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- || Review, Journal: Anticancer Potential of the Plant-Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches. (Pubmed Central) - Aug 7, 2023
As a conclusion, it can be proposed that gracillin could serve as a hopeful chemotherapeutic agent. However, further extensive clinical research is recommended to establish its safety, efficacy, and therapeutic potential in cancer treatment.
- | chloroquine phosphate / Generic mfg.
Journal: Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer. (Pubmed Central) - Aug 7, 2023
In conclusion, shikonin could induce necroptosis and impaired autophagic flux through RIP3/p62/Keap1 complex regulatory system, necroptosis could inhibit the process of autophagy via RIP3. Combining shikonin with late autophagy inhibitor could further activate necroptosis via disturbing RIP3 degradation in bladder cancer in vitro and in vivo.
- | hydroxychloroquine / Generic mfg.
Journal: PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis. (Pubmed Central) - Aug 7, 2023
In addition, hydroxychloroquine (HCQ), an autophagy inhibitor, significantly reversed the protective effects from PTP1B knockdown...Taken together, our data demonstrated that PTP1B silencing protects against BMSCs senescence and mitigates SOP via activating AMPK-mediated mitophagy. Targeting PTP1B may represent a promising interventional strategy to attenuate SOP.
- | Tavalisse (fostamatinib) / Rigel, Kissei
Journal: Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis. (Pubmed Central) - Aug 5, 2023
Altogether, this study reveals a novel functional relationship between TLK2 and the mTORC1/ASNS axis in GC. Therefore, TLK2 may serve as a potential therapeutic target for GC.
- | MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Journal: LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma. (Pubmed Central) - Aug 4, 2023
Therefore, TLK2 may serve as a potential therapeutic target for GC. XXYLT1-AS2 plays an oncogenic role in HCC progression through inhibition of autophagy via promoting the degradation of TFEB, and thus could be a novel target for HCC treatment.
- || Preclinical, Review, Journal: Autophagy characteristics of phytoestrogens in management and prevention of diseases: A narrative review of in-vivo and in-vitro studies. (Pubmed Central) - Aug 3, 2023
The collaborative research on animal models, utilization of genetic techniques, and administration of pharmacologically active substances has indicated the possible therapeutic benefits of autophagy modulation in various illnesses. Further research is required to illustrate the pathways by which phytoestrogens modulate autophagy and the possible therapeutic effects on these diseases.
- | 5-fluorouracil / Generic mfg.
Preclinical, Journal: Geraniol suppresses tumour growth and enhances chemosensitivity of 5-fluorouracil on breast carcinoma in mice: involvement of miR-21/PTEN signalling. (Pubmed Central) - Aug 3, 2023
Further research is required to illustrate the pathways by which phytoestrogens modulate autophagy and the possible therapeutic effects on these diseases. It can be concluded that geraniol could represent a promising avenue for breast cancer treatment as well as a potential sensitizing agent when combined with chemotherapeutic drugs.
- | Journal: Sugar Starvation Disrupts Lipid Breakdown by Inducing Autophagy in Embryonic Axes of Lupin (Lupinus spp.) Germinating Seeds. (Pubmed Central) - Aug 2, 2023
Additionally, based on ultrastructure observation, we documented that, under sugar starvation conditions lipophagy (autophagic degradation of whole lipid droplets) may also occur but this type of selective autophagy seems to be restricted under starvation conditions. Our results also show that autophagy occurs at the very early stages of plant growth and development, including the cells of embryonic seed organs, and allows cell survival under starvation conditions.
- | Journal: miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO-Induced Lung Fibrosis. (Pubmed Central) - Aug 2, 2023
These results show that miR-29a-3p overexpression can partially reverse the fibrotic effects by activating autophagy of the pulmonary epithelial cells regulated by the Akt3/mTOR pathway. Therefore, targeting miR-29a-3p may provide a new therapeutic strategy for silica-induced pulmonary fibrosis.
- | chloroquine phosphate / Generic mfg.
