- |||||||||| Review, Journal: Metallic Nanoparticles in the Food Sector: A Mini-Review. (Pubmed Central) - Feb 16, 2022
This review summarizes recent developments in the use of MNPs in the field of food science and technology. Additionally, a brief overview of MNP synthesis and characterization techniques is provided, as well as of the toxicity, biosafety and regulatory issues of MNPs in the agricultural, feed and food sectors.
- |||||||||| Journal: Antibacterial Effect of Oregano Essential Oil against Vibrio vulnificus and Its Mechanism. (Pubmed Central) - Feb 16, 2022
It was indicated that OEO inactivated V. vulnificus by generating ROS which caused lipid peroxidation of cell membranes, thereby reducing the permeability and integrity of cell membranes and causing morphological changes to cells, but there was no obvious damage to DNA. In addition, OEO could effectively kill V. vulnificus in oysters at 25 °C, and the number of bacteria decreased by 48.2% after 0.09% OEO treatment for 10 h. The good inhibitory effect and bactericidal activity of OEO showed in this study, and the economy and security of OEO make it possible to apply OEO to control V. vulnificus contamination in oysters and other seafoods.
- |||||||||| Journal: Phytic Acid against Clostridium perfringens Type A: A Food Matrix Study. (Pubmed Central) - Feb 16, 2022
The PA-MD 1.5% and 2.5% had a similar performance to SS 10% and a similar or higher performance than 0.015% NO (p < 0.05). In an unprecedented way, the present study demonstrated that PA inhibited spore germination and vegetative cells growth of C. perfringens, highlighting its potential use as an alternative and natural preservative for the meat industry.
- |||||||||| Journal: Effect of Anolyte on S. Typhimurium and L. monocytogenes Growth in Minced Pork and Beef Cuts. (Pubmed Central) - Feb 16, 2022
Initially, anolyte significantly decreased TVC, however during the storage period (10-29 days) TVC increased but remained significantly lower compared to control. Anolyte was effective in reducing L. monocytogenes and S. Typhimurium counts throughout the study, and after 29 days of incubation, these bacteria could not be detected in the samples treated with anolyte.
- |||||||||| Preclinical, Journal: Fucoidan Regulates Starch Digestion: In Vitro and Mechanistic Study. (Pubmed Central) - Feb 16, 2022
This suggested that although fucoidan may not be absorbed via passive diffusion, there is potential for the fucoidan to be absorbed via other modes of absorption. Thus, there is a potential for the use of fucoidan as a functional ingredient in bread to reduce the glycemic potential of bread.
- |||||||||| Journal: Performance of Graphene/Polydimethylsiloxane Surfaces against S. aureus and P. aeruginosa Single- and Dual-Species Biofilms. (Pubmed Central) - Feb 16, 2022
Still, the effectiveness of these surfaces in suppressing single- and dual-species biofilm formation was confirmed by CLSM analysis, where a decrease in biofilm biovolume (83% for S. aureus biofilms and 42% for P. aeruginosa and dual-species biofilms) and thickness (on average 72%) was obtained. Overall, these results showed that pristine GNPs dispersed into the PDMS matrix were able to inhibit biofilm growth, being a starting point for the fabrication of novel surface coatings based on functionalized GNP/PDMS composites.
- |||||||||| Journal: The Improvement of the Irradiation Resistance of Amorphous MoS Films by Thermal Annealing. (Pubmed Central) - Feb 16, 2022
When the ion fluence reaches 1.09 × 10 ion/cm, for instance, the wear life of the MoS film annealed at 300 °C remains at 8.4 × 10 revolutions. The higher irradiation tolerance of MoS films comes from the reduction in intrinsic defects by thermal annealing, which increases the internal grain size and volume fraction of grain boundaries, further providing an effective sink for irradiation defects.
- |||||||||| Journal: Exploring Hydrothermal Synthesis of SAPO-18 under High Hydrostatic Pressure. (Pubmed Central) - Feb 16, 2022
The obtained solids were characterized with XRD, SEM, ICP-AES, TG and Al and P MAS NMR spectroscopy. The results highlight the importance of the external pressure effect on the hydrothermal synthesis of molecular sieves and its influence on the interaction between the organic molecule and the silicoaluminophosphate network.
