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- Impact of 2-AG inhibition on fear and stress responses in mice (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_12750;
Here, we found decreased exploratory behavior in DO34-treated mice as well as an increase in avoidant behavior after first exposure to shadow. While differences between vehicle and DO34 mice were observed in both behavioral paradigms, further studies observing both conditioned and innate defensive behaviors in response to various threatening stimuli are necessary to further understand stress-related pathology in humans.
- | Journal, Surgery: Effect of Proton Pump Inhibitor on the Outcome of Laryngeal Microsurgery in Patients With Vocal Fold Mucosal Disease With Reflux Symptoms. (Pubmed Central) - Jul 14, 2024
While differences between vehicle and DO34 mice were observed in both behavioral paradigms, further studies observing both conditioned and innate defensive behaviors in response to various threatening stimuli are necessary to further understand stress-related pathology in humans. Postoperative PPI administration in patients with VF benign mucosal disease with reflux symptoms might improve subjective and objective voice outcomes after LMS.
- | doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: In Vivo Investigation of Supportive Immunotherapeutic Combination of Bifidobacterium infantis 35624 and Doxorubicin in Murine Breast Cancer. (Pubmed Central) - Oct 22, 2023
was effective in tumor growth and regression of metastasis. Consequently, the combination of B. infantis milk and doxorubicin showed the best anti-tumor effect.
- | Journal: Bayes optimal informer sets for early-stage drug discovery. (Pubmed Central) - Jun 21, 2023
In both empirical settings BOISE exhibits better predictive performance than available methods. It also behaves well with missing data, where methods that use matrix completion show worse predictive
- | Journal, Tumor cell: Synthesis, characterization and antiproliferative effects of naphtho [2,3-b] thiophen-4,9-quinone on bladder tumor cells. (Pubmed Central) - Jun 20, 2023
The results showed selective cytotoxicity, colonies reduction, morphological change, inhibition of the cell migration process, induction of ROS production and cell cycle arrest. Naphtho [2,3-b] thiophen-4,9-quinone presents antiproliferative activity regardless TP53 status and may be a promising agent in the treatment of bladder cancer, as they have an oxidizing effect and interfere with cell cycle.
- | Journal: Acculturative Stress, Anxiety, and Depression in Latinx Youth: The Role of Behavioral Inhibition, Cultural Values, and Active Coping. (Pubmed Central) - Jun 19, 2023
Furthermore, active coping moderated the relationship between acculturative stress and depression, such that higher levels of active coping resulted in a stronger relationship between acculturative stress and depression than at lower levels. Findings from the current study make advancements towards an understanding of individual characteristics that interact with the experience of acculturative stress, anxiety, and depression.
- | Keytruda (pembrolizumab) / Merck (MSD)
Journal, Metastases: Pembrolizumab for advanced non-small cell lung cancer (NSCLC): Impact of autoimmune comorbidity and outcomes following treatment completion. (Pubmed Central) - Jun 19, 2023
Patients with previous AI diseases tolerate treatment well, and there is a non-significant trend for improved outcomes in this group. Patients who complete the course of pembrolizumab have significantly better survival outcomes than those who do not.
- | Journal: Self-regulation and Psychopathology in Young Children. (Pubmed Central) - Jun 19, 2023
Further, different sub-components of self-regulation relate to different dimensions of psychopathology in children. Interventions should target these areas in children at-risk for disorders.
- | Journal: Ternstroenol F: a new pentacyclic triterpenoid saponin isolated from the Australian rainforest plant Ternstroemia cherryi. (Pubmed Central) - Jun 15, 2023
Ternstroenol F was evaluated for its inhibitory effects on NO inhibition, cell viability and TNF- ? release in RAW 264.7 macrophages, displaying an IC values of 0.23, 0.81 and 1.84?
- | Cabometyx (cabozantinib tablet) / Takeda, Exelixis, Ipsen
Journal: Bilateral optic disc edema as a possible complication of cabozantinib use-a case report. (Pubmed Central) - May 1, 2023
Bilateral optic edema should be considered as a complication associated with cabozantinib. We propose discontinuation of the treatment in cases such as that, and pulse steroid therapy should be considered if there is no contraindication.
