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  • ||||||||||  Biomarker, Journal:  Biomarkers of diabetes: role in the pathogenesis of atrial fibrillation. (Pubmed Central) -  Mar 8, 2024   
    However, no data was found, including fructosamine, glycated albumin, 1,5 anhydroglucitol, fetuin-A, ?-hydroxybutyrate, mannose-binding lectin serine peptidase, transferrin, IL-1 receptor antagonist in AF. Understanding the interplay between diabetes and AF through the measurement of relevant biomarkers can contribute to better risk assessment, early detection, and the development of targeted therapeutic strategies for individuals at risk or already affected by these conditions.
  • ||||||||||  Preclinical, Journal:  Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice. (Pubmed Central) -  Mar 7, 2024   
    In atherogenic LDLR-KO mice, exposure to sFlt1-induced preeclampsia during pregnancy increases future atherosclerotic plaque inflammation, supporting the concept that preeclampsia directly exacerbates atherosclerotic inflammation independent of preexisting risk factors. This mechanism may contribute to ischemic vascular disease in women after preeclampsia pregnancy.
  • ||||||||||  The Prognostic Event for MAFLD: CVD or Extrahepatic Cancers? () -  Mar 5, 2024 - Abstract #APASL2024APASL_2950;    
    Accumulation of fat at ectopic locations and adipose tissue dysfunction have also been implicated in the development of MAFLD. Secretion of various hepatokines such as retinol-binding protein-4, fetuin-A, fibroblast-growth factor 21 and inflammatory cytokines, tumor-necrosisfactor alpha, C-reactive protein and interleukin-6 cause hepatic gluconeogenesis, glycogen synthesis and insulin resistance which together drives complications in these patients.
  • ||||||||||  Journal:  Longitudinal plasma proteomic profiling of EML4-ALK positive lung cancer receiving ALK-TKIs therapy. (Pubmed Central) -  Mar 4, 2024   
    Secretion of various hepatokines such as retinol-binding protein-4, fetuin-A, fibroblast-growth factor 21 and inflammatory cytokines, tumor-necrosisfactor alpha, C-reactive protein and interleukin-6 cause hepatic gluconeogenesis, glycogen synthesis and insulin resistance which together drives complications in these patients. This study contributes to the search for prognostic and drug-resistance biomarkers in plasma samples for ALK-TKI therapy and provides new insights into the mechanism of drug resistance and the selection of follow-up treatment.
  • ||||||||||  Biomarker, Journal:  Identification of potential biomarkers for neuromyelitis optica by quantitative proteomics. (Pubmed Central) -  Mar 1, 2024   
    This study contributes to the search for prognostic and drug-resistance biomarkers in plasma samples for ALK-TKI therapy and provides new insights into the mechanism of drug resistance and the selection of follow-up treatment. CSF NCAM1, serum NCAM1 and serum SST may serve as potential biomarkers for NMO patients and aid in the diagnosis of AQP4 antibody-negative NMO patients.
  • ||||||||||  Biomarker, Journal:  Characterization of the Plasma Proteomic Profile of Fabry Disease: Potential Sex- and Clinical Phenotype-specific Biomarkers. (Pubmed Central) -  Feb 24, 2024   
    All these proteins had a greater capacity to identify the presence of complications in FD patients than lyso-GB3, with apolipoprotein A-IV standing out as being more sensitive and effective in differentiating the presence and absence of chronic kidney disease in FD patients than renal markers such as creatinine, glomerular filtration rate and microalbuminuria. Identification of these potential biomarkers can help further our understanding of the pathophysiological processes that underlie the heterogeneous clinical manifestations associated with FD.
  • ||||||||||  Journal:  EVALUATION OF FETUIN-A LEVELS IN THE EARLY STAGE OF AUTOIMMUNE THYROIDITIS. (Pubmed Central) -  Feb 15, 2024   
    The findings of our study suggest that autoimmune thyroiditis without thyroid dysfunction is related to lower fetuin-A levels. Low fetuin-A levels are known to be associated with an increased risk of cardiovascular disease, suggesting that careful monitoring is required in patients with low fetuin-A levels.
