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- | sirolimus / Generic mfg.
Journal: Autophagy exerts a protective role in cervical spinal cord injury by microglia inhibition through the NF-?B pathway. (Pubmed Central) - May 15, 2023
More importantly, enhanced autophagy induced by rapamycin (RAP) suppressed the NF-?B pathway and alleviated cervical contusion SCI-induced neurological function damage in mice...In conclusion, our study demonstrated that autophagy played a protective role in cervical SCI by promoting microglia polarization toward M2 through the NF-?B pathway. Our study may provide a novel sight for SCI treatment.
- | sirolimus / Generic mfg.
Journal: Autophagy: A newly discovered protective mechanism in the marine rotifer Brachionus plicatilis in response to BDE-47 exposure. (Pubmed Central) - May 15, 2023
Additional proof of this relation was obtained from the direct opposite effects of the autophagy inhibitor bafilomycin A1 and the autophagy activator rapamycin: the former increased the MDA content significantly, whereas the latter decreased it significantly. The combined results suggested that autophagy alleviated oxidative stress and might be a newly discovered protective mechanism in B. plicatilis coping with BDE-47 exposure.
- | Journal: Geminiviral C2 proteins inhibit active autophagy to facilitate virus infection by impairing the interaction of ATG7 and ATG8. (Pubmed Central) - May 15, 2023
Furthermore, we uncovered that the C2-mediated autophagy inhibition mechanism is conserved in three other geminiviruses. In summary, we discovered a novel counter-defense strategy employed by geminiviruses that enlists their C2 proteins as disrupters of ATG7-ATG8 interactions to defeat antiviral autophagy.
- | Journal: MiR-217 regulates autophagy through OPG/RANKL/RANK in giant cell tumors. (Pubmed Central) - May 15, 2023
These results suggest that miR-217 upregulation could inhibit the occurrence and development of GCT by blocking autophagy. These findings offer an effective therapeutic target to improve the survival rates of patients with CGT in the future.
- Regulatory roles of the N6-methyladenosine demethylase FTO in cardiac remodeling (Station 8) - May 13, 2023 - Abstract #ESC2023ESC_4123;
However, the autophagic flux is ameliorated with mTORC1 inhibition in late-autophagy inhibited siFTO-iPS-CMs. Conclusion Our data unravel the novel roles of FTO demethylase in the course of cardiac remodeling, which opens doors to therapeutic interventions in the treatment of cardiac hypertrophy and heart failure.
- Cardiomyocyte-specific beta3-adrenergic receptor expression reduces infarct size inhibiting the autophagic flux in mice. (Station 5) - May 13, 2023 - Abstract #ESC2023ESC_3489;
Cardiomyocyte-specific overexpression of ?3-adrenergic receptor reduces infarct size and protects the heart affecting the autophagy machinery. Our results shed light on the role of the ?3AR in the mitochondrial quality control system, offering evidence of its potential use as a target to decrease IR injury in patients with acute myocardial infarction.
- Cardiometabolic rewiring in the context of doxorubicin-induced cardiotoxicity: fuel preference changes from fatty acids to glucose oxidation (Station 8) - May 13, 2023 - Abstract #ESC2023ESC_1803;
These results demonstrate that PI3K? promotes a maladaptive metabolic rewiring in the heart in response to DOX, with an increased glucose utilization via a GLUT4-dependent mechanism.
- ADAM8 deficiency in macrophages promotes angiogenesis to antagonize post-myocardial infarction cardiac injury (Station 8) - May 13, 2023 - Abstract #ESC2023ESC_743;
ADAM8 KO may promoting VEGFA secretion and inhibiting inflammatory factors secretion of macrophages via AMPK/autophagy pathway, further promoting angiogenesis and reducing fibrosis of infarcted myocardium, and attenuating heart function and adverse remodeling. ADAM8 may be a new target for treating myocardial infarction.
