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- | hydroxychloroquine / Generic mfg.
Journal: Autophagy inhibition recovers deficient ICD-based cancer immunotherapy. (Pubmed Central) - Oct 23, 2023
To circumvent this dilemma, we combined an ICD inducer (Shikonin, SHK) with an autophagy inhibitor (hydroxychloroquine, HCQ) for colon cancer immunotherapy...Furthermore, a systematic determination of the optimal dosage of combined LipSHK and LipHCQa suggested that autophagy inhibiting at an appropriate dosage level was beneficial for maximizing ICD-based antitumor immunity. This study proved that autophagy inhibitors can recover the deficient ICD-based antitumor immune response and present potential clinical applications for cancer immunotherapy.
- | thapsigargin / University of Nottingham, Pirbright Institute
Journal: SIRT-1 is required for release of enveloped enteroviruses. (Pubmed Central) - Oct 22, 2023
Inducing ER stress through thapsigargin treatment or SERCA2A knockdown in SIRT-1 knockdown cells had no additional effect on EV-D68 extracellular titers...In non-lytic conditions, EV-D68 is primarily released in an enveloped form, and SIRT-1 is required for this process. Our data show that SIRT-1, through its translocation to the cytosol, is critical to promote the release of enveloped EV-D68 viral particles.
- | Journal: Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation. (Pubmed Central) - Oct 22, 2023
In conclusion, we elucidated the role of the CD36-NLRP1-caspase-1 signaling pathway in OX-LDL-induced inflammation in fish and revealed for the first time that altering PE abundance in OX-LDL-treated cells could alleviate inflammasome-mediated inflammation by inducing autophagy. Given the relationship between OX-LDL-induced inflammation and atherosclerosis, this study prompts that the use of PE-rich foods promises to be a new strategy for atherosclerosis treatment in vertebrates.
- | Journal: MdHB7-like positively modulates apple salt tolerance by promoting autophagic activity and Na efflux. (Pubmed Central) - Oct 22, 2023
Overall, our findings provide insight into the mechanism underlying MdHB7-like-mediated salt tolerance in apple through the MdHB7-like-MdATG18a and MdHB7-like-MdCCX1 modules. These results will aid future studies on the mechanisms underlying stress-induced autophagy and the regulation of stress tolerance in plants.
- | Journal: Ameliorative effect of Luffa cylindrica fruits on Caenorhabditis elegans and cellular models of Alzheimer's disease-related pathology via autophagy induction. (Pubmed Central) - Oct 22, 2023
These results will aid future studies on the mechanisms underlying stress-induced autophagy and the regulation of stress tolerance in plants. Our findings highlight the potential of LCE as a functional food or drug for targeting AD pathology and promoting human health.
- | sirolimus / Generic mfg.
Journal: CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy. (Pubmed Central) - Oct 22, 2023
Then, the autophagy agonist Rapamycin and inhibitor 3-MA were used in a periodontitis mouse model to investigate periodontal tissue destruction...Finally, our research proved that silencing CKIP-1 reduces the expression of inflammatory cytokines in Pg-induced PDLC and HGF by regulating autophagy. Overall, a new role for CKIP-1 in regulating periodontal tissue inflammation was demonstrated in our study, and it is possible to treat periodontitis by targeting the CKIP-1 gene.
- || Review, Journal: Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives. (Pubmed Central) - Oct 22, 2023
In this article, we comprehensively introduce the molecular structure of CEP and its derivatives, describe in detail the pharmacological mechanisms of CEP in various diseases, and discuss how to chemically modify and design CEP to improve its bioavailability. In summary, this work will provide a reference for further research and clinical application of CEP.
- | Journal: 5-Heptadecylresorcinol Ameliorates Obesity-Associated Skeletal Muscle Mitochondrial Dysfunction through SIRT3-Mediated Mitophagy. (Pubmed Central) - Oct 20, 2023
In addition, AR-C17 administration (30 and 150 mg/kg/day) significantly improved high-fat-diet-induced mitochondrial dysregulation in mice skeletal muscle tissue via SIRT3-dependent mitophagy. Our findings indicate that skeletal muscle cells are responsive to AR-C17, which improves myogenesis and mitophagy in vitro and in vivo.
