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- THE RNA-BINDING PROTEIN TIA1 POTENTIATES SNCA PHOSPHORYLATION, AGGREGATION, AND TOXICITY (EXHIBITION) - Dec 23, 2022 - Abstract #ADPD2023ADPD_1867;
These findings suggest that TIA1 is potentially a crucial component of the pathogenetic mechanisms underlying alpha -synucleinopathies.
- OF PATHOLOGY, PRION-LIKE THE EFFECT OF APOLIPOPROTEIN E ON TAU SECRETION (EXHIBITION) - Dec 23, 2022 - Abstract #ADPD2023ADPD_1727;
And the tau is secreted in a non-membrane form, and the activities of lysosomes could determine the tau secretion property. Further study is necessary to clarify the ApoE-isoform-dependent effect on tau propagation and the significance of increased tau secretion by ApoE.
- gabapentin / Generic mfg.
A NOVEL ROLE OF TAU PROTEIN IN CHRONIC PAIN-DRIVEN HIPPOCAMPAL PATHOLOGY AND MEMORY DEFICITS (EXHIBITION) - Dec 23, 2022 - Abstract #ADPD2023ADPD_1719;
Molecular understanding experiments also included the analgesic drug, gabapentin or virus -driven overexpression of Rab35, a regulator of Tau degradation... Our findings reveal that exposure to chronic pain triggers Tau -related neuronal pathology in hippocampus and may be relevant for understanding how chronic pain precipitates memory loss leading to dementia.
- INHIBITION OF AUTOPHAGIC FLUX BY ABERRANT PROTEIN S-NITROSYLATION PROMOTES NEURONAL SECRETION AND CELL-TO-CELL TRANSMISSION OF AGGREGATED PROTEINS IN PARKINSON'S DISEASE/LEWY BODY DEMENTIA AND ALZHEIMER'S DISEASE (ONSITE - HALL G4) - Dec 23, 2022 - Abstract #ADPD2023ADPD_394;
Consequently, this impairment in autophagy increases extracellular vesicle-dependent secretion and spread of aggregated protein. Taken together, our evidence suggests that aberrant formation of SNO-p62 (in PD/LBD) and SNO-CTSB (in AD) represent pathogenic events contributing not only to inhibition of autophagic flux and potentiation of neuronal damage, but also to propagation of aggregated proteins between cells in the diseased brain.
- A GATING MUTATION IN RYANODINE RECEPTOR TYPE 2 RESCUES PHENOTYPES OF ALZHEIMER'S DISEASE MOUSE MODELS BY UPREGULATING NEURONAL AUTOPHAGY (ONSITE - HALL G4) - Dec 23, 2022 - Abstract #ADPD2023ADPD_385;
Conclusions Our results revealed that reduced basal activity of RyanR2-EQ channels disinhibited the autophagic pathway and led to increased amyloid clearance in these models. These data may explain why pharmacological inhibition of RyanR results in beneficial effects in a variety of AD models and may also provide additional targets for therapeutic intervention in AD.
- BAG3 PROMOTES AUTOPHAGY AND SUPPRESSES NLRP3 INFLAMMASOME ACTIVATION IN PARKINSON'S DISEASE (On-Demand Oral Gallery H) - Dec 23, 2022 - Abstract #ADPD2023ADPD_266;
These data may explain why pharmacological inhibition of RyanR results in beneficial effects in a variety of AD models and may also provide additional targets for therapeutic intervention in AD. The LPS -induced inflammatory environment inhibits autophagy, and overexpression of BAG3 can restore autophagy, which may be the main way for BAG3 to reduce neuronal inflammation in PD.
- | doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal, IO biomarker: Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats. (Pubmed Central) - Dec 22, 2022
The Akt agonist SC79 could invalidate all the protective effects of Daid both in vivo and in vitro. Daid reduced autophagy and apoptosis by inhibiting the PI3K/Akt pathway, thereby protecting the hearts from Dox-induced cardiac damage.
- | Journal: Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM). (Pubmed Central) - Dec 22, 2022
Together, we identified novel rapamycin-insensitive sphingosine metabolic signatures in TSC2-null LAM cells. Therapeutic targeting of aberrant SPHK1/S1P/S1PR3 signaling may have potent therapeutic benefit for patients with TSC/LAM or other hyperactive mTOR neoplasms with autophagy inhibition.