- | arecoline / Cogent Pharma
Journal: Tyrosine Sulphation of CXCR4 Induces the Migration of Fibroblast in OSF. (Pubmed Central) - Apr 21, 2023
Finally, in human OSF specimens, TPST-1 expression was directly correlated with the expression of CXCR4. These data indicate that the arecoline-induced tyrosine sulphation of CXCR4, which is regulated by TPST-1, might be a potential mechanism that contributes to FB migration in OSF.
- | Journal: Inhibition of Rgs10 aggravates periodontitis with collagen-induced arthritis via the NF-?B pathway. (Pubmed Central) - Apr 21, 2023
These data indicate that the arecoline-induced tyrosine sulphation of CXCR4, which is regulated by TPST-1, might be a potential mechanism that contributes to FB migration in OSF. Inhibition of Rgs10 in mice with periodontitis and rheumatoid arthritis can promote the progression of periodontitis, indicating the potential therapeutic role of Rgs10 in this condition.
- | Journal: Functional analysis of the miR-145/Fascin1 cascade in canine oral squamous cell carcinoma. (Pubmed Central) - Apr 21, 2023
The expression profile and functions of miR-145 in canine oral SCC are similar to those in human HNSCC. Thus, canine oral SCC may represent a valuable preclinical model for human HNSCC.
- ||| Xalkori (crizotinib) / Pfizer, Tagrisso (osimertinib) / AstraZeneca
P3 data, Journal, Real-world evidence, Real-world: Investigating the efficacy of osimertinib and crizotinib in phase 3 clinical trials on anti-cancer treatment-induced cardiotoxicity: are real-world studies the way forward? (Pubmed Central) - Apr 3, 2023
None of the patients who developed cardiotoxicity in the real-world study would have been eligible to participate in FLAURA and PROFILE 1014 study whereas n?=?4/7 and n?=?5/7 patients were eligible to participate in AURA3 and PROFILE 1007 trials, respectively. Although phase 3 clinical trials play an important role in understanding the effectiveness and give insights on side-effect profiles, real-world studies can show the real risk of cardiotoxicity more accurately and realistically.
- || Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
Retrospective data, Review, Journal, Combination therapy: A comprehensive evaluation of the safety of ipilimumab, nivolumab and their combination therapy: A systematic review and network meta-analysis. (Pubmed Central) - Apr 3, 2023
Although phase 3 clinical trials play an important role in understanding the effectiveness and give insights on side-effect profiles, real-world studies can show the real risk of cardiotoxicity more accurately and realistically. Nivolumab 3?mg/kg biweekly, nivolumab 240?mg weekly and nivolumab 3?mg/kg plus ipilimumab 1?mg/kg triweekly could be preferred due to the relatively low risk of TRAEs, TDAEs and SAEs.
- | sorafenib / Generic mfg.
Journal, HEOR, Cost-analysis: A cost analysis of sorafenib for desmoid tumors. (Pubmed Central) - Apr 3, 2023
Favorable RECIST outcomes were less likely and costlier. Patients should be informed of possible benefits of treatment versus potential financial burden.
- | Journal: Accelerating the discovery of the beyond rule of five compounds that have high affinities toward SARS-CoV-2 spike RBD. (Pubmed Central) - Mar 28, 2023
We found that the most promising candidates, namely, ZINC95628821, ZINC95617623, ZINC3979524, and ZINC261494658, strongly bind to the spike RBD and interfere with the human ACE2 receptor. These findings accelerate the rational design of selective inhibitors targeting the spike RBD protein of SARS-CoV-2.Communicated by Ramaswamy H. Sarma.
