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- | Journal: Plin2 inhibits autophagy via activating AKT/mTOR pathway in non-small cell lung cancer. (Pubmed Central) - Feb 16, 2024
In vivo study showed that Plin2 stimulated subcutaneous tumorigenesis of NSCLC cells in nude mice. Collectively, this study clarified the carcinogenic role of Plin2 and its molecular mechanism in NSCLC progression, which may facilitate a targeted therapy in the future.
- | Journal: Psychological stress induces hair regenerative disorders through corticotropin-releasing hormone-mediated autophagy inhibition. (Pubmed Central) - Feb 16, 2024
CRH regulates the local hypothalamic-pituitary-adrenal axis of hair follicles, but also plays an independent pathogenic role in stress-related hair regenerative disorders through CRH-mediated autophagy inhibition. This work contributes to the present understanding of hair loss and suggests that enhancing autophagy may have a therapeutic effect on stress-induced hair loss.
- | sirolimus / Generic mfg.
Journal: p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome. (Pubmed Central) - Feb 16, 2024
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy...p300 mislocalization by the disease-causing protein, progerin, activates mTORC1 and inhibits autophagy, phenotypes that are normalized by modulating p300 shuttling. These results reveal how nutrients regulate mTORC1, a cytoplasmic complex, by shuttling its positive regulator p300 in and out of the nucleus, and how this pathway is misregulated in Hutchinson-Gilford progeria syndrome, causing mTORC1 hyperactivation and defective autophagy.
- | Journal: Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis. (Pubmed Central) - Feb 15, 2024
Our results suggest that autophagy may be involved in the progression mechanism of endometriosis, and the mechanism of autophagy disorder in endometriosis is probably related to TFEB. TFEB may be a key molecule in promoting endometriosis.
- | dexamethasone / Generic mfg.
Journal: Andrographolide acts with dexamethasone to inhibit the growth of acute lymphoblastic leukemia CEM?C1 cells via the regulation of the autophagy?dependent PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Feb 15, 2024
In conclusion, the present study demonstrated that AND exhibited a synergistic anti-ALL effect with DEX via upregulation of GR, which was orchestrated by the autophagy-related PI3K/AKT/mTOR signaling pathway. The results of the present study therefore provided novel research avenues and strategies for the treatment of ALL.
- | GSK2334470 / GSK
Journal: Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis. (Pubmed Central) - Feb 15, 2024
Importantly, GSK470 and chloroquine synergistically inhibited the growth of RCC cells in vitro and in xenograft models, supporting the protective role of autophagy activation upon blockade of the PDPK1-Akt-mTOR signaling pathway. Our study provides new insight into PDPK1 inhibition combined with autophagy inhibition as a useful treatment strategy for RCC.
- IFN-GAMMA INDUCES ACUTE GRAFT-VERSUS-HOST DISEASE BY PROMOTING HMGB1-MEDIATED NUCLEAR-TO-CYTOPLASM TRANSLOCATION AND AUTOPHAGIC DEGRADATION OF P53 (CLYDE) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1729;
Increased IFN-? in the plasma induces the proliferation of CD4+ T cells and aGVHD development by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
- IFN-GAMMA INDUCES ACUTE GRAFT-VERSUS-HOST DISEASE BY PROMOTING HMGB1-MEDIATED NUCLEAR-TO-CYTOPLASM TRANSLOCATION AND AUTOPHAGIC DEGRADATION OF P53 (ePoster area) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1728;
Increased IFN-? in the plasma induces the proliferation of CD4+ T cells and aGVHD development by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
- | Journal: HDAC2 counteracts vascular calcification by activating autophagy in chronic kidney disease. (Pubmed Central) - Feb 14, 2024
Inhibition of autophagy using its specific inhibitor 3-MA blocked HDAC2's protective effect on osteogenic differentiation in ?-GP-treated VSMCs. Taken together, these results suggest that HDAC2 may protect against vascular calcification by the activation of autophagy, laying out a novel insight for the molecular mechanism in vascular calcification of CKD.
- | chloroquine phosphate / Generic mfg.