Journal: Autophagy Inhibition with Chloroquine Increased Pro-Apoptotic Potential of New Aziridine-Hydrazide Hydrazone Derivatives against Glioblastoma Cells. (Pubmed Central) - Aug 2, 2023
The new aziridine-hydrazide hydrazone derivatives, which present cytotoxic potential against glioblastoma cells comparable to or even higher than that of temozolomide, show promising results and, thus, should be further investigated as antineoplastic agents. Moreover, our findings suggest that the combination of an apoptosis inducer with an autophagy inhibitor could optimize chemotherapeutic efficiency, and the addition of an autophagy inhibitor should be considered as an optional adjunctive therapy minimizing the risk of tumor escape from treatment.
- | Journal, PARP Biomarker: Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells. (Pubmed Central) - Aug 2, 2023
These findings support the notion that HPSE promotes autophagy, providing evidence that RDS 3337 blocks autophagic flux. It indicates a role for HPSE inhibitors in the balance between apoptosis and autophagy in U87 human glioblastoma cells, suggesting a potential role for this new class of compounds in the control of tumor growth progression.
- | Journal, IO biomarker: Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies. (Pubmed Central) - Aug 2, 2023
More important, these ligands can act in synergy with MAPKi to more efficiently inhibit cell growth and overcome drug resistance in both BRAF wild-type and mutant melanoma. In conclusion, targeting PHBs represents a very promising therapeutic strategy in melanoma, regardless of mutational status.
- | resatorvid (TAK-242) / Takeda, Akaza Bioscience
Preclinical, Journal, IO biomarker: TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats. (Pubmed Central) - Aug 2, 2023
in the hippocampus. In conclusion, TAK-242 significantly reduced hippocampal neuronal damage by inhibiting autophagy and neuroinflammatory activity, possibly via the NF-?B signaling pathway.
- | Sutent (sunitinib) / Pfizer
Trial completion, Metastases: Sunitinib Malate and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Chemotherapy (clinicaltrials.gov) - Aug 2, 2023
P1, N=40, Completed, Sponsor: National Cancer Institute (NCI)
In conclusion, TAK-242 significantly reduced hippocampal neuronal damage by inhibiting autophagy and neuroinflammatory activity, possibly via the NF-?B signaling pathway. Active, not recruiting --> Completed
- | Journal: Cyanotoxins Increase Cytotoxicity and Promote Nonalcoholic Fatty Liver Disease Progression by Enhancing Cell Steatosis. (Pubmed Central) - Aug 1, 2023
Moreover, RNA sequencing (RNA seq) data suggested that exposure of human hepatocytes, HepaRG, and HCC HepG2 cells to MC-LR and CYN modulated expression levels of several genes that regulate non-alcoholic fatty liver disease (NAFLD). Our data suggest that low concentrations of cyanotoxins can cause hepatotoxicity and cell steatosis and promote NAFLD progression.
- | dimethyl fumarate / Generic mfg.
Journal: Dimethyl fumarate ameliorates Parkinsonian pathology by modulating autophagy and apoptosis via Nrf2-TIGAR-LAMP2/Cathepsin D axis. (Pubmed Central) - Aug 1, 2023
TIGAR expression upregulated LAMP2 expression and downregulated Cathepsin D, promoting autophagy and inhibiting apoptosis. Thus, it was proved that DMF confers neuroprotection against rotenone-induced dopaminergic neurodegeneration and could be used as a potential therapeutic agent for PD and its progression.
- | doxorubicin hydrochloride / Generic mfg.
Journal: M2b macrophages protect against doxorubicin induced cardiotoxicity via alternating autophagy in cardiomyocytes. (Pubmed Central) - Jul 31, 2023
Thus, it was proved that DMF confers neuroprotection against rotenone-induced dopaminergic neurodegeneration and could be used as a potential therapeutic agent for PD and its progression. Our study shows that M2b macrophages can help attenuate the DOX induced cardiotoxicity by regulating the autophagy level of cardiomyocytes.
- | chloroquine phosphate / Generic mfg., paclitaxel / Generic mfg.
Journal: Chloroquine Sensitizes Esophageal Carcinoma EC109 Cells to Paclitaxel by Inhibiting Autophagy. (Pubmed Central) - Jul 31, 2023
Furthermore, inhibiting Akt/mTOR pathway initiated autophagy and enhanced the sensitivity of EC109 to CQ and PTX. In summary, we suggest CQ could be used as a potential chemosensitizer for PTX in esophageal carcinoma treatment.