- | Journal: Isoliquiritin treatment of osteoporosis by promoting osteogenic differentiation and autophagy of bone marrow mesenchymal stem cells. (Pubmed Central) - Oct 20, 2023
ISL promoted the osteogenic differentiation of BMSCs through the p38/ERK-autophagy pathway and was therapeutically effective in treating osteoporosis in ovariectomized mice without any observed toxicity to vital organs. These results strongly suggest the promising potential of ISL as a safe and efficacious candidate drug for the treatment of osteoporosis.
- | Journal: Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation. (Pubmed Central) - Oct 19, 2023
Collectively, our results suggest that RAGE plays an important role in the recruitment and activation of alternatively activated macrophages by regulating autophagy, which contributes to MF. Thus, blockage of RAGE signaling may be an attractive therapeutic target for the treatment of hypertensive heart disease.
- | Journal: The STING-IRF3 signaling pathway, mediated by endoplasmic reticulum stress, contributes to impaired myocardial autophagic flux following ischemia/reperfusion. (Pubmed Central) - Oct 18, 2023
Rubicon ablation effectively counteracts the adverse effects of STING overexpression in cardiomyocytes. The data showed that STING-IRF3 signaling of ER stress receptors is particularly important in the progression of physiological M-I/R caused by the inhibition of autophagic flow in vivo and in vitro.
- | Preclinical, Journal: Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins. (Pubmed Central) - Oct 18, 2023
In this study, following heat stress, the decrease in CatSper protein distribution may lead to the structural disorder of CatSper channels, which could strongly affect autophagic activity. Also, disruption of spermatogenesis and sperm parameters may be the consequence of decreased autophagy activity.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal: Role of autophagy in cadmium-induced damage to the blood-testis barrier in mice (Pubmed Central) - Oct 17, 2023
Also, disruption of spermatogenesis and sperm parameters may be the consequence of decreased autophagy activity. CdCl2 can damage the integrity of the mouse BTB, which may be attributed to its ability to enhance the autophagy in Sertoli cells and regulate the expressions of BTB proteins.
- | sirolimus / Generic mfg.
Journal: Role of Rapamycin and 3-MA in oxidative damage of HLECs caused by two doses of UVB radiation. (Pubmed Central) - Oct 17, 2023
Autophagy played different roles in HLECs oxidative stress induced by two doses of UVB. It provides new ideas for reducing oxidative damage and apoptosis of HLECs to prevent or delay the progression of age-related cataract (ARC).
- | paclitaxel / Generic mfg.
Journal, Cancer stem: Aqueous Nyctanthes arbortristis and doxorubicin conjugated gold nanoparticles synergistically induced mTOR-dependent autophagy-mediated ferritinophagy in paclitaxel-resistant breast cancer stem cells. (Pubmed Central) - Oct 16, 2023
Results and NAT and doxorubicin loaded into AuNP showed enhanced stability and induced ferritinophagy in Pac/MCF-7 stem cells. The obtained results suggest that AuNP-NAT, combined with a low AuNP-Doxorubicin nanoconjugate dose, might be an effective anti-neoplastic drug targeting the necroptosis-autophagy axis, thereby reducing the adverse side-effects induced by the conventional chemotherapeutic drugs.
- | Journal: Nuciferine induces autophagy to relieve vascular cell adhesion molecule 1 activation via repressing the Akt/mTOR/AP1 signal pathway in the vascular endothelium. (Pubmed Central) - Oct 16, 2023
Mechanistical studies revealed that Akt/mTOR inhibition, rather than AMPK, SIRT1, and p38 signal pathways, contributed to nuciferine-activated autophagy, which further ameliorated TNF?-induced VCAM1 via repressing AP1 activation, independent of transcriptional regulation by IRF1, p65, SP1, and GATA6. Collectively, our data uncovered a novel biological function for nuciferine in protecting VCAM1 activation, implying its potential application in improving cardiovascular events.
- | Journal: CREBH promotes autophagy to ameliorate NASH by regulating Coro1a. (Pubmed Central) - Oct 15, 2023
The overexpression of Coro1a in LO2 liver cells inhibited autophagic flux and elevated inflammatory cytokine levels upon palmitic acid (PA) stimulation. Overall, our findings provide new insights into the regulatory role of CREBH in the progression of NASH and reveal that Coro1a is a novel target gene of CREBH based on the autophagy pathway.