- | cyclophosphamide / Generic mfg.
Journal: Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway. (Pubmed Central) - Dec 21, 2022
These findings suggest that BMSCs-exos promote LC autophagy by regulating the AMPK-mTOR signaling pathway, thereby ameliorating CPTD. This study provides novel evidence for the clinical improvement of CPTD using BMSCs-exos.
- | Journal: MicroRNAs Contribute to Host Response to Coxiella burnetii. (Pubmed Central) - Dec 21, 2022
We further explored the functions of miR-143-3p, an miRNA whose expression is downregulated in macrophages infected with C. burnetii, and show that increasing the abundance of this miRNA in human cells results in increased apoptosis and reduced autophagy-conditions that are unfavorable to C. burnetii intracellular growth. In sum, this study demonstrates that C. burnetii infection elicits a robust miRNA-based host response, and because miR-143-3p promotes apoptosis and inhibits autophagy, downregulation of miR-143-3p expression during C. burnetii infection likely benefits the pathogen.
- | repaglinide / Generic mfg.
Preclinical, Journal: Repaglinide Elicits a Neuroprotective Effect in Rotenone-Induced Parkinson's Disease in Rats: Emphasis on Targeting the DREAM-ER Stress BiP/ATF6/CHOP Trajectory and Activation of Mitophagy. (Pubmed Central) - Dec 21, 2022
Repaglinide restored striatum morphological alterations, intact neuron count, and neurobehavioral motor performance in rats examined by an open field, grip strength, and footprint gait analysis. Conclusively, repaglinide modulates the DREAM-ER stress BiP/ATF6/CHOP cascade, increases mitophagy/autophagy, inhibits apoptosis, and lessens oxidative stress, astrocyte/microglial activation, and neuroinflammation in PD.
- | paclitaxel / Generic mfg.
Journal: miR-142-3p improves paclitaxel sensitivity in resistant breast cancer by inhibiting autophagy through the GNB2-AKT-mTOR pathway. (Pubmed Central) - Dec 21, 2022
Mechanistically, miR-142-3p was found to amend PTX resistance by targeting GNB2, further revealing that the knockdown of GNB2 expression could activate the AKT-mTOR pathway. This study suggests that GNB2 is an essential target for miR-142-3p to restrain autophagy, providing a new reference value for improving breast cancer PTX treatment.
- | Journal: Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/Autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia. (Pubmed Central) - Dec 21, 2022
Our results demonstrated that SFN could inhibit the cytostatic autophagy-induced NLRP3 signaling pathway in Aβ-activated microglia by decreasing reactive oxygen species (ROS) production. These results provide novel insight into the potential role of SFN in AD therapy.
- | ebselen (SPI-1005) / Sound Pharma
Preclinical, Journal: Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice. (Pubmed Central) - Dec 21, 2022
Ultimately through cell culture and mouse xenograft tumor models, we established the impact of Ebselen on autophagy and tumor suppression via ATG4B inhibition other than apoptosis. These results suggest that old drug Ebselen as an ATG4B inhibitor through oxidative modification may be repurposed as a promising anti-colorectal cancer drug.
- | Journal: Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy. (Pubmed Central) - Dec 20, 2022
In vivo, histological staining revealed that intra-articular injection of OB attenuated the cartilage degradation, as well as reversed the expression level of anabolic and catabolic-related proteins such as Aggrecan, Collagen II, and MMP13 induced in DMM-induced OA models. The study verified that OB exhibited the chondroprotective effect by anti-inflammatory, inhibiting the PI3K/AKT/mTOR signaling pathway, and enhancing the autophagy process, indicating that OB might be a promising agent for the treatment of OA.
- | sirolimus / Generic mfg.
Preclinical, Journal: Effect of PhenylEthanol Glycosides from Cistanche Tubulosa on Autophagy and Apoptosis in H22 Tumor-Bearing Mice. (Pubmed Central) - Dec 20, 2022
Besides, we also discussed the role of autophagy with the help of HCQ and rapamycin...Finally, our results showed that excessive autophagy suppresses tumor growth, whereas inhibition of autophagy does the opposite, which indicated that CPhGs induced autophagic death in H22 hepatoma-bearing mice. These data altogether confirmed the involvement of apoptosis and autophagy in CPhGs treatment for HCC.
- | sirolimus / Generic mfg.