- | Preclinical, Journal: HSPB8-Mediated Actin Filament Reorganization by Promoting Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB) Injury in an In Vitro Model of Ischemic Stroke. (Pubmed Central) - Jul 31, 2023
Autophagy inhibition partially reversed the effect of HSPB8 on the RhoA/ROCK2/p-MLC pathway. Taken together, the present study revealed that the restoration of autophagic flux by overexpressing HSPB8, via the inhibition of the RhoA/ROCK2/p-MLC signaling pathway, reverses the aggregation of endothelial cytoskeleton actin, eventually alleviating OGD/R-induced BBB injury.
- | Journal: Association between intracerebral hemorrhage and cholesterol levels, and molecular mechanism underlying low cholesterol inhibiting autophagy in cerebral arterial smooth muscle cells leading to cell necrosis. (Pubmed Central) - Jul 31, 2023
Taken together, the present study revealed that the restoration of autophagic flux by overexpressing HSPB8, via the inhibition of the RhoA/ROCK2/p-MLC signaling pathway, reverses the aggregation of endothelial cytoskeleton actin, eventually alleviating OGD/R-induced BBB injury. Low cholesterol levels may inhibit autophagy through PI3K/Akt/mTOR signaling and induce arterial smooth muscle cell necrosis, thereby increasing the risk of ICH.
- | thapsigargin / University of Nottingham, Pirbright Institute
Journal: Mechanisms of autophagy and endoplasmic reticulum stress in the reversal of platinum resistance of epithelial ovarian cancer cells by naringin. (Pubmed Central) - Jul 31, 2023
Nar not only inhibited the autophagy in SKOV3/DDP cells by regulating the PI3K/AKT/mTOR signalling pathway, but also promoted apoptosis in SKOV3/DDP cells by targeting ER stress. Nar can reverse the cisplatin resistance in SKOV3/DDP cells through these two mechanisms.
- | Journal: Dendritic distribution of autophagosomes underlies pathway-selective induction of LTD. (Pubmed Central) - Jul 30, 2023
Our previous study shows that the high autophagy in adulthood disallows SC LTD induction. The reduction of autophagosomes from proximal to distal dendrites, combined with distinct LTD inducibility at SC and TAP synapses, suggests a model where the differential distribution of autophagosomes in dendrites gates LTD inducibility at specific circuits.
- | Preclinical, Journal: Protective effects of total saponins from Panax japonicus against high-fat diet-induced testicular Sertoli cell junction damage in mice (Pubmed Central) - Jul 29, 2023
The reduction of autophagosomes from proximal to distal dendrites, combined with distinct LTD inducibility at SC and TAP synapses, suggests a model where the differential distribution of autophagosomes in dendrites gates LTD inducibility at specific circuits. TSPJ alleviates high-fat diet-induced damages of testicular Sertoli cell junctions and spermatogenesis possibly by activating the AKT/mTOR signaling pathway and inhibiting autophagy of testicular Sertoli cells.
- || hydroxychloroquine / Generic mfg.
Review, Journal: Dual role of autophagy for advancements from conventional to new delivery systems in cancer. (Pubmed Central) - Jul 29, 2023
The review article explores a variety of organic nanoplatforms, such as lipid-based, polymer-based, and DNA-based systems, which incorporate autophagy-inhibiting drugs like hydroxychloroquine...Furthermore, metal-based, metal-oxide-based, silica-based, and quantum dot-based nanoplatforms selectively induce autophagy in tumors, leading to extensive cancer cell destruction. Additionally, this article discusses the current clinical status of autophagy-modulating drugs for cancer therapy with valuable insights of progress and potential of such approaches.
- | Journal: Inhibition of Autophagy and the Cytoprotective Role of Smac Mimetic against ROS-Induced Cancer: A Potential Therapeutic Strategy in Relapse and Chemoresistance Cases in Breast Cancer. (Pubmed Central) - Jul 28, 2023
Overall, the present investigation shows that SMC has therapeutic and cytoprotective potential against oxidative stress in cancer cells. These Smac mimetic compounds may be used as anti-cancer drugs as well as antioxidants alone or in conjunction with other commonly used antioxidants.
