 |
Companies | Products |
|
|
Products | |
Diseases | |
Trials |  |
News |  |
| «12...3132333435363738394041...135136» |
- | azithromycin / Generic mfg.
Journal: Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics. (Pubmed Central) - May 1, 2023
As drug-repurposing, our results indicate that AZM is a potent autophagy inhibitor for cancer treatment, which acts by directly interacting with cytoskeletal proteins and perturbing their dynamics.
- Cannabinoids induce extracellular vesicle synthesis in hmoDCs that promote Treg cell polarization (Hall Y 05+06) - Apr 30, 2023 - Abstract #EAACI2023EAACI_916;
Conclusion Cannabinoids enhance EV biogenesis and secretion in hmoDCs, which play an essential role in the imprinted tolerogenic properties in human DCs, including Treg cell generation. The better understanding of the mode of action of DC-derived EVs on the induction of tolerance might well pave the way for the future development of alternative therapeutic strategies for different immune-mediated inflammatory diseases.
- | Journal: GSPE attenuates CSE-induced lung inflammation and emphysema by regulating autophagy via the reactive oxygen species/TFEB signaling pathway. (Pubmed Central) - Apr 29, 2023
Inhibiting autophagy through GSPE treatment diminishes CSE-induced lung inflammation by inhibiting the NLRP3 inflammasome. This study demonstrates that GSPE can ameliorate CSE-induced inflammation and emphysema via autophagy-induced NLRP3 inflammasome regulation through the ROS/TFEB signaling pathway in a COPD mouse model.
- | Journal: Autophagy Inhibition as a Potential Therapeutic Strategy for Breast Cancer with Mitochondrial Translation Defect Caused by CBFB-Deficiency. (Pubmed Central) - Apr 28, 2023
Studies using in vivo models have shown that inhibiting autophagy selectively eliminates breast tumor cells with mitochondrial translation defects resulting from CBFB deficiency. Our results suggest that autophagy inhibition may be an effective treatment option for breast tumors carrying CBFB alterations.
- | sirolimus / Generic mfg.
Journal: The Role of LincRNA-EPS/Sirt1/Autophagy Pathway in the Neuroprotection Process by Hydrogen against OGD/R-Induced Hippocampal HT22 Cells Injury. (Pubmed Central) - Apr 28, 2023
Intriguingly, the protection of H against neuronal OGD/R injury was abolished by rapamycin...Taken together, the findings proved that neuronal cell injury caused by OGD/R is efficiently prevented by H via modulating lincRNA-EPS/Sirt1/autophagy-dependent pathway. It was hinted that lincRNA-EPS might be a potential target for the H treatment of CI/R injury.
- | GSK2606414 / GSK, Institute of Cancer Research, Dartmouth College, salubrinal / Soochow University
Journal: KDELC2 Upregulates Glioblastoma Angiogenesis via Reactive Oxygen Species Activation and Tumor-Associated Macrophage Proliferation. (Pubmed Central) - Apr 28, 2023
expression in THP-1 macrophages, indicating that mitochondrial ROS and autophagy could also interrupt THP-1-M1 macrophage polarization. In conclusion, mitochondrial ROS, ER stress, and the TAMs resulting from OE-KDELC2 glioblastoma cells play important roles in upregulating glioblastoma angiogenesis.
- | cisplatin / Generic mfg.
Journal: CLIC1-mediated autophagy confers resistance to DDP in gastric cancer. (Pubmed Central) - Apr 27, 2023
Cisplatin (DDP) has been approved as a critical chemotherapy drug to treat various kinds of solid tumors...These experiments suggest that CLIC1 could alter the sensitivity of gastric cancer cells to DDP by activating autophagy. Overall, the results of this study recommend a novel mechanism of DDP resistance in gastric cancer.
- | Preclinical, Journal: Resolvin D1 attenuates depressive-like behavior in LPS-challenged mice by promoting microglial autophagy. (Pubmed Central) - Apr 27, 2023
Notably, the aforesaid effects of RvD1 were eliminated by 3-MA, demonstrating that microglial autophagy was modulated. In conclusion, our findings shed new light on the involvement of microglial autophagy in SAE and emphasize the potential benefits of RvD1 as a promising therapeutic agent in the treatment of
- | GSK 2245840 / GSK
Journal: Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2. (Pubmed Central) - Apr 27, 2023
In addition, co-administration of 3-methyladenine, an autophagy inhibitor, or Bafilomycin A1, a lysosome inhibitor, abolished the suppressive effects of SRT2104 on PKM2 abundance, inflammatory response and multiple organ injury. Therefore, promotion of autophagic degradation of PKM2 might be a novel mechanism underlying the anti-inflammatory benefits of SIRT1 activator.