- | Journal: The Combined Inhibition of Autophagy and Diacylglycerol Acyltransferase-Mediated Lipid Droplet Biogenesis Induces Cancer Cell Death during Acute Amino Acid Starvation. (Pubmed Central) - Oct 14, 2023
Autophagy-dependent LD biogenesis was also observed in the aggressive triple-negative MDA-MB-231 breast cancer cells deprived of amino acids, but these cells were not sensitized to starvation by the combined inhibition of LD biogenesis and autophagy. These findings reveal that while targeting autophagy-driven and DGAT-mediated LD biogenesis reduces the resilience of HeLa cervical cancer cells to amino acid deprivation, this strategy may not be successful in other cancer cell types.
- | temozolomide / Generic mfg.
Journal: Inhibition of O-GlcNAcylation Reduces Cell Viability and Autophagy and Increases Sensitivity to Chemotherapeutic Temozolomide in Glioblastoma. (Pubmed Central) - Oct 14, 2023
Combined, these results indicated a role for O-GlcNAcylation in governing cell proliferation, autophagy, cell death, and TMZ response, thereby indicating possible therapeutic implications for treating GB. These findings pave the way for further research and the development of novel treatment approaches which may contribute to improved outcomes and increased survival rates for patients facing this challenging disease.
- | Preclinical, Journal: Preconditioning of exosomes derived from human olfactory ensheathing cells improved motor coordination and balance in an SCA3/MJD mouse model: A new therapeutic approach. (Pubmed Central) - Oct 14, 2023
SCA3 mouse cerebellar tissues treated with hsa-miRNA-6780-5p-enriched exosomes showed decreased expression of polyQ and increased expression of LC3II/I, an autophagy marker. In conclusion, our findings can serve as a basis for developing an alternative therapeutic strategy for SCA3 disease treatment using miRNA-enriched exosomes derived from chemically preconditioned cells.
- | Journal: PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells. (Pubmed Central) - Oct 14, 2023
Further studies using autophagy inhibitor, RNA interference, RT-qPCR, western blot, and CCK-8 assay in 16-HBE cells have confirmed that autophagy is temporarily initiated by cigarette smoke extract, but insufficient autophagy leads to cell death. PSAT1 induced by CSE promotes autophagy and resists insufficient autophagy caused by CSE through Akt/mTOR pathway in human bronchial epithelial cells, playing a protective role.
- CREG1 Deletion Inhibits Autophagy and Causes Cardiomyocyte Damage Under Nutritional Stress (Zone 1, Science and Technology Hall, Level 2) - Oct 12, 2023 - Abstract #AHA2023AHA_8806;
PSAT1 induced by CSE promotes autophagy and resists insufficient autophagy caused by CSE through Akt/mTOR pathway in human bronchial epithelial cells, playing a protective role. CREG1 protects the heart from nutritional stress-induced injury, likely through the promotion of autophagic flux.
- ezurpimtrostat (GNS561) / Genoscience Pharma, Genfit, Avastin (bevacizumab) / Roche, Tecentriq (atezolizumab) / Roche
EZURPIMTROSTAT AUTOPHAGY BLOCKER, A PALMITOYL-PROTEIN THIOESTERASE 1 (PPT1) INHIBITOR, AND ATEZOLIZUMAB/BEVACIZUMAB TRIPLE COMBINATION REGIMEN ENHANCES ANTITUMOR EFFICACY IN HEPATOCELLULAR CARCINOMA (Republic Ballroom) - Oct 11, 2023 - Abstract #AASLD2023AASLD_930;
P2b
This study reports that GNS561 potentiates the anti-tumor effect of atezolizumab/bevacizumab combination emphasizing PPT1 inhibitors' therapeutic interest in combination with immunotherapy in HCC. This triple therapy is currently tested in the randomized phase 2 clinical trial ABE-LIVER, in first line setting in advanced HCC.
- chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
ROLE OF AUTOPHAGY IN HEPATIC ACETYLOME REGULATION (Ballroom A) - Oct 11, 2023 - Abstract #AASLD2023AASLD_254;
Wild type (WT) mice were injected with chloroquine (60mg/ Kg, i.p) for 6 consecutive days to inhibit autophagy...In contrast, autophagy activation by fasting or rapamycin treatment increased the level of hepatic acetylome... In conclusion, autophagy regulates the hepatic acetylome as an important mechanism for protecting liver against injury and causing liver damage.
