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- || Review, Journal: Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications. (Pubmed Central) - Nov 8, 2022
FGF-23 (Fibroblast growth factor), Sclerostin, and Klotho are thought to be the emerging factors involved in the CKD-MBD leading to vascular calcification process and cardiovascular mortality. This review summarizes the brief pathological basis of vascular calcification in CKD, current and emerging approaches including the vast arrangement of contributors and inhibitors for the early identification and treatment.
- | Preclinical, Journal: Calciprotein Particle Synthesis Strategy Determines In Vitro Calcification Potential. (Pubmed Central) - Nov 4, 2022
In contrast, CPP-B1 and D1 were unable to induce calcification of hVSMC, and endogenous CPP derived from pooled serum of dialysis patients were only able to calcify hVSMC to a small extent compared to CPP2.CPP synthesized using different protocols appear morphologically similar, but in vitro calcification potency is dependent on composition and how the CPP are quantified. Synthetic CPP are not comparable to endogenous CPP in terms of the calcification propensity.
- | Journal: Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation (Pubmed Central) - Nov 2, 2022
Synthetic CPP are not comparable to endogenous CPP in terms of the calcification propensity. The results of the "metabolic memory" markers analysis may indicate their contribution to the persistence of the metabolic consequences of CKD and DM 1 after achievement of normoglycemia and renal function restoration and their possible participation in development of recurrent nephropathy, vascular calcification, and bone disorders.
- | Biomarker, Journal: Identification and Validation of Novel Biomarkers and Potential Targeted Drugs in Cholangiocarcinoma: Bioinformatics, Virtual Screening, and Biological Evaluation. (Pubmed Central) - Nov 1, 2022
AHSG, F2, TTR, and KNG1 could be novel biomarkers for CCA. Molport-003-703-800 targets CDK1 and work as potential cell cycle inhibitors, thereby having potential for consideration for new chemotherapeutics for CCA.
- | Journal: Alpha 2-Heremans-Schmid glycoprotein (AHSG) gene polymorphism (rs4918) is associated with coronary artery calcification in incident peritoneal dialysis patients. (Pubmed Central) - Nov 1, 2022
Molport-003-703-800 targets CDK1 and work as potential cell cycle inhibitors, thereby having potential for consideration for new chemotherapeutics for CCA. AHSG gene polymorphism rs4918 affects serum fetuin-A levels and is significantly associated with both CAC and CAC progression in a cohort of patients receiving PD.
- | Preclinical, Journal: Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic analysis. (Pubmed Central) - Oct 29, 2022
The results obtained using different techniques were well matched, with a good correlation between the in vitro and in vivo experiments. Thus, the proteomic analysis of biological responses to biomaterials in vitro is a useful tool for predicting their impact in vivo.
- | Preclinical, Journal: Investigation of Fetuin-A pathway in diabetes mellitus formation in rats exposed to elf magnetic fields. (Pubmed Central) - Oct 29, 2022
There was an increase in the Fetuin-A, Glucose, HbA1c, and Hba1c IFCC values in both of the experimental groups compared to the control group. We believe that an increase in these values may cause Type 3 diabetes.
- | Journal, PD(L)-1 Biomarker, IO biomarker: Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss. (Pubmed Central) - Oct 29, 2022
Intervention with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass loss. Collectively, our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO.
- || Clinical data, Journal: Ectodysplasin A is associated with the presence and severity of coronary artery disease and poor long-term clinical outcome in patients presenting with ST-elevation myocardial infarction. (Pubmed Central) - Oct 28, 2022
We found that EDA levels were significantly higher in patients with STEMI and that EDA levels were proportional to the severity of CAD (p < 0.001) also EDA levels may be an independent predictor of poor clinical outcome in patients with STEMI. These results suggest that EDA is closely related to the presence and severity of CAD.
- Improved RNA-Seq Results on Recalcitrant FFPE Diseased Liver Resections Using Ultrasonic Isolation () - Oct 24, 2022 - Abstract #AMP2022AMP_634;
This was presumably due to the method's effects on removal of fragments of degraded RNA, and/or improved homogenization of fibrotic diseased tissue sections. Improved bulk RNA-Seq results and the independent probe-based transcriptome analysis showed weak/moderate to strong rank order of expression level, indicating that the relative abundances of RNAs were consistent between profiling methods and suggesting suitability for further characterization.
- sirolimus / Generic mfg.
LIVER AND ADIPOSE TISSUE CROSSTALK IN ALCOHOL ASSOCIATED LIVER DISEASE: THE ROLE OF mTOR () - Oct 23, 2022 - Abstract #AASLD2022AASLD_1582;
Adipocyte but not hepatocyte ablation of Mtor pathway contributes to acute alcohol-induced liver injury with increased inflammation. Our results demonstrate a critical role of adipocyte mTOR in regulating the adipose tissue-liver crosstalk in ALD.