- |||||||||| Preclinical, Journal: Cancer Cytotoxicity of a Hybrid Hyaluronan-Superparamagnetic Iron Oxide Nanoparticle Material: An In-Vitro Evaluation. (Pubmed Central) - Feb 16, 2022
Comparison showed that the present material could target U87MG cells at a higher rate than NIH3T3 control cells, with a viability inhibition rate of 34% observed at day two and no cytotoxicity observed in NIH3T3 normal fibroblasts during the three-day experimental period. Supported by mass spectrometry images confirming that the nanoparticles accumulated on the surface of cancer cells, the fabricated materials can reasonably be suggested as a candidate for both magnetic resonance imaging applications and as an injectable anticancer agent.
- |||||||||| Journal: Enhancement of Biofunctionalization by Loading Manuka Oil on TiO Nanotubes. (Pubmed Central) - Feb 16, 2022
A concentration of manuka oil in the range of 0.02% to less than 1% can have a synergistic effect on antibacterial activity and excellent biocompatibility. A manuka oil coating (especially with a concentration of 0.5%) on the TiO nanotube layer can be expected not only to prevent stenosis of the connective tissue around the mesh and inflammation by microbial infection but also to be effective in stable and rapid bone regeneration.
- |||||||||| Journal: The Impact of the COVID-19 Outbreak on Patients' Adherence to PCSK9 Inhibitors Therapy. (Pubmed Central) - Feb 16, 2022
The COVID-19 lockdown caused a remarkable lack of adherence to PCSK9i therapy, risking negative implications for the health status of patients at high cardiovascular risk. Facilitating patients' access to PCSK9i and enhancing telemedicine seem to be effective strategies to ensure the continuity of care and appropriate management of these patients.
- |||||||||| Journal: Treatment-Resistant Depression in Poland-Epidemiology and Treatment. (Pubmed Central) - Feb 16, 2022
During all of the treatment steps, patients most often received a selective serotonin reuptake inhibitor (SSRI) and a serotonin norepinephrine reuptake inhibitor (SNRI). (4) TRD is a serious problem, affecting approximately one fourth of all depressive patients and nearly 35,000 Poles.
- |||||||||| ezetimibe / Generic mfg.
Review, Journal: The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern? (Pubmed Central) - Feb 16, 2022
As lipid lowering agents including statins, ezetimibe and anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have shown good therapeutic results, the guidelines are constantly lowering the "optimal" LDL-C goals...In this review we aimed to shed light on this troubling association and identify the potential risk factors of such a potential adverse reaction. With respect to the data presented, we concluded that in patients with high risk of ICH, a cautious approach and individualized therapy strategy are advised when considering aggressive LDL reduction.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Procoralan (ivabradine) / Amgen, Servier, Ono Pharma
Review, Journal: Adaptive Servo-Ventilation as a Novel Therapeutic Strategy for Chronic Heart Failure. (Pubmed Central) - Feb 16, 2022
The aggregate benefit of these additional therapeutic strategies in addition to foundational medical therapy may be a promising option in the selected candidates who do not achieve acceptable clinical and quality-of-life improvements with oral medical therapy alone. Now is the era to reconsider the implication of an adaptive servo-ventilation-therapy-incorporated medical therapeutic strategy for patients with congestive heart failure.
- |||||||||| Review, Journal: Cell Death in AMD: The Rationale for Targeting Fas. (Pubmed Central) - Feb 16, 2022
We review the data that support targeting programmed cell death through inhibition of the Fas receptor as a novel approach to preserve these structures and that this effect results from inhibiting both canonical death pathway activation and reducing the associated inflammatory response. These data lay the groundwork for current clinical strategies targeting the Fas pathway in this devastating disease.
- |||||||||| Review, Journal: Taurine and Its Derivatives: Analysis of the Inhibitory Effect on Platelet Function and Their Antithrombotic Potential. (Pubmed Central) - Feb 16, 2022
Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.