- | Journal, IO biomarker: Acrylamide interferes with autophagy and induces apoptosis in Neuro-2a cells by interfering with TFEB-regulated lysosomal function. (Pubmed Central) - May 13, 2023
These findings strongly suggested that TFEB- regulated lysosomal function is responsible for ACR-caused autophagic flux inhibition and apoptosis in Neuro-2a cells. The present study hopes to explore new sensitive indicators in the mechanism of ACR neurotoxicity and thus provide new targets for the prevention and treatment of ACR intoxication.
- | Lenvima (lenvatinib) / Eisai, Merck (MSD)
Journal: Overexpression of the lncRNA HOTAIRM1 promotes lenvatinib resistance by downregulating miR-34a and activating autophagy in hepatocellular carcinoma. (Pubmed Central) - May 12, 2023
HOTAIRM1 is an independent drug resistance factor which significantly associated with the efficacy of lenvatinib in HCC. HOTAIRM1 may downregulation of miR-34a and upregulation of Beclin-1, leading to activation of autophagy, thereby inducing lenvatinib resistance in HCC.
- | Mekinist (trametinib) / Novartis, BeiGene
Trial completion, Enrollment change, Trial completion date: Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC). (clinicaltrials.gov) - May 12, 2023
P2, N=2, Completed, Sponsor: National Cancer Institute (NCI)
HOTAIRM1 may downregulation of miR-34a and upregulation of Beclin-1, leading to activation of autophagy, thereby inducing lenvatinib resistance in HCC. Recruiting --> Completed | N=30 --> 2 | Trial completion date: Dec 2025 --> Dec 2022
- PROTEOMIC ANALYSIS REVEALS AUTOPHAGY INHIBITION IN MYELODYSPLASTIC SYNDROMES () - May 12, 2023 - Abstract #EHA2023EHA_3409;
The subsequent comparison between patients with MDS of different prognosis showed that the loss of autophagy activity was more pronounced in low risk patients, highlighting the existence of molecular differences between MDS categories. Figure 1.
- bortezomib / Generic mfg.
GUIZHI FULING CAPSULE REGULATES AUTOPHAGY TO INTERFERE WITH BORTEZOMIB-INDUCED PERIPHERAL NEUROPATHY () - May 12, 2023 - Abstract #EHA2023EHA_2939;
*Correspondence to: Xing Cui, M.D and Ph.D. Taishan Scholar, Professor.
- P5091 / Progenra
CRIP1 INDUCES PIS RESISTANCE BY FORMING A COMPLEX WITH USP7 /PA200 AND ENHANCING PROTEASOME ACTIVITY AND AUTOPHAGY IN MULTIPLE MYELOMA (Poster area) - May 12, 2023 - Abstract #EHA2023EHA_1064;
CRIP1 is a potential target for MM therapy, can simultaneously inhibit proteasome activity and autophagy. Multiple myeloma, Protein-protein interaction, Drug resistance, Proteasome inhibitor
- chloroquine phosphate / Generic mfg.
ULTIMATE CLARIFICATION OF THE RELATIONSHIP BETWEEN ASPARAGINE SYNTHETASE ACTIVITY AND SENSITIVITY OF LEUKEMIA TO L-ASPARAGINASE (Poster area) - May 12, 2023 - Abstract #EHA2023EHA_968;
Importantly, ASNS activity correlates with ASNS protein levels in Asn-deplete conditions. In general,ASNS- plus cells are less sensitive to Asn-depletion than ASNS- null cells.
- bortezomib / Generic mfg., carfilzomib / Generic mfg.
PROTEASOME INHIBITORS INDUCE DNA DAMAGE AND MITOTIC CATASTROPHE IN ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) VIA AUTOPHAGY-MEDIATED DEGRADATION OF WEE1 (Poster area) - May 12, 2023 - Abstract #EHA2023EHA_949;
Moreover, carfilzomib trigger autophagy-mediated degradation of WEE1 in ALL via induction of ER-stress. The findings provide mechanistic insights of carfilzomib in ALL and rationalize the introduction of novel approach of combination treatment of carfilzomib with other DNA damaging agents.