- ELEVATED LEVELS OF SERUM HEPATOKINE, Lect2 IS ASSOCIATED WITH INCREASED AND DYSFUNCTIONAL CIRCULATING NEUTROPHILS IN ALCOHOL-ASSOCIATED HEPATITIS PATIENTS () - Oct 23, 2022 - Abstract #AASLD2022AASLD_1573;
Hepatokines, FGF21 and Fetuin-A, were upregulated ( p<0.05) in ALD compared to HC. Lect2 was also increased in human liver with ALD as compared to HC ( p<0.005) .
- | Biomarker, Journal: Alpha-2-Heremans-Schmid-glycoprotein (AHSG) a potential biomarker associated with prognosis of chromophobe renal cell carcinoma: The PROPOLIS study. (Pubmed Central) - Oct 21, 2022
AHSG could predict potential prognostic and may be a diagnostic biomarker in chRCC. This study illustrated that AHSG may be a potential therapeutic target and prognostic genetic marker for chRCC.
- | Journal: Fetuin-A and Its Association with Anthropometric, Atherogenic, and Biochemical Parameters and Indices among Women with Polycystic Ovary Syndrome. (Pubmed Central) - Oct 21, 2022
Future studies that take these variables into account will need to be undertaken. More information on the relationship between fetuin-A concentrations and anthropometric indices would aid us in establishing a greater degree of accuracy on this matter.
- NurOwn (MSC-NTF) / BrainStorm Cell Therap
NurOwn (MSC-NTF) Phase 2 Clinical Trial in Progressive MS: Effects on CSF Neuroprotective Biomarkers (ePoster Area) - Oct 18, 2022 - Abstract #ECTRIMS2022ECTRIMS_1810;
Intrathecal MSC-NTF cell treatment consistently increased CSF neuroprotective biomarkers, confirming the proposed mechanism of action of NurOwn in PMS. These observations support further investigation to address the important unmet medical need in this disorder.
- | Biomarker, Journal: Post-translational modifications glycosylation and phosphorylation of the major hepatic plasma protein fetuin-A are associated with CNS inflammation in children. (Pubmed Central) - Oct 14, 2022
Phosphorylation of fetuin-A was more abundant in serum samples than in CSF, suggesting that phosphorylation may regulate fetuin-A influx into the CNS. These results may help establish Fetuin-A as a potential biomarker for neuroinflammatory diseases.
- Biomarkers of the Aging Kidney: A Proteomic Analysis of Renal Microstructures at Different Cortical Depths (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3812;
Conclusion Proteins, particularly of deep cortex, that regulate matrix remodeling, mitochondrial function, inflammation, & metabolic homeostasis may play a role in aging. Figure 1
- Diagnostic Performance of a Unique Fragment of Human Fetuin-A for Patients Undergoing Native Kidney Biopsy (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2400;
ROC curve analyses comparing the predictability in distinguishing the different grades of IFTA of the uPTM-Fet-A/Cre (ng/mg) with uPCR (mg/mg). The area under the curve (AUC) represents the probability to discriminate the presence of > 10% (A), > 25% (B), or > 50% (C) IFTA in the tissue samples.
- Vascular Calcification Is Associated With Fetuin-A and Cortical Bone Porosity in Stone Formers (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2020;
Upon multivariate regression analysis, BMI (β 0.31, p<0.01), serum Fet-A (β -0.29, p=0.02) and tibial Ct.Po (β 0.26, p=0.03) were independently associated with AAC (Table 1). Conclusion This study demonstrates associations of reduced circulating Fet-A levels and higher tibial porosity with AAC, supporting Fet-A as central mediator in the kidney-bone-vasculature axis.
- Identification of biomarkers associated with placenta suffering among pregnant women in Benin, a malaria-endemic area (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1937;
The final results will be presented during the ASTM meeting. Allowing the identification, at an early stage of pregnancy, of a placenta ‘under stress’ in a MiPcontext would represent an important step forwards in terms of improving the quality of obstetric care offered to high-risk women.
- | Journal: Decreases in hepatokine Fetuin-A levels are associated with hepatic hypoperfusion and predict cardiac outcomes in patients with heart failure. (Pubmed Central) - Oct 5, 2022
Allowing the identification, at an early stage of pregnancy, of a placenta ‘under stress’ in a MiPcontext would represent an important step forwards in terms of improving the quality of obstetric care offered to high-risk women. Liver-derived hepatokine Fetuin-A may be a novel target involved in the cardio-hepatic interactions, as well as a useful biomarker for predicting the prognosis in patients with HF.