- | Journal: Computational investigation of the alkaloids of Pilocarpus microphyllus species as phytopharmaceuticals for the inhibition of sterol 14?-demethylase protease of Trypanosoma cruzi. (Pubmed Central) - Mar 28, 2023
The molecules of isopilosine, epiisopiloturine, epiisopilosine, and pilosine showed up the lowest binding energies by molecular docking, good human intestinal absorption, low penetration in the blood-brain barrier, antiprotozoal and anticarcinogenic activities in ADMET studies. It has been observed a better binding affinity of the sterol 14?-demethylase protease with isopilosine in molecular dynamics and MM-PBSA studies, which indicates it as a potential drug candidate for Chagas disease.Communicated by Ramaswamy H. Sarma.
- | Journal: Computational studies on the cholinesterase, beta-secretase 1 (BACE1) and monoamine oxidase (MAO) inhibitory activities of endophytes-derived compounds: towards discovery of novel neurotherapeutics. (Pubmed Central) - Mar 28, 2023
MD simulation of the unbound and complexed enzymes with corynesidone A showed that the complexes were stable throughout the simulation time. Given the exceptional inhibitory activity of endophytes-derived corynesidone A against the four selected targets, its ability to permeate the BBB, excellent drugability properties as well as its stability when complexed with the enzymes, it is a good candidate for further studies towards development of new neurotherapeutics.Communicated by Ramaswamy H. Sarma.
- | Journal: Computational approaches for evaluation of isobavachin as potential inhibitor against t877a and w741l mutations in prostate cancer. (Pubmed Central) - Mar 28, 2023
Based on the results of Molecular Docking, Drug-likeness, and ADMET testing, ten structures, including six complexes and three receptors were subjected to molecular dynamics simulation of 100?ns covering RMSD, RMSF, Rg, and MM/PBSA. Based on the simulation results, Isobavachin, IsoMod4, and IsoMod7 were concluded to be stable and exhibited potential properties for developing a novel drug to combat prostate cancer and its associated drug-resistance.
- | Preclinical, Journal: Elucidating the inhibitory mechanism of yeast ?-glucosidase by phytocompounds from Scoparia dulcis through in vitro and in silico approach. (Pubmed Central) - Mar 28, 2023
Molecular dynamics simulation was carried out to further understand the interaction and stability between glucosidase and ligands of SD. Taken together, the study reveals that the potency of SD is due to synergistic effect of active phytochemicals in it and suggest that their properties can be utilized for anti-diabetic treatment strategies.Communicated by Ramaswamy H. Sarma.
- | ketoconazole / Generic mfg.
Journal: The molecular docking and molecular dynamics study of flavonol synthase and flavonoid 3'-monooxygenase enzymes involved for the enrichment of kaempferol. (Pubmed Central) - Mar 28, 2023
The current work provides wide-ranging structural and functional information about FLS and F3'H enzymes showing detailed molecular mechanism of kaempferol biosynthesis and its degradation and hence kaempferol enrichment. Finding of the present work opens up new possibilities for future research towards enrichment of kaempferol by using activator (ascorbate) for FLS and inhibitor (ketoconazole) for F3'H as well as for its large-scale production using in vitro approaches.Communicated by Ramaswamy H. Sarma.
- | Journal: Deciphering the molecular mechanisms of selective non-covalency demonstrated differentially by 9-Allylnaphtho[1,8-ef]isoindole-7,8,10(9H)-trione (C11) against fibroblast growth factor receptors 1-4. (Pubmed Central) - Mar 28, 2023
We believe rational insights from this study will contribute to the structure-based design of highly specific FGFR1 inhibitors. Communicated by Ramaswamy H. Sarma.
- | Journal: Molecular dynamics simulations of aqueous systems of inhibitor candidates for adenosine-5'-phosphosufate reductase. (Pubmed Central) - Mar 28, 2023
RMSD, RDF, and hydrogen bonds results revelated that all ligands left the cube site, while in the active site, some ligands remained in their docking region, pointing to the enzyme active site as the best target for the selected ligands. The binding energy results of ligands hydroxamic acid (HXA) and catechol (CAT) showed that they bonded favorably to the enzyme and key residues of the active site contributed significantly to the protein-ligand bind, indicating HAX and CAT may compete with the substrate for interactions with these residues and displaying potential as candidates for experimental studies about APSrAB inhibitors.Communicated by Ramaswamy H. Sarma.