- cabergoline / Generic mfg.
Dopaminergic Agonist Cabergoline Inhibits Autophagic Flux in Beta Pancreatic Cells (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_663;
We conclude that CAB is able to increase autophagic vesicle formation and, in addition, to decrease autophagic flux after 24h of stimulation in MIN6B1 pancreatic beta cells. This work was funded by CONICET, ANPCyT, Fundaci
- | chloroquine phosphate / Generic mfg.
Journal: Modulatory role of BV6 and chloroquine on the regulation of apoptosis and autophagy in non-small cell lung cancer cells. (Pubmed Central) - May 10, 2023
Both BV6 and CQ modulated in vitro expression of caspases and LC3-II which have critical regulatory roles in apoptosis and autophagy, respectively. Our findings suggest that BV6 and CQ could be promising candidates in NSCLC treatment and there is a need to explore them in vivo and in clinical applications.
- | Sutent (sunitinib) / Pfizer
Trial completion date, Trial primary completion date, Metastases: Sunitinib Malate and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Chemotherapy (clinicaltrials.gov) - May 10, 2023
P1, N=40, Active, not recruiting, Sponsor: National Cancer Institute (NCI)
Our findings suggest that BV6 and CQ could be promising candidates in NSCLC treatment and there is a need to explore them in vivo and in clinical applications. Trial completion date: Apr 2023 --> Jul 2023 | Trial primary completion date: Apr 2023 --> Jul 2023
- | Journal: Mechanism of Notch Signal Regulating Alveolar Epithelial Cell Autophagy after Infection with Klebsiella Pneumoniae. (Pubmed Central) - May 9, 2023
alveolar epithelial cells. Inhibiting the Notch signaling pathway may restrain KPN-induced A549 cell autophagy and inflammation response, shedding new insights for the treatment of pneumonia.
- | sirolimus / Generic mfg.
Journal: Ischemic postconditioning protects against acute kidney injury after limb ischemia reperfusion by regulating HMGB1 release and autophagy. (Pubmed Central) - May 9, 2023
In addition, rapamycin (autophagy activator) treatment increased the levels of inflammatory cytokine expression levels and decreased renal function, reversed the protective effect of I-PostC against LIR-induced AKI. In conclusion, I-PostC could play a protective role against AKI by regulating the release of HMGB1 and inhibiting autophagy activation.
- | MRT68921 / University of Dundee
Journal, Cancer stem: Evaluation of the Effectiveness of Various Autophagy Inhibitors in A549 Cancer Stem Cells. (Pubmed Central) - May 8, 2023
In the present work, we selected a panel of autophagy inhibitors (Autophinib, SBI-0206965, Siramesine, MRT68921, and IITZ-01), some of whom have been recently identified as effective autophagy inhibitors in cancer cells...Moreover, Autophinib-treated A549 cells are unable to form spheroids, which indicates a reduction in stemness. Thus, among the drugs studied, only Autophinib can be considered a potential agent against cancer stem cells.
- | Journal: Knockdown of KAT5/KIF11 induces autophagy and promotes apoptosis in anaplastic thyroid cancer cells. (Pubmed Central) - May 8, 2023
Upregulation of KIF11 expression reversed the effects of KAT5 silencing on the proliferative activity, apoptosis and autophagy of 8505C cells. In conclusion, the results indicated that KAT5 induced autophagy and promoted apoptosis of ATC cells by targeting KIF11, which may provide a promising target for the treatment of ATC.
- | Journal: Acrylamide induces human chondrocyte cell death by initiating autophagy?dependent ferroptosis. (Pubmed Central) - May 8, 2023
Hence, ACR inhibited cell proliferation and contributed to cell death by inducing autophagy-dependent ferroptosis while promoting autophagy by activating AMPK-ULK1-mTOR signaling in human chondrocytes. It was hypothesized that the presence of ACR in foodstuffs may increase the risk of AS and that decreasing ACR in food products is of importance.
