoma (Poster Area) - May 30, 2020 - Abstract #EASLILCI2020EASL-ILC-I-1355;
In summary, our findings suggested that GYS2 serves as a prognostic factor and functions as a tumor suppressor by inhibiting autophagy and interpreting glycogenic homeostasis in HCC. GYS2 might be a promising target for prevention, treatment and prognostic prediction of HCC.
- | Journal: Epithelial-mesenchymal transition suppresses ERas to activate autophagy in retinal pigment epithelial cells in proliferative vitreoretinopathy. (Pubmed Central) - May 22, 2020
GYS2 might be a promising target for prevention, treatment and prognostic prediction of HCC. Our study revealed the role of ERas in the pathogenesis of PVR through EMT and provided a novel therapeutic target for PVR prevention and treatment.
- |||| temuterkib (LY3214996) / Eli Lilly
New P2 trial, Combination therapy, Metastases: LY3214996 +/- HCQ in Pancreatic Cancer (clinicaltrials.gov) - May 12, 2020
P2, N=52, Not yet recruiting, Sponsor: Brian Wolpin, MD, MPH
- | Mekinist (trametinib) / Novartis, BeiGene
Enrollment open, Metastases: CHLOROTRAMMEL: MEK and Autophagy Inhibition in Metastatic/Locally Advanced, Unresectable Neuroblastoma RAS (NRAS) Melanoma (clinicaltrials.gov) - May 7, 2020
P=N/A, N=29, Recruiting, Sponsor: Hospices Civils de Lyon
Our study revealed the role of ERas in the pathogenesis of PVR through EMT and provided a novel therapeutic target for PVR prevention and treatment. Not yet recruiting --> Recruiting
- | xevinapant (AT-406) / Debiopharm, Ascenta
Journal: The Strong Inhibitory Effect of Combining Anti-Cancer Drugs AT406 and Rocaglamide with Blue LED Irradiation on Colorectal Cancer Cells. (Pubmed Central) - May 4, 2020
Furthermore, little to no cell inhibition or damage of normal MRC-5 cells were seen after treatment. The combination of blue LED irradiation and two anti-cancer drugs causes apoptosis of colorectal cancer cells by activating the apoptotic pathway, inhibiting autophagy and proliferation pathways as well as the production of reactive oxygen species (ROS).
- | sirolimus / Generic mfg.
Journal: Autophagy regulates lipid production and contributes to the sebosuppressive effect of retinoic acid in human SZ95 sebocytes. (Pubmed Central) - May 2, 2020
The combination of blue LED irradiation and two anti-cancer drugs causes apoptosis of colorectal cancer cells by activating the apoptotic pathway, inhibiting autophagy and proliferation pathways as well as the production of reactive oxygen species (ROS). Autophagy plays an important role in the modulation of lipogenesis in human sebocytes and is involved in the sebostatic effect of 13-cis-RA.
- | temozolomide / Generic mfg.
Journal: Micro-RNA29b Enhances the Sensitivity of GlioblastomaMultiforme Cells to Temozolomide by Promoting Autophagy. (Pubmed Central) - Apr 11, 2020
Autophagy plays an important role in the modulation of lipogenesis in human sebocytes and is involved in the sebostatic effect of 13-cis-RA. miR-29b potentiates TMZ sensitivity against GBM cells by inducing autophagy and the combined use of miR-29 mimic and TMZ might represent a potential therapeutic strategy for GBM patients.
- | monalizumab (IPH2201) / AstraZeneca, Innate, ezurpimtrostat (GNS561) / Genoscience Pharma, Genfit, avdoralimab (IPH5401) / Innate
Enrollment open, Metastases: IMMUNONCOVID: Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection (clinicaltrials.gov) - Apr 6, 2020
P2, N=273, Recruiting, Sponsor: Centre Leon Berard
miR-29b potentiates TMZ sensitivity against GBM cells by inducing autophagy and the combined use of miR-29 mimic and TMZ might represent a potential therapeutic strategy for GBM patients. Not yet recruiting --> Recruiting
- | monalizumab (IPH2201) / AstraZeneca, Innate, ezurpimtrostat (GNS561) / Genoscience Pharma, Genfit, avdoralimab (IPH5401) / Innate
New P2 trial, Metastases: IMMUNONCOVID: Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection (clinicaltrials.gov) - Apr 2, 2020
P2, N=273, Not yet recruiting, Sponsor: Centre Leon Berard