  • ||||||||||  Preclinical, Journal:  Nrf2 inhibition regulates intracellular lipid accumulation in mouse insulinoma cells and improves insulin secretory function. (Pubmed Central) -  Jan 15, 2024   
    Suppression of Nrf2 by siRNA showed a reduced expression of lipogenic genes, ablation of lipid droplets, decrease in the number of apoptotic cells, and restoration of insulin secretion with a corresponding increase of Pdx1, BETA2, and Ins1 gene expression. Our study thus suggested an important aspect of lipid accumulation in the pancreatic ?-cells contributing to ?-cell dysfunction and demonstrated the role of Fetuin-A in CD36 expression, with a possible way of restoring ?-cell function by targeting Nrf2.
  • ||||||||||  Biomarker, Journal:  Discovery and validation of protein biomarkers for monitoring the effectiveness of drug treatment for major depressive disorder. (Pubmed Central) -  Jan 15, 2024   
    Eight selected biomarkers, including Apolipoproteins A-I, Complement factor H, Complement C5, Complement C1q subcomponent subunit B, Alpha-2-HS-glycoprotein, Complement C1q subcomponent subunit C, Vitamin D-binding protein and Corticosteroid-binding globulin were distinguished between disease states, and protein levels in the drug-treated group were similar to those in the control group. These markers can be used to monitor the effectiveness of drug treatment.
  • ||||||||||  Encephalomyosynangiosis Promotes Mature Angiogenesis After Ischemic Stroke (Poster Hall, Halls 5-6) -  Jan 9, 2024 - Abstract #ISC2024ISC_643;    
    EMS-treated mice exhibited an early improvement in sensory motor deficits post-stroke. Analysis of the angiogenesis and proteomic profile array data unveiled a downregulation of antiangiogenic factors (such as interleukin-10 and Fetuin A) and an upregulation of pro-angiogenic cytokines or growth factors (including Fibroblast Growth Factor and C-X-C Motif Chemokine 12) in the EMS group.
  • ||||||||||  Journal:  Proteomic Profiling of Early Secreted Proteins in Response to Lipopolysaccharide-Induced Vascular Endothelial Cell EA.hy926 Injury. (Pubmed Central) -  Nov 25, 2023   
    Furthermore, a potential interaction analysis of predominant DAMPs-related proteins using STITCH 5.0 revealed the following associations with pathways: response to stress; bacterium; and LPS (GO:0080134; 0009617; 0032496). Markedly, alpha-2-HS-glycoprotein (AHSG or fetuin-A) and lactotransferrin (LTF) potentially presented since the first hour of LPS stimulation, and were highly up-regulated at 24 h. Taken together, we reported proteomic profiling of vascular endothelial cell-specific DAMPs in response to early an in vitro LPS stimulation, suggesting that these early damage-response protein candidates could be novel early biomarkers associated with sepsis.
  • ||||||||||  Journal:  Humoral and cellular factors inhibit phosphate-induced vascular calcification during the growth period. (Pubmed Central) -  Nov 16, 2023   
    Furthermore, culture in high Pi medium increased the mRNA level of tissue-nonspecific alkaline phosphatase (TNAP), which degrades pyrophosphate, only in the adult aorta. Collectively, our findings indicate that the aorta in growing mouse may be resistant to Pi-induced vascular calcification via a mechanism in which high serum fetuin-A levels and suppressed TNAP expression.
  • ||||||||||  Incorporation of O-Glycopeptides into FVIII Decreases Its Immunogenicity (SDCC - Room 33) -  Nov 3, 2023 - Abstract #ASH2023ASH_915;    
    Our findings underscore the significant impact of post-translational modification on protein immunogenicity, particularly in the case of FVIII. Additionally, FVIII-FibA shows promising potential for clinical applications, not only in the development of new recombinant FVIII products but also in gene therapy approaches.