- | Journal: miR-210 promotes hepatocellular carcinoma progression by modulating macrophage autophagy through PI3K/AKT/mTOR signaling. (Pubmed Central) - May 8, 2023
miR-210 can promote autophagy of M2 macrophages via PI3K/AKT/mTOR signaling pathway. M2 macrophage-derived miR-210 promotes the malignant progression of HCC via autophagy, suggesting that macrophage autophagy may serve as a new therapeutic target for HCC, and targeting miR-210 may reset the effect of M2 macrophages on HCC.
- | Journal, PARP Biomarker, IO biomarker: Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis. (Pubmed Central) - May 8, 2023
BBR had a protective effect on mouse fibrotic livers and reduced serum aspartate aminotransferase and alanine aminotransferase levels. Collectively, these results reveal a novel mechanism of BBR-induced autophagy inhibition triggering apoptosis in HSCs, providing a reliable experimental and theoretical basis for developing BBR-based candidate drugs for LF.
- | Journal: Calycosin alleviates cerebral ischemia/reperfusion injury by repressing autophagy via STAT3/FOXO3a signaling pathway. (Pubmed Central) - May 7, 2023
Collectively, these results reveal a novel mechanism of BBR-induced autophagy inhibition triggering apoptosis in HSCs, providing a reliable experimental and theoretical basis for developing BBR-based candidate drugs for LF. Treatment with CA attenuated CIRI by reducing excessive autophagy via STAT3/FOXO3a signal pathway in rat and PC12 cells.
- | Journal: LAMP3 induces lysosome-dependent cell death by impairing autophagic caspase-8 degradation in Sj (Pubmed Central) - May 7, 2023
LAMP3 overexpression induced lysosomal dysfunction, resulting in lysosome-dependent cell death via impaired autophagic caspase-8 degradation, and restoring lysosomal function by GLP-1R agonists could prevent this. These findings suggested that LAMP3-induced lysosomal dysfunction is central to disease development and a target for therapeutic intervention in SjD.
- | chloroquine phosphate / Generic mfg.
Preclinical, Journal: Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux. (Pubmed Central) - May 7, 2023
Intriguingly, blocking AFB1-induced autophagic flux generated ROS- and TRPML1-dependent cell death, as shown by the decreased apoptosis in the presence the free radical scavenger N-Acetyl-L-cysteine and the TRPML1 inhibitor ML-SI1. Overall, these results showed that AFB1 promoted apoptosis of IPEC-J2 cells by disrupting autophagic flux through activation of the ROS/TRPML1 pathway.
- | erastin - Whitehead Institute for Biomedical Research, Dana / Farber Cancer Institute, Columbia University, Prolexys
Journal: Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS. (Pubmed Central) - May 7, 2023
Melatonin combined with erastin exhibits synergistic anticancer effects without adverse reactions. Herein, this combination might become a promising alternative strategy for oral cancer treatment.
- | temozolomide / Generic mfg.
Journal: In Situ Nitric Oxide Gas Nanogenerator Reprograms Glioma Immunosuppressive Microenvironment. (Pubmed Central) - May 7, 2023
Here, this work designs hybrid drug-loaded nanoliposomes by co-loading the chemotherapeutic drug temozolomide (TMZ) and nitric oxide (NO) prodrug JS-K with sphingosine-1-phosphate molecules (S1P) on the surface...The positive immune response in turn effectively activates the enhanced efficacy of chemotherapy. NO gas generated nanoliposomes thus have attractive paradigm-shifting applications in the treatment of "cold" tumors across a range of immunosuppressive indications.