Journal: Non-cytopathic bovine viral diarrhoea virus 2 induces autophagy to enhance its replication. (Pubmed Central) - Dec 20, 2022
Our results demonstrate that ncp BVDV2 infection induced autophagy in MDBK cells via anti-apoptosis and PKR suppression. Therefore, autophagy may play a role in establishing persistent infection caused by ncp BVDV.
- | chloroquine phosphate / Generic mfg., digoxin / Generic mfg.
Journal, Immunogenic cell death: 3'-epi-12β-hydroxyfroside-mediated autophagy degradation of RIPK1/RIPK3 necrosomes leads to anergy of immunogenic cell death in triple-negative breast cancer cells. (Pubmed Central) - Dec 20, 2022
These findings indicate that HyFS-mediated autophagic degradation of RIPK1/RIPK3 necrosomes leads to inactivation of ICD in TNBC cells. Moreover, combined treatment with HyFS and an autophagy inhibitor may enhance the antitumor activities, suggesting an alternative therapeutic for TNBC treatment.
- | Journal: Effects of autophagy inhibition by 3-methyladenine on encystation, morphology, and metabolites of Cryptocaryon irritans. (Pubmed Central) - Dec 18, 2022
Furthermore, the metabolic analysis revealed suppression of metabolites, such as lipids, amino acids, and carbohydrates. These results demonstrate that 3MA can inhibit autophagy in C. irritans, thus hindering encystation, suppressing the metabolism of metabolites, and altering morphological ultrastructure in these parasites.
- | sirolimus / Generic mfg.
Journal: Asiaticoside attenuates oxygen-glucose deprivation/reoxygenation-caused injury of cardiomyocytes by inhibiting autophagy. (Pubmed Central) - Dec 17, 2022
Rapamycin, an autophagy inductor, reversed the influences of asiaticoside on autophagy, cytotoxicity, oxidative stress, and myocardial injury, while 3-methyadanine, an autophagy inhibitor, played an opposite effect...Transfection with si-β-catenin attenuated the influences of asiaticoside on autophagy, cytotoxicity, oxidative stress, and myocardial injury. In conclusion, asiaticoside protected against OGD/R-induced cardiomyocyte cytotoxicity, oxidative stress, and myocardial injury via blunting autophagy through activating the Wnt/β-catenin signaling, indicating the therapeutic potential of asiaticoside in myocardial ischemia/reperfusion injury.
- | Journal: Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma. (Pubmed Central) - Dec 16, 2022
In conclusion, asiaticoside protected against OGD/R-induced cardiomyocyte cytotoxicity, oxidative stress, and myocardial injury via blunting autophagy through activating the Wnt/β-catenin signaling, indicating the therapeutic potential of asiaticoside in myocardial ischemia/reperfusion injury. Our study suggests that PKMYT1 functions as an oncogene and may be a new target for HCC treatment.
- | Journal: Hyperlipidemia impacts osteogenesis via lipophagy. (Pubmed Central) - Dec 16, 2022
These results demonstrate that lipophagy functions differently in diverse high-fat environments, suggesting that cellular and organismal changes in response to high-fat stimuli are dynamic. This may provide new ideas for improving bone dysfunction caused by lipid metabolism disorders.
- | Journal: Hypoxic stress accelerates the propagation of pathological alpha-synuclein and degeneration of dopaminergic neurons. (Pubmed Central) - Dec 16, 2022
Hypoxia was shown to accelerate the pathological progression and damage phenotype in PD model mice. The results provided a promising research target for determining common interventions for PD in the future.
- | Journal: USP9x promotes CD8 T-cell dysfunction in association with autophagy inhibition in septic liver injury. (Pubmed Central) - Dec 16, 2022
In the in vivo studies, autophagy is significantly increased in hepatic CD8 T cells of septic mice with conditional knockout of mammalian target of rapamycin. This study shows that USP9x has the potential to be used as a therapeutic target in septic liver injury.
- || Review, Journal, IO biomarker: Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. (Pubmed Central) - Dec 16, 2022
Overall results suggest that neurodegeneration is in part due to the intensity and duration of spike protein exposure, patient advanced age, cellular autophagy activity, and activation, function and regulation of p53. Finally, the neurologically damaging effects can be cumulatively spike-protein dependent, whether exposure is by natural infection or, more substantially, by repeated mRNA vaccination.