- | Journal: RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis. (Pubmed Central) - Jul 28, 2023
These Smac mimetic compounds may be used as anti-cancer drugs as well as antioxidants alone or in conjunction with other commonly used antioxidants. These findings elucidate molecular mechanisms linking necroptosis to the STING pathway, and suggest a potential benefit of therapeutic targeting of necroptosis in STING-driven inflammatory diseases.
- | Journal: Perylenediimides with Enhanced Autophagy Inhibition for a Dual-Light Activatable Photothermal Gas Therapy. (Pubmed Central) - Jul 28, 2023
Remarkably, in a mouse subcutaneous tumor model, significant tumor ablation can be achieved following dual light activated photothermal gas therapy. This work offers a promising and straightforward approach to constructing activatable perylenediimide-based photothermal agents for enhancing the effectiveness of photothermal gas therapy.
- | metformin / Generic mfg.
Journal: Metformin Alleviates Sepsis-associated Myocardial Injury by Enhancing AMPK/mTOR Signaling Pathway-mediated Autophagy. (Pubmed Central) - Jul 27, 2023
Treatment with compound C, an AMPK inhibitor, reversed the metformin-induced autophagy in LPS-treated H9c2 cells. In conclusion, metformin pretreatment alleviates LPS-induced myocardial injury by activating AMPK/mTOR pathway-mediated autophagy.
- | Journal: METTL3 promotes hyperoxia-induced pyroptosis in neonatal bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy. (Pubmed Central) - Jul 27, 2023
In conclusion, METTL3-mediated cell pyroptosis promotes BPD by regulating the m6A modification of ATG8. This may provide new insight into the development of BPD.
- etoposide IV / Generic mfg.
PPM1D/WIP1 phosphatase mediates basal and genotoxic stress-induced autophagy via ULK-1 de-phosphorylation () - Jul 27, 2023 - Abstract #ESMO2023ESMO_1723;
Methods Etoposide was used to induce autophagy and Chloroquin (CQ) for inhibition...In addition Wip1 dependent autophagy in response to chemotherpy agents may cause resistance to chemotherapy. Thus targeting of Wip1-Ulk1 may lead enhancement of the chemotherapy response as a promising therapetic strategy.
- hydroxychloroquine / Generic mfg., everolimus / Generic mfg.
A phase II trial targeting disseminated dormant tumor cells with hydroxychloroquine, everolimus or the combination to prevent recurrent breast cancer ("CLEVER") (Bilbao Auditorium - NCC) - Jul 27, 2023 - Abstract #ESMO2023ESMO_1287;
P2
Conclusions The CLEVER trial provides proof-of-principle that therapeutic targeting of dormant BC is feasible and active in eliminating DTCs by targeting dormancy-specific mechanisms. Follow up for recurrence and survival is ongoing.
- | Journal: Autophagy suppression facilitates macrophage M2 polarization via increased instability of NF-?B pathway in hepatocellular carcinoma. (Pubmed Central) - Jul 26, 2023
Altogether, we illustrated that macrophage autophagy was involved in the process of HCC cells domesticating M2 macrophage polarization via the NF-?B pathway. These results provide a new target to interfere with the polarization of macrophages to M2-like phenotype during HCC progression.
- | chloroquine phosphate / Generic mfg., decitabine / Generic mfg.
Journal, Epigenetic controller: RNautophagic regulation of DNMT3a-dependent DNA methylation by Linc00942 enhances chemoresistance in gastric cancer. (Pubmed Central) - Jul 25, 2023
Inhibition of autophagy increases Linc00942 expression to promote chemoresistance and autophagy activation or hypomethylating agent decitabine restores chemosensitivity by reducing global DNA methylation. Overall, this study identifies a novel methylation cascade linking impaired RNautophagy to global hypermethylation in chemoresistance, and provides a rationale for repurposing decitabine to overcome chemoresistance in cancer treatment.