- | Journal: Treating to Target Glycaemia in Type 2 Diabetes Pregnancy. (Pubmed Central) - Mar 27, 2023
Knowledge of the epidemiology, pathophysiology and unique management considerations of early-onset type 2 diabetes is essential to provide evidence-based care to pregnant women with type 2 diabetes. This narrative review will discuss contemporary data regarding type 2 diabetes pregnancy outcomes and the increasing recognition that different types of diabetes may require different treatment strategies before, during and after pregnancy.
- | Journal: Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles. (Pubmed Central) - Mar 21, 2023
This narrative review will discuss contemporary data regarding type 2 diabetes pregnancy outcomes and the increasing recognition that different types of diabetes may require different treatment strategies before, during and after pregnancy. Our findings show a novel EV-dependent mechanism for the rapid mobilization of neutrophils to peripheral blood from a splenic reserve and establish a proof of concept for functional manipulation of EV-communications through genetic alteration of parent cells.
- | atorvastatin / Generic mfg.
Preclinical, Journal: Guanxinping ameliorates atherosclerosis via MAPK/NF-?B signaling pathway in ApoE mice. (Pubmed Central) - Mar 20, 2023
Our results show that GXP could ameliorate atherosclerosis, which is mediated by inhibition of the MAPK/NF-?B signaling pathway in ApoE mice. This study provides evidence that GXP might be a promising drug for the treatment of AS.
- || Review, Journal: The role of non-ionizing electromagnetic radiation on female fertility: A review. (Pubmed Central) - Mar 16, 2023
Non-ionizing radiation also upsurges the free radical load in the uterus and ovary, which leads to inhibition of cell growth and DNA disruptions. In conclusion, non-ionizing electromagnetic radiations can cause alterations in both germ cells as well as in their nourishing environment and also affect other female reproductive parameters that might lead to infertility.
- | Journal: Degradation of rhodamine B by persulfate activated with green tea iron nanoparticles. (Pubmed Central) - Mar 16, 2023
A possible RhB degradation pathway was the chromophore destruction and ring-opening processes using GT-Fe NPs/PS, which produced a range of low molecular weight carboxylic acids (oxalic acid, lactic acid, acetic acid, and formic acid). GT-Fe NPs seem to be a promising persulfate activator in comparison to common activators such as CA-Fe.
- || Retrospective data, Review, Journal: Does noninvasive brain stimulation combined with other therapies improve upper extremity motor impairment, functional performance, and participation in activities of daily living after stroke? A systematic review and meta-analysis of randomized controlled trial. (Pubmed Central) - Mar 15, 2023
GT-Fe NPs seem to be a promising persulfate activator in comparison to common activators such as CA-Fe. The NIBS did not produce any significant improvement in WMFT as compared to sham NIBS (MD0.91 [95% CI, -0.89 to 2.70; p =
- | Journal: Perioperative Renin Angiotensin System Inhibitors Improve Major Outcomes of Heart Failure Patients Undergoing Cardiac Surgery: A Propensity-Adjusted Cohort Study. (Pubmed Central) - Mar 13, 2023
Pre- and postoperative use of RASi was associated with better outcomes for the patients who have HF and undergo CABG and/or valve surgeries. Preoperative continuation and postoperative restoration are warranted in these patients.
- | Journal: miR-485-5p alleviates obstructive sleep apnea syndrome with hypertension by inhibiting PI3K/AKT signaling pathway via downregulating HIF3A expression. (Pubmed Central) - Mar 9, 2023
MiR-485-5p alleviates OSAS with hypertension by inhibiting the PI3K/Akt pathway via downregulating HIF3A expression through the PI3K/AKT pathway. These findings suggest that miR-485-5p has the potential for treating OSAS-associated hypertension.
- | Preclinical, Journal: Transcutaneous vagus nerve stimulation attenuates autoantibody-mediated cardiovagal dysfunction and inflammation in a rabbit model of postural tachycardia syndrome. (Pubmed Central) - Mar 4, 2023
These findings suggest that miR-485-5p has the potential for treating OSAS-associated hypertension. Autoantibody inhibition of cholinergic ligand activity may be involved in the development of cardiovagal dysfunction and inflammation associated with POTS, both of which can be improved by vagal stimulation.