- Piqray (alpelisib) / Novartis
Preclinical evidence for synergistic effects of autophagy inhibitor and alpelisib in PI3KCA mutated non-small cell lung cancer: Implications for future clinical trials. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_6414;
Based on the results of the combination experiment of alpelisib and autophagy inhibitors, Chloroquine (CQ) was selected for further study. Based on these results, a Phase 1 clinical trial is currently being planned.
- Margenza (margetuximab) / MacroGenics, ZAI Lab, Lumakras (sotorasib) / Amgen
No checkmate in metastatic setting: Navigating real world patients applying personalized therapy based on extensive tumor profiling. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_4730;
ETP offers a chance for a majority of late stage patients often characterized by visceral crisis to prolong PFS with acceptable ECOG status. ETP is a milestone as cancer itself is a complex disease with the need for complex solutions.
- | chloroquine phosphate / Generic mfg., vinblastine / Generic mfg.
Journal: Thyroid hormone upregulates LAMP2 expression and lysosome activity. (Pubmed Central) - Apr 26, 2023
In the presence of the lysosomal autophagy inhibitors bafilomycin A1, chloroquine and ammonium chloride, we observed substantial accumulation of LAMP2 but not LAMP1 protein...More specifically, the protective effect of T against ER stress-induced death was abolished by knockdown of LAMP2. Our collective results indicate that T not only promotes lysosomal gene expression but also LAMP protein stability and microtubule assembly, leading to enhancement of lysosomal activity in digesting any additional autophagosomal burden.
- | Journal, IO biomarker: The mechanism by which miR-494-3p regulates PGC1-?-mediated inhibition of mitophagy in cardiomyocytes and alleviation of myocardial ischemia-reperfusion injury. (Pubmed Central) - Apr 26, 2023
MiR-494-3p can target and negatively regulate the expression of PGC1-? to inhibit mitophagy in cardiomyocytes.
- | PD98059 / Wayne State University
Journal: SIRT6 ameliorates LPS-induced apoptosis and tight junction injury in ARDS through the ERK1/2 pathway and autophagy. (Pubmed Central) - Apr 25, 2023
Meanwhile, the SIRT6-specific inhibitor OSS_128167 also activated the ERK1/2 pathway and inhibited lung autophagy. These results suggested that SIRT6 could ameliorate the loss of tight junction proteins, inflammation, and apoptosis in LPS-induced ARDS by inhibiting the ERK1/ 2 pathway and enhancing autophagy, indicating that SIRT6 plays a beneficial role in ARDS and might be a potential therapeutic target for ARDS.
- | Journal: The interaction between Hsp90-mediated unfolded protein response and autophagy contributes to As/ Se combination-induced apoptosis of acute promyelocytic leukemia cells. (Pubmed Central) - Apr 25, 2023
Moreover, As/Se combination blocks hepatic infiltration in an APL-NCG mouse model of extramedullary infiltration. Taken together, these findings provide novel agents and therapeutic approaches for APL.
- | dorsomorphin (Compound C) / EMD Serono
Journal: Forsythoside A regulates autophagy and apoptosis through the AMPK/mTOR/ULK1 pathway and alleviates inflammatory damage in MAC-T cells. (Pubmed Central) - Apr 25, 2023
Taken together, these results indicate that FTA can alleviate LPS-induced inflammation and oxidative stress in MAC-T cells, attenuate impairments in autophagy, and inhibit apoptosis. However, these effects were blocked by CC, which suggests that FTA inhibits LPS-induced autophagy, apoptosis, and inflammatory damage in MAC-T cells by activating the AMPK pathway.
- | Journal: Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy. (Pubmed Central) - Apr 25, 2023
Overall, abamectin caused respiratory system toxicity in carp via triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy. The study suggests that abamectin has a profound toxicity mechanism in the respiratory system of carp, contributing to a better understanding of pesticide risk assessment in aquatic systems.
- | sirolimus / Generic mfg.