- | Preclinical, Journal: Ameliorating effect of 6-week swimming exercise on mice with experimental autoimmune encephalomyelitis (EAE) by reducing fetuin-A and increasing AMPK & NAD levels in liver tissue. (Pubmed Central) - Sep 29, 2022
Also, levels of AMPK and NAD markedly increased in C57BL/6 mice with EAE. Doing regular exercise may limit the body's inflammatory responses and reduce the severity of MS by regulating the expression of fetuin-A and increasing AMPK and NAD levels in liver tissue.
- | Journal: Reduced hip bone mineral density is associated with high levels of calciprotein particles in patients with Fabry disease. (Pubmed Central) - Sep 29, 2022
Doing regular exercise may limit the body's inflammatory responses and reduce the severity of MS by regulating the expression of fetuin-A and increasing AMPK and NAD levels in liver tissue. Low hip BMD was associated with high CPP-II in patients with Fabry disease, but further work is needed to investigate the relevance of sex-related differences and to establish whether CPP measurement may aid assessment of bone disease in this setting.
- | Journal: Exome-Wide Association Study Reveals Host Genetic Variants Likely Associated with the Severity of COVID-19 in Patients of European Ancestry. (Pubmed Central) - Sep 24, 2022
Of these few notable known genes include, HLA-DQB1, AHSG, ALOX5AP, MUC5AC, SMPD1, SPG7, SPEG,GAS6, and SERPINA12. These results enhance our understanding of the pathomechanisms underlying the COVID-19 clinical spectrum and may be exploited to prioritize biomarkers for predicting disease severity, as well as to improve treatment strategies in individuals of European ancestry.
- || apremilast / Generic mfg.
Clinical, P4 data, Journal: Association of Apremilast With Vascular Inflammation and Cardiometabolic Function in Patients With Psoriasis: The VIP-A Phase 4, Open-label, Nonrandomized Clinical Trial. (Pubmed Central) - Sep 23, 2022
P4
The findings of this nonrandomized clinical trial suggest that apremilast has a neutral association with aortic vascular inflammation, variable but generally beneficial associations with a subset of cardiometabolic biomarkers, and associations with reductions in visceral and subcutaneous fat, indicating that the drug may have an overall benefit for patients with cardiometabolic disease and psoriasis. ClinicalTrials.gov Identifier: NCT03082729.
- | metformin / Generic mfg.
Preclinical, Journal: Hepatoprotective potential of flavonoid-rich extracts from Gongronema latifolium benth leaf in type 2 diabetic rats via fetuin-A and tumor necrosis factor-alpha. (Pubmed Central) - Sep 14, 2022
ClinicalTrials.gov Identifier: NCT03082729. Hence, FREGL (particularly at a low dose) may play a substantial role in mitigating the hepatopathy complication associated with diabetes mellitus.
- | Journal: Altered Circulating Leptin, hGH, and IGF-I in Prediabetes and Screening-Diagnosed T2DM Unrelated to Metabolic Syndrome in Women Post Gestational Diabetes. (Pubmed Central) - Sep 12, 2022
Based on our study, altered Leptin and hGH/IGF-I signaling could potentially contribute to the pathophysiology of prediabetes and T2DM unrelated to metabolic syndrome. Further mechanistic investigations of these signaling pathways in the context of lean T2DM are necessary to test causal relationships.
- | Journal: Comparative proteomics reveals genetic mechanisms of body weight in Hu sheep and Dorper sheep. (Pubmed Central) - Sep 10, 2022
In the current study, the label-free method was used to identify the proteins and pathways related to BW using LT muscle of Hu sheep and Dorper sheep with different BW. These findings will provide new candidate proteins and vital pathways into the molecular mechanisms involved growth traits in sheep.
- | Observational data, Journal: Serum fetuin-A and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis. (Pubmed Central) - Aug 24, 2022
Serum fetuin-A levels in early pregnancy were positively associated with risk of GDM, particularly in those with normal waist circumference. However, we found no genetic evidence for a causal association.
- | Journal: Fetuin-A mediates the difference in adipose tissue insulin resistance between young adult pakistani and norwegian patients with type 2 diabetes. (Pubmed Central) - Aug 22, 2022
However, we found no genetic evidence for a causal association. Fetuin-A may contribute to explain the discrepancy in T2DM prevalence between Pakistani and Norwegians patients by influencing AT-IR.