- | Journal: Butyrate Ameliorates Intraocular Bacterial Infection by Promoting Autophagy and Attenuating the Inflammatory Response. (Pubmed Central) - Dec 16, 2022
Collectively, our study demonstrated the protective mechanisms of butyrate in ameliorating bacterial endophthalmitis. Therefore, butyrate derivatives could be explored as immunomodulatory and anti-bacterial therapeutics to improve visual outcomes in ocular bacterial infections.
- | Journal: Autophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer. (Pubmed Central) - Dec 16, 2022
The expression of ACAT1 is related to prostate cancer. Studying the underlying mechanism may provide a new perspective on the treatment of prostate cancer.
- | LY294002 / Eli Lilly
Journal: Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells. (Pubmed Central) - Dec 16, 2022
We here investigate how Sirt3 regulates doxorubicin (DOX)-induced senescence in lung cancer A549 cells...Importantly, the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) partially abolished the antioxidant stress and antiaging effects of Sirt3, while the autophagy activator rapamycin (Rap) potentiated these effects of Sirt3, demonstrating that autophagy mediates the anti-aging effects of Sirt3...The PI3K inhibitor LY294002 promoted the antioxidant stress and antiaging effects of Sirt3, while the AKT activator SC-79 reversed these effects of Sirt3. Taken together, Sirt3 counteracts DOX-induced senescence by improving autophagic flux.
- | Journal: Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate. (Pubmed Central) - Dec 16, 2022
We also find p21, as a physiological inhibitor of autophagy, to have oncogenic activity during early events of tumor development while its inhibition favors survival and growth of cancer cells in the established tumor. Our data, thereby, reveal the potential role of autophagy in antagonistic functional duality of p21 in cancer.
- | Journal: The lectin DrfL inhibits cell migration, adhesion and triggers autophagy-dependent cell death in glioma cells. (Pubmed Central) - Dec 16, 2022
Noteworthy, inhibition of autophagy and caspase-8 were both able to attenuate cell death in GBM cells treated with DrfL. Our results indicate that DrfL cytotoxicity against GBM involves modulation of cell pathways, including MAPKs and Akt, which are associated with autophagy and caspase-8 dependent cell death.
- | Journal: Cryptosporidium parvum regulates HCT-8 cell autophagy to facilitate survival via inhibiting miR-26a and promoting miR-30a expression. (Pubmed Central) - Dec 16, 2022
The study found that C. parvum could regulate autophagy by inhibiting miR-26a and promoting miR-30a expression to facilitate the proliferation of parasites. These results revealed a new mechanism for the interaction of C. parvum with host cells.
- | Journal: Jujuboside A attenuates sepsis-induced cardiomyopathy by inhibiting inflammation and regulating autophagy. (Pubmed Central) - Dec 13, 2022
These results revealed a new mechanism for the interaction of C. parvum with host cells. In conclusion, the findings indicated that JuA attenuates cardiac function via blocking inflammasome-mediated apoptosis and pyroptosis, at the same time by enhancing autophagy in SIC, heralding JuA as a potential therapy for sepsis.
- Erbitux (cetuximab) / Eli Lilly, EMD Serono, Vectibix (panitumumab) / Amgen, Takeda, Braftovi (encorafenib) / Ono Pharma, Pierre Fabre, Pfizer
A single-arm, phase II study of autophagy modulation using hydroxychloroquine in addition to encorafenib and cetuximab or panitumumab in metastatic BRAF-mutated colorectal cancer refractory to standard therapy. (On Demand | Level 1, West Hall; Poster Board No. P4) - Dec 13, 2022 - Abstract #ASCOGI2023ASCO_GI_925;
This is the first trial exploring autophagy modulation in advanced, BRAF-mutated colon cancer. This study aims to show that autophagy inhibition with HCQ circumvents acquired resistance to BRAF + EGFR inhibition in advanced colon cancer.
- || Review, Journal: A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion. (Pubmed Central) - Dec 13, 2022
Finally, we will summarize the latest advances in the interaction between SIRT1 and autophagy in cerebral I/R injury. A good understanding of these relationships would serve to consolidate a framework of mechanisms underlying SIRT1's neuroprotective effects and provides evidence for the development of drugs targeting SIRT1.