Journal: Mitochondrial Hydrogen Peroxide Activates PTEN and Inactivates Akt Leading to Autophagy Inhibition-Dependent Cell Death in Neuronal Models of Parkinson's Disease. (Pubmed Central) - Apr 25, 2023
Overexpression of dominant negative PTEN, constitutively active Akt and/or pretreatment with rapamycin rescued the cells from PD toxins-induced downregulation of ATG5/LC3-II and upregulation of p62, as well as consequential autophagosome diminishment and apoptosis in the cells...Taken together, the results indicate that PD toxins can elicit mitochondrial HO, which can activate PTEN and inactivate Akt leading to autophagy inhibition-dependent neuronal apoptosis, and Parkin plays a critical role in this process. Our findings suggest that co-manipulation of the PTEN/Akt/autophagy signaling by antioxidants may be exploited for the prevention of neuronal loss in PD.
- || Review, Journal: Research Progress on Autophagy Regulation by Active Ingredients of Traditional Chinese Medicine in the Treatment of Acute Lung Injury. (Pubmed Central) - Apr 24, 2023
Studies have shown that autophagy may play a beneficial or harmful role in acute lung injury (ALI), and ALI has been treated with traditional Chinese medicine designed to promote or inhibit autophagy. In this paper, the molecular mechanism and common pathways regulating autophagy and the relationship between autophagy and ALI are introduced, and the active ingredients of traditional Chinese medicine that improve ALI symptoms by regulating autophagy are summarized.
- | sirolimus / Generic mfg.
Journal: Estrogen alleviates post-hemorrhagic shock mesenteric lymph-mediated lung injury through autophagy inhibition. (Pubmed Central) - Apr 24, 2023
In this paper, the molecular mechanism and common pathways regulating autophagy and the relationship between autophagy and ALI are introduced, and the active ingredients of traditional Chinese medicine that improve ALI symptoms by regulating autophagy are summarized. The role of estrogen reducing PHSML-mediated ALI is associated with the inhibition of autophagy.
- | Journal: Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer. (Pubmed Central) - Apr 23, 2023
To overcome this cross-talk, we used a low-iron diet and demonstrated that this augmented the response to autophagy inhibition therapy in PDAC-bearing mice. Our work highlights a critical link between autophagy, iron metabolism, and mitochondrial function that may have implications for PDAC progression.
- | sirolimus / Generic mfg.
Journal: Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X?, mTOR and MAPK pathways. (Pubmed Central) - Apr 21, 2023
Interestingly, the LL-37-induced distribution of tight junction proteins and improvement in the tight junction barrier were inhibited in autophagy-deficient keratinocytes and keratinocytes and skin models treated with autophagy inhibitors, indicating that the LL-37-mediated tight junction barrier is associated with autophagy activation. Collectively, these findings suggest that LL-37 is a potential therapeutic target for skin diseases characterized by dysfunctional autophagy and skin barriers.
- | Journal: Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis. (Pubmed Central) - Apr 20, 2023
These results demonstrate lyso-Gb3 induces necroptosis via autophagy and suggest that lyso-Gb3 inflamed retinal pigment epithelial cells trigger endothelial dysfunction via the autophagy-dependent necroptosis pathway. This study suggests the involvement of a novel autophagy-dependent necroptosis pathway in the regulation of endothelial dysfunction in Fabry disease.
- | fluphenazine / Generic mfg.
Journal: Repurposing fluphenazine to suppress melanoma brain, lung and bone metastasis by inducing G0/G1 cell cycle arrest and apoptosis and disrupting autophagic flux. (Pubmed Central) - Apr 20, 2023
In a lung metastasis model, FPZ reduced the proportion of M2 macrophages and increased the proportion of CD8 T cells and NK cells in vivo, thereby promoting an anticancer immune response. The findings of this study indicate that FPZ is a potential drug candidate for treating metastatic melanoma.
- | Preclinical, Journal: Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection. (Pubmed Central) - Apr 20, 2023
PI3K/AKT inhibition promoted mitochondrial autophagy in macrophages. Mitochondrial autophagy induction activated the downstream gene mTOR of the PI3K/AKT pathway, alleviated pulmonary inflammatory reactions, and decreased leukocyte counts.
- | Journal: Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca homeostasis in yeast. (Pubmed Central) - Apr 20, 2023
The overexpression of ORF3a confers calcineurin-dependent Ca tolerance and activates a Ca sensitive FKS2-luciferase reporter, suggesting a possible ORF3a-mediated Ca efflux from the vacuole. Taken together, we show that viral accessory proteins can be functionally investigated in yeast cells and that SARS-CoV-2 ORF3a and ORF7a proteins interfere with autophagosome formation and processing as well as with Ca homeostasis from distinct cellular targets.
