- |||||||||| Journal: Bayes optimal informer sets for early-stage drug discovery. (Pubmed Central) - Jun 21, 2023
In both empirical settings BOISE exhibits better predictive performance than available methods. It also behaves well with missing data, where methods that use matrix completion show worse predictive
- |||||||||| Journal, Tumor cell: Synthesis, characterization and antiproliferative effects of naphtho [2,3-b] thiophen-4,9-quinone on bladder tumor cells. (Pubmed Central) - Jun 20, 2023
The results showed selective cytotoxicity, colonies reduction, morphological change, inhibition of the cell migration process, induction of ROS production and cell cycle arrest. Naphtho [2,3-b] thiophen-4,9-quinone presents antiproliferative activity regardless TP53 status and may be a promising agent in the treatment of bladder cancer, as they have an oxidizing effect and interfere with cell cycle.
- |||||||||| Journal: Self-regulation and Psychopathology in Young Children. (Pubmed Central) - Jun 19, 2023
Further, different sub-components of self-regulation relate to different dimensions of psychopathology in children. Interventions should target these areas in children at-risk for disorders.
- |||||||||| arecoline / Cogent Pharma
Journal: Tyrosine Sulphation of CXCR4 Induces the Migration of Fibroblast in OSF. (Pubmed Central) - Apr 21, 2023
Finally, in human OSF specimens, TPST-1 expression was directly correlated with the expression of CXCR4. These data indicate that the arecoline-induced tyrosine sulphation of CXCR4, which is regulated by TPST-1, might be a potential mechanism that contributes to FB migration in OSF.
- |||||||||| Journal: Inhibition of Rgs10 aggravates periodontitis with collagen-induced arthritis via the NF-?B pathway. (Pubmed Central) - Apr 21, 2023
These data indicate that the arecoline-induced tyrosine sulphation of CXCR4, which is regulated by TPST-1, might be a potential mechanism that contributes to FB migration in OSF. Inhibition of Rgs10 in mice with periodontitis and rheumatoid arthritis can promote the progression of periodontitis, indicating the potential therapeutic role of Rgs10 in this condition.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
Retrospective data, Review, Journal, Combination therapy: A comprehensive evaluation of the safety of ipilimumab, nivolumab and their combination therapy: A systematic review and network meta-analysis. (Pubmed Central) - Apr 3, 2023
Although phase 3 clinical trials play an important role in understanding the effectiveness and give insights on side-effect profiles, real-world studies can show the real risk of cardiotoxicity more accurately and realistically. Nivolumab 3?mg/kg biweekly, nivolumab 240?mg weekly and nivolumab 3?mg/kg plus ipilimumab 1?mg/kg triweekly could be preferred due to the relatively low risk of TRAEs, TDAEs and SAEs.
- |||||||||| sorafenib / Generic mfg.
Journal, HEOR, Cost-analysis: A cost analysis of sorafenib for desmoid tumors. (Pubmed Central) - Apr 3, 2023
Favorable RECIST outcomes were less likely and costlier. Patients should be informed of possible benefits of treatment versus potential financial burden.
- |||||||||| Journal: Computational approaches for evaluation of isobavachin as potential inhibitor against t877a and w741l mutations in prostate cancer. (Pubmed Central) - Mar 28, 2023
Based on the results of Molecular Docking, Drug-likeness, and ADMET testing, ten structures, including six complexes and three receptors were subjected to molecular dynamics simulation of 100?ns covering RMSD, RMSF, Rg, and MM/PBSA. Based on the simulation results, Isobavachin, IsoMod4, and IsoMod7 were concluded to be stable and exhibited potential properties for developing a novel drug to combat prostate cancer and its associated drug-resistance.
- |||||||||| Journal: Molecular dynamics simulations of aqueous systems of inhibitor candidates for adenosine-5'-phosphosufate reductase. (Pubmed Central) - Mar 28, 2023
RMSD, RDF, and hydrogen bonds results revelated that all ligands left the cube site, while in the active site, some ligands remained in their docking region, pointing to the enzyme active site as the best target for the selected ligands. The binding energy results of ligands hydroxamic acid (HXA) and catechol (CAT) showed that they bonded favorably to the enzyme and key residues of the active site contributed significantly to the protein-ligand bind, indicating HAX and CAT may compete with the substrate for interactions with these residues and displaying potential as candidates for experimental studies about APSrAB inhibitors.Communicated by Ramaswamy H. Sarma.