Journal: Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction. (Pubmed Central) - Feb 14, 2024
Autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) not only antagonized HPP-induced autophagy but also attenuated the inhibitory effects of HPP on MB49 cell proliferation in the co-culture system...HPP induced bladder cancer cell autophagy by regulating macrophages in the co-culture system, resulting in the inhibition of cancer cell proliferation. The PI3K/Akt/mTOR pathway was involved in HPP-induced autophagy in the co-culture system.
- | Journal, IO biomarker: Toll-like receptor 4 Mediated Autophagy regulates Airway Smooth Muscle Cells behavior. (Pubmed Central) - Feb 13, 2024
Significantly, our study demonstrated that autophagy inhibition reversed the promotion effect of LPS on ASMC proliferation and migration. These findings suggest that TLR4 may modulate ASMC behavior through the regulation of autophagy.
- | Journal: AKR1C3 silencing inhibits autophagy-dependent glycolysis in thyroid cancer cells by inactivating ERK signaling. (Pubmed Central) - Feb 13, 2024
The in vivo results suggested that AKR1C3 knockdown inhibited the development of subcutaneous TPC-1 tumors in nude mice and inactivated the ERK signaling. Collectively, AKR1C3 silencing inhibited autophagy-dependent glycolysis in thyroid cancer by inactivating ERK signaling.
- | everolimus / Generic mfg.
Journal: Everolimus inhibits hepatoblastoma by inducing autophagy-dependent ferroptosis. (Pubmed Central) - Feb 13, 2024
Importantly, the induction of ferroptosis by everolimus was significantly reversed in the presence of autophinib, an autophagy inhibitor, indicating the autophagy-dependent of everolimus-induced ferroptosis. Taken together, these findings suggest that everolimus holds promise as an effective anti-hepatoblastoma drug, with its mechanism of action potentially involving the induction of autophagy-dependent ferroptosis in hepatoblastoma cells.
- | sirolimus / Generic mfg.
Journal: Activation of autophagy promotes the inhibitory effect of curcumin analog EF-24 against MDA-MB-231 cancer cells. (Pubmed Central) - Feb 13, 2024
Moreover, removal of EF-24-activated ROS with NAC significantly reversed migration ability of MDA-MB-231 cells, indicating that EF-24 exerted an inhibitory effect through a ROS-mediating pathway. These results will help to elucidate the antitumor mechanism of curcumin analogs and to explore future potential clinical applications.
- | Journal: Roles of flavonoids in ischemic heart disease: Cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury. (Pubmed Central) - Feb 12, 2024
These results will help to elucidate the antitumor mechanism of curcumin analogs and to explore future potential clinical applications. This review serves as a reference for designing a daily diet to prevent or reduce damages following ischemia and screening of flavonoids for clinical application.
- | Journal: Research Progress in the Role of Liquid-Liquid Phase Separation in Human Cancer (Pubmed Central) - Feb 11, 2024
According to published findings, many biological macromolecules can regulate transcriptional translation, expression, post-transcriptional modification, cell signal transduction, and other biological processes through phase separation. Therefore, further expansion of the research field of phase separation and in-depth investigation of its molecular mechanisms and regulatory processes hold extensive research potential.
- | indomethacin / Generic mfg.
Preclinical, Journal: Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans. (Pubmed Central) - Feb 10, 2024
AA protects against diabetic ischemic myocardial damage by promoting mitochondrial autophagy and renewal, which is related to AA derived PGI2 signaling. AA may represent a new strategy to treat diabetic myocardial ischemic injury.
- | Journal: Mitochondrial sodium/calcium exchanger (NCLX) regulates basal and starvation-induced autophagy through calcium signaling. (Pubmed Central) - Feb 9, 2024
Furthermore, chelation did not exhibit an additive effect on NCLX inhibition of autophagy, demonstrating that mitochondrial Ca2+ efflux regulates autophagy through the modulation of Ca2+ signaling. Collectively, our results show that the mitochondrial Ca2+ extrusion pathway through NCLX is an important regulatory node linking nutrient restriction and autophagy regulation.