- | Journal: Cotton Leaf Curl Multan virus C4 protein suppresses autophagy to facilitate viral infection. (Pubmed Central) - Apr 19, 2023
Moreover, plants infected with mutated CLCuMuV-C4R54K develop less severe symptoms with decreased levels of viral DNA. These findings reveal a molecular mechanism underlying how the DNA virus CLCuMuV deploys a VSA to subdue host cellular antiviral autophagy defense and uphold viral infection in plants.
- | dorsomorphin (Compound C) / EMD Serono
Preclinical, Journal: Electroacupuncture alleviates traumatic brain injury by inhibiting autophagy via increasing IL-10 production and blocking the AMPK/mTOR signaling pathway in rats. (Pubmed Central) - Apr 18, 2023
Both AMPK agonist AICAR and IL-10 neutralizing antibody treatments reversed the effects of EA on the related protein levels of autophagy and the AMPK/mTOR signaling pathway, and abolished the protective effects of EA on TBI rats. In conclusion, EA treatment promoted neurological function recovery and alleviated pathological damage and neuronal apoptosis in TBI rats through inhibiting excessive autophagy via increasing IL-10 production and blocking the AMPK/mTOR signaling pathway.
- || Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Auxora (zegocractin) / CalciMedica
Review, Journal: Trends and recent developments in pharmacotherapy of acute pancreatitis. (Pubmed Central) - Apr 18, 2023
However, challenges for exploring targeted treatment approaches include disease complexity, timing of therapeutic intervention, and establishing appropriate clinical endpoints. Understanding the role of specific biomarkers may help in identifying appropriate targets for drug discovery and facilitate determining relevant clinical study endpoints to monitor disease severity and progression, thereby aiding in design of more precise therapies with improved clinical outcomes.
- | doxycycline / Generic mfg.
Journal, IO biomarker: Nanodrug Inducing Autophagy Inhibition and Mitochondria Dysfunction for Potentiating Tumor Photo-Immunotherapy. (Pubmed Central) - Apr 15, 2023
Herein, a liposome nanodrug co-encapsulating doxycycline hydrochloride (Doxy) and chlorin e6 (Ce6) to simultaneously induce autophagy inhibition and mitochondria dysfunction for potentiating tumor photo-immunotherapy is developed...The nanodrugs elicit remarkable antitumor therapy by combining Ce6-mediated PDT and Doxy-induced autophagy inhibition and mitochondria dysfunction. The developed nanodrugs represent a highly efficient strategy for improving cancer immunotherapy.
- | Journal: DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway. (Pubmed Central) - Apr 15, 2023
These results suggested that DBP-induced oxidative stress activated the MAPK pathway, inhibited the PI3K pathway, which in turn inhibited the SIRT1/PGC-1? pathway and Nrf2 pathway, thereby causing cell autophagy and necroptosis.
- | chloroquine phosphate / Generic mfg.
Journal: Fusobacterium nucleatum outer membrane vesicles activate autophagy to promote oral cancer metastasis. (Pubmed Central) - Apr 15, 2023
Fn OMVs not only induced cancer metastasis but also activated autophagic flux. Blocking autophagic flux weakened Fn OMV-stimulated cancer metastasis.
- PROTECTIVE ROLE OF THE PODOCYTE IL-15 / STAT5 PATHWAY IN EXPERIMENTAL FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS (Amber 6) - Apr 15, 2023 - Abstract #ERAEDTA2023ERA_EDTA_731;
Blocking autophagic flux weakened Fn OMV-stimulated cancer metastasis. In conclusion, activating podocyte STAT5 with commercially available IL-15 represents a potential new therapeutic avenue for FSGS.
- | Journal: Tomato chlorosis virus p22 interacts with NbBAG5 to inhibit autophagy and regulate virus infection. (Pubmed Central) - Apr 14, 2023
NbBAG5 inhibited the expression of mitophagy-related genes and the number of autophagosomes, thereby regulating viral infection by affecting mitophagy. In summary, this study demonstrated that ToCV p22 affects autophagy by interacting with NbBAG5, established the association between viral infection, BAG proteins family, and the autophagy pathway, and explained the molecular mechanism by which ToCV p22 interacts with NbBAG5 to inhibit autophagy to regulate viral infection.