- | Journal, IO biomarker: Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis. (Pubmed Central) - May 6, 2023
Considering the pathophysiological consequences of ROS-mediated apoptosis and autophagy, a combinatorial approach, including apoptosis inhibition and autophagy activation, a therapeutic strategy to treat male idiopathic infertility. Understanding the crosslink between apoptosis and autophagy under stress conditions in male germ cells may play an essential role in developing therapeutic strategies to treat infertility.
- | Journal: Chemo- and Diastereoselective Cycloisomerization/[2 + 3] Cycloaddition of Enynamides: Synthesis of Spiropyrazolines as Potential Anticancer Reagents. (Pubmed Central) - May 5, 2023
The compound 3u exhibits obvious anticancer activity by inducing apoptosis in RKO cells. The combination of compound 3u and an autophagy inhibitor could improve its anti-proliferation capacities.
- THE PREDICTIVE VALUE OF URINARY CONGOPHILIA AS A BIOMARKER IN PREGNANT AND NON-PREGNANT WOMEN WITH LUPUS NEPHRITIS. (Focussed Oral Room 9) - May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_1885;
CRR is related to disease activity rather than pregnancy. Figure 1: ROC curve to test the diagnostic accuracy assessment of CRR to capture high LN activity status (NIH-AI >10) versus lower LN activity status (NIH-AI ?10).
- chloroquine phosphate / Generic mfg.
AUTOPHAGY REGULATES TUBULAR CELL SENESCENCE IN DIABETIC KIDNEY DISEASE (Focussed Oral Room 9) - May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_1842;
Renal tubular cell senescence is closely associated with DKD progression. Autophagic flow may be involved in high glucose-induced renal tubular cell senescence.
- | sirolimus / Generic mfg.
Journal: Liensinine ameliorates ischemia-reperfusion-induced brain injury by inhibiting autophagy via PI3K/AKT signaling. (Pubmed Central) - May 3, 2023
An in vitro ischemia-reperfusion (I/R) neuronal cell model was established and pretreated with liensinine or rapamycin (RAPA)...However, addition of RAPA reversed the effects of liensinine treatment and aggravated brain tissue injury. Therefore, liensinine can play a neuroprotective role in CIRI by inhibiting autophagy through regulation of the PI3K/Akt pathway.
- | sirolimus / Generic mfg.
Journal: Autophagy and unfolded protein response induction: a crosstalk between street rabies virus and the host. (Pubmed Central) - May 3, 2023
However, alterations in CASP3 gene expression were only observed when the vector and the virus were simultaneously injected into the cells. Overall, protection and autophagy against cell death induced by SRABV infection can be achieved by activating the ER stress pathway, followed by a marked increase in the expression of ATF6, CHOP, ASK1, and CASP3 genes.
- | dexmedetomidine / Generic mfg.
Preclinical, Journal: Dexmedetomidine mitigates neuroinflammation and improves early postoperative neurocognitive dysfunction in rats by enhancing autophagy. (Pubmed Central) - May 3, 2023
In conclusion, our study indicated that Dex inhibited hippocampal neuroinflammation and ameliorated PND by enhancing autophagy after surgery in rats, which was related to the LKB1/AMPK/ULK1 signaling pathway. These findings provide a potential therapeutic prospect for PND.
- || Review, Journal: Puerarin: a potential natural neuroprotective agent for neurological disorders. (Pubmed Central) - May 3, 2023
This review will contribute to the development of puerarin as a novel clinical drug candidate for the treatment of neurological disorders. However, well-designed, high-quality, large-scale, multicenter randomized clinical studies are needed to determine the safety and clinical utility of puerarin in patients with neurological disorders.
- | Torin1 / InvivoGen
Journal: TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation. (Pubmed Central) - May 3, 2023
Taken together, these results suggest that transcription factor EB is involved in the development of diabetic retinopathy. In addition, transcription factor EB protects human retinal capillary endothelial cells from high glucose-induced endothelial damage via autophagy.