- | Journal: LRP10 and ?-synuclein transmission in Lewy body diseases. (Pubmed Central) - Feb 9, 2024
Finally, we show that this truncated patient-derived LRP10 protein species (LRP10splice) binds to wild-type LRP10, reduces LRP10 wild-type levels, and antagonises the effect of LRP10 on ?-synuclein levels and distribution. Together, this work provides initial evidence for a possible functional role of LRP10 in LBDs by modulating intra- and extracellular ?-synuclein levels, and pathogenic mechanisms linked to the disease-associated c.1424?+?5G?>?A LRP10 variant, pointing towards potentially important disease mechanisms in LBDs.
- | Journal: Azoramide ameliorates cadmium-induced cytotoxicity by inhibiting endoplasmic reticulum stress and suppressing oxidative stress. (Pubmed Central) - Feb 9, 2024
Additionally, we also found that azoramide significantly decreased ER stress-associated radical oxidative species production, attenuated p38 MAPK and JNK signaling, and inhibited autophagy, thus suppressing apoptosis in HK-2 and ARPE-19 cells. Our study investigated the effect of azoramide on Cd-induced cytotoxicity and revealed that azoramide may be a therapeutic drug for Cd poisoning.
- | Journal: Co-exposure of carbon black and cadmium induces autophagy and inflammation in human bronchial epithelial cells via PERK pathway (Pubmed Central) - Feb 9, 2024
The results of factorial analysis showed that exposure to CBNPs and Cd had significant effects on the expression of P62, LC3 and IL6 (P0.05) . CBNPs-Cd combined exposure may inhibit autophagy and increase inflammation in human bronchial epithelial cells through activation of PERK-eIf2?-ATF4 pathway.
- | paclitaxel / Generic mfg.
Journal, Combination therapy: GBP2 enhances paclitaxel sensitivity in triple?negative breast cancer by promoting autophagy in combination with ATG2 and inhibiting the PI3K/AKT/mTOR pathway. (Pubmed Central) - Feb 9, 2024
It functions as a critical regulator of activated autophagy by co?acting with ATG2 and inhibiting the PI3K/AKT/mTOR pathway, which contributes to increasing sensitivity of TNBC cells to PTX. Therefore, GBP2 is a promising therapeutic target for enhancing TNBC treatment.
- | Journal, IO biomarker: Study on SH-SY5Y autophagy inhibition and apoptosis induced by methanol extract of Zanthoxylum armatum DC. based on mTOR signal pathway. (Pubmed Central) - Feb 9, 2024
Consequently, this study suggests that MZADC triggers the mTOR pathway through oxidative stress in SH-SY5Y cells, ultimately leading to apoptosis. Understanding the toxicity mechanisms associated with ZADC can offer a valuable theoretical and experimental basis for its development and utilization.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Journal: Autophagy activation alleviates the LPS-induced inflammatory response in endometrial epithelial cells in dairy cows. (Pubmed Central) - Feb 9, 2024
These data indicated that LPS-induced inflammation was related to the inhibition of autophagy in BEECs. Thus, the activation of autophagy may represent a novel therapeutic strategy for eliminating inflammation in BEECs.
- | Journal: Berberine Alleviates Ischemic Brain Injury by Enhancing Autophagic Flux via Facilitation of TFEB Nuclear Translocation. (Pubmed Central) - Feb 8, 2024
Meanwhile, autophagy inhibitor 3-Methyladenine (3-MA) also slightly neutralized the pharmacological effect of berberine on ameliorating autophagic/lysosomal dysfunction. Our study suggests that berberine-induced neuroprotection against ischemic stroke is elicited by enhancing autophagic flux via facilitation of TFEB nuclear translocation in neurons.