- | cisplatin / Generic mfg.
Journal: Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma. (Pubmed Central) - Oct 11, 2023
DCA increased cisplatin sensitivity in cholangiocarcinoma cells via increasing the mitochondria oxidative stress and cell growth inhibition. Synergistic effects of DCA and CQ were observed in cholangiocarcinoma cells, which further increased the cisplatin sensitivity via both metabolic reprogramming and inhibition of the stress response autophagy.
- || Review, Journal: Updating the therapeutic role of ginsenosides in breast cancer: a bibliometrics study to an in-depth review. (Pubmed Central) - Oct 11, 2023
Through meticulous bibliometric analysis and an exhaustive review of pertinent research, we explore and summarize the mechanism of action of ginsenosides in treating breast cancer, including inducing apoptosis, autophagy, inhibiting epithelial-mesenchymal transition and metastasis, and regulating miRNA and lncRNA. This scholarly endeavor not only provides novel prospects for the application of ginsenosides in the treatment of breast cancer but also suggests future research directions for researchers.
- | sirolimus / Generic mfg.
Journal: Intranasal insulin alleviates traumatic brain injury by inhibiting autophagy and endoplasmic reticulum stress-mediated apoptosis through the PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Oct 9, 2023
Interestingly, the mTOR inhibitor rapamycin partially blocked the pro-autophagy and anti-apoptosis effects of intranasal insulin both on days 1 and 3 post TBI. Our results suggest that intranasal insulin can ameliorate TBI by regulating autophagy and ER stress-mediated apoptosis through the PI3K/AKT/mTOR signaling pathway, providing a promising therapeutic strategy for TBI.
- | Journal: Tight Junction Protein 1 Suppresses Kidney Renal Clear Cell Carcinoma Cells Proliferation by Inducing Autophagy. (Pubmed Central) - Oct 8, 2023
TJP1 overexpression significantly suppressed cell proliferation and tumor growth in 786-O cells, whereas the addition of an autophagy inhibitor diminished its inhibitory function. Taken together, these results suggest that TJP1 serves as a favorable prognostic marker and induces autophagy to suppress cell proliferation and tumor growth in KIRC.
- | Journal: Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-?1/Smad pathway: implications for liver cancer. (Pubmed Central) - Oct 8, 2023
AKF-PD alleviates liver fibrosis by inhibiting HSC autophagy via the transforming growth factor (TGF)-?1/Smadpathway. Our study provided some implications about how liver fibrosis was connected with liver cancer by SMAD2/SMAD3 and autophagy.
- | dorsomorphin (Compound C) / EMD Serono
Preclinical, Journal: AMPK inhibitor, compound C, inhibits coronavirus replication in vitro. (Pubmed Central) - Oct 7, 2023
In addition, treatment with compound C in combination with chloroquine synergistically inhibited coronavirus replication. These results suggest that compound C can be considered as a potential drug candidate for COVID-19.
- | Journal: Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer. (Pubmed Central) - Oct 7, 2023
Mechanistically, Scop induced autophagy initiation by reducing P21-activated kinase 1 (PAK1) expression and subsequently repressing the AKT/mTOR signaling pathway. Collectively, our study suggests that Scop is a potential anti-CRC therapeutic option and provides an underlying molecular mechanism for its antitumour effect in CRC.
- | Journal: COTE1 Facilitates Intrahepatic Cholangiocarcinoma Progression via Beclin1-Dependent Autophagy Inhibition. (Pubmed Central) - Oct 6, 2023
Furthermore, the suppression of COTE1 knockdown on cellular growth and invasion was rescued/aggravated by Beclin1 inhibition/accumulation. Our data, for the first time, illustrate that COTE1 is an oncogene in ICC pathogenesis, and the ectopic COTE1 expression promotes ICC proliferation and invasion via Beclin1-dependent autophagy inhibition.
- | metformin / Generic mfg.
Journal: Metformin activates AMPK and mTOR to Inhibit RANKL-stimulated osteoclast formation. (Pubmed Central) - Oct 6, 2023
Our data, for the first time, illustrate that COTE1 is an oncogene in ICC pathogenesis, and the ectopic COTE1 expression promotes ICC proliferation and invasion via Beclin1-dependent autophagy inhibition. Metformin activates the AMPK pathway while functioning as an activator of mTOR, thereby leading to the inhibition of autophagy and osteoclast differentiation.