- |||||||||| Journal: Treating to Target Glycaemia in Type 2 Diabetes Pregnancy. (Pubmed Central) - Mar 27, 2023
Knowledge of the epidemiology, pathophysiology and unique management considerations of early-onset type 2 diabetes is essential to provide evidence-based care to pregnant women with type 2 diabetes. This narrative review will discuss contemporary data regarding type 2 diabetes pregnancy outcomes and the increasing recognition that different types of diabetes may require different treatment strategies before, during and after pregnancy.
- |||||||||| Journal: Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles. (Pubmed Central) - Mar 21, 2023
This narrative review will discuss contemporary data regarding type 2 diabetes pregnancy outcomes and the increasing recognition that different types of diabetes may require different treatment strategies before, during and after pregnancy. Our findings show a novel EV-dependent mechanism for the rapid mobilization of neutrophils to peripheral blood from a splenic reserve and establish a proof of concept for functional manipulation of EV-communications through genetic alteration of parent cells.
- |||||||||| Review, Journal: The role of non-ionizing electromagnetic radiation on female fertility: A review. (Pubmed Central) - Mar 16, 2023
Non-ionizing radiation also upsurges the free radical load in the uterus and ovary, which leads to inhibition of cell growth and DNA disruptions. In conclusion, non-ionizing electromagnetic radiations can cause alterations in both germ cells as well as in their nourishing environment and also affect other female reproductive parameters that might lead to infertility.
- |||||||||| Journal: Degradation of rhodamine B by persulfate activated with green tea iron nanoparticles. (Pubmed Central) - Mar 16, 2023
A possible RhB degradation pathway was the chromophore destruction and ring-opening processes using GT-Fe NPs/PS, which produced a range of low molecular weight carboxylic acids (oxalic acid, lactic acid, acetic acid, and formic acid). GT-Fe NPs seem to be a promising persulfate activator in comparison to common activators such as CA-Fe.
- |||||||||| Journal: A Central Role for Magnesium Homeostasis during Adaptation to Osmotic Stress. (Pubmed Central) - Mar 2, 2023
These coordinated fluxes of K and Mg are orchestrated by cyclic-di-AMP, an essential second messenger in Firmicutes. These findings amend the conventional model for osmoadaptation and reveal that Mg limitation is the proximal cause of the bacteriostasis that precedes resumption of growth.
- |||||||||| Journal: Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection. (Pubmed Central) - Mar 2, 2023
In this work, we show that interfering with either the synthesis or attachment of spike N-glycans significantly reduces the spread of SARS-CoV-2 infection in vitro, including that of several variants. As new SARS-CoV-2 variants, with various degrees of resistance against current vaccines, are likely to continue appearing, halting virus glycosylation using repurposed human drugs could result in a complementary strategy to reducing the spread of COVID-19 worldwide.
- |||||||||| Journal: Dissecting the Structural and Conductive Functions of Nanowires in Geobacter sulfurreducens Electroactive Biofilms. (Pubmed Central) - Mar 2, 2023
However, their structural contributions to electron transfer in anode biofilm have not been elucidated. Based on studies of mutants lacking one or more of these facilitators, our results support a cytochrome-mediated electron transfer process in Geobacter biofilms and highlight the structural contribution of nanowires in anode biofilm formation, which contributes to biofilm formation and current generation, thereby providing a strategy to increase current generation.
- |||||||||| Journal: Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets. (Pubmed Central) - Mar 2, 2023
Utilizing a genome-wide functional analysis in a fission yeast cell-based system, we identified 12 viral candidates, including ORF3a, which cause cellular oxidative stress, inflammation, apoptosis, and necrosis that contribute to cytopathogenicity and COVID-19. Our findings indicate that antiviral agents targeting ORF3a could have a great impact on COVID-19.
- |||||||||| Journal: Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth. (Pubmed Central) - Mar 2, 2023
This study provides evidence that the pathogenic fungus C. albicans communicates with human monocytes and induces the release of a human miRNA that promotes fungal growth. This mechanism represents an unexpected cross-species interaction and implies that an inhibition of specific miRNAs offers new possibilities for the treatment of human fungal infections.