- | Journal: FTO attenuates LPS-induced acute kidney injury by inhibiting autophagy via regulating SNHG14/miR-373-3p/ATG7 axis. (Pubmed Central) - Feb 8, 2024
Furthermore, the SNHG14/miR-373-3p/ATG7 interaction network contributes to the regulatory effect of FTO on LPS-induced HK-2 cell viability, apoptosis and autophagy. These results suggested demethylase FTO suppressed the mA modification of lncRNA SNHG14 and inhibits autophagy in LPS-induced AKI via regulating miR-373-3p/ATG7, which provided an important novel perspective for understanding sepsis-associated AKI and is conducive for developing new therapeutic targets and strategies.
- | Journal: miR-214-3p promotes the pathogenesis of Parkinson's disease by inhibiting autophagy. (Pubmed Central) - Feb 8, 2024
Furthermore, mechanistic investigations identify ATG3 as a target, shedding light on miR-214-3p's regulatory role in autophagy. These findings enhance our understanding of PD pathogenesis and propose miR-214-3p as a potential biomarker and therapeutic target for modulating autophagy and neuronal survival in PD.
- | Journal: miR-664a-5p promotes experimental membranous nephropathy progression through HIPK2/Calpain1/GS?-mediated autophagy inhibition. (Pubmed Central) - Feb 8, 2024
miR-664a-5p can horizontally enter podocytes through exosomes resulting in podocytes injury. Targeted inhibition of miR-664a-5p can reduce the apoptosis of renal tubule cells and podocytes, and may improve the MN progression.
- | Bay11-7082 / Bayer
Preclinical, Journal: Nuclear factor-kappaB mediates the survival of rat kidney cells after cadmium exposure via promoting autophagy and inhibiting apoptosis. (Pubmed Central) - Feb 8, 2024
Activation of NF-?B by activator phorbol-12-myristate-13-acetate (PMA) alleviates Cd-induced apoptosis and autophagy inhibition, and then attenuates Cd-induced NRK-52E cells injury. In conclusion, Cd exposure promotes the activation of NF-?B, and activated NF-?B mediates the survival of NRK-52E cells after Cd exposure via promoting autophagy and inhibiting apoptosis.
- | Journal: Promotion of Inflammation, Apoptosis, and Inhibition of Autophagy by Overexpression of lncRNA SNHG12 in Acute Kidney Injury. (Pubmed Central) - Feb 7, 2024
In conclusion, Cd exposure promotes the activation of NF-?B, and activated NF-?B mediates the survival of NRK-52E cells after Cd exposure via promoting autophagy and inhibiting apoptosis. SNHG12 promotes inflammation, apoptosis, and autophagy by targeting the miR-1270/TUBB axis in AKI.
- || Review: A global bibliometric and visualized analysis of the links between the autophagy and acute myeloid leukemia. (Pubmed Central) - Feb 7, 2024
The current research hotspots are mainly genetic regulation, autophagy inhibition, and autophagy-related targeted drugs. In future, autophagy will remain the focus of the AML field, with research trends likely to focus more on AML chemotherapy resistance and mitochondrial autophagy.
- || Review, Journal: The Contributions of the Endolysosomal Compartment and Autophagy to APOE?4 Allele-Mediated Increase in Alzheimer's Disease Risk. (Pubmed Central) - Feb 6, 2024
ApoE4 impairs vesicle recycling and endosome trafficking, impairs the synthesis of autophagy genes, resists being dissociated from its receptors and degradation, and forms a stable folding intermediate that could disrupt lysosome structure. Drugs such as molecular correctors that target ApoE4 molecular structure and enhance autophagy may ameliorate the endosome-lysosome-autophagy-mediated increase in AD risk in APOE4 individuals.
- | doxorubicin hydrochloride / Generic mfg.
Journal: MHY1485 promotes adriamycin sensitivity in HepG2 cells by inhibiting autophagy. (Pubmed Central) - Feb 6, 2024
The results of the detection of the autophagy-related protein LC3A also indicated that MHY1485 activates mTOR and can affect the phosphorylation level of ULK1, inhibit autophagy, and enhance the sensitivity of liver cancer cells to adriamycin. In summary, MHY1485 can enhance the sensitivity of adriamycin-resistant cells to adriamycin by activating mTOR and blocking the autophagy process in cells; therefore, mTOR may become a potential target for the treatment of liver cancer.