- | cisplatin / Generic mfg.
Journal, Cancer stem: SEC61 translocon subunit gamma enhances low-dose cisplatin-induced cancer-stem cell properties of head and neck squamous cell carcinoma via enhancing Ca-mediated autophagy. (Pubmed Central) - Oct 6, 2023
CDDP-induced CSC properties, including CSC marker expression, sphere formation, colony formation, and invasive capabilities could be suppressed by shSEC61G and chloroquine, a specific autophagy inhibitor. Findings of this study revealed the contribution of SEC61G in promoting cisplatin-induced CSC properties of HNSCC cells via promoting Ca-mediated autophagy.
- | nimodipine / Generic mfg.
Journal: Active fraction of Polyrhachis vicina (Roger) alleviated cerebral ischemia/reperfusion injury by targeting SIRT3-mediated mitophagy and angiogenesis. (Pubmed Central) - Oct 5, 2023
AFPR promoted angiogenesis through activating mitophagy after cerebral ischemia reperfusion, which might partially involved in the amelioration of SIRT3-mediated regulation on Pink1/Parkin axis. Our study will shed new light on the role of SIRT3 in ischemic brain, especially in regulating mitophagy and angiogenesis after stroke.
- | Lynparza (olaparib) / Merck (MSD), AstraZeneca
Preclinical, Journal: PARP1 inhibition protects mice against Japanese encephalitis virus infection. (Pubmed Central) - Oct 5, 2023
Small molecular inhibitors of PARP1, olaparib, and 3-aminobenzamide (3-AB) significantly reduce clinical signs and viral load in the serum and brains of mice and improve survival...PARP1-mediated AKT inactivation promotes autophagy and JEV pathogenesis by increasing the FoxO activity. Thus, our findings demonstrate PARP1 as a potential mediator of JEV pathogenesis that can be effectively targeted for treating JE.
- | chloroquine phosphate / Generic mfg.
Journal: Bacterial lipoprotein plays an important role in the macrophage autophagy and apoptosis induced by Salmonella typhimurium and Staphylococcus aureus. (Pubmed Central) - Oct 4, 2023
and p62 protein (P < 0.05)...Furthermore, we found that the autophagy inhibitor 3-methyladenine prevented BLP- and infection-induced macrophage apoptosis. BLP is not only required for autophagy and apoptosis activation in macrophages but also for regulating the balance between autophagy and apoptosis.
- | Journal: p38/MK2 signaling stimulates host cells autophagy pathways to restrict Salmonella infection. (Pubmed Central) - Oct 3, 2023
Inhibition of autophagy with bafilomycin A1 showed increased bacterial counts in treated cells compared to control cell. Overall, these results indicate that p38/MK2-mediated protein phosphorylation modulates the host cell susceptibility to Salmonella infection by affecting the autophagy pathways.
- | Journal, IO biomarker: Inhibition of autophagy promotes sonodynamic therapy-induced apoptosis of pancreatic cancer cells. (Pubmed Central) - Oct 3, 2023
Overall, these results indicate that p38/MK2-mediated protein phosphorylation modulates the host cell susceptibility to Salmonella infection by affecting the autophagy pathways. Autophagy was activated in SDT-treated PC cells, and inhibition of autophagy promoted cell apoptosis in PC cells.
- | thapsigargin / University of Nottingham, Pirbright Institute
Journal: The Ferroptosis Induced by Palmitic Acid via CD36 Activating ER Stress to Break Calcium-Iron Balance in Colon Cancer Cells. (Pubmed Central) - Oct 3, 2023
In general, we report for the first time that PA can selectively induce ferroptosis in colon cancer cells with high expression of CD36 by activating ER stress/ER calcium release/transferrin-dependent ferroptosis. This provides a new strategy and basis for the precise treatment of tumors.
- | EZM2302 / GSK, Ipsen
Journal, IO biomarker: Carm1 Inhibition Potentiates Irradiation-Induced Antitumor Immunity via Tumor Intrinsic STING Pathway Activation. (Pubmed Central) - Oct 3, 2023
Mechanically, Carm1 deficiency directly activated the cGAS-STING pathway by interacting with TBK1 and increased mtDNA accumulation in cytoplasm by inhibiting autophagy. These findings provided new strategies for targeting Carm1 to boost the efficacy of radiotherapy.