- | Journal: Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles. (Pubmed Central) - Dec 13, 2022
The Rac1-GTP level in serum EVs from the CTP-treated mice was reduced in vivo. CTP inhibited autophagy in hepatocytes by reducing Rac1-GTP and thus affect the amount of Rac1-GTP in hepatocyte-derived EVs and the formation of EVs, which attenuated hepatic fibrosis via inhibiting HSC activation.
- | Journal: 1,4-Naphthoquinone-coated black carbon nanoparticles up-regulation POR/FTL/IL-33 axis in THP1 cells. (Pubmed Central) - Dec 13, 2022
We first applied proteomics to study the damage mechanism of 1,4 NQ-BC on THP1 cells. Our research will enrich knowledge of the mechanism by which 1,4 NQ-BC damages human macrophages and identify important therapeutic targets and adverse outcome pathways for 1,4 NQ-BC-induced damage.
- | Preclinical, Journal: Nano-selenium Alleviates Cadmium-Induced Mouse Leydig Cell Injury, via the Inhibition of Reactive Oxygen Species and the Restoration of Autophagic Flux. (Pubmed Central) - Dec 13, 2022
In addition, ROS scavenger, N-acetyl-L-cysteine (NAC) or autophagy inhibitor, 3-methyladenine (3-MA) reversed cadmium-induced ROS generation, autophagosome accumulation, and autophagy-related protein expression levels, which confirmed that cadmium induced TM3 cell injury via ROS signal pathway and blockage of autophagic flux. Collectively, our results reveal that Nano-se attenuates Cd-induced TM3 cell toxicity through the inhibition of ROS production and the amelioration of autophagy disruption.
- | Journal: Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. (Pubmed Central) - Dec 12, 2022
In addition, SFA vs. MUFA regulation of NRF2 may underlie their harmful vs. beneficial effects. Our study reveals NRF2 as a key player in the development and progression of fatty liver disease and that NRF2 activation could serve as a potential therapeutic strategy.
- | Journal: Hydroxysafflor Yellow A Exerts Neuroprotective Effects via HIF-1α/BNIP3 Pathway to Activate Neuronal Autophagy after OGD/R. (Pubmed Central) - Dec 12, 2022
The inhibition of HIF1A diminished the activation of autophagy induced with HSYA, while the inhibition of autophagy increased cell apoptosis and blocked the neuroprotective effect of HSYA, suggesting that the neuroprotective effect of HSYA should be mediated by activating the HIF1A/BNIP3 signaling pathway to induce autophagy. These results demonstrate that HSYA may be a promising agent for treating IS.
- | Journal: Elaiophylin Inhibits Tumorigenesis of Human Lung Adenocarcinoma by Inhibiting Mitophagy via Suppression of SIRT1/Nrf2 Signaling. (Pubmed Central) - Dec 12, 2022
Thus, the present study reports that elaiophylin has potent anti-tumor properties in LADC, which effect is likely mediated through suppressing the SIRT1/Nrf2 signaling. In conclusion, elaiophylin may be a novel drug candidate for LADC and SIRT1 may be a new therapeutic target for such devastating malignancy.
- || Review, Journal: New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways. (Pubmed Central) - Dec 12, 2022
A multitude of preclinical findings have shown the function of botanicals in regulating cell autophagy and its potential impact on cancer therapy; however, the number of related clinical trials to date remains low. In this regard, further pre-clinical and clinical studies are warranted to better clarify the utility of natural compounds and their modulatory effects on autophagy, as fine-tuning of autophagy could be translated into therapeutic applications for several cancers.
- || Review, Journal: An Epigenetic LINE-1-Based Mechanism in Cancer. (Pubmed Central) - Dec 12, 2022
Cancer phenotypes would thus emerge as a consequence of the unscheduled reactivation of embryonic gene expression patterns in an inappropriate context, triggering de-differentiation and aberrant proliferation in differentiated cells. Depending on the intensity of the stressing stimuli and the level of LINE-1 response, diverse degrees of malignity would be generated.
- | chloroquine phosphate / Generic mfg.
Journal, PARP Biomarker, IO biomarker: 4-O-Methylascochlorin-Mediated BNIP-3 Expression Controls the Balance of Apoptosis and Autophagy in Cervical Carcinoma Cells. (Pubmed Central) - Dec 12, 2022
These results indicate that MAC induces apoptosis to promote cell death and stimulates autophagy to promote cell survival by increasing BNIP-3 expression. This study also showed that co-treatment of cells with MAC and CQ further enhanced the death of cervical cancer cells.
