Antithrombin III inhib 
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  • ||||||||||  Clinical, Journal:  Assessment of Antithrombin III and Protein C in Saudi Myocardial Infarction Patients. (Pubmed Central) -  Oct 22, 2021   
    The present study reveals a new role of FXR in hemostatic homeostasis and indicates that FXR might act as a potential therapeutic target for diseases related to hypercoagulation. A deficiency of AT III and protein C were not strong significant risk factors for myocardial infarction.
  • ||||||||||  enoxaparin sodium / Generic mfg.
    [VIRTUAL] ANCA Negative, Yet Pulmonary Embolism Positive () -  Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_3816;    
    Replication of the pattern in genetically linked populations around the world may affect management of stroke in those populations. Introduction Pauci immunue glomerulonephritis(GN) with negative ANCA serology occurs in ~1/3 of pauci immune GN patients.ANCA negative patients are thought to have a lower incidence of extra-renal involvement but poorer renal prognosis than those who are ANCA-positive.We present a case of ANCA-negative Pauci-immune Rapidly Progressive GN(RPGN),returning 4 weeks after diagnosis with pulmonary embolism(PE) Case Description A 39-year-old male presented(pre-pandemic) with 2 weeks of fever and chills.For ~3 years,he has had intermittent arthralgia,dyspnea,facial and ankle swelling with gross hematuria and a 12lb weight gain 2 months prior to admission.Baseline creatinine(Cr) was 1.3(0.7-1.3mg/dl) a month prior.On admission Cr was 2.6, Alb 3mg/dl and Urinalysis noted protein 100mg/dl,RBC 20-30 and WBC 10-20.A 24 hour urine protein measured 8g/day.Serologies were positive for dsDNA1:10 and Antistreptolysin O,with negative ANA,ANCA,anti-GBM,SPEP,Hepatitis B,C,HIV and normal C3/C4.Renal sonogram noted normal sized kidneys with increased echogenicity.A renal Biopsy was done and Methylprednisolone pulse therapy commenced.His renal biopsy showed focal necrotizing and crescentic GN with negative IF,consistent with pauci-immune GN.Cr peaked at 3.6 and IV Cyclophosphamide was given.He was discharged on Prednisone with Rituximab given 2 weeks later.4 weeks after discharge,Cr improved to 1.3,however he represented with SOB,pleuritic chest pain and hemoptysis.CT chest revealed acute bilateral PE.Malignancy work-up and lower extremity dopplers were negative.He had normal IgG,A,M,antithrombin III,prothrombin gene analysis,protein C,S activity and factor X with negative Lupus anti-coagulant and antiphospholipid Ab.He was started,then discharged on Enoxaparin for anticoagulation Discussion Renal disease manifests as a pauci-immune GN in ANCA-Associated Vasculitis(AAV).~ 1/3 of patients with pauci immune vasculitis are ANCA negative.Whether these patients should be included in the spectrum of AAV or are a separate pathophysiologic mechanism is unknown.Our patient presented with RPGN and a PE after initial treatment despite negative ANCA panel and current evidence suggesting a lower incidence of other organ involvement.The presence of an underlying pulmonary vasculitis could not be excluded.We postulate that all patients with ANCA negative RPGN should be followed for additional organ involvement and further study of this patient population is warranted
  • ||||||||||  warfarin / Generic mfg.
    [VIRTUAL] THE UNKNOWN: POST COVID-19 COAGULOPATHY WITH WARFARIN FAILURE () -  Oct 13, 2021 - Abstract #CHEST2021CHEST_645;    
    Extensive research is being conducted to expand our understanding of COVID-19 and its effect on the coagulation cascade, we still have gaps to bridge in our knowledge. Thus, there is a need for developing guidelines for the treatment and monitoring of patients that fail first-line treatment.
  • ||||||||||  tranexamic acid oral / Generic mfg.
    Journal:  Coagulation and Fibrinolytic Disorder (Pubmed Central) -  Oct 8, 2021   
    Patients with a high D-dimer level despite a good level of consciousness on admission are more likely to be "talk and deteriorate." Administration of tranexamic acid, an anti-fibrinolytic agent, early in the acute phase of TBI may reduce mortality...However, excessive administration should also be avoided. Thus, in the acute phase of TBI, coagulation and fibrinolytic activity changes dynamically and may adversely affect the complicated injury; therefore, monitoring coagulation and fibrinolytic parameters while conducting treatment is recommended.