- | sirolimus / Generic mfg.
Preclinical, Journal: miR-30a-3p Regulates Autophagy in the Involution of Mice Mammary Glands. (Pubmed Central) - Oct 2, 2023
Overexpression of miR-30a-3p inhibited autophagy and altered mammary structure in the involution of the mammary glands of mice, which was indicative of alteration in mammary remodeling. Taken together, these results elucidated the molecular mechanisms of miR-30a-3p as a key induction mediator of autophagy by targeting Atg12 within the transition period between lactation and involution in mammary glands.
- | Journal: Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence. (Pubmed Central) - Oct 2, 2023
We conduct a further analysis, suggesting F1 could bind in proximity to the TRF2 heterodimer interface, potentially enhancing dimerization stability. These findings suggest that F1 may be a promising natural remedy for anti-aging, and restoring TRF2 could potentially prevent telomere-dependent diseases commonly associated with the aging process.
- || Review, Journal: Autophagy Modulation as a Potential Therapeutic Strategy in Osteosarcoma: Current Insights and Future Perspectives. (Pubmed Central) - Oct 2, 2023
Despite promising findings, future studies are needed to elucidate the molecular mechanisms of autophagy and its relationship to OS, as well as the mechanisms underlying the functioning of autophagic modulators. Careful evaluation is required as autophagy modulation may have adverse effects on normal cells, and the optimization of autophagic modulators for use as drugs in OS is imperative.
- | Journal: Green tea catechin prevents oxidative stress-regulated autophagy and apoptosis signaling, and inhibits tenderness in postmortem bovine longissimus thoracis et lumborum muscle. (Pubmed Central) - Oct 2, 2023
Careful evaluation is required as autophagy modulation may have adverse effects on normal cells, and the optimization of autophagic modulators for use as drugs in OS is imperative. Ultimately, tenderness at 24 and 120
- | 5-fluorouracil / Generic mfg.
Journal: Melatonin Potentiates Sensitivity to 5-Fluorouracil in Gastric Cancer Cells by Upregulating Autophagy and Downregulating Myosin Light-Chain Kinase. (Pubmed Central) - Oct 2, 2023
This indicates that autophagy is involved in tumor metastasis, which may be related to inhibition of the MLCK signaling pathway. Our findings indicate that melatonin can improve the effectiveness of 5-fluorouracil in gastric cancer and could be used as a supplemental agent in the treatment of gastric cancer with 5-fluorouracil.
- | obatoclax (GX 15-070) / Teva
Journal: Atg5 knockout induces alternative autophagy via the downregulation of Akt expression. (Pubmed Central) - Oct 2, 2023
Therefore, our study provides evidence that alternative autophagy may contribute to tumorigenesis in cells with an impaired Atg5-dependent autophagy pathway. The online version contains supplementary material available at 10.1007/s43188-023-00191-3.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Catalpol Inhibits Autophagy to Ameliorate Doxorubicin-Induced Cardiotoxicity via the AKT-mTOR Pathway. (Pubmed Central) - Oct 1, 2023
DOX-induced myocardial apoptosis was also inhibited by CTP treatment in mice. In addition, CTP decreased the levels of Beclin1 and LC3II/LC3I, increased the levels of P62, and activated the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in DOX-treated mice.CTP ameliorated DOX-induced cardiotoxicity by inhibiting oxidative stress, myocardial apoptosis, and autophagy via the AKT-mTOR pathway.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal: Autophagy reduces aortic calcification in diabetic mice by reducing matrix vesicle body-mediated IL-1? release. (Pubmed Central) - Sep 30, 2023
These results suggested that MVB-mediated IL-1? release may be an effective target for treating vascular calcification.
- | chloroquine phosphate / Generic mfg.
Journal, IO biomarker: Effects of dietary chloroquine on fish growth, hepatic intermediary metabolism, antioxidant and inflammatory responses in turbot. (Pubmed Central) - Sep 29, 2023
was depressed in the chloroquine group. Our results would extend the knowledge on the role of autophagy in teleost and assist in improving fishery production.