- |||||||||| Review, Journal: The Role of Sclerostin in Bone Diseases. (Pubmed Central) - Feb 16, 2022
Antisclerostin antibodies have recently been approved for the treatment of osteoporosis, and several animal studies and clinical trials are currently under way to evaluate the effectiveness of antisclerostin antibodies in the treatment of other than osteoporosis skeletal disorders and cancer with promising results. Understanding the exact role of sclerostin may lead to new therapeutic approaches for the treatment of skeletal disorders.
- |||||||||| Review, Journal, Checkpoint inhibition: Checkpoint Inhibitors and the Gut. (Pubmed Central) - Feb 16, 2022
However, emerging recognition of checkpoint inhibitor-related adverse events has complicated the status of checkpoint inhibitor-related therapies. This review article discusses gastrointestinal adverse events as a result of checkpoint inhibitor therapy, as well as limitations of current guidelines, thus providing recommendations for guideline revision and future study direction.
- |||||||||| Review, Journal, IO biomarker: Current Controversies and Challenges on BRAF V600K-Mutant Cutaneous Melanoma. (Pubmed Central) - Feb 16, 2022
Both target therapy with BRAF inhibitors + MEK inhibitors and immunotherapy with anti-checkpoint blockades are effective in melanoma V600K, although no sufficient evidence can currently support a formal recommendation for first line treatment choice in IIIC unresectable/IV stage patients. Still, melanoma V600K represents an unmet medical need and a marker of poor prognosis for cutaneous melanoma.
- |||||||||| Journal: Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM-CHK2 Pathway. (Pubmed Central) - Feb 16, 2022
Gene expression analysis of CCNDBP1-overexpressed cells and Ccndbp1 knockout mice revealed that Ccndbp1 activated the Atm-Chk2 pathway through the inhibition of Ezh2 expression, accounting for resistance to DNA damage. Our study demonstrated that by inhibiting EZH2, CCNDBP1 contributed to the activation of the ATM-CHK2 pathway to alleviate DNA damage, leading to chemoresistance.
- |||||||||| Review, Journal, Checkpoint inhibition: The Potential Cardiotoxicity of Immune Checkpoint Inhibitors. (Pubmed Central) - Feb 16, 2022
The rising numbers of patients being treated with ICIs make this potential cardiotoxic effect one of paramount importance for further investigation and understanding. This review will discuss the most recent data on different cardiotoxic effects of ICIs treatment.
- |||||||||| meropenem / Generic mfg.
Journal: Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing. (Pubmed Central) - Feb 16, 2022
This study aimed to develop and evaluate biopolymer-based thermoreversible injectable hydrogels for effective wound-healing applications and the controlled drug delivery of meropenem...The in vivo studies in Sprague Dawley (SD) rats presented accelerated healing with the drug-loaded injectable hydrogel, while 90% wound closure with the unloaded injectable hydrogel, 70% in the positive control group (SC drug), and 60% in the negative control group was observed (normal saline) after fourteen days. In vivo wound closure analysis confirmed that the developed polymeric hydrogel has synergistic wound-healing potential.
- |||||||||| Journal: Green Extraction of Carrageenans from Mastocarpus stellatus. (Pubmed Central) - Feb 16, 2022
A wide palette of viscous features was identified for recovered hybrid carrageenans, with the strongest rheology properties observed at the same temperature. It should be remarked that the maximum inhibitory effect was also obtained at 130 °C for both the ovarian carcinoma cell line (A2780) (65%, IC: 0.31 mg/mL) and lung carcinoma cell line (A549) (59%, IC: 0.41 mg/mL).
- |||||||||| Journal: Probing Oxygen-to-Hydrogen Peroxide Electro-Conversion at Electrocatalysts Derived from Polyaniline. (Pubmed Central) - Feb 16, 2022
The selectivity towards HO was 65-80% for polyaniline and nickel-modified polyaniline. The production rate was 974 ± 83, 1057 ± 64 and 1042 ± 74 µmol h for calcined polyaniline, calcined nickel-modified polyaniline and Vulcan XC 72R (state-of-the-art electrocatalyst), respectively, which corresponds to 487 ± 42, 529 ± 32 and 521 ± 37 mol kg h (122 ± 10, 132 ± 8 and 130 ± 9 mol kg cm) for faradaic efficiencies of 58-78%.
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