- Tagrisso (osimertinib) / AstraZeneca
Synthetic Lethality Targeting Programmed Cell Death Reverses the Osimertinib Resistance Induced by ARID1A Deficiency in LUAD (Exhibit Hall) - Jul 25, 2023 - Abstract #IASLCWCLC2023IASLC_WCLC_1276;
Effects of GSK-126, simvastatin and osimertinib on ARID1A-kd cells were explored. EZH2 inhibitor could reverse the cancer progression and osimertinib resistance induced by ARID1A-kd in LUAD via inhibiting proteasome function.
- CSNK1D and CSNK1E Inhibition Regulates Autophagy by Promoting Autophagic Flux in Lung Cancer (Exhibit Hall) - Jul 25, 2023 - Abstract #IASLCWCLC2023IASLC_WCLC_1215;
EZH2 inhibitor could reverse the cancer progression and osimertinib resistance induced by ARID1A-kd in LUAD via inhibiting proteasome function. Our results provide evidence for the role of CSNK1D/E in cancer cell autophagy, which suggests the impact of CSNK1D/E inhibition for tumorigenesis and its significance as a potential therapeutic target in lung cancer.
- | Preclinical, Journal: Autotaxin promotes the degradation of the mucus layer by inhibiting autophagy in mouse colitis. (Pubmed Central) - Jul 25, 2023
In vitro, we obtained consistent results. Thus, we concluded that ATX could inhibit autophagy through the AMPK pathway, which consequently disordered the mucus barrier and aggravated intestinal inflammation.
- | Journal: The miR-224-5p/SIRT3/AMPK/mTOR axis is involved in the melatonin-mediated inhibition of glucocorticoid-induced osteoporosis by activating autophagy. (Pubmed Central) - Jul 24, 2023
Additionally, miR-224-5p inhibited SIRT3 expression and AMPK pathway activation. In summary, we discovered that melatonin suppressed glucocorticoid-induced osteoporosis and autophagy inhibition via the miR-224-5p/SIRT3/AMPK/mTOR axis.
- | Journal: Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy. (Pubmed Central) - Jul 24, 2023
To our knowledge, this is the first report on a disrupting intrinsic protective mechanism of cancer cells for tumor pyroptosis therapy. This work highlights that autophagy as a checkpoint plays a key regulative role in pyroptosis therapy, which would motivate the future design of therapeutic regimens.
- | Preclinical, Journal: Maternal protein deficiency alters primary cilia length in renal tubular and impairs kidney development in fetal rat. (Pubmed Central) - Jul 24, 2023
However, the cilia elongation induced by DYNLT1 knockdown was not autophagy-dependent, but associated with reactive oxygen species (ROS) accumulation. We elucidated that intrauterine protein malnutrition led to deregulation of ciliogenesis factors and cilia elongation in renal tubular epithelial, inhibited ?-catenin signaling, and induced cell apoptosis and ultimately, compromised kidney development.
- | thapsigargin / University of Nottingham, Pirbright Institute
Journal: Botulinum toxin type A activates protective autophagy by modulating endoplasmic reticulum stress in hypoxia/reoxygenation-treated endothelial cells. (Pubmed Central) - Jul 24, 2023
Following pretreatment with 1.6 U/mL BTXA and the addition of the ER stress inducer Thapsigargin (Tg), the ER stress inhibitor 4-phenylbutyrate (4-PBA), and the inhibitor of autophagy Bafilomycin A1 (Baf A1), respectively, HDMECs were then subjected to H/R treatment...There were no cytoprotective effects from either excessive activation or reduction of ER stress. Our results are consistent with the notion that autophagy and moderate ER stress are critical for cellular longevity and, consequently, functional integrity and may represent a potential therapeutic target.
- | sirolimus / Generic mfg.
Journal: Tanshinone?A inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via 14-3-3?/Akt/Beclin1 pathway. (Pubmed Central) - Jul 24, 2023
In conclusion, TSN could increase 14-3-3? expression and regulate Akt/Beclin1 pathway, inhibit excessive autophagy, maintain the mitochondrial function, improve energy supply and redox equilibrium, alleviate apoptosis, and ultimately protect myocardium against I/R injury.
- | chloroquine phosphate / Generic mfg.