- | chloroquine phosphate / Generic mfg.
Journal: A Polyoxometalate-Encapsulated Metal-Organic Framework Nanoplatform for Synergistic Photothermal-Chemotherapy and Anti-Inflammation of Ovarian Cancer. (Pubmed Central) - Dec 12, 2022
In this study, polyoxometalates and a chloroquine diphosphate (CQ) co-loaded metal-organic framework nanoplatform with hyaluronic acid coating was constructed for efficient ovarian cancer therapy and anti-inflammation...Therefore, we combined the excellent properties of these materials to synthesize a nanoplatform and explored its therapeutic effects in various aspects. This work provides a promising novel prospect for PTT/anti-inflammation/anti-autophagy combinations for efficient ovarian cancer treatment through the fine tuning of material design.
- || Eyevinal (ibudilast) / MediciNova
Preclinical, Review, Journal: Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence. (Pubmed Central) - Dec 12, 2022
The clinical trials in ALS and progressive MS also show some promising results. Herein, we aim to provide an update on the emerging preclinical and clinical evidence on the therapeutic potential of ibudilast in these disorders, discuss the potential challenges and suggest the future directions.
- | chloroquine phosphate / Generic mfg.
Journal: Resveratrol Ameliorates Fibrosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease via the Autophagy-Lysosome Pathway. (Pubmed Central) - Dec 12, 2022
Resveratrol effects were reversed by the addition of the late autophagy inhibitor chloroquine. These results suggest that resveratrol attenuates pulmonary fibrosis, increases autophagic flux, and modulates the autophagy-lysosome pathway, and particularly it may work by improving the formation of autophagic lysosomes, which may be an effective treatment for induced RA-ILD.
- | 5-fluorouracil / Generic mfg.
Journal: Porric acid E, a natural compound from Rhytidhysteron sp. BZM-9, suppresses colorectal cancer growth via an autophagy-dependent pathway. (Pubmed Central) - Dec 10, 2022
Additionally, compared with fluorouracil (5-FU), porric acid E exhibited a more potent inhibitory effect on CRC HT29 cells...Moreover, porric acid E treatment could markedly suppress subcutaneous HT29 xenograft tumor growth in vivo. Bioinformatics prediction indicated that Beclin-1 might be the potential target of porric acid E. These findings might afford a useful and important method for the treatment of CRC through fungal endophyte-derived natural compounds.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Journal: Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB. (Pubmed Central) - Dec 10, 2022
Furthermore, we found that Gs-Rb1 promoted the nucleus translocation of the transcription factor EB (TFEB) and the target role of miR-128, thus stimulating autophagic flux. Therefore, our results showed that Gs-Rb1 enhanced the transcription of TFEB and its downstream lysosome-related genes by inhibiting miR-128, improved the degradation ability of lysosomes to autophagosomes, and then promoted autophagic lipid degradation.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal: Benzophenones alter autophagy and ER stress gene expression in pancreatic beta cells in vitro. (Pubmed Central) - Dec 10, 2022
In relation to ER stress, BP3 inhibited unspliced and spliced Xbp1 mRNA levels in the presence or absence of CQ, totally counteracted CQ-induced Chop gene expression, and partially reverted CQ-induced Grp78/Bip mRNA levels, while BP2 also partially inhibited Grp78/Bip mRNA induction by CQ. In conclusion, BPs, principally BP3, affect cellular adaptive responses related to autophagy, lysosomal biogenesis, and ER stress in pancreatic beta cells, indicating that BP exposure could lead to beta cell dysfunction.
- | Preclinical, Journal: Bloodletting Acupuncture at Jing-Well Points Alleviates Myocardial Injury in Acute Altitude Hypoxic Rats by Activating HIF-1α/BNIP3 Signaling-Mediated Mitochondrial Autophagy and Decreasing Oxidative Stress. (Pubmed Central) - Dec 10, 2022
In conclusion, BPs, principally BP3, affect cellular adaptive responses related to autophagy, lysosomal biogenesis, and ER stress in pancreatic beta cells, indicating that BP exposure could lead to beta cell dysfunction. BAJP is an effective treatment for AHH-induced myocardial injury, and the mechanism might involve increasing HIF-1α/BNIP3 signaling-mediated autophagy and decreasing oxidative stress.