CHRM5 antag 
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  • ||||||||||  Journal:  Recessive CHRM5 variant as a potential cause of neurogenic bladder. (Pubmed Central) -  Jul 19, 2023   
    However, functional in vitro studies did not reveal evidence to strengthen the status as a candidate gene. Discovering additional families with CHRM5 variants could help to further assess the genes' candidate status.
  • ||||||||||  Muscarinic M5 receptor modulates DAT through G protein βϒ subunits (SDCC Halls B-H) -  Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_2663;    
    Similar experiments in the M5R KO mice are in progress. Collectively, these results suggest that M5R is expressed in the terminal of dopamine fibers and may interact with the DAT through Gβϒ subunits.
  • ||||||||||  Journal:  Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder. (Pubmed Central) -  Sep 13, 2022   
    Tissue-specific genes of the prefrontal cortex (PFC) in MDD-, such as IGFBP2 and HTR1A, were involved in disease-related functions, such as response to glucocorticoid, taste transduction, and tissue-specific genes of PFC in BP-, such as CHRM5 and LTB4R2, were involved in neuroactive ligand-receptor interaction. We also found PFC tissue-specific genes including SST and CRHBP were shared in MDD-BP, SST was enriched in neuroactive ligand-receptor interaction, and CRHBP shown was related to the regulation of hormone secretion and hormone transport.
  • ||||||||||  Journal:  Genetic diversity and selection in Puerto Rican horses. (Pubmed Central) -  Feb 25, 2022   
    The lack of the detectable signature of selection associated with the DMRT3 in the PRPF would be expected if this native breed was originally derived from the genetic pool of PRNPB horses established earlier and most of the founders already had the mutant allele. Consequently, selection specific to PRPF later focused on allels in other genes (including CHRM5, CYP2E1, MYH7, SRSF1, PAM, PRN and others) that have not been previously associated with the prized paso gait phenotype in Puerto Rico or anywhere else.
  • ||||||||||  Intensive Care Unit delirium is associated with impaired expression of key genes that regulate Rapid Eye Movement sleep and circadian rhythm (Virtual Only) -  Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_5843;    
    These sleep-wake changes were associated with impaired expression of BDNF, Chrm1 and Chrm3 , key genes for the regulation of circadian rhythm and REM sleep. The changes in circadian rhythm and REM sleep induced by A/S/I are consistent with those experienced by patients with ICU delirium, and support the use of our animal model for future mechanistic studies on the role of sleep disturbances in the pathogenesis of delirium.; Grant Support: Department Of Anesthesiology, University of Virginia Health Systems
  • ||||||||||  tamoxifen / Generic mfg.
    Journal:  Regulation of the Muscarinic M Receptor by Myocardin-Related Transcription Factors. (Pubmed Central) -  Sep 21, 2021   
    Accordingly, MRTF-B conferred responsiveness to the muscarinic agonist carbachol in Ca imaging experiments...Tamoxifen inducible knockout of Srf in smooth muscle reduced Srf (by 54±4%) and Chrm3 (by 41±6%) in the urinary bladder at 10days, but Srf was much less reduced or unchanged in aorta, ileum, colon, trachea, and esophagus...Single cell RNA-sequencing revealed that Mrtfb dominates in ECs, while Myocd dominates in SMCs, raising the possibility that Chrm3 may be driven by Mrtfb-Srf in the endothelium and by Myocd-Srf in SMCs. These findings define a novel transcriptional control mechanism for muscarinic M receptors in human cells, and in mice, that could be targeted for therapy.
  • ||||||||||  Race, copy number variation, and local hog concentration in breast cancer mortality (Virtual Meeting II: E-Posters) -  May 16, 2020 - Abstract #AACRII2020AACR-II_3435;    
    Besides, atropine had no effect on adipogenic and osteogenic differentiation of MSCs. Our findings suggest that living in a county with a high concentration of hogs may increase breast cancer mortality risk among AA women, and the high frequency of CNVs varies by race; both CNV and county hog concentration may contribute to racial disparities in breast cancer mortality among AA and EA women in North Carolina.
  • ||||||||||  Journal:  Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates. (Pubmed Central) -  Apr 20, 2019   
    Not a single separate (nontetraploidization) duplicate has been identified in any vertebrate species. These results clarify the evolution of the vertebrate mAChR family and reveal a doubled repertoire in zebrafish, inviting studies of gene neofunctionalization and subfunctionalization.