- | Journal: Effects of berberine hydrochloride on immune response in the crab Charybdis japonica. (Pubmed Central) - Aug 22, 2022
When A. hydrophila was added, the neutralization of 300 mg/L berberine hydrochloride maximized the activities of Caspas8, LZM, ACP and AKP. Our results provide a new understanding of the potential effects of berberine hydrochloride on the immune system mechanisms in crustaceans.
- | Journal: Decreased plasma fetuin-A level as a novel bioindicator of poor prognosis in community-acquired pneumonia: A multi-center cohort study. (Pubmed Central) - Aug 17, 2022
Plasma fetuin-A levels were decreased in patients with CAP. Fetuin-A can reliably predict mortality in patients with CAP, and is a useful diagnostic indicator of SCAP.
- | Journal: Differential gene expression analysis after DAPK1 knockout in hepatocellular carcinoma cells. (Pubmed Central) - Aug 10, 2022
Moreover, western blot analysis results revealed that changes in the levels of proteins encoded by the four key genes after DAPK1 knockout were consistent with those seen in the database screening. These results provide a direction for further studies on the DAPK1 gene and on the mechanism through which DAPK1 leads to hepatocellular carcinoma development.
- || Review, Journal: The structure, biosynthesis, and biological roles of fetuin-A: A review. (Pubmed Central) - Aug 6, 2022
Information was gathered manually from various journals via electronic searches using PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. Studies written in English and cohort, case-control, cross-sectional, or experimental studies were considered in the review, otherwise excluded.
- || Review, Journal: Tissue chaperoning-the expanded functions of fetuin-A beyond inhibition of systemic calcification. (Pubmed Central) - Aug 4, 2022
Unbalanced depletion of fetuin-A in this context may be the critical event, triggering a vicious cycle of progressive calcification, inflammation, and tissue injury. Hence, we designate fetuin-A as tissue chaperone and propose the potential use of exogenous fetuin-A as prophylactic agent or emergency treatment in conditions that are associated with acute depletion of endogenous protein.
- || Review, Journal: Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation. (Pubmed Central) - Aug 3, 2022
It serves to highlight the molecular mechanisms underlying the effects of these organokines and their clinical significance. Insights into the roles and mechanisms of these organokines could provide novel and potential therapeutic targets for obesity-induced inflammation.
- | Biomarker, Journal: Identifying the Antitumor Effects of Curcumin on Lung Adenocarcinoma Using Comprehensive Bioinformatics Analysis. (Pubmed Central) - Aug 3, 2022
We found that curcumin significantly inhibited the proliferation, migration, and invasion of LUAD cells and significantly decreased the expression of the INS and GCG genes. The results of this study suggest that the therapeutic effects of curcumin on LUAD may be achieved through the intervention of INS and GCG, which may act as potential biomarkers for LUAD prevention and treatment.
- | Journal: Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers. (Pubmed Central) - Jul 29, 2022
The results of this study suggest that the therapeutic effects of curcumin on LUAD may be achieved through the intervention of INS and GCG, which may act as potential biomarkers for LUAD prevention and treatment. This study suggests an association between reduced circulating Fet-A levels and increased bone Ct.Po with VC in SF.
- | Journal: Fetuin-A in Activated Liver Macrophages Is a Key Feature of Non-Alcoholic Steatohepatitis. (Pubmed Central) - Jul 29, 2022
In conclusion, fetuin-A is produced by steatotic hepatocytes at early timepoints in MAFLD and correlates with insulin resistance both in mice and humans. In NASH, fetuin-A also co-localizes with activated liver macrophages and could be interpreted as a signal released by damaged hepatocytes.
- | Preclinical, Journal: Inhibition of Osteoblast Differentiation by JAK2 Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. (Pubmed Central) - Jul 27, 2022
This suggested that the mutation re-programs megakaryocytes to express a cluster of genes, which together could orchestrate greater suppression of osteogenesis in male mice. These findings provide mechanistic insight into the effect of JAK2 mutation on bone, encouraging future examination of patients with this or other PMF-inducing mutations.
- | INZ701 / Inozyme Pharma
Preclinical, Journal: INZ-701, a recombinant ENPP1 enzyme, prevents ectopic calcification in an Abcc6 mouse model of pseudoxanthoma elasticum. (Pubmed Central) - Jul 17, 2022
The extent of calcification corresponds to the local expression of two calcification inhibitors, osteopontin and fetuin-A. These results suggest that INZ-701 might provide a therapeutic approach for PXE, a disease with high unmet needs and no approved treatment.
- | Journal: Fetuin-A expression in human umbilical vein endothelial cells and amnion cells of patients with gestational diabetes mellitus. (Pubmed Central) - Jul 14, 2022
These results suggest that INZ-701 might provide a therapeutic approach for PXE, a disease with high unmet needs and no approved treatment. There is a correlation between fetal macrosomia, neonatal hypoglycemia, placental weight, and fetuin-A expression of HUVECs in patients with GDM.