  • ||||||||||  Journal:  Transcriptome Analysis to Elucidate the Effects of Milk Replacer Feeding Level on Intestinal Function and Development of Early Lambs. (Pubmed Central) -  Oct 27, 2023   
    Overall, 1179 differentially expressed genes were identified, which were enriched in nutrient metabolism, coagulation cascades, and other pathways. Further, intensive MR feeding affected insulin sensitivity to reduce excessive glucose interception by intestinal tissues to ensure adequate absorbed glucose release into the portal circulation and promoted lipid and protein degradation in intestinal tissues to meet the energy demand of intestinal cells by regulating AHSG, IGFBP1, MGAT2, ITIH, and CYP2E1 expression.
  • ||||||||||  Journal:  Effects of vasicine in neuroinflammatory zebrafish model. (Pubmed Central) -  Oct 27, 2023   
    Behavioral parameters and biochemical evaluations revealed that vasicine was effective in treatment against neuroinflammatory models of surgery, chemical, xenotransplantation. Attenuation of cognitive dysfunction in all three neuroinflammation zebrafish models by vasicine in this study may recommend vasicine as a potential molecule for treating neuroinflammatory and neurodegenerative diseases.
  • ||||||||||  Longitudinal plasma proteomic profiling of EML4-ALK positive lung cancer receiving ALK-TKIs therapy (Exhibition area) -  Oct 6, 2023 - Abstract #ESMOAsia2023ESMO_Asia_1050;    
    Finally, we validated the prognostic efficacy of baseline plasma CRP, SAA1, AHSG, SERPINA4, and TF in another independent NSCLC cohort undergoing ALK-TKI treatment. Conclusions This study contributes to the search for prognostic and drug-resistance biomarkers in plasma samples for ALK-TKI therapy and provides new insights into the mechanism of drug resistance and the selection of follow-up treatment.
  • ||||||||||  Reduced Fetuin-A Levels Are Associated With Exercise Intolerance in Patients With Heart Failure and Predict the Risk of Adverse Outcomes (Zone 2, Science and Technology Hall, Level 2) -  Sep 21, 2023 - Abstract #AHA2023AHA_7444;    
    Conclusions This study contributes to the search for prognostic and drug-resistance biomarkers in plasma samples for ALK-TKI therapy and provides new insights into the mechanism of drug resistance and the selection of follow-up treatment. Reduced Fetuin-A levels were associated with exercise intolerance in patients with HF, and those with decreased levels of both Fetuin-A and peak VO2 were at the highest risk of adverse outcomes.
  • ||||||||||  Review, Journal:  Osteoporosis and vascular calcifications. (Pubmed Central) -  Sep 12, 2023   
    Investigation of animal and in vitro models has identified several potential mechanisms for this reciprocal bone-vascular regulation, such as vitamin K and D sufficiency, AGEs-RAGE interaction, OPG/RANKL/RANK, Fetuin A, estrogen deficiency and phytoestrogen supplementation, microbiota and its relation to diet, among others. Complete elucidation of these potential mechanisms, as well as their clinical validation via controlled studies, will provide a basis for pharmacological intervention that could simultaneously promote bone and vascular health.
  • ||||||||||  Journal:  Hepatokine Profile in Adolescents with Polycystic Ovary Syndrome: A Case-Control Study. (Pubmed Central) -  Sep 9, 2023   
    Among the PCOS patients, the FGF21 concentrations were significantly higher in those with NAFLD, whereas a 1 pg/mL increase in the FGF21 concentration increased the odds of NAFLD diagnosis by liver ultrasound by 1%, suggesting FGF21 as a potential biomarker for hepatic disease in females with PCOS in adolescence. Fetuin A was the least differentiated hepatokine between the PCOS patients and controls with the least associations with metabolic and hormonal parameters.