- | Journal: A novel teleost microRNA regulates autophagy and NF-?B activation during bacterial infection. (Pubmed Central) - May 2, 2023
Novel-m0089-3p overexpression, as well as E. tarda infection, activated NF-?B and stimulated the expression of inflammatory cytokines. Together these results revealed an important role of novel-m0089-3p in response to bacterial infection.
- | Journal: Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway. (Pubmed Central) - May 2, 2023
Moreover, induction of autophagy promotes echovirus replication and viral protein VP1 expression, while inhibition of autophagy impairs VP1 expression. Our findings suggest that autophagy can be induced by echovirus infection via regulating mTOR/ULK1 signaling pathway and exhibits a proviral function, revealing the potential role of autophagy in echovirus infection.
- | chloroquine phosphate / Generic mfg.
Journal: Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction. (Pubmed Central) - May 2, 2023
Our data suggest that TRF2 depletion can inhibit cell growth, proliferation, and migration through the combined action of ferroptosis, autophagic death, and apoptosis in GC cells. The results indicate that TRF2 might be used as a potential target to develop therapeutic strategies for treating GC.
- | Journal, Metastases: Glycoprotein Non-Metastatic Melanoma Protein B Restricts PRRSV Replication by Inhibiting Autophagosome-Lysosome Fusion. (Pubmed Central) - May 2, 2023
Using a specific inhibitor, we confirmed that the inhibition of autophagosome-lysosome fusion significantly inhibited viral replication. Taken together, our data demonstrate that GPNMB inhibits PRRSV replication by inhibiting the autophagosome-lysosome fusion and provides a novel therapeutic target for virus infection.
- | Journal: Protective Effect of Ferulic Acid on Lipopolysaccharide-Induced BV2 Microglia Inflammation via AMPK/mTOR Signaling Pathway. (Pubmed Central) - May 2, 2023
and its regulatory effect on AMPK/mTOR were destroyed by 3-MA and CC, which further indicated that FA's inhibitory effect on neuroinflammation is related to its activation of the AMPK/mTOR autophagy signaling pathway. In a word, our experimental results show that FA can inhibit LPS-induced neuroinflammation of BV2 microglia by activating the AMPK/mTOR signaling pathway, and FA may be a potential drug for treating neuroinflammatory diseases.
- || Review, Journal: Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer. (Pubmed Central) - May 2, 2023
We also highlight the research on natural compounds that are particularly promising autophagy modulators for CRC treatment with clinical evidence. Overall, this review illustrates the importance of autophagy in CRC and provides perspectives for these natural autophagy regulators as new therapeutic candidates for CRC drug development.
- | Preclinical, Journal: Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3. (Pubmed Central) - May 1, 2023
Human SCA3 neuronal progenitor cells also show a relative increase in K63-Ub proteins upon autophagy inhibition. We conclude that wild-type and mutant ATXN3 differentially impact K48-Ub- and K63-Ub-modified proteins in the brain in a region- and age-dependent manner.
- | chloroquine phosphate / Generic mfg.
Journal: Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway. (Pubmed Central) - May 1, 2023
baumannii OmpA induced autophagy in BMDCs involving the PI3K/mTOR pathway. Our study may provide a novel therapeutic target and theoretical basis for treating infections caused by A. baumannii.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation. (Pubmed Central) - May 1, 2023
Importantly, the use of early autophagy inhibitor 3-MA protected cardiomyocyte cells from DOX-induced cardiotoxicity in vitro and in a chronic AIC mouse model. Our findings demonstrate that inhibiting early stage of autophagy may be an effective preventative therapeutic strategy to protect cardiac function from AIC.
- | paracetamol / Generic mfg.
Journal: Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition. (Pubmed Central) - May 1, 2023
The underlying molecular mechanism was associated with the NLRP3 inflammasome inhibition which was likely driven by the upregulated autophagy activity. Our study underpins the traditional use of PTH in protecting liver through its anti-inflammatory action.