- | Preclinical, Journal: Activin A alleviates neuronal injury through inhibiting cGAS-STING-mediated autophagy in mice with ischemic stroke. (Pubmed Central) - Apr 14, 2023
Furthermore, Activin A depended on ACVR1C receptor to exert neuroprotective effects in 1?h MCAO/R treated mice. Our findings showed that Activin A alleviated neuronal ischemic injury through inhibiting cGAS-STING-mediated excessive autophagy in mice with ischemic stroke, which may suggest a potential therapeutic target for ischemic stroke.
- | paricalcitol / Generic mfg.
Journal: Vitamin D ameliorates podocyte injury by enhancing autophagy activity in diabetic kidney disease. (Pubmed Central) - Apr 14, 2023
Our findings showed that Activin A alleviated neuronal ischemic injury through inhibiting cGAS-STING-mediated excessive autophagy in mice with ischemic stroke, which may suggest a potential therapeutic target for ischemic stroke. Vitamin D ameliorates podocyte injury of DKD by enhancing podocyte autophagy activity, which may become a potential candidate autophagy activator for the therapeutic interventions for DKD.
- | Preclinical, Journal, IO biomarker, Metastases: Tanshinone IIA relieves arthritis by inhibiting autophagy of fibroblast-like synoviocytes via matrix metalloproteinase9/receptor for advanced glycation end product/toll-like receptor 9 signal axis in mice with collagen-induced arthritis. (Pubmed Central) - Apr 13, 2023
Finally, animal experiments confirmed that TIIA affected autophagy by regulating the MMP9/RAGE/TLR9 axis, and finally improve the symptoms of RA in mice. Conclusively, TIIA may inhibit expression of MMP9 to suppress the combination of RAGE and TLR9, thereby inhibiting RA-FLS proliferation and affecting autophagy, eventually improve the RA.
- | Journal: Edaravone promotes viability of random skin flaps via activating PI3K/Akt/mTOR signalling pathway-mediated enhancement of autophagy. (Pubmed Central) - Apr 12, 2023
Furthermore, EDA-induced autophagy was mediated through downregulating PI3K/Akt/mTOR signalling pathway. The findings showed that EDA ameliorated viability of random skin flaps by promoting angiogenesis, suppressing oxidative stress and apoptosis, which may be mediated by autophagic activation through downregulating PI3K/AKT/mTOR signalling pathway.
- chloroquine phosphate / Generic mfg., sorafenib / Generic mfg.
Lysosomotropic PIP5K inhibitors sensitize hepatic cancer to reative oxygen species by inhibiting proliferative and adaptive pathway (Poster Area) - Apr 12, 2023 - Abstract #EASLILC2023EASL_ILC_2295;
PIP5K inhibitors sensitized cancer cells to mild ROS. Thus, targeting PIP5K will overcome limitations of standard RTK, autophagy and Nrf2 inhibitors.
- dexamethasone / Generic mfg.
Autophagy regulates the generation and differentiation of chemically derived hepatic progenitors (CdHs) (Poster Area) - Apr 12, 2023 - Abstract #EASLILC2023EASL_ILC_2198;
In conclusion, all these findings indicate that autophagy regulates the generation of CdHs and the differentiation of CdHs into CdH-Heps. This research was supported by the National Research Foundation of Korea (2022R1A2C2004593), and the Korean Fund for Regenerative Medicine funded by Ministry of Science and ICT, and Ministry of Health and Welfare (21A0401L1).
- hydroxychloroquine / Generic mfg.
Unravelling an autophagy-dependent role of vitamin D in preserving gut integrity in experimental NASH (Poster Area) - Apr 12, 2023 - Abstract #EASLILC2023EASL_ILC_608;
These effects were mediated, at least in part, by modulating different tight junction proteins expression that is autophagy dependent. Figure: Immunohistochemical analysis against tight junction proteins, claudin-1 and occludin, in ileal sections of mice belonging to different treatment groups presented as means
- hydroxychloroquine / Generic mfg.
Effect of vitamin D receptor signaling on endoplasmic reticulum stress in non-alcohol related steatohepatitis: exploring potential autophagy dependence (Poster Area) - Apr 12, 2023 - Abstract #EASLILC2023EASL_ILC_590;
Figure: Effect of CAL on IRE1a protein levels in normal, HFD, CAL-treated, and CAL+HCQ-treated groups, as determined by ELISA. Statistical analysis was performed using One-way ANOVA followed by Tukey Kramer post hoc test for multiple comparisons.