- | Journal: A Central Role for Magnesium Homeostasis during Adaptation to Osmotic Stress. (Pubmed Central) - Mar 2, 2023
These coordinated fluxes of K and Mg are orchestrated by cyclic-di-AMP, an essential second messenger in Firmicutes. These findings amend the conventional model for osmoadaptation and reveal that Mg limitation is the proximal cause of the bacteriostasis that precedes resumption of growth.
- | Journal: Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection. (Pubmed Central) - Mar 2, 2023
In this work, we show that interfering with either the synthesis or attachment of spike N-glycans significantly reduces the spread of SARS-CoV-2 infection in vitro, including that of several variants. As new SARS-CoV-2 variants, with various degrees of resistance against current vaccines, are likely to continue appearing, halting virus glycosylation using repurposed human drugs could result in a complementary strategy to reducing the spread of COVID-19 worldwide.
- | Journal: Dissecting the Structural and Conductive Functions of Nanowires in Geobacter sulfurreducens Electroactive Biofilms. (Pubmed Central) - Mar 2, 2023
However, their structural contributions to electron transfer in anode biofilm have not been elucidated. Based on studies of mutants lacking one or more of these facilitators, our results support a cytochrome-mediated electron transfer process in Geobacter biofilms and highlight the structural contribution of nanowires in anode biofilm formation, which contributes to biofilm formation and current generation, thereby providing a strategy to increase current generation.
- | Journal: Signal Peptidase-Mediated Cleavage of the Anti-? Factor RsiP at Site 1 Controls ? Activation and ?-Lactam Resistance in Bacillus thuringiensis. (Pubmed Central) - Mar 2, 2023
The discovery that the signal peptidase SipP is required for ? activation highlights an increasing role for signal peptidases in signal transduction, as well as in antibiotic resistance.
- | Journal: Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets. (Pubmed Central) - Mar 2, 2023
Utilizing a genome-wide functional analysis in a fission yeast cell-based system, we identified 12 viral candidates, including ORF3a, which cause cellular oxidative stress, inflammation, apoptosis, and necrosis that contribute to cytopathogenicity and COVID-19. Our findings indicate that antiviral agents targeting ORF3a could have a great impact on COVID-19.
- | Journal: Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth. (Pubmed Central) - Mar 2, 2023
This study provides evidence that the pathogenic fungus C. albicans communicates with human monocytes and induces the release of a human miRNA that promotes fungal growth. This mechanism represents an unexpected cross-species interaction and implies that an inhibition of specific miRNAs offers new possibilities for the treatment of human fungal infections.
- | Journal: Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis. (Pubmed Central) - Mar 2, 2023
This interaction takes place under conditions of potassium starvation if DarB is present in the apo form and the cells are in need of glutamate. Thus, DarB links potassium availability to the control of central metabolism.
- | Journal: Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis. (Pubmed Central) - Mar 2, 2023
Moreover, constitutive activation of this response through deletion of the anti-sigma factor gene rseA or exposure of bacilli to drugs that target the cell wall was found to potently drive pyrazinamide susceptibility independent of environmental pH. These findings force a paradigm shift in our understanding of pyrazinamide action and open new avenues for improving diagnostic and therapeutic tools for tuberculosis.
- | GS-441524 / Copycat Sci
Preclinical, Journal: Co-administration of Favipiravir and the Remdesivir Metabolite GS-441524 Effectively Reduces SARS-CoV-2 Replication in the Lungs of the Syrian Hamster Model. (Pubmed Central) - Mar 2, 2023
Moreover, co-administration of these drugs to naive hamsters efficiently protected them from airborne transmission of the virus from infected animals. Since both drugs are nucleotide analogs that interfere with the RNA-dependent RNA polymerases of many RNA viruses, these findings may also help encourage co-administration of antivirals to combat future pandemics.