Journal: 1,8-Cineole ameliorates endothelial injury and hypertension induced by L-NAME through regulation of autophagy via PI3K/mTOR signaling pathway. (Pubmed Central) - Jul 24, 2023
The addition of autophagy inhibitor CQ increases the expression of eNOS. Taken together, our results indicate that 1,8-Cineole has potential beneficial promising antihypertension depending on the integrity of vascular endothelial structure and function induced by L-NAME, and the mechanism involves ameliorating autophagy by regulatiing of PI3K/mTOR.
- | acetylcysteine solution / Generic mfg.
Journal: Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced cardiac anomalies through reconciliation of autophagy and ferroptosis. (Pubmed Central) - Jul 24, 2023
Induction of ferroptosis could eliminate the cardioprotective effect of NAC. In conclusion, catalase rescues LPS-induced cardiac dysfunction by regulating oxidative stress, autophagy, ferroptosis, apoptosis, and mitochondrial damage in cardiomyocytes.
- | sirolimus / Generic mfg.
Journal: Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway. (Pubmed Central) - Jul 24, 2023
In conclusion, catalase rescues LPS-induced cardiac dysfunction by regulating oxidative stress, autophagy, ferroptosis, apoptosis, and mitochondrial damage in cardiomyocytes. RBP4 is an injurious factor in the pathogenesis of diabetic AS, and it promotes the phenotypic switch of VSMCs via activating RhoA/ROCK1 pathway and inhibiting autophagy.
- | hydroxychloroquine / Generic mfg.
Journal: Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy. (Pubmed Central) - Jul 22, 2023
RBP4 is an injurious factor in the pathogenesis of diabetic AS, and it promotes the phenotypic switch of VSMCs via activating RhoA/ROCK1 pathway and inhibiting autophagy. CIRT effectively killed the pancreatic cancer cells by inhibiting their autophagy-inducing abilities.
- | Journal: Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase. (Pubmed Central) - Jul 21, 2023
This paper presents the adaptation of this luciferase-based assay to automated high-throughput screening. We describe the workflow and optimization for exemplary high-throughput analysis of cellular ATG4B activity.
- | oxaliplatin / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker, Tumor cell: C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy. (Pubmed Central) - Jul 21, 2023
tropicalis) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system...tropicalis can down-regulate tumor cell-intrinsic PD-1 expression via enhancing tumor cells autophagy levels to promote CRC progression. It may provide a new idea and mechanism for answering why the immune monoclonal antibody treatment is ineffective in cancer patients.
- | fluvastatin / Generic mfg.
Journal: Acidity-Responsive Nanoreactors Destructed "Warburg Effect" for Toxic-Acidosis and Starvation Synergistic Therapy. (Pubmed Central) - Jul 21, 2023
In the nanoreactor, the fluvastatin (Flu) could reduce lactate efflux by inhibiting the lactate-proton transporter (monocarboxylate transporters, MCT4), resulting in intracellular lactate accumulation...Cellular dysfunction under pHi acidification and impaired Adenosine Triphosphate (ATP) synthesis under starvation synergistically promote tumor cell apoptosis. Both in vitro and in vivo studies demonstrate that this combinational approach of toxic-acidosis/starvation therapy could effectively destruct the "Warburg Effect" to inhibit tumor growth and anti-metastatic effects.
- carbamazepine / Generic mfg.
Protective Effect Of Carbamazepine On Hemorrhagic Shock And Resuscitation-induced Acute Lung Injury In Rats (Hall D-9) - Jul 20, 2023 - Abstract #ASA2023ASA_3155;
DMSO group), CBZ + chloroquine (CQ) + HSR group (5. Our data certified that CBZ pretreatment ameliorated HSR-induced ALI by suppressing inflammation, at least in part by enhancing autophagy.
- metformin / Generic mfg.
Ubiquitin-like Protein Fat10 Mediates Cardioprotective Effect Of Metformin Against Ischemic Myocardial Injury By Suppressing Autophagy (Exhibit Hall) - Jul 20, 2023 - Abstract #ASA2023ASA_1755;
Next, we plan to construct the FAT10-knockout mouse models with the CRISPR-Cas9 technique to verify our findings. This is a novel mechanism through which FAT10 regulates autophagy as a cardiac protector, has significant clinical application value in the future.