- | Preclinical, Journal: Loss of mitogen-activated protein kinase phosphate-5 aggravates islet dysfunction in mice with type 1 and type 2 diabetes. (Pubmed Central) - Feb 6, 2024
These findings provide valuable insights into the molecular pathogenesis of diabetes and highlight the significant role of MKP-5. Moreover, this knowledge holds promise for novel therapeutic strategies targeting MKP-5 for diabetes management.
- | sirolimus / Generic mfg.
Journal: Bushenhuoluo Decoction improves polycystic ovary syndrome by regulating exosomal miR-30a-5p/ SOCS3/mTOR/NLRP3 signaling-mediated autophagy and pyroptosis. (Pubmed Central) - Feb 6, 2024
Moreover, this knowledge holds promise for novel therapeutic strategies targeting MKP-5 for diabetes management. Collectively, BSHLD suppressed autophagy and pyroptosis to improve POCS by regulating exosomal miR-30a-5p/SOCS3/mTOR signaling.
- | sirolimus / Generic mfg.
Journal: The roles of autophagy in the treatment of diabetic nephropathy with rapamycin. (Pubmed Central) - Feb 6, 2024
Hyperglycemic can inhibit the autophagic activity of HMC, promote cell apoptosis, enhance ECM accumulation, and facilitate the DN progression. In contrast, rapamycin can elicit autophagy, decrease mesangial matrix proliferation, and therefore impede DN progression.
- || Review, Journal: Advances in the study of autophagy in breast cancer. (Pubmed Central) - Feb 5, 2024
It is also because of this interrelationship between the two that regulation of autophagy in the treatment of breast cancer is now an important strategy in clinical treatment. In this article, we systematically survey the recent research findings, elucidating the multifaceted role of autophagy in breast cancer and its underlying mechanisms, with the aim of contributing new references to the clinical management of breast cancer.
- | Journal: Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. (Pubmed Central) - Feb 5, 2024
The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
- | Preclinical, Journal: Activation of the p62-Keap1-Nrf2 pathway improves pulmonary arterial hypertension in MCT-induced rats by inhibiting autophagy. (Pubmed Central) - Feb 3, 2024
Importantly, overexpression of p62 reduced oxidative stress and the NADPH oxidase expression in PAH rats. Overall, activation of the p62-Keap1-Nrf2 positive feedback signaling axis reduces the proliferation and migration of PASMCs and alleviates PAH by inhibiting autophagy and oxidative stress.
- Mechanistic study of EPHB2 affecting the sensitivity of cervical cancer radiotherapy by regulating autophagy through AKT/mTOR pathway () - Feb 3, 2024 - Abstract #SGO2024SGO_418;
Overall, activation of the p62-Keap1-Nrf2 positive feedback signaling axis reduces the proliferation and migration of PASMCs and alleviates PAH by inhibiting autophagy and oxidative stress. EPHB2 can enhance the sensitivity of cervical cancer cells to radiotherapy by down-regulating the autophagy pathway via the AKT/mTor pathway.
- | oxaliplatin / Generic mfg.
Journal: Huaier Regulates Oxaliplatin Resistance in Colorectal Cancer by Regulating Autophagy and Inhibiting the Wnt/?-catenin Signalling Pathway. (Pubmed Central) - Feb 3, 2024
EPHB2 can enhance the sensitivity of cervical cancer cells to radiotherapy by down-regulating the autophagy pathway via the AKT/mTor pathway. This study proved that Huaier can regulate autophagy, inhibit the Wnt/?-catenin signalling pathway and reverse the drug resistance of OXA-resistant CRC cells.
- | sirolimus / Generic mfg.
Journal: Q-switched 1064?nm Nd: YAG laser restores skin photoageing by activating autophagy by TGF?1 and ITGB1. (Pubmed Central) - Feb 2, 2024
Also, we identified a direct interaction between TGFB1 and ITGB1 and participated in laser irradiation-activated autophagy, thereby inhibiting UVB-mediated oxidative stress further reducing skin ageing. Q-switched 1064?nm Nd: YAG laser treatment inhibited UVB-induced oxidative stress and restored skin photoageing by activating autophagy, and TGF?1 and ITGB1 directly incorporated and participated in this process.