- | docetaxel / Generic mfg.
Journal: Sympathetic ?-adrenergic receptor blockade overcomes docetaxel resistance in prostate cancer. (Pubmed Central) - Apr 12, 2023
Statistical analysis was performed using One-way ANOVA followed by Tukey Kramer post hoc test for multiple comparisons. Our data demonstrate that ?-AR inhibitor-induced autophagy and apoptosis contribute to the effectiveness responses to docetaxel in castration-resistant prostate cancer, and in combination with pharmacological agents of ?-AR and autophagy inhibitors may provide a potential therapeutic strategy to enhance the limited capacity of docetaxel to control castration-resistant prostate cancer.
- | Preclinical, Journal: Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson's disease depression model rats. (Pubmed Central) - Apr 12, 2023
At the same time, acupuncture upregulates p-mTOR expression, inhibits autophagy, and promotes synaptic protein expression. Therefore, we concluded that acupuncture might improve the behavior of DPD model rats by activating the mTOR pathway, inhibiting autophagy from removing ?-syn and repairing synapses.
- | Lynparza (olaparib) / Merck (MSD), AstraZeneca
Journal, PARP Biomarker: Mitochondria-associated endoplasmic reticulum membranes dysfunction contributes to PARP-1-dependent cell death under oxidative stress in retinal precursor cells. (Pubmed Central) - Apr 12, 2023
Results showed that receptor-interacting protein kinase (RIPK) 1 inhibitor (necrostatin-1) and PARP-1 inhibitor (olaparib) protected retinal precursor cells from H O -induced death, while a pan-caspase inhibitor (Z-VAD-FMK) failed to protect R28 cells...MAM dysregulation also contributed to H O -induced PARP-1-dependent cell death. However, more studies are required to decipher the link between the modulation of Mfn2 expression, changes in MAM integrity, and alterations in mitochondrial performances.
- | Journal, PARP Biomarker: Inhibition of autophagic flux by the curcumin analog EF-24 and its antiproliferative effect on MCF-7 cancer cells. (Pubmed Central) - Apr 12, 2023
Additional investigation of EF-24 should be performed in future studies to assess its antiproliferation and antimigratory effects on MCF-7 cells. However, the current results provide a solid foundation for the potential in vivo anticancer activity of this compound.
- | Journal: Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3?/mTOR signaling: A potential mechanism involved in prognostic performance of Klotho in coronary atherosclerotic disease. (Pubmed Central) - Apr 11, 2023
However, the current results provide a solid foundation for the potential in vivo anticancer activity of this compound. Prognostic significance of Klotho in CAD is potentially ascribed to its anti-endothelial senescence effect via autophagic flux restoration by inhibiting Wnt3a/ GSK-3?/mTOR signaling.
- | sorafenib / Generic mfg.
Journal, Tumor cell: An ATG4B inhibitor blocks autophagy and sensitizes Sorafenib inhibition activities in HCC tumor cells. (Pubmed Central) - Apr 11, 2023
More importantly, combination of DC-ATG4in with Sorafenib synergized the cancer cell killing effect and proliferation inhibition activities on HCC cells. Our data suggested that inactivation of autophagy via ATG4B inhibition may be a viable strategy to sensitize existing targeted therapy such as Sorafenib in the future.
- | chloroquine phosphate / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal, PARP Biomarker: Chloroquine synergizes doxorubicin efficacy in cervical cancer cells through flux impairment and down regulation of proteins involved in the fusion of autophagosomes to lysosomes. (Pubmed Central) - Apr 11, 2023
Our data suggested that inactivation of autophagy via ATG4B inhibition may be a viable strategy to sensitize existing targeted therapy such as Sorafenib in the future. Our data suggest that a combination of DOX
- | NT-157 / Purple Biotech
Journal: Repressing IRS1/2 by NT157 inhibits the malignant behaviors of ovarian cancer through inactivating PI3K/AKT/mTOR pathway and inducing autophagy. (Pubmed Central) - Apr 11, 2023
However, the autophagy inhibitor 3-MA partly reversed NT-157-mediated antitumor effects. In conclusion, this study disclosed that NT157 suppressed the malignant phenotypes of ovarian cancer cells by inducing autophagy and hampering the expression of IRS1/2 and PI3K/AKT/mTOR pathway.