- | Journal: Serum Calcification Propensity T50 Associates with Disease Severity in Patients with Pseudoxanthoma Elasticum. (Pubmed Central) - Jul 11, 2022
To conclude, shorter serum T50-indicative of a higher calcification propensity-was associated with a more severe phenotype in PXE patients. This study indicates, for the first time, that serum T50 might be a clinically relevant biomarker in PXE and may thus be of importance to future therapeutic trials.
- || Biomarker, Review, Journal: Multi-Variable Biomarker Approach in Identifying Incident Heart Failure in Chronic Kidney Disease Results from the Chronic Renal Insufficiency Cohort (CRIC) Study. (Pubmed Central) - Jul 10, 2022
A basic panel of four blood biomarkers (BNP, FGF23, fibrinogen, and hsTnT) can be used as a standalone score to predict incident HF in patients with CKD allowing early identification of patients at high-risk for HF. Addition of biomarker score to clinical risk model modestly reclassifies HF risk and slightly improves discrimination.
- vildagliptin / Generic mfg.
Fetuin-a promotes lipid induced DPP4 expression in pancreatic beta cells (Short Oral Discussion Area) - Jul 9, 2022 - Abstract #EASD2022EASD_1076;
The results indicated palmitate with Fetuin-A potentiate DPP4 expression in pancreatic beta cells following TLR4-NF-kB pathway. Use of DPP4 inhibitor, Vildagliptin, repress fetuin-A level in beta cells, subside inflammatory cytokines and reduce fat accumulation in palmitate+Fetuin-A treatment indicating restoration of insulin secretion and beta cell function.
- | Biomarker, Journal: Could Fetuin-A Be a Biomarker for Autism Spectrum Disorder and Cognitive Developmental Delay? (Pubmed Central) - Jul 8, 2022
The cutoff value for the serum fetuin-A levels for cognitive developmental delay and autism spectrum disorder was 518 µg/liter, according to the results of ROC analysis (84.6% sensitivity and 91.4% specificity, AUC: 0.95, p < 0.001). The findings suggest that the serum fetuin-A level may be used to diagnose autism spectrum disorder and cognitive developmental delays.
- | Journal: Alpha-2 Heremans Schmid Glycoprotein (AHSG) promotes the proliferation of bladder cancer cells by regulating the TGF-β signalling pathway. (Pubmed Central) - Jul 1, 2022
Finally, the expression level of AHSG in the urine of BC patients was significantly higher than that of healthy subjects by ELISA, with specificity. Our study concluded that AHSG might be a novel marker of BC that promotes the proliferation of BC cells by regulating the TGF-β signaling pathway.
- | Journal: Ultra-stable high internal phase emulsions stabilized by protein-anionic polysaccharide Maillard conjugates. (Pubmed Central) - Jun 25, 2022
The emulsion stabilized by SC-AHSG conjugate had the lowest mean droplet size (363.07 ± 34.56 nm), orderly-packed oil droplets with monomodal distribution, the highest zeta potential (-27.70 ± 0.70 mV), high storage stability (no creaming or oil-off) and was ultra-stable against environmental stresses. Results of this research are helpful for development of emulsion-based foods with novel functionality.
- | Journal: Long-distance transit alters liver and skeletal muscle physiology of beef cattle. (Pubmed Central) - Jun 22, 2022
The abundance of several proteins (alpha-2-HS-glycoprotein) and metabolites (lactate, citrate, tri-hydroxybutyric acid, and leucine) associated with energy metabolism were altered in the liver and muscle of TRANS. The differential responses for DEPR versus TRANS steers indicate muscle plays an important role in how cattle respond to and recover from transportation stress.
- | Journal: Plasma Proteomic Analysis Identified Proteins Associated with Faulty Neutrophils Functionality in Decompensated Cirrhosis Patients with Sepsis. (Pubmed Central) - Jun 19, 2022
Proteins such as DNAJC13, GPI, GSTP1, PNP, ANPEP, COTL1, PGAM1, PROS1, MPO, SERPINA3 and MMRN1 showed positive correlation with neutrophils activity and number, oxidative burst activity and clinical parameters such as MELD, MELD Na and Bilirubin. Proteomic analysis revealed that faulty functionality of neutrophils may be due to the autophagy proteins i.e., DNAJC13, AHSG, TMSB4X, PROS1 and SERPINA3, which can be used as therapeutic targets in decompensated cirrhosis patients with sepsis.