- | Journal: Orientin alleviates ox-LDL-induced oxidative stress, inflammation and apoptosis in human vascular endothelial cells by regulating Sestrin 1 (SESN1)-mediated autophagy. (Pubmed Central) - Feb 2, 2024
The further experiments indicated that SESN1 silencing or 3-MA addition reversed the inhibitory effects of Orientin on the oxidative stress, inflammation and apoptosis of HUVECs. Collectively, Orientin could induce autophagy by activating SESN1 expression, thereby regulating AMPK/mTOR signaling in ox-LDL-induced HUVECs.
- | semaxanib (SU5416) / Pfizer
Journal: RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension. (Pubmed Central) - Feb 2, 2024
Treatment with the RAB7 activator ML-098 reduced established PH in chronic hypoxia/SU5416 rats. In conclusion, we demonstrate here for the first time the fundamental impairment of EC function by loss of RAB7, causing PH, and show RAB7 activation as a potential therapeutic strategy in a preclinical model of PH.
- | Journal: NUPR1 contributes to activate TFE3-dependent autophagy leading to cervical cancer proliferation. (Pubmed Central) - Feb 1, 2024
Overall, silencing NUPR1 reduced autophagy by inhibiting TFE3 in cervical cancer. Our results supply new evidence for the use of NUPR1 as a therapeutic target in cervical cancer.
- | Visudyne (verteporfin) / Novartis
Journal: YAP promotes the healing of ischemic wounds by reducing ferroptosis in skin fibroblasts through inhibition of ferritinophagy. (Pubmed Central) - Feb 1, 2024
In conclusion, these findings indicate that ferroptosis, regulated by YAP through ferritinophagy inhibition, presents a novel mechanism responsible for the delayed healing of ischemic wounds. Understanding this process could offer promising therapeutic targets to improve wound healing in ischemic conditions.
- | ezurpimtrostat (GNS561) / Genoscience Pharma, Genfit
Journal, PD(L)-1 Biomarker, IO biomarker: Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8 Lymphocyte Repopulation in Hepatocellular Carcinoma. (Pubmed Central) - Feb 1, 2024
Understanding this process could offer promising therapeutic targets to improve wound healing in ischemic conditions. Ezurpimtrostat turns cold tumors into hot tumors and, thus, could improve T cell-mediated immunotherapies in liver cancer.
- | Journal: Evaluation of immune microenvironment in IgG4-related sialadenitis. (Pubmed Central) - Jan 31, 2024
This study reveals altered immune microenvironment in peripheral blood mononuclear cells and labial salivary gland tissues in IgG4-related sialadenitis. Autophagy inhibitors and DNA topoisomerase inhibitors show promise as potential targets for treating IgG4-related sialadenitis, providing a novel therapeutic strategy for this disease.
- | Journal: Inhibition of Autophagy Aggravates Arachis hypogaea L. Skin Extracts-Induced Apoptosis in Cancer Cells. (Pubmed Central) - Jan 31, 2024
Significantly, inhibition of autophagy enhanced AHE- and AHE-2-induced cytotoxicity and apoptosis. Together, these findings not only elucidate the anticancer potential of peanut skin extracts against melanoma and CRC cells but also provide a new insight into autophagy implicated in peanut skin extracts-induced cancer cell death.
- || chloroquine phosphate / Generic mfg., hydroxychloroquine / Generic mfg., deoxyglucose / Generic mfg.
PK/PD data, Preclinical, Journal: 2-Deoxyglucose and hydroxychloroquine HPLC-MS-MS analytical methods and pharmacokinetic interactions after oral (Pubmed Central) - Jan 31, 2024
We observed significant negative PK interactions, probably at the intestinal absorption level, between 2-DG and HCQ taken simultaneously by mouth. Future optimization efforts are warranted for their combination regimen for clinical translation.