- | antiviral therapeutics / Cyclica, Chinese Academy of Medical Sciences
Journal: Gasdermin D Inhibits Coronavirus Infection by Promoting the Noncanonical Secretion of Beta Interferon. (Pubmed Central) - Mar 2, 2023
These findings showed that GSDMD dampens coronavirus infection by an uncovered GSDMD-mediated IFN secretion, which may present a novel target of coronavirus antiviral therapeutics...We here show that alphacoronavirus TGEV triggered pyroptosis and upregulated GSDMD expression, while GSDMD broadly suppressed the infection of enteric coronavirus TGEV and PDCoV by its pore-forming activity via promoting unconventional release of IFN-?. Our study highlights the importance of GSDMD as a regulator of innate immunity and may open new avenues for treating coronavirus infection.
- | Journal: Commensal Pseudomonas fluorescens Strains Protect Arabidopsis from Closely Related Pseudomonas Pathogens in a Colonization-Dependent Manner. (Pubmed Central) - Mar 2, 2023
As we found that commensal Pseudomonas were also able to protect against an agricultural pathogen, this system may be broadly relevant for identifying strains and mechanisms to control agriculturally important pathogens. This work also suggests that beneficial plant-associated microbes may be useful for engineering soils where microbial complexity is low, such as hydroponic, or disturbed agricultural soils.
- | Journal: Inhibitory KIR2DL2 receptor and HHV-8 in classic or endemic Kaposi sarcoma. (Pubmed Central) - Feb 27, 2023
A significantly higher prevalence of KIR2DL2 in c-KS patients than in all the other subjects was also confirmed comparing age-matched groups. Based on these results, the inhibitory KIR2DL2 genotype appears to be a possible cofactor which increases the risk of developing c-KS in HHV8-positive, immunocompetent subjects, while it seems less relevant in e-KS pathogenesis.
- | Journal: Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. (Pubmed Central) - Feb 27, 2023
Due to their ChEs and hCAs inhibition, these compounds (1-7) may be considered as leads for investigations in neurodegenerative diseases. All these results revealed that the 4-amino-5,6-dichloropyrimidine (7) (K value of 0.201
- | Journal: Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants. (Pubmed Central) - Feb 17, 2022
All these results revealed that the 4-amino-5,6-dichloropyrimidine (7) (K value of 0.201 The heparin polysaccharide nanoparticles block the interaction between heparan sulfate/S protein and inhibit the infection of both wild-type SARS-CoV-2 pseudovirus and the mutated strains through pulmonary delivery.Image 1.
- || Review, Journal, Epigenetic controller: The Role of Histone Acetylation in Mesenchymal Stem Cell Differentiation. (Pubmed Central) - Feb 17, 2022
In this article, we focused on how histone acetylation may result in differentiation into mesenchymal stem cells as well as histone acetylation function. Moreover, histone acetylation followed by the action of histone deacetylase inhibitors, which can result in the differentiation of stem cells into other types of cells such as adipocytes, chondrocytes, osteocytes, neurons, and other lineages, were also reviewed.
- | acetylcysteine solution / Generic mfg.
Preclinical, Journal: N-Acetylcysteine Induces Apoptotic, Oxidative and Excitotoxic Neuronal Death in Mouse Cortical Cultures. (Pubmed Central) - Feb 17, 2022
The ROS generation was almost completely abolished by treatment with Trolox or ascorbic acid. These findings demonstrate that NAC can cause oxidative, apoptotic, and excitotoxic neuronal death in mouse neuronal cultures.
- | Avastin (bevacizumab) / Roche
Journal: Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis. (Pubmed Central) - Feb 17, 2022
Following interventions, the patient's condition gradually improved, both clinically and radiographically. Mediastinal lymph node enlargement causing dysphagia can be a presenting sign of a metastatic lesion from treated cervical cancer.A PEG tube is helpful in relieving dysphagia caused by metastatic mediastinal lymph node enlargement and as bridge for nutrition during chemotherapy.The VEGF inhibitor bevacizumab can be used in advanced metastatic cervical cancer.Check-point inhibitors like pembrolizumab can be used in metastatic cervical cancer.