  • ||||||||||  Clinical, Journal:  Thromboembolism risk among patients with diabetes/stress hyperglycemia and COVID-19. (Pubmed Central) -  Oct 3, 2021   
    Thromboembolism risk is higher among patients with diabetes/stress hyperglycemia and COVID-19 pneumonia and is associated to poor clinical outcome. In case of SARS-Cov-2 infection patients with diabetes/stress hyperglycemia could be considered for a more intensive prophylactic anticoagulation regimen.
  • ||||||||||  Journal:  Influence of Human Jaw Periosteal Cells Seeded β-Tricalcium Phosphate Scaffolds on Blood Coagulation. (Pubmed Central) -  Sep 29, 2021   
    However, a notable increase in thrombin-antithrombin III (TAT) complex levels, as well as fibrin fiber accumulation on JPC-seeded β-TCP scaffolds, was detected compared to the scaffolds without JPCs. Thus, this study demonstrated that besides the scaffold material the cells colonizing the scaffolds can also influence hemostasis, which can influence the regeneration of bone tissue.
  • ||||||||||  Journal:  Prediction of portal vein thrombosis after hepatectomy for hepatocellular carcinoma. (Pubmed Central) -  Sep 26, 2021   
    A high incidence of PVT was found in hepatocellular carcinoma patients after hepatectomy. The frequency of the Pringle maneuver is a potential risk factor for postoperative PVT, and the postoperative/preoperative TAT and D-dimer ratios may be used as early predictors of PVT after hepatectomy for hepatocellular carcinoma.
  • ||||||||||  Perioperative Management Of Hereditary Antithrombin-iii Deficiency (Exhibit Hall) -  Sep 25, 2021 - Abstract #ASA2021ASA_4413;    
    Close perioperative monitoring of functional ATIII levels with calculated intraoperative ATIII factor concentrate therapy gave adequate AT activity levels to best curb the increased VTE risk in this patient. These methods can be used to better guide perioperative management of ATIII deficiency in patients.
  • ||||||||||  Journal:  Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer's Disease Diagnosis. (Pubmed Central) -  Sep 10, 2021   
    These data indicate that impaired PS translation and synthesis or possible secretion impairment is the main pathogenesis of this family with hereditary PSD and thrombophilia. Our study justifies further investigations of biological pathways involving coagulation/anticoagulation factors in relation to dementia, including dementia resulting from Alzheimer's-type neurodegeneration.
  • ||||||||||  enoxaparin sodium / Generic mfg.
    A Rare Case of Superior Mesenteric Vein Thrombosis With Antithrombin III Deficiency and Recent COVID-19 mRNA Vaccination (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_941;    
    Further history revealed that he received both doses of the Pfizer-BioNTech (BNT162b2) mRNA COVID-19 vaccine, with the second dose administered 75 days prior to admission...It is important to bring awareness to uncommon adverse events that may be linked to COVID-19 mRNA vaccine administration so that providers and patients can be aware of the possibility of these events and not delay diagnosis and treatment. Figure: Computed tomography (CT) of the abdomen and pelvis revealing diffuse SMV thrombosis with adjacent fat stranding.
  • ||||||||||  Journal:  Proteomics of pseudoexfoliation materials in the anterior eye segment. (Pubmed Central) -  Sep 4, 2021   
    Both genetic and environmental risk factors have been implicated to be involved in the development of PEX and PEXG. This field is at an early stage of investigation identifying how these factors modify proteins both at the expression and functional level to cause changes leading to the pathophysiology of PEX glaucoma.
  • ||||||||||  Review, Journal:  Localized intravascular coagulation in venous malformations: A system review. (Pubmed Central) -  Sep 2, 2021   
    It is characterized by the elevation of D-dimers and fibrin degradation products, low levels of fibrinogen, FV, FVIII, FXIII, and antithrombin III, and sometimes minor-to-moderate thrombocytopenia. Here we reviewed the clinical manifestations, pathogenesis, diagnosis, and treatment of localized intravascular coagulopathy in venous malformations.
  • ||||||||||  Journal:  Effects of long-term high-altitude exposure on fibrinolytic system. (Pubmed Central) -  Jul 31, 2021   
    HGB showed no relationship with fibrinolytic parameters in HA cohort. This study demonstrates that HA environment has a significant effect on fibrinolytic system and provides a foundation for further studies on HA hypobaric hypoxia-induced thrombotic disease.