- |||||||||| antiviral therapeutics / Cyclica, Chinese Academy of Medical Sciences
Journal: Gasdermin D Inhibits Coronavirus Infection by Promoting the Noncanonical Secretion of Beta Interferon. (Pubmed Central) - Mar 2, 2023
These findings showed that GSDMD dampens coronavirus infection by an uncovered GSDMD-mediated IFN secretion, which may present a novel target of coronavirus antiviral therapeutics...We here show that alphacoronavirus TGEV triggered pyroptosis and upregulated GSDMD expression, while GSDMD broadly suppressed the infection of enteric coronavirus TGEV and PDCoV by its pore-forming activity via promoting unconventional release of IFN-?. Our study highlights the importance of GSDMD as a regulator of innate immunity and may open new avenues for treating coronavirus infection.
- |||||||||| Journal: Inhibitory KIR2DL2 receptor and HHV-8 in classic or endemic Kaposi sarcoma. (Pubmed Central) - Feb 27, 2023
A significantly higher prevalence of KIR2DL2 in c-KS patients than in all the other subjects was also confirmed comparing age-matched groups. Based on these results, the inhibitory KIR2DL2 genotype appears to be a possible cofactor which increases the risk of developing c-KS in HHV8-positive, immunocompetent subjects, while it seems less relevant in e-KS pathogenesis.
- |||||||||| Journal: Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants. (Pubmed Central) - Feb 17, 2022
All these results revealed that the 4-amino-5,6-dichloropyrimidine (7) (K value of 0.201 The heparin polysaccharide nanoparticles block the interaction between heparan sulfate/S protein and inhibit the infection of both wild-type SARS-CoV-2 pseudovirus and the mutated strains through pulmonary delivery.Image 1.
- |||||||||| Review, Journal, Epigenetic controller: The Role of Histone Acetylation in Mesenchymal Stem Cell Differentiation. (Pubmed Central) - Feb 17, 2022
In this article, we focused on how histone acetylation may result in differentiation into mesenchymal stem cells as well as histone acetylation function. Moreover, histone acetylation followed by the action of histone deacetylase inhibitors, which can result in the differentiation of stem cells into other types of cells such as adipocytes, chondrocytes, osteocytes, neurons, and other lineages, were also reviewed.
- |||||||||| Avastin (bevacizumab) / Roche
Journal: Dysphagia as a Rare Presentation of Cervical Cancer with Mediastinal Metastasis. (Pubmed Central) - Feb 17, 2022
Following interventions, the patient's condition gradually improved, both clinically and radiographically. Mediastinal lymph node enlargement causing dysphagia can be a presenting sign of a metastatic lesion from treated cervical cancer.A PEG tube is helpful in relieving dysphagia caused by metastatic mediastinal lymph node enlargement and as bridge for nutrition during chemotherapy.The VEGF inhibitor bevacizumab can be used in advanced metastatic cervical cancer.Check-point inhibitors like pembrolizumab can be used in metastatic cervical cancer.
- |||||||||| Journal: Advanced HIV Infection in Treatment-Naïve Individuals: Effectiveness and Persistence of Recommended 3-Drug Regimens. (Pubmed Central) - Feb 17, 2022
Compared with B/F/TAF, bDRV initiators were statistically less likely to suppress to <50 copies/mL (aHR, 0.72; 95% CI, 0.52-0.99) and <200 copies/mL (aHR, 0.55; 95% CI, 0.43-0.70); no statistically significant difference was detected with DTG or EVG/c. Among people with advanced HIV infection, those initiating B/F/TAF were less likely to discontinue/modify their regimen than those on any other regimen, and more likely to achieve viral suppression compared with those on bDRV but not compared with those on other integrase inhibitors.
- |||||||||| Journal: Contribution of Biologic Response Modifiers to the Risk of Coccidioidomycosis Severity. (Pubmed Central) - Feb 17, 2022
AI does not increase the risk of any specific CM clinical presentation, and BRM treatment of most AI patients does not lead to severe CM. However, BRMs significantly increase the risk of DCM, and prospective studies are needed to identify the immunogenetic subset that permits BRM-associated DCM.
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